Influence of ganglioside combined with methylprednisolone sodium succinate on efficacy and neurological function in patients with acute myelitis

BACKGROUND Acute myelitis(AM)can lead to sudden sensory,motor and autonomic nervous dysfunction,which negatively affects their daily activities and quality of life,so it is necessary to explore optimization from a therapeutic perspective to curb the progression of the disease.AIM To investigate the effect of ganglioside(GM)combined with methylprednisolone sodium succinate(MPSS)on the curative effect and neurological function of patients with AM.METHODS First,we selected 108 AM patients visited between September 2019 and September 2022 and grouped them based on treatment modality,with 52 patients receiving gamma globulin(GG)+MPSS and 56 patients receiving GM+MPSS,assigned to the control group(Con)and observation group(Obs),respectively.The therapeutic effect,neurological function(sensory and motor function scores),adverse events(AEs),recovery(time to sphincter function recovery,time to limb muscle strength recovery above grade 2,and time to ambulation),inflammatory factors(IFs)[interleukin(IL)-6,C-reactive protein(CRP),and tumor necrosis factor(TNF)-α]and other data of the two groups were collected for evaluation and comparison.RESULTS The Obs had:(1)A significantly higher response rate of treatment than the Con;(2)Higher scores of sensory and motor functions after treatment that were higher than the baseline(before treatment)and higher than the Con levels;(3)Lower incidence rates of skin rash,gastrointestinal discomfort,dyslipidemia,osteoporosis and other AEs;(4)Faster posttreatment recovery of sphincter function,limb muscle strength and ambulation;and(5)Markedly lower posttreatment IL-6,CRP and TNF-αlevels than the baseline and the Con levels.CONCLUSION From the above,it can be seen that GM+MPSS is highly effective in treating AM,with a favorable safety profile comparable to that of GG+MPSS.It can significantly improve patients’neurological function,speed up their recovery and inhibit serum IFs.

Design,delivery and efficacy testing of therapeutic nucleic acids used to inhibit hepatitis C virus gene expression in vitro and in vivo

Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are

Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review

The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative.

Continuous Wear of Hydrogel Contact Lenses for Therapeutic Use

Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one week of continuous therapeutic wear during 10 years. The reason for prescription of CLs, the primary disease, the duration of CL wear and the complications were assessed retrospectively. Results: The predominant reason for prescription of CLs was relief of pain or a foreign-body sensation (62.3%) and protection of the corneal epithelium (20.6%). The primary disease was post-penetrating keratoplasty (36.8%), followed by corneal epithelial erosion (14.5%), post-lamellar keratoplasty (14.0%) and bullous keratopathy (12.2%). The average duration of wearing single lens was 6.5 ± 3.2 days. The average duration of wearing CLs in total was 9.2 ± 10.7 months. The most frequent problem associated with continuous wear of CLs was their dropping out of CLs (12.3%). The complications associated with CLs included conjunctivitis with papillary hyperplasia, corneal erosion and superficial punctate keratitis, but corneal ulcer and corneal infiltrates were not found. Conclusion: Serious complications were not shown changing the lenses every week to keep to the prescribed time limit for continuous therapeutic wear, even if corneal epithelial barrier function is impaired.

Comparison of long-lasting therapeutic effects between succimer and penicillamine on hepatolenticular degeneration

AIM To compare the long term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD). METHODS One hundred and twenty patients with HLD were divided into 2 groups. Group A ( n =60) received Suc 750mg , po. bid. Group B ( n =60) received Pen 250mg , po. qid. The period of maintenance treatment varied from 6 months to 3 years, averaging 1 5 years. Symptoms and therapeutic effects were evaluated by modified Goldstein scale. RESULTS The total effectiveness of group A in two different periods of treatment were 80% and 85% respectively, higher than those of group B (58% and 59% respectively) ( P <0 05). Suc also had obvious curative effects for the patients who failed in the use of Pen. There were fewer side effect in group A than in group B ( P <0 05). Suc and Pen could increase urinary copper excretion effectively and continually. CONCLUSION Suc is more effective and safer than Pen. Clinically, it can replace Pen as first choice drug for long term maintenance therapy of HLD.

Functional dyspepsia of ulcer-dysmotility type:clinical incidence and therapeutic strategy

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Therapeutic role of template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract

Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional nodes for tumors of the right renal pelvis or the right upper two-thirds of the ureter. A prospective study showed that an anatomical templatebased lymphadenectomy significantly improved patient survival in tumors of the renal pelvis. This benefit was more evident for patients with p T2 stage tumors or higher. The risk of regional node recurrence is significant reduced by template-based lymphadenectomy,which is likely to be associated with improved patient survival. The removal of lymph node micrometastases is assumed to be the reason for therapeutic benefit following lymphadenectomy. The number of resected lymph nodes can be used to assess the quality of lymphadenectomy,but not to determine the extent of lymphadenectomy. The guidelines currently recommend lymphadenectomy for patients with muscle-invasive disease,even though the current recommendation grades are still low. The present limitation of lymphadenectomy is the lack of standardization of the extent of lymphadenectomy and the randomized trials. Further studies are warranted to collect the evidence to support lymphadenectomy.

