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Fibromatosis-like metaplastic carcinoma of the breast:Two case reports
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作者 Wei-Yu Bao Jiang-Hong Zhou +1 位作者 Yan Luo Yun Lu 《World Journal of Clinical Cases》 SCIE 2023年第18期4384-4391,共8页
BACKGROUND Fibromatosis-like metaplastic carcinoma is classified as a rare type of metaplastic carcinoma of the breast by the 2012 WHO pathological and genetic classification criteria for breast tumors,which takes hyp... BACKGROUND Fibromatosis-like metaplastic carcinoma is classified as a rare type of metaplastic carcinoma of the breast by the 2012 WHO pathological and genetic classification criteria for breast tumors,which takes hyperplastic spindle cells as the main component and is often misdiagnosed as benign stromal proliferative lesions or benign mesenchymal tumors of the breast because of its mild morphology.Here,we collected the clinical data of 2 cases of fibromatosis-like metaplastic carcinoma of the breast and performed pathomorphological observation and immunohistochemical staining of the surgically resected specimens.According to the clinical features,imaging features,immunophenotype,diagnosis and differential diagnosis of 2 cases of fibromatosis-like metaplastic carcinoma of the breast,it was further differentiated.CASE SUMMARY Case 1:A 56-year-old postmenopausal female was admitted due to"right breast mass for over 1 year and local ulceration for over 1 mo".Physical examination showed a mass with a diameter of 4.5 cm×5.5 cm palpable at 2.5 cm from the nipple at 1 o'clock in the right breast.The skin on the surface of the mass ruptured about 3 cm,with a small amount of exudation and bleeding,less clear boundary,hard texture,fair activity,without obvious tenderness.No obvious abnormality was palpable in the left breast.No enlarged lymph nodes were palpable in the bilateral axillae and bilateral supraclavicular region.After removing the mass tissue,it was promptly sent to the pathology department for examination.Case 2:Female,52-years-old,premenopausal,admitted due to"right breast mass for more than 3 mo".Physical examination showed a 4.0 cm×4.0 cm diameter mass palpable at 2.0 cm of the nipple in the lower outer 7 o'clock direction of the right breast,with less clear boundary,hard texture,fair activity,no significant tenderness,no palpable significant abnormalities in the left breast,and no palpable enlarged lymph nodes in the bilateral axillae and bilateral supraclavicular region.The mass was resected and sent for pathological examination.Postoperative pathological examination revealed fibromatosis-like metaplastic carcinoma of the breast in both patient 1 and patient 2.No systemic therapy and local radiotherapy were performed after surgery,and no tumor recurrence or metastasis was observed.CONCLUSION Fibromatosis-like metaplastic carcinoma of the breast is a rare subtype of metaplastic carcinoma that is often misdiagnosed,and the diagnosis relies on medical history collection,complete sampling,and full use of immunohistochemical assessment.The risk of lymph node and distant metastasis is low,and the current treatment is based on complete surgical resection.The efficacy of systemic radiotherapy and chemotherapy is not clear. 展开更多
关键词 Breast cancer Fibromatosis-like metaplastic carcinoma metaplastic carcinoma Spindle cell lesion PATHOLOGY
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Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital 被引量:6
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作者 Hailiang Tang Huaping Sun +17 位作者 Hong Chen Ye Gong Ying Mao Qing Xie Liqian Xie Mingzhe Zheng Daijun Wang Hongda Zhu Xiaoming Che Ping Zhong Kang Zheng Shiqi Li Weimin Bao Jianhong Zhu Xuanchun Wang Xiaoyuan Feng Xiancheng Chen Liangfu Zhou 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第1期112-118,共7页
