miRNA451a与胰岛素抵抗及糖尿病肾病的关系

2型糖尿病是一种发病机制复杂,以胰岛素抵抗、β细胞数量减少与功能障碍为特征的疾病,糖尿病肾脏病(Diabetes Kidney Disease, DKD)是糖尿病常见的慢性并发症之一,是由糖尿病引起的慢性肾脏病(CKD)。近年来,一些研究表明,miRNA451a与胰岛素抵抗存在一定关系,在糖肾中发生表达的改变,影响糖肾的进展。本文综述了胰岛素抵抗和糖肾的发病机制与miRNA451a的关系,为更深入地了解miRNA51a对2型糖尿病及糖肾的发病机制及治疗提供参考。Type 2 diabetes is a complex disease characterized by insulin resistance, reduced β-cells and its dysfunction. Diabetic kidney disease (DKD) is one of the common chronic complications of diabetes and is chronic kidney disease (CKD) caused by diabetes. In recent years, several studies have shown that a certain relationship between miRNA451a and insulin resistance, and its altered expression occurs in DKD, affecting the progression of DKD. This review summarizes the relationship between insulin resistance and DKD with miRNA451a to provide a further understanding of the pathogenesis and treatment of miRNA51a in type 2 diabetes and DKD.

miRNA451用于法医学血液鉴别的可行性研究

目的探讨m iRNA451是否可以用于法医学血液类物证的鉴别。方法以法医学常见血液类(外周血和月经血)及非血液类(精液、唾液、阴道分泌液)体液样本为研究对象,提取总RNA,以RT-qPCR方法检测1^聊八451的表达,利用5?5522.0进行统计分析。结果111丨1^八451在外周血及月经血中均具有高表达的特点,且表达量显著高于在唾液、精液及阴道分泌液等非血液类物证中的表达量(6组P均<0.05);放置一年的血斑中miRNA451表达量与新鲜血液无显著差异。结论miRNA451在血液类体液样本中的表达水平显著高于非血液类体液样本,且稳定性良好,可作为法医学血液类体液样本鉴别的良好分子标记物。