A kind of novel environmental-friendly composite absorbent material was designed and prepared in this paper.Nanoscale metal-organic frameworks(MOFs)were embedded in the skeleton of cotton micro fibrillated cellulose.B...A kind of novel environmental-friendly composite absorbent material was designed and prepared in this paper.Nanoscale metal-organic frameworks(MOFs)were embedded in the skeleton of cotton micro fibrillated cellulose.By scanning electron microscope(SEM),we observed that a large number of MOFs were attached to the cellulose skeleton.In addition,under the condition of 1800 r/min vortex,the structure of the composite material was stable and was not easily damaged by external forces.The water contact angle test showed that the composite material had excellent hydrophilicity and could be used for the adsorption of pollutants.Then,the material was characterized by energy dispersive X-ray spectroscopy(EDX),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR)and BET adsorption.Through verification,the material had very stable reusability(n=10).The composite material was applied to the solid phase extraction of water samples,such as rain water,toning water and fruit juice,and was quantitatively analyzed by high performance liquid chromatography(HPLC)-UV.This method was then applied to the extraction of four parabens(methyl-,ethyl-,propyl-,and butylparaben)from real samples,yielding limits of detection(LODs)of 0.29-0.58 ng/mL.The linear range was 2-500 ng/mL.The inter-day and intra-day recoveries were 90.7%-106.0%and 87.1%-109.3%,respectively(relative standard deviation<10.8%).展开更多
Atrial fibrillation(AF) is the most commonly encountered clinical arrhythmia associated with pronounced mortality and morbidity, which are related to palpitations, fainting, congestive heart failure, and stroke. Prolo...Atrial fibrillation(AF) is the most commonly encountered clinical arrhythmia associated with pronounced mortality and morbidity, which are related to palpitations, fainting, congestive heart failure, and stroke. Prolonged episodes of AF promote AF persistence mainly due to electrical remodelling that alters ion-channel expression and/or function. Micro RNAs(mi RNAs), a new class of noncoding mR NAs of around 22 nucleotides in length, have recently emerged as one of the key players in the geneexpression regulatory networks. The potential roles of miR NAs in controlling AF have recently been investigated. Several recent studies have provided promising results for a better understanding of the molecular mechanisms of AF. In this review, we summarize the mechanism of miR NAs as regulators of ion-channel gene expression and their role in causing AF through electrical remodelling.展开更多
Atrial fibrillation(AF)is the most frequent arrhythmogenic syndrome in humans.With an estimate incidence of1%-2%in the general population,AF raises up to almost10%-12%in 80+years.Thus,AF represents nowadays a highly p...Atrial fibrillation(AF)is the most frequent arrhythmogenic syndrome in humans.With an estimate incidence of1%-2%in the general population,AF raises up to almost10%-12%in 80+years.Thus,AF represents nowadays a highly prevalent medical problem generating a large economic burden.At the electrophysiological level,distinct mechanisms have been elucidated.Yet,despite its prevalence,the genetic and molecular culprits of this pandemic cardiac electrophysiological abnormality have remained largely obscure.Molecular genetics of AF familiar cases have demonstrated that single nucleotide mutations in distinct genes encoding for ion channels underlie the onset of AF,albeit such alterations only explain a minor subset of patients with AF.In recent years,analyses by means of genome-wide association studies have unraveled a more complex picture of the etiology of AF,pointing out to distinct cardiac-enriched transcription factors,as well as to other regulatory genes.Furthermore a new layer of regulatory mechanisms have emerged,i.e.,post-transcriptional regulation mediated by non-coding RNA,which have been demonstrated to exert pivotal roles in cardiac electrophysiology.In this manuscript,we aim to provide a comprehensive review of the genetic regulatory networks that if impaired exert electrophysiological abnormalities that contribute to the onset,and subsequently,on self-perpetuation of AF.展开更多
Microfibrillated cellulose(MFC)-collagen composite films were prepared with a dispersion of acid swollen collagen fibers and carboxylated MFC at different ratios in an alkaline homogenous system.The surface topographi...Microfibrillated cellulose(MFC)-collagen composite films were prepared with a dispersion of acid swollen collagen fibers and carboxylated MFC at different ratios in an alkaline homogenous system.The surface topographic results obtained from SEM analyses indicated that the MFC entangled uniformly with collagen in the film and formed a closely interwoven network to reinforce the film structure.However,the MFC addition decreased the smoothness and light transparency of the films due to the aggregation of MFC.Compared to the film prepared with pure collagen,the hybrid composite film showed a higher strength and Young’s modulus but lower elongation.The swelling of the composite film in water increased with the increase of the MFC ratio in the film matrix.DSC and TG analyses demonstrated that adding MFC to collagen benefited the thermal stability of the films,due to the conformational and crystal changes in the MFC/collagen structure indicated by the FT-IR and XRD results.The MFC/collagen composite film can potentially be used as an edible material in the food and packaging industry,in particular for meat products.展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.22074052 and 22004046)the Science and Technology Developing Foundation of Jilin Province of China(No.20200404173YY).