Objective: Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the cl... Objective: Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases. Methods: 15 patients underwent surgical treatment for intracranial metaplastic meningioma between 2001 and 2010 at Neurosurgery Department of Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, treatment strategy, pathological findings and prognosis of all patients were analyzed retrospectively. Results: Among the 15 cases (10 males and 5 females), the age ranged from 22 to 74 years old (the mean age was 50.67-year old). The clinical manifestations include headache, dizziness, seizure attack, vision decrease, and weakness of bilateral lower limbs. All the patients received surgical treatment, combined with radiotherapy in some cases. In the follow-up period, recurrence occurred in 2 cases, of which 1 patient died of other system complications. Conclusions: Metaplastic meningiomas are characterized by focal or widespread mesenchymal differentiation with formation of bone, cartilage, fat, and xanthomatous tissue elements. Surgical removal is the optimal therapy, and the overall prognosis is well. But recurrence may occur in some cases, thus radiotherapy is necessary for such kind of patients. 展开更多
关键词 metaplastic meningioma FOLLOW-UP mesenchymal differentiation
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Metaplastic breast cancer with chondrosarcomatous differentiation combined with concurrent bilateral breast cancer:A case report 被引量:1
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作者 Si-Yuan Yang Yang Li +4 位作者 Jian-Yun Nie Shou-Tao Yang Xiao-Juan Yang Mao-Hua Wang Ji Zhang 《World Journal of Clinical Cases》 SCIE 2022年第15期5064-5071,共8页
BACKGROUND Metaplastic breast carcinoma(MBC)is a rare subtype of invasive breast cancer comprising malignant epithelial and mesenchymal cells.Compared with other invasive breast cancers,MBC is not only histologically ... BACKGROUND Metaplastic breast carcinoma(MBC)is a rare subtype of invasive breast cancer comprising malignant epithelial and mesenchymal cells.Compared with other invasive breast cancers,MBC is not only histologically distinctly heterogeneous but also has a rapid and aggressive growth pattern,which leads to a significant risk of recurrence and mortality.CASE SUMMARY In this study,we report the case of a patient with a large left breast mass diagnosed with bilateral invasive ductal carcinoma in both breasts after a preoperative core needle aspiration biopsy of the bilateral breast mass.The patient received neoadjuvant chemotherapy and underwent bilateral breast modified radical mastectomy.Postoperative pathology suggested carcinosarcoma with predominantly chondrosarcoma in the left breast and invasive ductal carcinoma(luminal B)in the right breast.As the patient did not achieve complete pathological remission after six cycles of neoadjuvant chemotherapy,we administered six months of intensive capecitabine treatment.Then the patient was switched to continuous treatment with endocrine therapy using letrozole+goserelin,and the patient is currently in stable condition.However,as MBC of the breast is concurrently diagnosed with chondrosarcoma differentiation,our case is sporadic.CONCLUSION Given the variety of immunohistochemical types of bilateral breast cancer,achieving effective chemotherapy should be a key research focus. 展开更多
关键词 metaplastic breast cancer Invasive ductal carcinoma CARCINOSARCOMA Chondrosarcoma differentiation Bilateral breast cancer Case report
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Clinicopathological Study of Epithelial Metaplastic Breast Cancer 被引量:1
