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Support design method for deep soft-rock tunnels in non-hydrostatic high in-situ stress field
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作者 ZHENG Ke-yue SHI Cheng-hua +3 位作者 ZHAO Qian-jin LEI Ming-feng JIA Chao-jun PENG Zhu 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2431-2445,共15页
Due to the long-term plate tectonic movements in southwestern China,the in-situ stress field in deep formations is complex.When passing through deep soft-rock mass under non-hydrostatic high in-situ stress field,tunne... Due to the long-term plate tectonic movements in southwestern China,the in-situ stress field in deep formations is complex.When passing through deep soft-rock mass under non-hydrostatic high in-situ stress field,tunnels will suffer serious asymmetric deformation.There is no available support design method for tunnels under such a situation in existing studies to clarify the support time and support stiffness.This study first analyzed the mechanical behavior of tunnels in non-hydrostatic in-situ stress field and derived the theoretical equations of the ground squeezing curve(GSC)and ground loosening curve(GLC).Then,based on the convergence confinement theory,the support design method of deep soft-rock tunnels under non-hydrostatic high in-situ stress field was established considering both squeezing and loosening pressures.In addition,this method can provide the clear support time and support stiffness of the second layer of initial support.The proposed design method was applied to the Wanhe tunnel of the China-Laos railway in China.Monitoring data indicated that the optimal support scheme had a good effect on controlling the tunnel deformation in non-hydrostatic high in-situ stress field.Field applications showed that the secondary lining could be constructed properly. 展开更多
关键词 non-hydrostatic stress field high in-situ stress deep soft-rock tunnel squeezing pressure loosening pressure support design method
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Novel damage constitutive models and new quantitative identification method for stress thresholds of rocks under uniaxial compression
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作者 DU Kun YI Yang +3 位作者 LUO Xin-yao LIU Kai LI Peng WANG Shao-feng 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2658-2675,共18页
Four key stress thresholds exist in the compression process of rocks,i.e.,crack closure stress(σ_(cc)),crack initiation stress(σ_(ci)),crack damage stress(σ_(cd))and compressive strength(σ_(c)).The quantitative id... Four key stress thresholds exist in the compression process of rocks,i.e.,crack closure stress(σ_(cc)),crack initiation stress(σ_(ci)),crack damage stress(σ_(cd))and compressive strength(σ_(c)).The quantitative identifications of the first three stress thresholds are of great significance for characterizing the microcrack growth and damage evolution of rocks under compression.In this paper,a new method based on damage constitutive model is proposed to quantitatively measure the stress thresholds of rocks.Firstly,two different damage constitutive models were constructed based on acoustic emission(AE)counts and Weibull distribution function considering the compaction stages of the rock and the bearing capacity of the damage element.Then,the accumulative AE counts method(ACLM),AE count rate method(CRM)and constitutive model method(CMM)were introduced to determine the stress thresholds of rocks.Finally,the stress thresholds of 9 different rocks were identified by ACLM,CRM,and CMM.The results show that the theoretical stress−strain curves obtained from the two damage constitutive models are in good agreement with that of the experimental data,and the differences between the two damage constitutive models mainly come from the evolutionary differences of the damage variables.The results of the stress thresholds identified by the CMM are in good agreement with those identified by the AE methods,i.e.,ACLM and CRM.Therefore,the proposed CMM can be used to determine the stress thresholds of rocks. 展开更多
关键词 stress threshold acoustic emission damage constitutive model damage element quantitative method
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Stress tensor determination by modified hydraulic tests on pre-existing fractures:Method and stress constraints
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作者 Guiyun Gao Chenghu Wang Ke Gao 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第5期1637-1648,共12页
The hydraulic testing of pre-existing fractures(HTPF)is one of the most promising in situ stress measurement methods,particularly for three-dimensional stress tensor determination.However,the stress tensor determinati... The hydraulic testing of pre-existing fractures(HTPF)is one of the most promising in situ stress measurement methods,particularly for three-dimensional stress tensor determination.However,the stress tensor determination based on the HTPF method requires at least six tests or a minimum of 14-15 tests(under different conditions)for reliable results.In this study,we modified the HTPF method by considering the shear stress on each pre-existing fracture,which increased the number of equations for the stress tensor determination and decreased the number of tests required.Different shear stresses were