Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 ...Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.展开更多
[目的]分析mi R-196a-2基因多态位点rs11614913与乳腺癌易感性的关系。[方法]检索外文数据库Pubmed、Science Direct和中文数据库CNKI、万方,收集截止到2016年5月31日发表的关于mi R-196a-2基因多态位点rs11614913与乳腺癌易感关系的病...[目的]分析mi R-196a-2基因多态位点rs11614913与乳腺癌易感性的关系。[方法]检索外文数据库Pubmed、Science Direct和中文数据库CNKI、万方,收集截止到2016年5月31日发表的关于mi R-196a-2基因多态位点rs11614913与乳腺癌易感关系的病例对照研究,按纳入与排除标准筛选文献,利用Meta分析的方法对各研究数据进行统计学处理及异质性检验,评估发表偏倚并进行敏感性分析。[结果]共纳入15篇研究mi R-196a-2基因多态位点rs11614913与乳腺癌易感关系的文献,包括6362例病例和7392例对照,结果显示：等位基因模型（T vs C）、隐形模型（TT vs CC＋CT）和相加模型（TT vs CC）与降低乳腺癌发病风险相关,差异均有统计学意义（OR=0.89,95%CI：0.81~0.99;OR=0.83,95%CI：0.72~0.96;OR=0.79,95%CI：0.65~0.97）。按种族进行亚组分析后发现,在亚洲人群中,等位基因模型（T vs C）、显性模型（TT＋CT vs CC）、隐形模型（TT vs CC＋CT）和相加模型（TT vs CC）也与降低乳腺癌发病风险相关（OR=0.85,95%CI：0.75~0.95;OR=0.83,95%CI：0.70~0.99;OR=0.78,95%CI：0.67~0.91;OR=0.72,95%CI：0.57~0.91）,其余模型均不能认为与乳腺癌的易感性相关。高加索人群的各遗传模型均与乳腺癌的发病风险无显著相关性。[结论]mi R-196a-2基因多态位点rs11614913的T等位基因和TT基因型可能与降低乳腺癌的发病风险相关。展开更多
文摘Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.
文摘[目的]分析mi R-196a-2基因多态位点rs11614913与乳腺癌易感性的关系。[方法]检索外文数据库Pubmed、Science Direct和中文数据库CNKI、万方,收集截止到2016年5月31日发表的关于mi R-196a-2基因多态位点rs11614913与乳腺癌易感关系的病例对照研究,按纳入与排除标准筛选文献,利用Meta分析的方法对各研究数据进行统计学处理及异质性检验,评估发表偏倚并进行敏感性分析。[结果]共纳入15篇研究mi R-196a-2基因多态位点rs11614913与乳腺癌易感关系的文献,包括6362例病例和7392例对照,结果显示：等位基因模型（T vs C）、隐形模型（TT vs CC＋CT）和相加模型（TT vs CC）与降低乳腺癌发病风险相关,差异均有统计学意义（OR=0.89,95%CI：0.81~0.99;OR=0.83,95%CI：0.72~0.96;OR=0.79,95%CI：0.65~0.97）。按种族进行亚组分析后发现,在亚洲人群中,等位基因模型（T vs C）、显性模型（TT＋CT vs CC）、隐形模型（TT vs CC＋CT）和相加模型（TT vs CC）也与降低乳腺癌发病风险相关（OR=0.85,95%CI：0.75~0.95;OR=0.83,95%CI：0.70~0.99;OR=0.78,95%CI：0.67~0.91;OR=0.72,95%CI：0.57~0.91）,其余模型均不能认为与乳腺癌的易感性相关。高加索人群的各遗传模型均与乳腺癌的发病风险无显著相关性。[结论]mi R-196a-2基因多态位点rs11614913的T等位基因和TT基因型可能与降低乳腺癌的发病风险相关。