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作者 Masahiro Kitada Shunsuke Yasuda +3 位作者 Nana Takahashi Satoshi Okazaki Kei Ishibashi Satoshi Hayashi 《Journal of Cancer Therapy》 2016年第13期1039-1044,共7页
Introduction: Metaplastic breast cancer (MBC) is a rare pathological type with an incidence rate of not more than 1%, and has been reported to be often detected after its progression and highly malignant with a high p... Introduction: Metaplastic breast cancer (MBC) is a rare pathological type with an incidence rate of not more than 1%, and has been reported to be often detected after its progression and highly malignant with a high proportion of triple negative type tumors, with poor outcomes as compared to IDC [1] [2] [3]. We analyzed clinicopathological characteristics of patients who underwent surgery for epithelial MBC at our department. Patients and Methods: From January 2000 to March 2014, a total of 2120 patients underwent surgery for breast cancer, and MBC was diagnosed in 15 of these patients. Fourteen of the 15 had epithelial MBC and were included in this study. The present study compared clinopathological characteristics of MBC with those of IDC of triple negative type (TN type group) and IDC of non-triple negative type (IDC group). Results: Breast conserving surgery was performed in 7 patients with MBC (50%), a proportion clearly lower than the 64.3% in the IDC group. The mean tumor size was 3.8 cm, which was greater than the 2.13 cm in the TN type group and the 1.7 cm in the IDC group. About nuclear grade, the proportion of grade III was 57.1%, markedly higher than the 38.6% in the TN type group and the 12.6% in the IDC group. All patients were estrogen receptor (ER) and progesterone receptor (PgR) negative;11 patients were TN type tumors and 3 were HER2 type. Conclusion: We studied patients who underwent surgery for epithelial MBC. The examined cases showed clinopathological characteristics of the disease, including large tumors with a highly malignant nature at the initial detection, higher Ki-67 levels, ER and PgR negativity (all cases), mostly TN type, and a high recurrence rate. 展开更多
关键词 Breast Cancer metaplastic Breast Cancer Triple Negative Type Epithelial-Mesenchymal Transition
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Male metaplastic breast cancer with poor prognosis:A case report
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作者 Hyun Yul Kim Seungju Lee +5 位作者 Dong-il Kim Chang Shin Jung Jee Yeon Kim Kyung Jin Nam Ki Seok Choo Youn Joo Jung 《World Journal of Clinical Cases》 SCIE 2022年第15期4964-4970,共7页
BACKGROUND Metaplastic breast cancer(MBC)is a rare subtype of breast cancer.They constitute less than 1%of breast cancer cases and are much rarer in males.There are few reports of MBC because of its rarity.MBC,an aggr... BACKGROUND Metaplastic breast cancer(MBC)is a rare subtype of breast cancer.They constitute less than 1%of breast cancer cases and are much rarer in males.There are few reports of MBC because of its rarity.MBC,an aggressive type of cancer,is refractory to common treatment modalities of breast cancer and has a poor prognosis.CASE SUMMARY We report a case of MBC in a 78-year-old man.He visited our clinic with a palpable mass on the left breast with no masses in the axillary areas.He had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer,but there was no family history of malignancy.The breast mass was visible on ultrasonography,mammography,and magnetic resonance imaging,and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower lobe.The patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung metastasis.Total mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was performed.However,multiple metastases appeared 3 mo after surgery in the brain,chest,and abdomen,and the patient died 5 mo after the initial diagnosis.CONCLUSION MBC is an aggressive and extremely rare breast cancer type.Further case reports are needed to determine the optimal treatment. 展开更多