attributed to different fractures by random sampling;therefore,the stress tensors were obtained by searching for the optimal solution using the least squares criterion based on the Monte Carlo method.Thereafter,we constrained the stress tensor based on the tensile strength criterion,compressive strength criterion,and vertical stress constraints.The inverted stress tensors were presented and analyzed based on the tensorial nature of the stress using the Euclidean mean stress tensor.Two stress-measurement campaigns in Weifang(Shandong Province,China)and Mercantour road tunnel(France)were implemented to highlight the validity and efficiency of the modified HTPF(M-HTPF)method.The results showed that the M-HTPF method can be applied for stress tensor inversion using only three to four tests on pre-existing fractures,neglecting the stress gradient.The inversion results were confined to relatively small distribution dispersions and were significantly reliable and stable due to the shear stresses on the fractures and the stress constraints employed.The M-HTPF method is highly feasible and efficient for complete stress tensor determination in a single borehole. 展开更多
关键词 stress tensor Hydraulic tests on pre-existing fractures Mean stress stress constraint Hydraulic fracturing
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A continuous and long-term in-situ stress measuring method based on fiber optic. Part I: Theory of inverse differential strain analysis
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作者 Kun-Peng Zhang Mian Chen +2 位作者 Chang-Jun Zhao Su Wang Yong-Dong Fan 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1171-1189,共19页
A method for in-situ stress measurement via fiber optics was proposed. The method utilizes the relationship between rock mass elastic parameters and in-situ stress. The approach offers the advantage of long-term stres... A method for in-situ stress measurement via fiber optics was proposed. The method utilizes the relationship between rock mass elastic parameters and in-situ stress. The approach offers the advantage of long-term stress measurements with high spatial resolution and frequency, significantly enhancing the ability to measure in-situ stress. The sensing casing, spirally wrapped with fiber optic, is cemented into the formation to establish a formation sensing nerve. Injecting fluid into the casing generates strain disturbance, establishing the relationship between rock mass properties and treatment pressure.Moreover, an optimization algorithm is established to invert the elastic parameters of formation via fiber optic strains. In the first part of this paper series, we established the theoretical basis for the inverse differential strain analysis method for in-situ stress measurement, which was subsequently verified using an analytical model. This paper is the fundamental basis for the inverse differential strain analysis method. 展开更多
关键词 In-situ stress Fiber optic Orthotropic elastic Differential evolution ABAQUS
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Probabilistic-Ellipsoid Hybrid Reliability Multi-Material Topology Optimization Method Based on Stress Constraint
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作者 Zibin Mao Qinghai Zhao Liang Zhang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期757-792,共36页
This paper proposes a multi-material topology optimization method based on the hybrid reliability of the probability-ellipsoid model with stress constraint for the stochastic uncertainty and epistemic uncertainty of m... This paper proposes a multi-material topology optimization method based on the hybrid reliability of the probability-ellipsoid model with stress constraint for the stochastic uncertainty and epistemic uncertainty of mechanical loads in optimization design.The probabilistic model is combined with the ellipsoidal model to describe the uncertainty of mechanical loads.The topology optimization formula is combined with the ordered solid isotropic material with penalization(ordered-SIMP)multi-material interpolation model.The stresses of all elements are integrated into a global stress measurement that approximates the maximum stress using the normalized p-norm function.Furthermore,the sequential optimization and reliability assessment(SORA)is applied to transform the original uncertainty optimization problem into an equivalent deterministic topology optimization(DTO)problem.Stochastic response surface and sparse grid technique are combined with SORA to get accurate information on the most probable failure point(MPP).In each cycle,the equivalent topology optimization formula is updated according to the MPP information obtained in the previous cycle.The adjoint variable method is used for deriving the sensitivity of the stress constraint and the moving asymptote method(MMA)is used to update design variables.Finally,the validity and feasibility of the method are verified by the numerical example of L-shape beam design,T-shape structure design,steering knuckle,and 3D T-shaped beam. 展开更多
关键词 stress constraint probabilistic-ellipsoid hybrid topology optimization reliability analysis multi-material design
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A modified smoothed particle hydrodynamics method considering residual stress for simulating failure and its application in layered rock mass