文摘A kind of novel environmental-friendly composite absorbent material was designed and prepared in this paper.Nanoscale metal-organic frameworks(MOFs)were embedded in the skeleton of cotton micro fibrillated cellulose.By scanning electron microscope(SEM),we observed that a large number of MOFs were attached to the cellulose skeleton.In addition,under the condition of 1800 r/min vortex,the structure of the composite material was stable and was not easily damaged by external forces.The water contact angle test showed that the composite material had excellent hydrophilicity and could be used for the adsorption of pollutants.Then,the material was characterized by energy dispersive X-ray spectroscopy(EDX),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR)and BET adsorption.Through verification,the material had very stable reusability(n=10).The composite material was applied to the solid phase extraction of water samples,such as rain water,toning water and fruit juice,and was quantitatively analyzed by high performance liquid chromatography(HPLC)-UV.This method was then applied to the extraction of four parabens(methyl-,ethyl-,propyl-,and butylparaben)from real samples,yielding limits of detection(LODs)of 0.29-0.58 ng/mL.The linear range was 2-500 ng/mL.The inter-day and intra-day recoveries were 90.7%-106.0%and 87.1%-109.3%,respectively(relative standard deviation<10.8%).
基金Supported by Grants BFU2012-38111(Ministerio de Economíay Competitividad,Gobierno de Espaa),Nos.CTS-1614,P08-CTS-03878,BIO-302(Junta de Andalucia)and AFM2012-16074(AFM)
文摘Atrial fibrillation(AF) is the most commonly encountered clinical arrhythmia associated with pronounced mortality and morbidity, which are related to palpitations, fainting, congestive heart failure, and stroke. Prolonged episodes of AF promote AF persistence mainly due to electrical remodelling that alters ion-channel expression and/or function. Micro RNAs(mi RNAs), a new class of noncoding mR NAs of around 22 nucleotides in length, have recently emerged as one of the key players in the geneexpression regulatory networks. The potential roles of miR NAs in controlling AF have recently been investigated. Several recent studies have provided promising results for a better understanding of the molecular mechanisms of AF. In this review, we summarize the mechanism of miR NAs as regulators of ion-channel gene expression and their role in causing AF through electrical remodelling.
基金Supported by A CNIC translational grant(CNIC2006/08)to Franco Dthe University of Jaén on translational biomedicine to Franco D(UJA2013/01)
文摘Atrial fibrillation(AF)is the most frequent arrhythmogenic syndrome in humans.With an estimate incidence of1%-2%in the general population,AF raises up to almost10%-12%in 80+years.Thus,AF represents nowadays a highly prevalent medical problem generating a large economic burden.At the electrophysiological level,distinct mechanisms have been elucidated.Yet,despite its prevalence,the genetic and molecular culprits of this pandemic cardiac electrophysiological abnormality have remained largely obscure.Molecular genetics of AF familiar cases have demonstrated that single nucleotide mutations in distinct genes encoding for ion channels underlie the onset of AF,albeit such alterations only explain a minor subset of patients with AF.In recent years,analyses by means of genome-wide association studies have unraveled a more complex picture of the etiology of AF,pointing out to distinct cardiac-enriched transcription factors,as well as to other regulatory genes.Furthermore a new layer of regulatory mechanisms have emerged,i.e.,post-transcriptional regulation mediated by non-coding RNA,which have been demonstrated to exert pivotal roles in cardiac electrophysiology.In this manuscript,we aim to provide a comprehensive review of the genetic regulatory networks that if impaired exert electrophysiological abnormalities that contribute to the onset,and subsequently,on self-perpetuation of AF.
基金The authors would like to acknowledge the financial support provided by,National High Technology Research and Development Program of China(No.2013AA102204)Special Fund for Agro-scientific Research in the Public Interest of China(No.201303082)。
文摘Microfibrillated cellulose(MFC)-collagen composite films were prepared with a dispersion of acid swollen collagen fibers and carboxylated MFC at different ratios in an alkaline homogenous system.The surface topographic results obtained from SEM analyses indicated that the MFC entangled uniformly with collagen in the film and formed a closely interwoven network to reinforce the film structure.However,the MFC addition decreased the smoothness and light transparency of the films due to the aggregation of MFC.Compared to the film prepared with pure collagen,the hybrid composite film showed a higher strength and Young’s modulus but lower elongation.The swelling of the composite film in water increased with the increase of the MFC ratio in the film matrix.DSC and TG analyses demonstrated that adding MFC to collagen benefited the thermal stability of the films,due to the conformational and crystal changes in the MFC/collagen structure indicated by the FT-IR and XRD results.The MFC/collagen composite film can potentially be used as an edible material in the food and packaging industry,in particular for meat products.