关键词 Breast neoplasm MALE Triple-negative breast cancer metaplastic breast cancer Adjuvant treatment Case report
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Metaplastic Carcinoma of the Breast: A Clinical Study of 7 Cases from Balochistan
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作者 Abdul Hameed Baloch Shakeela Daud +7 位作者 Jameela Shuja Adeel Ahmad Fateh Ali Mohammad Akram Dost Mohammad Baloch Abdul Majeed Cheema Mohammad Iqbal Jamil Ahmad 《Advances in Breast Cancer Research》 2014年第3期106-110,共5页
Metaplastic carcinomas of the breast are rare heterogenous neoplasms characterized by adenocarcinoma with dominant areas of spindle cells, squamous and/or other mesenchymal differentiation, that comprise of <5% of ... Metaplastic carcinomas of the breast are rare heterogenous neoplasms characterized by adenocarcinoma with dominant areas of spindle cells, squamous and/or other mesenchymal differentiation, that comprise of <5% of all invasive breast cancers. Our objective in this study was to review the pathological features and clinical outcomes for metaplastic carcinoma of breast in breast cancer patients registered in CENAR (Center for Nuclear Medicines and Radiotherapy), Balochistan. Present study was performed on 7 patients affected with metaplastic carcinoma of breast, who were registered patients in CENAR. Informed consent was taken from the patients and BMI was calculated by measuring the height and weight of the patients. Available clinical history obtained by retrieving the patients file and a copy of biopsy report was also obtained from the file. Metaplastic carcinoma of breast was 4.11% of all 170 breast cancer cases registered in CENAR from 2010-2012. Mean age was 40 years ranging from 25 - 50 years. Four subtypes of metaplastic carcinoma of breast were reported in this study;DCIS component was present in one case and mean tumor size was 6.12 cm ranging from 3.5 - 10 cm. Metaplastic carcinomas of breast are rare heterogenous neoplasm with different characteristics, demographics and tumor biology and accounts for almost >5% of all breast cancer cases. 展开更多
关键词 BREAST Cancer metaplastIC CARCINOMA of BREAST CENAR BALOCHISTAN BMI MBC
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Special Features of Metaplastic Breast Cancer in Tunisian Women
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作者 Raja Briki Ons Cherif +4 位作者 Mouna Derouich Anouar Chaieb Sassi Boughizane Abdeljalil Khlifi Hedi Khairi 《Open Journal of Obstetrics and Gynecology》 2018年第13期1310-1323,共14页
Introduction: Metaplastic breast carcinomas are a rare, heterogeneous group of breast malignancies characterized by an intrinsically aggressive histology and an unfavorable prognosis. Objective: To determine the clini... Introduction: Metaplastic breast carcinomas are a rare, heterogeneous group of breast malignancies characterized by an intrinsically aggressive histology and an unfavorable prognosis. Objective: To determine the clinical and pathological characteristics of metaplastic breast cancers in Tunisian patients, and evaluate their impact on its evolution. Methods: A retrospective study of 44 cases of metaplastic cancers archived during a 26-year period in the Cancer Registry of the Tunisian Center. Results: The frequency of metaplastic cancer was 0.97%. Mean age at diagnosis was 55.4 years (range 26 - 84). Average time to diagnosis was 5.5 months. Average clinical tumor size was 4.95 cm (range 1.5 - 15). Axillary ipsilateral adenopathy