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作者 XIA Chengzhi SHI Zhenming KOU Huanjia 《Journal of Mountain Science》 SCIE CSCD 2024年第6期2091-2112,共22页
Residual strength is an indispensable factor in evaluating rock fracture,yet the current Smoothed Particle Hydrodynamics(SPH)framework rarely considers its influence when simulating fracture.An improved cracking strat... Residual strength is an indispensable factor in evaluating rock fracture,yet the current Smoothed Particle Hydrodynamics(SPH)framework rarely considers its influence when simulating fracture.An improved cracking strategy considering residual stress in the base bond SPH method was proposed to simulate failures in layered rocks and slopes and verified by experimental results and other simulation methods(i.e.,the discrete element method).Modified Mohr–Coulomb failure criterion was applied to distinguish the mixed failure of tensile and shear.Bond fracture markψwas introduced to improve the kernel function after tensile damage,and the calculation of residual stress after the damage was derived after shear damage.Numerical simulations were carried out to evaluate its performance under different stress and scale conditions and to verify its effectiveness in realistically reproducing crack initiation and propagation and coalescence,even fracture and separation.The results indicate that the improved cracking strategy precisely captures the fracture and failure pattern in layered rocks and rock slopes.The residual stress of brittle tock is correctly captured by the improved SPH method.The improved SPH method that considers residual strength shows an approximately 13%improvement in accuracy for the safety factor of anti-dip layered slopes compared to the method that does not consider residual strength,as validated against analytical solutions.We infer that the improved SPH method is effective and shows promise for applications to continuous and discontinuous rock masses. 展开更多
关键词 Smoothed particle hydrodynamics Cracking strategy Residual stress Layered rock Crack propagation
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Characteristic stress variation and microcrack evolution of granite subjected to uniaxial compression using acoustic emission methods
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作者 Yunge Zhao Xibing Li +2 位作者 Linqi Huang Zhichao Zhang Zihou Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第9期3511-3523,共13页
The size of mineral grain has a significant impact on the initiation and propagation of microcracks within rocks.In this study,fine-,medium-,and coarse-grained granites were used to investigate microcrack evolution an... The size of mineral grain has a significant impact on the initiation and propagation of microcracks within rocks.In this study,fine-,medium-,and coarse-grained granites were used to investigate microcrack evolution and characteristic stress under uniaxial compression using the acoustic emission(AE),digital image correlation(DIC),and nuclear magnetic resonance(NMR)measurements.The experimental results show that the characteristic stress of each granite decreased considerably with increasing grain sizes.The inflection points of the b-value occurred earlier with an increase in grain sizes,indicating that the larger grains promote the generation and propagation of microcracks.The distribution characteristics of the average frequency(AF)and the ratio of rise time to amplitude(RA)indicate that the proportion of shear microcracks increases with increasing grain size.The NMR results indicate that the porosity and the proportion of large pores increased with increasing grain size,which may intensify the microcrack evolution.Moreover,analysis of the DIC and AE event rates suggests that the high-displacement regions could serve as a criterion for the degree of microcrack propagation.The study found that granites with larger grains had a higher proportion of high-displacement regions,which can lead to larger-scale cracking or even spalling.These findings are not only beneficial to understand the pattern of microcrack evolution with different grain sizes,but also provide guidance for rock monitoring and instability assessment. 展开更多
关键词 Grain size Acoustic emission(AE) Characteristic stress Microcrack evolution Fracture mode
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A novel indirect optical method for rock stress measurement using microdeformation field analysis
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作者 Yujie Feng Peng-Zhi Pan +2 位作者 Zhaofeng Wang Xufeng Liu Shuting Miao 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第9期3616-3628,共13页