阿奇霉素序贯疗法联合甲泼尼龙治疗儿童支原体肺炎的临床疗效

目的 研讨采用阿奇霉素序贯疗法联合甲泼尼龙治疗儿童支原体肺炎的临床效果。方法 针对2019年11月至2023年12月期间,在我院接受治疗感染支原体肺炎的儿童120例,数字表法随机分为成2组,即60例对照组和60例实验组,对照组患病儿童治疗方案为阿奇霉素序贯疗法,实验组患病儿童治疗方案采取阿奇霉素联合甲泼尼龙,分析和对比不同分组患病儿童的疗效、发生不良反应、炎性因子[反应蛋白(CrP)、降钙素原(PCT)、白介素-10(IL-10)]、通气状况[动脉氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、动脉氧饱和度(SaO_(2))]、免疫血球素[IgA、IgG、IgM]的差异。结果 对照组患病儿童的治疗有效率达86.7%,实验组患病儿童治疗有效率达98.3%(P<0.05),不良反应方面数据显示,实验组患病儿童比对照组患病儿童优势很明显(P<0.05)。炎症因子:治疗后,对照和实验两组儿童炎症因子的指标值都下降显著PCT(P=0.036),CRP(P=0.047),IL-10(P=0.048)(P<0.05),实验组患病儿童CRP、IL-10、PCT炎症因子明显要比对照组更低。通气状况:治疗后,对照和实验两组儿童PaO_(2)和SaO_(2)要比治疗前高,PaCO_(2)要比治疗前低,而且实验组明显要比对照组好。免疫血球素:治疗后,对照和实验两组儿童IgA、IgM、IgG要比治疗前高,而且实验组明显要比对照组好。结论 采用阿奇霉素序贯疗法联合甲泼尼龙在儿童感染支原体肺炎临床治疗中能起到更好疗效,能很大程度上缩短患病儿童的康复时间、比较安全,治疗方式值得临床上加以推广。

Controversies regarding transplantation of mesenchymal stem cells

Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and research.We delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface markers.The heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety apprehensions.Moreover,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine effects.We also assess the current status of clinical trials and the ever-evolving regulatory landscape.As we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery methods.Our review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation.

Clinacanthus nutans:a review of the medicinal uses,pharmacology and phytochemistry

Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bites,lesions caused by herpes simplex virus,diabetes,and gout in Malaysia.Indonesia.Thailand and China.Phylochemieal investigations documented the varied contents of bioaclive compounds from litis plant namely flavonoids,glycosides,glycoglyeerolipids.cerebrosides and monoacylmonogalatosylglycerol.The pharmacological experiment proved that various types of extracts and pure compounds from this species exhibited a broad range of biological properties such as anti-inflammatory,antiviral,antioxidant,and anti-diabetic activities.The lindings of toxicity study showed that extracts from this plant did not show any toxicity thus it can be used as strong therapeutic agents for specific diseased conditions.However,further experiments on chemical components and their mode of action showing biological activities are required to elucidate the complete phytochemical profile and assess to confirm their suitability tor future drugs.This review summarizes the medicinal uses,phytochemistry and pharmacology of this plant in order to explore its therapeutic potential and gaps necessitating for prospected research work.

High-intensity focused ultrasound extracorporeal ablation of liver tissuesin rabbits

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阿奇霉素联合甲强龙治疗肺炎支原体肺炎效果分析

目的探讨对肺炎支原体肺炎患儿采用阿奇霉素+甲强龙治疗后的临床效果。方法简单随机选取2022年6月—2023年6月东莞市长安医院80例肺炎支原体肺炎患儿,以治疗方案的不同分为参照组和研究组,参照组(n=40)施以阿奇霉素治疗;研究组(n=40)在参照组基础上施以甲强龙治疗;比较两组患儿临床症状消失时间、治疗效果、炎症指标和不良反应发生情况。结果研究组治疗总有效率为97.50%高于参照组的80.00%,差异有统计学意义(χ^(2)=6.135,P<0.05);研究组临床症状消失时间、发热消失时间和肺部啰音消失时间分别是(7.85±2.65)d、(4.83±1.39)d和(7.93±1.25)d,均短于参照组,差异有统计学意义(P<0.05);治疗前,两组患儿炎症水平比较,差异无统计学意义(P>0.05);治疗后,研究组炎症水平低于参照组,差异有统计学意义(P<0.05)。两组患儿不良反应发生情况比较,差异无统计学意义(P>0.05)。结论临床给予阿奇霉素联合甲强龙治疗肺炎支原体肺炎,可明显提高治疗效果,缩短咳嗽消失时间、发热消失时间以及肺部啰音消失时间,明显改善炎症指标。