was present at diagnosis in 45.9%. The clinical stages IIB (31.8%) and IIA (22.7%) predominated. Squamous metaplasia was the most common (68%) followed by the heterologous mesenchymal subtype. Ganglionic invasion was histologically proven in 17 cases, of which 77% had only adenocarcinomatous contingents. Absence of hormone receptor expression and HER2 overexpression predominated. Primary surgery was carried out in 95% of cases. Average follow-up was 40 months (range 2 - 135). Average overall survival (OS) was 74 months, 63% at 5 years and 60% at 10 years. Average progression free survival (PFS) was 29 months (range 3 - 129), 38% at 5 years and 32% at 10 years. Factors significantly influencing OS and PFS were histological lymph node involvement (p = 0.001 and p = 0.002 respectively). Conclusion: Metaplastic breast cancer observed in Tunisian women constitutes a histological type with an unfavorable prognosis whose improvement requires a more adapted therapeutic strategy. 展开更多
关键词 BREAST metaplastIC Cancer PATHOLOGY PROGNOSIS
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Metaplastic meningioma with pure and extensive cartilaginous transformation: A diagnostic dilemma
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作者 Oumar Coulibaly Justin Onen +8 位作者 Amal Harmouch Boutarbouh Majhouba Adil Melhaoui Yasser Arkha Loubna Rifi Said Derraz Sanaa Sefiani Abdessamad El Ouahabi Abdeslam El Khamlichi 《Case Reports in Clinical Medicine》 2013年第7期390-394,共5页
Meningiomas are the most common extra-axial central nervous system tumours and often discovered in the middle to late adult life and especially in women. About 85%-90% of meningiomas are benign, 5%-10% are intermediat... Meningiomas are the most common extra-axial central nervous system tumours and often discovered in the middle to late adult life and especially in women. About 85%-90% of meningiomas are benign, 5%-10% are intermediate-grade, and 3%-5% are malignant. Metaplastic meningioma is a rare subtype of WHO Grade I meningioma histologically characterized by the presence of mesenchymal components. The presence of pure and extensive cartilaginous differentiation in meningiomas is extremely rare and remains a diagnostic dilemma. We report, perhaps the first case of this entity in a 52-year-old woman and discuss the pathogenesis, the imaging features and the histopathologicals data. 展开更多
关键词 MENINGIOMA metaplastic Meningioma Pure Cartilaginous Differentiation Diagnostic Dilemma
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Metaplastic carcinoma of the right breast and simultaneous giant ovarian teratoma:a case report 被引量:1
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作者 Shuang Li Qing-Zhu Wei 《Chinese Journal of Cancer》 SCIE CAS CSCD 2012年第10期500-504,共5页
We describe here a female patient who presented with a breast mass and giant abdominal mass.Fine needle aspiration cytology of the breast mass and histological examination after modified radical mastectomy confirmed m... We describe here a female patient who presented with a breast mass and giant abdominal mass.Fine needle aspiration cytology of the breast mass and histological examination after modified radical mastectomy confirmed metaplastic carcinoma of the breast.The epithelial components were formed by infiltrating ductal carcinoma with poor differentiation,and the sarcomatous components were formed by fibrosarcoma and osteosarcoma.Histological examination of the abdominal mass confirmed ovarian teratoma.The patient underwent modified radical mastectomy of the right breast and laparoscopic excision of the abdominal mass in the lower right quadrant.Having underwent six courses of chemotherapy,the patient is now in her tenth month after surgery and under follow-up,and she has no relapsed disease.These two diseases have never seen in one patient before.The case we report here provides some new data for research and clinical experience and it may also provide a new insight into the relationship between metaplastic breast carcinoma and ovarian teratoma. 展开更多