Stress measurement plays a crucial role in geomechanics and rock engineering,especially for the design and construction of large-scale rock projects.This paper presents a novel method,based on the traditional stress r... Stress measurement plays a crucial role in geomechanics and rock engineering,especially for the design and construction of large-scale rock projects.This paper presents a novel method,based on the traditional stress relief approach,for indirectly measuring rock stress using optical techniques.The proposed method allows for the acquisition of full-field strain evolution on the borehole’s inner wall before and after disturbance,facilitating the determination of three-dimensional(3D)stress information at multiple points within a single borehole.The study focuses on presenting the method’s theoretical framework,laboratory validation results,and equipment design conception.The theoretical framework comprises three key components:the optical imaging method of the borehole wall,the digital image correlation(DIC)method,and the stress calculation procedure.Laboratory validation tests investigate strain field distribution on the borehole wall under varying stress conditions,with stress results derived from DIC strain data.Remarkably,the optical method demonstrates better measurement accuracy during the unloading stage compared to conventional strain gauge methods.At relatively high stress levels,the optical method demonstrates a relative error of less than 7%and an absolute error within 0.5 MPa.Furthermore,a comparative analysis between the optical method and the conventional contact resistance strain gauge method highlights the optical method’s enhanced accuracy and stability,particularly during the unloading stage.The proposed optical stress measurement device represents a pioneering effort in the application of DIC technology to rock engineering,highlighting its potential to advance stress measurement techniques in the field. 展开更多
关键词 Rock stress measurement Optical technology Digital image correlation(DIC)technology Micro-deformation field
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Exploring the Limits of a Deflection-Based Method for the Estimation of Dynamic Stress in Beams
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作者 Archie Keys Jordan Cheer 《Journal of Dynamics, Monitoring and Diagnostics》 2024年第1期40-48,共9页
Estimation of the dynamic stress in structures,such as beams and plates,has previously been made using the relationship between stress and velocity spatial maxima based on far-field assumptions.This paper presents a m... Estimation of the dynamic stress in structures,such as beams and plates,has previously been made using the relationship between stress and velocity spatial maxima based on far-field assumptions.This paper presents a method for the estimation of dynamic stress in a beam using Euler–Bernoulli beam theory,where deflection data from a grid of measurement points on the surface of the beam is used to estimate the dynamic bending stress in the structure.The limitations of the method are investigated via response data provided by a numerical model of a freefree beam.A nondimensional wavenumber analysis is used to determine the number of points required for an accurate estimate of stress.Beams with a range of material and geometric parameters are modeled in order to explore the limits of the estimation method,and parameters representative of several real-world materials are used to assess the suitability of the method for practical applications. 展开更多
关键词 BEAMS dynamic stress structural dynamics VIBRATION
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Rock Stress Measurement Methods in Rock Mechanics—A Brief Overview 被引量:1
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作者 Mohammed Sazid Khaled Hussein Khalid Abudurman 《World Journal of Engineering and Technology》 2023年第2期252-272,共21页
The current brief review paper on rock stress measurement methods is very crucial factors in mining, civil infrastructure, geothermal energy, nuclear underground disposal, large underground oil storage caverns, etc as... The current brief review paper on rock stress measurement methods is very crucial factors in mining, civil infrastructure, geothermal energy, nuclear underground disposal, large underground oil storage caverns, etc as well as in geology and geophysical area. Measurement of in situ rock stress is a very challenging and difficult quantity and not possible to measure directly. Measure the deformation or displacements or hydraulic factors by perturbing the rock and converting the measured quantity into rock stress. There are two main categories for measuring methods: direct and indirect methods. The most common methods of direct in situ stress techniques are briefly described including advantages, disadvantages and limitations. Moreover, authors included the application of Artificial Intelligence (AI) for rock stress measurement methods. 展开更多
关键词 Rock stress In Situ stress Hydraulic Fracturing Flat Jack and Artificial Intelligence
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Application of Nonlinear Lamb Wave Mixing Method for Residual Stress Measurement in Metal Plate 被引量:1
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作者 Jingpin Jiao Li Li +3 位作者 Xiang Gao Quan Cheng Cunfu He Bin Wu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第1期211-223,共13页