阿奇霉素联合甲泼尼龙琥珀酸钠治疗小儿重症支原体肺炎的疗效探讨

目的 探究在对小儿重症支原体肺炎患儿治疗时采用阿奇霉素与甲泼尼龙琥珀酸钠结合方法后的效果。方法 方便选取2021年9月—2023年7月无锡市惠山区人民医院收治的153例小儿重症支原体肺炎患儿为研究对象,选择随机数表法分为对照组和研究组,对照组76例采用红霉素,研究组77例采用阿奇霉素与甲泼尼龙琥珀酸钠结合治疗方法。比较两组治疗效果,同时对比分析临床各症状消失时间、不良反应、C反应蛋白(C-reactive protein, CRP)水平。结果 研究组总有效率为96.10%,高于对照组的80.26%,差异有统计学意义(χ^(2)=9.246,P<0.05);研究组临床发热、咳嗽、肺啰音各症状消失时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应对比,差异无统计学意义(P>0.05);研究组CRP指标水平低于对照组,差异有统计学意义(P<0.05)。结论 在对小儿重症支原体肺炎患儿治疗时,选择阿奇霉素与甲泼尼龙琥珀酸钠结合方案,可提高治疗效果,缩短症状消失时间,无明显不良反应发生,改善炎症指标。

The role of drug utilization evaluation in medical sciences

Background:Drug utilization evaluation(DUE)is defined by the World Health Organization(WHO)and focuses on the medical,social,and economic consequences of pharmaceutical marketing,distribution,prescribing,and usage in society.The WHO recommends a physician to every 1000 people.According to the recent data from the Health Ministry in 2019,in which 1.16 million doctors are of active population with just 80%,or 0.9 million,practicing.As a result,a ratio of 0.68 doctors for every 1000 people,which is much below as per the WHO reports.This article describes history,types,WHO guidelines,need and purpose of DUE.Objective:The main aim of this paper is to provide information about the rational use of medication in outpa­tient and inpatient department with special emphasis of DUEs.It also provides awareness directly to healthcare professionals,researchers,academicians,pharmacist and nurses to reduce the irrationality of medicines.Methods:The method used to compile this review information gathered from websites,Google scholar,PubMed,Research gate,and studies published on DUE from July 20 to Oct 22 were included as source of information.Results:We studied more than 35 published study on DUE,that reveals most of the physicians prescribed branded drugs not generic drugs,but WHO prescribing indicator allows to prescribe generic drugs in the hospital pharmacy to maintain better inventory control.It may also help to prevent pharmacist misunderstanding during dispensing.Conclusion:The use of generic prescription names avoids the possibility of medication product duplication and lowers patient costs.It is important to remember that incorrect medication prescriptions have impact on both patients and their family members.WHO indicators identify irrational prescribing behaviours to make therapy more rational and cost-effective.

中枢神经系统脱髓鞘疾病应用甲强龙治疗的效果分析

目的分析中枢神经系统脱髓鞘疾病采用注射用甲泼尼龙琥珀酸钠(甲强龙)进行治疗的临床疗效。方法选择2020年8月至2022年9月收治的中枢神经系统脱髓鞘性疾病患者50例,以不同治疗模式分为观察组甲强龙治疗和对照组地塞米松治疗,各组25例。结果观察组治疗后的总有效率以及对照组治疗后的总有效率分别为92.00%和68.00%,组间数据对比P<0.05;观察组治疗后的不良反应发生率以及对照组治疗后的不良反应发生率分别为4.00%和24.00%,组间数据对比P<0.05;治疗前比较观察组和对照组患者的神经功能评分组间并无统计学意义,治疗后观察组患者神经功能评分显著降低,组间数据对比P<0.05;治疗前比较观察组和对照组患者的AT-Ⅱ、MDA和LPO水平组间并无统计学意义,治疗后观察组患者AT-Ⅱ、MDA和LPO水平显著改善,组间上述数据对比P<0.05;护理前观察组和对照组患者健康情况、躯体疾病、生理职能、情感职能和社会职能评分经对比,组间数据P>0.05;护理后组间数据对比P<0.05。结论临床治疗中枢神经系统脱髓鞘疾病患者的过程中,采用甲强龙可将整体效果提升,同时无严重不良反应,可改善神经功能和有关指标。