关键词 乳房肿块 乳腺癌 畸胎瘤 病例报告 卵巢 病理组织学检查 纤维肉瘤 分化程度
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Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple‐negative breast cancer
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作者 Yue Song Guiying Bai +5 位作者 Xiaoqing Li Liyan Zhou Yiran Si Xiaohui Liu Yilin Deng Yehui Shi 《Cancer Innovation》 2023年第5期376-390,共15页
Background:Metaplastic breast carcinoma(MBC)is a rare breast cancer subtype;most cases are triple‐negative breast cancers(TNBCs)and are poorly responsive to conventional systemic therapy.Few potential diagnostic and ... Background:Metaplastic breast carcinoma(MBC)is a rare breast cancer subtype;most cases are triple‐negative breast cancers(TNBCs)and are poorly responsive to conventional systemic therapy.Few potential diagnostic and prognostic markers for distinguishing between metaplastic TNBC and nonmetaplastic TNBC have been discovered.We performed bioinformatic analysis to explore the underlying mechanism by which metaplastic TNBC differs from nonmetaplastic TNBC and provides potential pathogenic genes of metaplastic TNBC.Methods:Differentially expressed genes(DEGs)in metaplastic tumors and nonmetaplastic tumors from TNBC patients were screened using GSE165407.The GSE76275 data set and The Cancer Genome Atlas(TCGA)database were used to screen DEGs in TNBC and non‐TNBC.Metascape and DAVID were used for the Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and Gene Ontology(GO)analysis of DEGs.Online databases,including UALCAN,GEPIA,HPA,Breast Cancer Gene‐Expression Miner,and quantitative PCR and western blot,were used to examine KLK5 messenger RNA and protein expression in breast cancer.Analysis of KLK5‑associated genes was performed with TCGA data,and the LinkedOmics database was used to detect the genes co‐expressed with KLK5.STRING(Search Tool for the Retrieval of Interacting Genes)and Cytoscape were used to screen for hub genes.Kaplan‑Meier plotter was used for survival analysis.Results:KLK5 was identified among the DEGs in nonmetaplastic TNBC and metaplastic TNBC.The KLK5 gene was overexpressed in nonmetaplastic TNBC but downregulated in metaplastic TNBC.KEGG and GO analyses revealed that epithelial‐to‐mesenchymal transition was a pathogenic mechanism in metaplastic TNBC and an important pathway by which KLK5 and its associated genes DSG1and DSG3 influence metaplastic TNBC progression. Prognosis analysis showedthat only low expression of KLK5 in metaplastic TNBC had clinical significance.Conclusion: Our research indicated that KLK5 may be a pivotal moleculewith a key role in the mechanism of tumorigenesis in metaplastic TNBC. 展开更多
关键词 bioinformatics analysis differentially expressed genes EMT KLK5 metaplastic breast carcinoma
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形态学不典型的化生型胸腺瘤1例并文献复习
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作者 王金文 孔梅 《临床与病理杂志》 CAS 2024年第3期483-487,共5页
化生型胸腺瘤(metaplastic thymoma,MT)是一类罕见类型的胸腺瘤,目前国内外多以小规模研究和个案报道对经典组织学形态的MT进行总结。现报道1例形态学不典型的MT,患者,男,44岁,因“体检发现纵隔肿物1月余”入院。影像学提示纵隔占位,患... 化生型胸腺瘤(metaplastic thymoma,MT)是一类罕见类型的胸腺瘤,目前国内外多以小规模研究和个案报道对经典组织学形态的MT进行总结。现报道1例形态学不典型的MT,患者,男,44岁,因“体检发现纵隔肿物1月余”入院。影像学提示纵隔占位,患者于2022年10月在浙江大学医学院附属第一医院行“纵隔肿物切除术”,大体观:灰黄脂肪样组织一块,切面见一灰白肿物,质稍硬,界限尚清。镜检示:低倍镜下肿瘤呈结节状,无明显纤维包膜,未见分叶状结构,血管周围间隙不明显,区域可见少量胶原纤维分隔;高倍镜下深染区由丰富的上皮样细胞和少许胖梭形细胞组成,背景中仅见少许淋巴细胞,部分瘤细胞呈漩涡状结构伴鳞状分化。免疫组织化学染色示:P40、P63、细胞角蛋白19(cytokeratin 19,CK19)和广谱角蛋白(cytokeratin-pan,CK-pan)阳性,黏蛋白-1(mucin-1,MUC-1)和波形蛋白(vimentin)少量阳性,CD3、CD5少量T淋巴细胞阳性,P53部分弱至中等阳性,β-联蛋白膜阳性,CD20、CD117、配对框8(paired box protein 8,PAX-8)、嗜铬粒蛋白A(chromogranin A,CgA)、突触素(synapsin,Syn)、末端脱氧核苷酸转移酶(terminal transferase,TdT)、信号转导及转录激活因子(signal transducer and activator of transcription,STAT)6和睾丸核蛋白(nuclear protein of the testis,NUT)均阴性,细胞增殖指数Ki-67低表达。YES关联蛋白1-主导控制样转录激活蛋白2(Yes associated protein 1-mastermind like transcriptional coactivator 2,YAP1-MAML2)融合基因荧光原位杂交检测结果为阳性。术后病理诊断为MT。Masaoka分期为Ⅱ期。患者术后予6次放射治疗,随访14个月为无病生存状态。 展开更多