Harmonic nonlinear ultrasound can offer high sensitivity for residual stress measurements;however,it cannot be used for local stress measurements at a point in space and exhibits nonlinear distortions in the experimen... Harmonic nonlinear ultrasound can offer high sensitivity for residual stress measurements;however,it cannot be used for local stress measurements at a point in space and exhibits nonlinear distortions in the experimental system.This paper presents a feasibility study on the measurement of residual stress in a metal plate using a nonlinear Lamb wave-mixing technique.The resonant conditions for two Lamb waves to generate a mixing frequency wave are obtained via theoretical analysis.Finite element simulations are performed to investigate the nonlinear interactions between the two Lamb waves.Results show that two incident A0 waves interact in regions of material nonlinearity and generate a rightward S0 wave at the sum frequency.Residual stress measurement experiments are conducted on steel plate specimens using the collinear Lamb wave-mixing technique.By setting different delays for two transmitters,the generated sum-frequency component at different spatial locations is measured.Experimental results show that the spatial distribution of the amplitude of the sum-frequency component agrees well with the spatial distribution of the residual stress measured using X-rays.The proposed collinear Lamb wave-mixing method is effective for measuring the distribution of residual stress in metal plates. 展开更多
关键词 Residual stress Lamb wave Collinear wave mixing Nondestructive testing Resonant conditions
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Frequency Domain Fatigue Evaluation on SCR Girth-Weld Based on Structural Stress 被引量:1
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作者 ZHANG Long ZHAO Tian-feng 《China Ocean Engineering》 SCIE EI CSCD 2024年第2期255-270,共16页
The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating platform.The harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone t... The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating platform.The harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone to fatigue failure.The structural stress fatigue theory and Master S-N curve method provide accurate predictions for the fatigue damage on the welded joints,which demonstrate significant potential and compatibility in multi-axial and random fatigue evaluation.Here,we propose a new frequency fatigue model subjected to welded joints of SCR under multiaxial stress,which fully integrates the mesh-insensitive structural stress and frequency domain random process and transforms the conventional welding fatigue technique of SCR into a spectrum analysis technique utilizing structural stress.Besides,a full-scale FE model of SCR with welds is established to obtain the modal structural stress of the girth weld and the frequency response function(FRF)of modal coordinate,and a biaxial fatigue evaluation about the girth weld of the SCR can be achieved by taking the effects of multi-load correlation and pipe-soil interaction into account.The research results indicate that the frequency-domain fatigue results are aligned with the time-domain results,meeting the fatigue evaluation requirements of the SCR. 展开更多
关键词 SCR girth weld random vibration self(cross)power spectrum structural stress method biaxial fatigue damage
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Ferroptosis and endoplasmic reticulum stress in ischemic stroke 被引量:6
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作者 Yina Li Mingyang Li +4 位作者 Shi Feng Qingxue Xu Xu Zhang Xiaoxing Xiong Lijuan Gu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期611-618,共8页
Ferroptosis is a form of non-apoptotic programmed cell death,and its mechanisms mainly involve the accumulation of lipid peroxides,imbalance in the amino acid antioxidant system,and disordered iron metabolism.The prim... Ferroptosis is a form of non-apoptotic programmed cell death,and its mechanisms mainly involve the accumulation of lipid peroxides,imbalance in the amino acid antioxidant system,and disordered iron metabolism.The primary organelle responsible for coordinating external challenges and internal cell demands is the endoplasmic reticulum,and the progression of inflammatory diseases can trigger endoplasmic reticulum stress.Evidence has suggested that ferroptosis may share pathways or interact with endoplasmic reticulum stress in many diseases and plays a role in cell survival.Ferroptosis and endoplasmic reticulum stress may occur after ischemic stroke.However,there are few reports on the interactions of ferroptosis and endoplasmic reticulum stress with ischemic stroke.This review summarized the recent research on the relationships between ferroptosis and endoplasmic reticulum stress and ischemic stroke,aiming to provide a reference for developing treatments for ischemic stroke. 展开更多
关键词 cell death endoplasmic reticulum stress ferroptosis ischemic stroke lipid peroxidation
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Grain Yield,Biomass Accumulation,and Leaf Photosynthetic Characteristics of Rice under Combined Salinity-Drought Stress 被引量:1
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作者 WEI Huanhe GENG Xiaoyu +7 位作者 ZHANG Xiang ZHU Wang ZHANG Xubin CHEN Yinglong HUO Zhongyang ZHOU Guisheng MENG Tianyao DAI Qigen 《Rice science》 SCIE CSCD 2024年第1期118-128,I0023,共12页