USE OF CELL-BASED BIOASSAY FOR THE QUALITY CONTROL OF BOTANICAL THERAPEUTICS

The single most important factor in modernization efforts of traditional oriental medicines is the limited understanding of active compounds responsible for claimed therapeutic effects.Indeed,the unknown identity of biologically active molecules generates major difficulties associated with botanical therapeutics in general.This includes management of raw materials,poor understanding of

糖皮质激素治疗间接性外伤性视神经病变的研究进展

间接性外伤性视神经病变（ITON）是头部外伤后视力受损的重要原因之一。糖皮质激素是目前常用的治疗ITON的方法，然而由于缺乏足够的循证医学证据支持，长期以来这种疗法的有效性和安全性等一直备受争议。近年的部分研究显示，超大剂量糖皮质激素的应用对ITON无益，这给传统的治疗理念带来了巨大的冲击。目前糖皮质激素在ITON治疗过程中的应用仍有许多临床问题尚待解决，也缺乏足够的证据，亟待国际和国内实施规范化的多中心、随机对照临床试验（RCTs），以探索有效的治疗方案，提供规范化的治疗标准。

甲基强的松龙冲击疗法抢救失明的小儿急性视神经炎的临床研究

目的 评价甲基强的松龙冲击疗法抢救失明的小儿急性视神经炎的疗效。方法 小儿组 :选择无肾上腺皮质激素禁忌症的失明小儿急性视神经炎 2 2例 (34眼 )为研究对象。用大剂量甲基强的松龙静脉滴注 ,每天剂量按小儿公斤体重计算。每天 1次 ,3～ 5天为 1疗程。以后再用常规疗法。成人组 :选择无肾上腺皮质激素禁忌症的失明成人急性视神经炎 16例 (2 4眼 )为对照组。甲基强的松龙 5 0 0～10 0 0mg静脉滴注 ,每天 1次 ,3～ 5天为 1疗程。以后再用常规疗法。结果 小儿组 :显效 (视力提高至 0 5～ 1 0 ) 2 2眼 ,占 6 4 7% ;有效 (视力提高至 0 1～ 0 4) 9眼 ,占 2 6 5 % ;总有效率 :91 2 % ;无效 (指数 ) :3眼 ,占 8 8%。成人组 :评价疗效标准与小儿组相同。显效 :9眼 ,占 37 5 % ;有效 :7眼 ,占 2 9.17% ;总有效率 :6 6 6 7% ;无效 :8眼 ,占 33 33%。两组疗效有差异 (P <0 0 2 5 )。结论 甲基强的松龙冲击疗法治疗失明小儿急性视神经炎 ,作用迅速可靠 ,疗效高 ,未发现副作用 ,随访无复发。

甲基强的松龙治疗儿童过敏性紫癜肾炎临床观察

目的观察甲基强的松龙冲击治疗儿童过敏性紫癜肾炎的临床疗效。方法分析30例行甲基强的松龙治疗的过敏性紫癜肾炎患儿的临床资料。结果经甲基强的松龙冲击治疗后,30例患儿中23例尿常规阴转或明显好转,总有效率达76·67%。在使其尿常规短期内阴转方面,轻型较重型、病程<3个月者较>3个月者显示了明显的优越性(P<0·05)。5例经皮肾穿刺术的患者,2例病理类型为IIb者对甲基强的松龙冲击治疗的效果较2例Ⅲb者好。在甲基强的松龙冲击治疗过程中,未见出现肾损伤加重现象及严重并发症发生。结论甲基强的松龙早期静脉冲击对儿童过敏性紫癜肾炎有一定治疗作用。

大剂量甲基强的松龙治疗获得性噬血细胞综合征的临床分析

目的观察大剂量甲基强的松龙治疗获得性噬血细胞综合征(HPS)的治疗效果。方法采用大剂量甲基强的松龙(4 mg.kg-1.d-1)治疗获得性HPS患者14例。结果 14例获得性HPS患者临床表现为发热(100%)、血清铁蛋白升高(85.7%)、高三酰甘油血症(78.6%)、肝脾肿大(71.4%)、天门冬氨酸氨基转移酶升高(71.4%)、淋巴结肿大(64.3%)、直接胆红素升高(64.3%)、贫血(51.7%)、乳酸脱氢酶升高(57.1%)、中性粒细胞减少(50.0%)和血小板减少(50.0%)。14例患者采用大剂量甲基强的松龙治疗后临床症状和体征明显改善,实验室检查指标均恢复正常6例(42.9%);临床症状改善,实验室指标较前好转,但未完全恢复正常6例(42.9%);死于疾病进展2例(14.2%)。结论大剂量甲基强的松龙治疗获得性HPS可能具有较好疗效。