关键词 化生型胸腺瘤 病理特征 YAP1-MAML2基因
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化生性乳腺癌临床病理特征及诊疗分析
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作者 郜海涛 魏娅 《现代医药卫生》 2024年第17期2931-2935,共5页
目的探讨化生性乳腺癌(MpBC)的临床病理特征和疗效。方法回顾性分析2014年1月至2022年12月该院收治的46例经病理检查证实的MpBC患者临床资料,分析其临床病理学特征、疗效和生存状况。中位随访时间50.9个月。结果46例患者均为女性,中位年... 目的探讨化生性乳腺癌(MpBC)的临床病理特征和疗效。方法回顾性分析2014年1月至2022年12月该院收治的46例经病理检查证实的MpBC患者临床资料,分析其临床病理学特征、疗效和生存状况。中位随访时间50.9个月。结果46例患者均为女性,中位年龄52岁。80.4%(37/46)的患者分子亚型为三阴性,梭形细胞癌是最常见的组织学亚型[32.6%(15/46)]。46例患者均进行手术治疗,最常见的远处转移是肺部[57.1%(8/14)]。3、5年无进展生存率分别为78.0%、61.3%,3、5年总生存率分别为82.9%、64.3%。肿瘤病理分级3级、淋巴结转移、细胞核增殖抗原-67(Ki-67)>50%为MpBC患者预后的危险因素(P<0.05);Ki-67>50%为MpBC患者预后的独立危险因素(P<0.05)。结论MpBC病程进展快,总生存状况较差,手术切除是MpBC的首选治疗方法,Ki-67>50%是其预后的独立危险因素。 展开更多
关键词 化生性乳腺癌 临床病理特征 诊断 治疗 预后
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超声检查征象logistics回归鉴别乳腺化生性癌和浸润性导管癌
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作者 符凤妹 方锋凯 符妹垂 《医学影像学杂志》 2024年第5期82-86,共5页
目的 探讨乳腺病变超声检查征象在乳腺化生性癌和浸润性导管癌中的鉴别诊断价值。方法 选取在我院经手术病理证实的117例乳腺肿瘤患者的超声声像图,根据病理结果分为化生性癌组36例和浸润性导管癌组81例,就其超声检查征象进行单因素分析... 目的 探讨乳腺病变超声检查征象在乳腺化生性癌和浸润性导管癌中的鉴别诊断价值。方法 选取在我院经手术病理证实的117例乳腺肿瘤患者的超声声像图,根据病理结果分为化生性癌组36例和浸润性导管癌组81例,就其超声检查征象进行单因素分析,将超声检查征象中有统计学意义的参数设为自变量进行Logistic回归分析。结果 单因素分析显示,超声检查肿瘤大小、回声类型、后方回声和生长方位在鉴别乳腺化生性癌和浸润性导管癌中差异均有统计学意义(P<0.05);多因素中肿瘤大小、回声类型、后方回声和生长方位是鉴别二者的独立影响因素,建立的回归方程为:Logistic (Y)=-2.209+1.335X1+2.186X2-1.149X3-1.734X4 (X1:肿瘤大小;X2:回声类型;X3:后方回声;X4:生长方位),ROC曲线下面积0.901,Logistic回归模型鉴别乳腺化生性癌和浸润性导管癌的灵敏度、特异度、准确率分别是61.1%、96.3%和87.2%。结论 多因素分析在鉴别乳腺化生性癌和浸润性导管癌中有较好的诊断效能,超声检查显示肿瘤大小、回声类型、后方回声和生长方位可作为综合判断二者的可靠指标。 展开更多
关键词 乳腺癌 浸润性导管癌 乳腺化生性癌 超声检查
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乳腺浸润性导管癌新辅助化疗后转化为化生性鳞状细胞癌1例并文献复习
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作者 秦亚萍 付悦 +4 位作者 肖楚蓉 伍金凤 唐娟 陈灵凤 肖胜军 《现代肿瘤医学》 CAS 2024年第9期1638-1642,共5页
目的:探讨新辅助化疗后病理类型转化为化生性鳞状细胞癌(metaplasia squamous cell carcinoma,MSCC)的乳腺浸润性导管癌临床病理特征。方法:报道1例乳腺浸润性导管癌在新辅助化疗后原发灶病理完全缓解(pathological complete response,p... 目的:探讨新辅助化疗后病理类型转化为化生性鳞状细胞癌(metaplasia squamous cell carcinoma,MSCC)的乳腺浸润性导管癌临床病理特征。方法:报道1例乳腺浸润性导管癌在新辅助化疗后原发灶病理完全缓解(pathological complete response,pCR)、腋窝淋巴结转移灶转化为MSCC的病例;复习相关文献归纳总结其临床病理特征。结果:本例初诊为乳腺浸润性导管癌、腋窝淋巴结转移灶伴有局灶鳞状化生,在新辅助化疗后原发灶完全缓解,腋窝淋巴结转移灶完全转化为MSCC,影像显示淋巴结呈囊性改变,HE染色显示囊腔被覆鳞状上皮,形态学符合高分化鳞状细胞癌。免疫组化染色显示该病例分子分型为三阴性型:ER、PR、HER2均阴性。7例(本例加文献报道的6例)新辅助化疗前诊断均为浸润性导管癌,患者中位年龄56岁;5例为原发、2例为复发病例,其中4例有淋巴结转移;分子分型多为三阴性乳腺癌(5/7例);新辅助化疗后7例均转化为MSCC,1例(本例)原发灶pCR,5例淋巴结转移灶中,1例pCR、3例转化为MSCC、1例没有转化。结论:新辅助化疗可以诱导乳腺浸润性导管癌转化为MSCC,这类病例具有独特临床病理特征;探讨其转化的潜在分子机制,对临床个体化治疗及预后评估具有指导意义。 展开更多
关键词 乳腺肿瘤 浸润性导管癌 乳腺化生性癌 化生性鳞状细胞癌 新辅助化疗
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乳腺双相型化生性癌伴癌周导管内乳头状瘤一例报告
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作者 唐雨 陈昆涛 吴杰 《遵义医科大学学报》 2024年第10期1008-1012,共5页
目的初步探讨乳腺双相型化生性癌伴癌周导管内乳头状瘤的影像学、免疫组化表型、鉴别诊断。方法回顾性收集本院收治的1例经病理证实的乳腺双相型化生性癌伴癌周导管内乳头状瘤患者的病理结果与影像学资料,并复习相关文献。结果患者右乳... 目的初步探讨乳腺双相型化生性癌伴癌周导管内乳头状瘤的影像学、免疫组化表型、鉴别诊断。方法回顾性收集本院收治的1例经病理证实的乳腺双相型化生性癌伴癌周导管内乳头状瘤患者的病理结果与影像学资料,并复习相关文献。结果患者右乳无痛、质韧肿物,组织形态学显示肿瘤为囊性,灶状囊内见灰白色凸起,凸起区域细胞呈片状、巢状排列,细胞上皮样,部分梭形,细胞核明显异型,核分裂象易见,并见大量坏死,囊壁纤维化明显伴出血、灶状钙化及含铁血黄素沉积;肿瘤周围乳腺组织部分区域呈纤维腺瘤样增生,灶状见导管内乳头状瘤。结论乳腺化生性癌发病机制目前不明确,病理学表现复杂,影像学表现无突出特征,易误诊,免疫组化对鉴别诊断有帮助。本例患者为双相型乳腺化生性癌,且Her-2表达阳性,国内外仅见散在报道。 展开更多
关键词 乳腺化生性癌 影像学 病理学
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22例乳腺化生性癌临床病理特征分析 被引量:1