Simultaneous stresses of salinity and drought often coincide during rice-growing seasons in saline lands,primarily due to insufficient water resources and inadequate irrigation facilities.Consequently,combined salinit... Simultaneous stresses of salinity and drought often coincide during rice-growing seasons in saline lands,primarily due to insufficient water resources and inadequate irrigation facilities.Consequently,combined salinity-drought stress poses a major threat to rice production.In this study,two salinity levels(NS,non-salinity;HS,high salinity)along with three drought treatments(CC,control condition;DJ,drought stress imposed at jointing;DH,drought stress imposed at heading)were performed to investigate their combined influences on leaf photosynthetic characteristics,biomass accumulation,and rice yield formation.Salinity,drought,and their combination led to a shortened growth period from heading to maturity,resulting in a reduced overall growth duration.Grain yield was reduced under both salinity and drought stress,with a more substantial reduction under the combined salinity-drought stress.The combined stress imposed at heading caused greater yield losses in rice compared with the stress imposed at jointing.Additionally,the combined salinity-drought stress induced greater decreases in shoot biomass accumulation from heading to maturity,as well as in shoot biomass and nonstructural carbohydrate(NSC)content in the stem at heading and maturity.However,it increased the harvest index and NSC remobilization reserve.Salinity and drought reduced the leaf area index and SPAD value of flag leaves and weakened the leaf photosynthetic characteristics as indicated by lower photosynthetic rates,transpiration rates,and stomatal conductance.These reductions were more pronounced under the combined stress.Salinity,drought,and especially their combination,decreased the activities of ascorbate peroxidase,catalase,and superoxide dismutase,while increasing the contents of malondialdehyde,hydrogen peroxide,and superoxide radical.Our results indicated a more significant yield loss in rice when subjected to combined salinity-drought stress.The individual and combined stresses of salinity and drought diminished antioxidant enzyme activities,inhibited leaf photosynthetic functions,accelerated leaf senescence,and subsequently lowered assimilate accumulation and grain yield. 展开更多
关键词 antioxidant defense system combined salinity-drought stress drought stress photosynthetic characteristics RICE salinity stress
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Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx 被引量:2
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作者 Ziqian Xiang Pengfei Zhang +15 位作者 Chunwang Jia Rongkun Xu Dingren Cao Zhaoning Xu Tingting Lu Jingwei Liu Xiaoxiong Wang Cheng Qiu Wenyang Fu Weiwei Li Lei Cheng Qiang Yang Shiqing Feng Lianlei Wang Yunpeng Zhao Xinyu Liu 《Bone Research》 SCIE CAS CSCD 2024年第2期334-348,共15页
To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanica... To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanical stress.Piezo1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron gatekeeper.Furthermore,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical stress.Moreover,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases. 展开更多
关键词 stress OVERLOAD CHANNEL
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A Review on Sources,Extractions and Analysis Methods of a Sustainable Biomaterial:Tannins 被引量:2
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作者 Antonio Pizzi Marie-Pierre Laborie Zeki Candan 《Journal of Renewable Materials》 EI CAS 2024年第3期397-425,共29页
Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly ... Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based products.They are a definite class of sustainable materials of the forestry industry.They have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries,such as wood adhesives,metal coating,pharmaceutical/medical applications and several others.This review presents the main sources,either already or potentially commercial of this forestry by-materials,their industrial and laboratory extraction systems,their systems of analysis with their advantages and drawbacks,be these methods so simple to even appear primitive but nonetheless of proven effectiveness,or very modern and instrumental.It constitutes a basic but essential summary of what is necessary to know of these sustainable materials.In doing so,the review highlights some of the main challenges that remain to be addressed to deliver the quality and economics of tannin supply necessary to fulfill the industrial production requirements for some materials-based uses. 展开更多
关键词 TANNINS FLAVONOIDS SOURCES extraction methods analysis methods
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Impact of effective stress on permeability for carbonate fractured-vuggy rocks 被引量:1
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作者 Ke Sun Huiqing Liu +5 位作者 Juliana Y.Leung Jing Wang Yabin Feng Renjie Liu Zhijiang Kang Yun Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期942-960,共19页
