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Midbrain enkephalin expression in a rat migraine model following intragastric scorpion powder administration 被引量:9
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作者 Gang Yao Xiangdan Luo +1 位作者 Dihui Ma Tingmin Yu 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第12期903-907,共5页
Scorpion has strong analgesic effects, but its analgesic mechanisms remain unclear. This study investigated the effects of scorpion powder on enkephalin expression in the midbrain of rats with nitroglycerin-induced mi... Scorpion has strong analgesic effects, but its analgesic mechanisms remain unclear. This study investigated the effects of scorpion powder on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine at mRNA and protein levels. Results confirmed that migraine rat abnormal behavior was significantly improved, and proenkephalin mRNA expression was significantly increased following treatment with scorpion. The number of methionine-enkephalin- positive cells in the migraine rats following treatment with scorpion was significantly increased, but no significant difference in the number of leucine-enkephalin-positive cells was detectable compared with migraine and normal rats. Taken together, these results show that scorpion exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine rats. 展开更多
关键词 PROENKEPHALIN methionine-enkephalin LEUCINE-ENKEPHALIN MIGRAINE SCORPION rats
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Effects of Toutongning capsule on enkephalin expression in a rat migraine headache model 被引量:7
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作者 Gang Yao Yuhong Man +2 位作者 Jingjing Qi Tingmin Yu Dihui Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第9期661-665,共5页
Toutongning capsule is used for the treatment of migraine headaches, and has yielded therapeutically beneficial effects. However, whether Toutongning capsule exerts its effects via endogenous opioid peptides remains p... Toutongning capsule is used for the treatment of migraine headaches, and has yielded therapeutically beneficial effects. However, whether Toutongning capsule exerts its effects via endogenous opioid peptides remains poorly understood. This study investigated the effects of Toutongning capsule on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine headache at the mRNA and protein levels. Results confirmed that proenkephalin mRNA levels were significantly upregulated following treatment with Toutongning capsule. The numbers methionine-enkephalin and leucine-enkephalin-positive cells were significantly greater in the migraine headache rats following treatment with Toutongning capsule compared with the model group. Taken together, these results show that Toutongning capsule exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine headache rats. 展开更多
关键词 PROENKEPHALIN methionine-enkephalin LEUCINE-ENKEPHALIN migraine headache Toutongning capsule neural regeneration
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Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain 被引量:6
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作者 Fu-Jun Zhai Song-Ping Han +4 位作者 Tian-Jia Song Ran Huo Xing-Yu Lan Rong Zhang Ji-Sheng Han 《Neuroscience Bulletin》 SCIE CAS CSCD 2022年第4期403-416,共14页
Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats.The analgesic effect of SCS with moderate mechani... Spinal cord stimulation(SCS)-induced analgesia was characterized,and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats.The analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20%and 80%motor thresholds.Various frequencies(2,15,50,100,10000 Hz,and 2/100 Hz dense-dispersed)of SCS were similarly effective.SCS-induced analgesia was maintained without tolerance within 24 h of continuous stimulation.SCS at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal fluid.The analgesic effect of 2 Hz was abolished byμorκopioid receptor antagonist.The effect of 100 Hz was prevented by aκantagonist,and that of 10 kHz was blocked by any of theμ,δ,orκreceptor antagonists,suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors. 展开更多
关键词 SCS ANALGESIA Opioid receptors methionine-enkephalin DYNORPHIN ENDORPHINS
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