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作者 陆保成 陈智敏 +2 位作者 潘思琼 韦冬密 以敏 《诊断病理学杂志》 2023年第5期433-436,441,共5页
目的探讨乳腺化生性癌(MBC)的临床病理特征。方法回顾22例乳腺化生性癌临床病理资料,分析其大体、光镜及免疫组化特征,并复习相关文献资料。结果22例均为女性,左乳11例,右乳11例,发病年龄35~72岁(中位年龄54岁),肿块最大径1.6~13 cm(平... 目的探讨乳腺化生性癌(MBC)的临床病理特征。方法回顾22例乳腺化生性癌临床病理资料,分析其大体、光镜及免疫组化特征,并复习相关文献资料。结果22例均为女性,左乳11例,右乳11例,发病年龄35~72岁(中位年龄54岁),肿块最大径1.6~13 cm(平均4.5 cm)。18例行手术治疗,淋巴结转移阳性率61.1%。组织学类型:鳞状细胞癌15例,梭形细胞癌1例,伴间叶分化的癌6例。免疫组化显示,19例ER、PR、HER-2均阴性,3例ER灶状阳性,2例PR灶状阳性,22例CK阳性。结论乳腺化生性癌是一组异质性肿瘤,恶性程度高,预后差,大多数为三阴性乳腺癌,具有独特的免疫表型,与其他肿瘤鉴别困难时,联合免疫组化标记上皮成分(CK)有助于明确诊断。 展开更多
关键词 乳腺 化生性癌 临床病理
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一种基于随机权神经网络的类增量学习与记忆融合方法
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作者 李德鹏 曾志刚 《自动化学报》 EI CAS CSCD 北大核心 2023年第12期2467-2480,共14页
连续学习(Continual learning,CL)多个任务的能力对于通用人工智能的发展至关重要.现有人工神经网络(Artificial neural networks,ANNs)在单一任务上具有出色表现,但在开放环境中依次面对不同任务时非常容易发生灾难性遗忘现象,即联结... 连续学习(Continual learning,CL)多个任务的能力对于通用人工智能的发展至关重要.现有人工神经网络(Artificial neural networks,ANNs)在单一任务上具有出色表现,但在开放环境中依次面对不同任务时非常容易发生灾难性遗忘现象,即联结主义模型在学习新任务时会迅速地忘记旧任务.为了解决这个问题,将随机权神经网络(Random weight neural networks,RWNNs)与生物大脑的相关工作机制联系起来,提出一种新的再可塑性启发的随机化网络(Metaplasticity-inspired randomized network,MRNet)用于类增量学习(Class incremental learning,Class-IL)场景,使得单一模型在不访问旧任务数据的情况下能够从未知的任务序列中学习与记忆融合.首先,以前馈方式构造具有解析解的通用连续学习框架,用于有效兼容新任务中出现的新类别;然后,基于突触可塑性设计具备记忆功能的权值重要性矩阵,自适应地调整网络参数以避免发生遗忘;最后,所提方法的有效性和高效性通过5个评价指标、5个基准任务序列和10个比较方法在类增量学习场景中得到验证. 展开更多
关键词 连续学习 灾难性遗忘 随机权神经网络 再可塑性启发
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乳腺化生性癌临床特点及超声表现
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作者 李静敏 邵玉红 +1 位作者 孙秀明 梁振威 《中国介入影像与治疗学》 北大核心 2023年第7期419-422,共4页
目的观察乳腺化生性癌(MBC)的临床特点及超声表现。方法回顾性分析经手术病理证实的37例单发MBC与74例乳腺非特殊型浸润性癌(IC-NST)患者(74个病灶)的临床资料及病灶超声表现。结果37个MBC病灶中,32个呈低回声、5个呈囊实性回声;9个呈... 目的观察乳腺化生性癌(MBC)的临床特点及超声表现。方法回顾性分析经手术病理证实的37例单发MBC与74例乳腺非特殊型浸润性癌(IC-NST)患者(74个病灶)的临床资料及病灶超声表现。结果37个MBC病灶中,32个呈低回声、5个呈囊实性回声;9个呈规则椭圆形,28个形态不规则;14个边缘光整,13个内见点状强回声微钙化,2个后方回声衰减;35个肿瘤均呈平行生长;CDFI示29个为AdlerⅡ或Ⅲ级血流。MBC与IC-NST患者之间,Ki-67表达、雌激素受体(ER)阳性、孕激素受体(PR)阳性、就诊原因、自觉肿物生长迅速与否、有无腋窝淋巴结转移,以及肿瘤最大径、回声、形态、边缘、方位及后方回声衰减差异均有统计学意义(P均<0.05);患者年龄、人表皮生长因子受体2(HER-2)阳性及肿瘤微钙化及Adler血流分级差异均无统计学意义(P均>0.05)。结论MBC临床及超声表现均有一定特异性,有助于诊断。 展开更多
关键词 超声检查 乳腺化生性癌 非特殊型浸润性乳腺癌
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化生性乳腺癌p53、EGFR的表达与其临床特征的相关性
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作者 欧禹瑛 朱德淼 《锦州医科大学学报》 2023年第2期23-28,共6页
目的 测量化生性乳腺癌中p53、EGFR的表达水平,并探讨该水平与其临床特征的相关性分析。方法 选取2009年1月至2022年9月在锦州医科大学附属第一医院乳腺外科收治的43例化生性乳腺癌患者作为研究对象,通过免疫组织化学染色的方法统计p53... 目的 测量化生性乳腺癌中p53、EGFR的表达水平,并探讨该水平与其临床特征的相关性分析。方法 选取2009年1月至2022年9月在锦州医科大学附属第一医院乳腺外科收治的43例化生性乳腺癌患者作为研究对象,通过免疫组织化学染色的方法统计p53和EGFR的阳性表达率,再经χ2检验、费舍确切概率法及斯皮尔曼相关方式的统计,分析并探讨p53、EGFR与其临床特征的相关性分析。结果 在化生性乳腺癌中,p53与EGFR的表达水平呈正相关(P<0.05);p53、EGFR的表达水平与肿瘤大小、Ki-67呈正相关(P<0.05);p53的表达水平还与年龄、淋巴结转移个数、临床分期呈正相关(P<0.05)。结论 根据p53、EGFR的表达水平,可预测患者化生性乳腺癌的进展程度,为临床的治疗决策提供进一步的参考。 展开更多
关键词 化生性乳腺癌 P53 EGFR 乳腺癌
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含有鳞状细胞癌成分的乳腺化生性癌的超声与病理特征 被引量:8
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作者 鄢磊 许翔 +3 位作者 叶小剑 王行富 陈晓宇 徐荣全 《中国医学影像技术》 CSCD 北大核心 2017年第3期410-413,共4页
目的观察含有鳞状细胞癌成分的乳腺化生性癌(MCSC)的声像图和病理学特征。方法回顾性分析7例经手术病理检查证实的MCSC患者的二维声像图及CDFI声像图特征,并与病理学表现进行对照分析。结果 7例MCSC病灶均为单发;最大径2.6~5.1cm;6例为... 目的观察含有鳞状细胞癌成分的乳腺化生性癌(MCSC)的声像图和病理学特征。方法回顾性分析7例经手术病理检查证实的MCSC患者的二维声像图及CDFI声像图特征,并与病理学表现进行对照分析。结果 7例MCSC病灶均为单发;最大径2.6~5.1cm;6例为混合回声,1例为低回声,6例病灶内均可见大小不一的无回声区;7例形态均呈微小或小分叶状、边缘模糊。CDFI显示病灶实性部分有较丰富血流,4例为Ⅲ级血流信号,2例为Ⅱ级血流信号,1例为Ⅰ级血流信号,频谱显示为高阻力动脉血流(阻力指数0.75~0.97)。术后病理大体标本示6例为囊实性,1例为实性,镜下病理5例表现为腺鳞癌,2例表现为纯鳞状细胞癌。免疫组化显示雌、孕激素受体和人表皮生长因子受体均为阴性者(三阴乳腺癌)4例。结论 MCSC声像图特征为体积较大、囊实性混合回声、瘤体后方回声增强、实性回声内血供丰富且动脉阻力高。 展开更多
关键词 超声检查 乳腺肿瘤 化生性癌 鳞状细胞癌 病理学
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