To gain insight into the flow mechanisms and stress sensitivity for fractured-vuggy reservoirs,several core models with different structural characteristics were designed and fabricated to investigate the impact of ef... To gain insight into the flow mechanisms and stress sensitivity for fractured-vuggy reservoirs,several core models with different structural characteristics were designed and fabricated to investigate the impact of effective stress on permeability for carbonate fractured-vuggy rocks(CFVR).It shows that the permeability performance curves under different pore and confining pressures(i.e.altered stress conditions)for the fractured core models and the vuggy core models have similar change patterns.The ranges of permeability variation are significantly wider at high pore pressures,indicating that permeability reduction is the most significant during the early stage of development for fractured-vuggy reservoirs.Since each obtained effective stress coefficient for permeability(ESCP)varies with the changes in confining pressure and pore pressure,the effective stresses for permeability of four representative CFVR show obvious nonlinear characteristics,and the variation ranges of ESCP are all between 0 and 1.Meanwhile,a comprehensive ESCP mathematical model considering triple media,including matrix pores,fractures,and dissolved vugs,was proposed.It is proved theoretically that the ESCP of CFVR generally varies between 0 and 1.Additionally,the regression results showed that the power model ranked highest among the four empirical models mainly applied in stress sensitivity characterization,followed by the logarithmic model,exponential model,and binomial model.The concept of“permeability decline rate”was introduced to better evaluate the stress sensitivity performance for CFVR,in which the one-fracture rock is the strongest,followed by the fracture-vug rock and two-horizontalfracture rock;the through-hole rock is the weakest.In general,this study provides a theoretical basis to guide the design of development and adjustment programs for carbonate fractured-vuggy reservoirs. 展开更多
关键词 Effective stress PERMEABILITY Carbonate fractured-vuggy rocks Structure characteristics stress sensitivity
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Overexpression of the transcription factor MdWRKY115 improves drought and osmotic stress tolerance by directly binding to the MdRD22 promoter in apple 被引量:1
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作者 Qinglong Dong Yi Tian +9 位作者 Xuemei Zhang Dingyue Duan He Zhang Kaiyu Yang Peng Jia Haoan Luan Suping Guo Guohui Qi Ke Mao Fengwang Ma 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第3期629-640,共12页
Abiotic stress reduces plant yield and quality.WRKY transcription factors play key roles in abiotic stress responses in plants,but the molecular mechanisms by which WRKY transcription factors mediate responses to drou... Abiotic stress reduces plant yield and quality.WRKY transcription factors play key roles in abiotic stress responses in plants,but the molecular mechanisms by which WRKY transcription factors mediate responses to drought and osmotic stresses in apple(Malus×domestica Borkh.)remain unclear.Here,we functionally characterized the apple GroupⅢWRKY gene MdWRKY115.qRT-PCR analysis showed that MdWRKY115 expression was up-regulated by drought and osmotic stresses.GUS activity analysis revealed that the promoter activity of MdWRKY115 was enhanced under osmotic stress.Subcellular localization and transactivation assays indicated that MdWRKY115 was localized to the nucleus and had a transcriptional activity domain at the N-terminal region.Transgenic analysis revealed that the overexpression of MdWRKY115 in Arabidopsis plants and in apple callus markedly enhanced their tolerance to drought and osmotic stresses.DNA affinity purification sequencing showed that MdWRKY115 binds to the promoter of the stress-related gene MdRD22.This binding was further verified by an electrophoretic mobility shift assay.Collectively,these findings suggest that MdWRKY115 is an important regulator of osmotic and drought stress tolerance in apple. 展开更多
关键词 APPLE MdWRKY115 Osmotic stress Drought stress Function analysis
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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior 被引量:1
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作者 Man Han Deyang Zeng +7 位作者 Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng 《Neural Regeneration Research》 SCIE CAS 2025年第1期159-173,共15页
Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice ... Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions. 展开更多
关键词 AMYGDALA chronic mild stress chronic social defeat stress corticolimbic system DEPRESSION HIPPOCAMPUS medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area
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Application of the extended Fourier amplitude sensitivity testing(FAST)method to inflated,axial stretched,and residually stressed cylinders 被引量:1
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作者 H.ASGHARI H.TOPOL +1 位作者 B.MARKERT J.MERODIO 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2023年第12期2139-2162,共24页
This paper is dedicated to applying the Fourier amplitude sensitivity test(FAST)method to the problem of mixed extension and inflation of a circular cylindrical tube in the presence of residual stresses.The metafuncti... This paper is dedicated to applying the Fourier amplitude sensitivity test(FAST)method to the problem of mixed extension and inflation of a circular cylindrical tube in the presence of residual stresses.The metafunctions and the Ishigami function are considered in the sensitivity analysis(SA).The effects of the input variables on the output variables are investigated,and the most important parameters of the system under the applied pressure and axial force such as the axial stretch and the azimuthal stretch are determined. 展开更多
关键词 sensitivity analysis(SA) Fourier amplitude sensitivity test(FAST)method cylindrical inflation nonlinear elasticity
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