The dynamic characteristics related to micro-motions, such as mechanical vibration or rotation, play an essential role in classifying and recognizing ballistic targets in the midcourse, and recent researches explore w...The dynamic characteristics related to micro-motions, such as mechanical vibration or rotation, play an essential role in classifying and recognizing ballistic targets in the midcourse, and recent researches explore ways of extracting the micro-motion features from radar signals of ballistic targets. In this paper, we focus on how to investigate the micro-motion dynamic characteristics of the ballistic targets from the signals based on infrared (IR) detection, which is mainly achieved by analyzing the periodic fluctuation characteristics of the target IR irradiance intensity signatures. Simulation experiments demonstrate that the periodic characteristics of IR signatures can be used to distinguish different micro motion types and estimate related parameters. Consequently, this is possible to determine the micro-motion dynamics of ballistic targets based on IR detection.展开更多
Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain,spinal cord and optic nerve leading to demyelination....Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain,spinal cord and optic nerve leading to demyelination.Focal demyelination is associated with relapsing-remitting multiple sclerosis,while progressive forms of the disease show axonal degeneration and neuronal loss.The tests currently used in the clinical diagnosis and management of multiple sclerosis have limitations due to specificity and sensitivity.MicroRNAs(miRNAs)are dysregulated in many diseases and disorders including demyelinating and neuroinflammatory diseases.A review of recent studies with the experimental autoimmune encephalomyelitis animal model(mostly female mice 6–12 weeks of age)has confirmed miRNAs as biomarkers of experimental autoimmune encephalomyelitis disease and importantly at the pre-onset(asymptomatic)stage when assessed in blood plasma and urine exosomes,and spinal cord tissue.The expression of certain miRNAs was also dysregulated at the onset and peak of disease in blood plasma and urine exosomes,brain and spinal cord tissue,and at the post-peak(chronic)stage of experimental autoimmune encephalomyelitis disease in spinal cord tissue.Therapies using miRNA mimics or inhibitors were found to delay the induction and alleviate the severity of experimental autoimmune encephalomyelitis disease.Interestingly,experimental autoimmune encephalomyelitis disease severity was reduced by overexpression of miR-146a,miR-23b,miR-497,miR-26a,and miR-20b,or by suppression of miR-182,miR-181c,miR-223,miR-155,and miR-873.Further studies are warranted on determining more fully miRNA profiles in blood plasma and urine exosomes of experimental autoimmune encephalomyelitis animals since they could serve as biomarkers of asymptomatic multiple sclerosis and disease course.Additionally,studies should be performed with male mice of a similar age,and with aged male and female mice.展开更多
The incidence of esophageal cancer is rising,mostly because the increasing incidence of esophageal adenocarcino main Western countries.Despit eimprovements in diagnosis and treatment,the overall5-year survival rates r...The incidence of esophageal cancer is rising,mostly because the increasing incidence of esophageal adenocarcino main Western countries.Despit eimprovements in diagnosis and treatment,the overall5-year survival rates remain low.Micro RNAs(mi RNAs)are small non-coding RNA molecules that regulate the expression of target genes.Recently,disease specific mi RNAs have been identified,which act as tumor suppressors or oncogenes.In this review,we will summarize the current knowledge about the function of aberrantly expressed mi RNAs in esophageal cancer.We selected 5 mi RNAs(mi RNA-21,-143,-145,-196a and let-7)based on the available literature,and described their potential role in regulating pathways that are deregulated in esophageal cancer.Finally we will highlight the current achievements of using and targeting mi RNAs.Because these mi RNAs likely have important regulatory roles in cancer development,they open a therapeutic window for new treatment modalities.展开更多
Hepatocellular carcinoma(HCC) is the leading primary liver cancer and its clinical outcome is still poor. MicroRNAs(mi RNAs) have demonstrated an interesting potential to regulate gene expression at post-transcription...Hepatocellular carcinoma(HCC) is the leading primary liver cancer and its clinical outcome is still poor. MicroRNAs(mi RNAs) have demonstrated an interesting potential to regulate gene expression at post-transcriptional level. Current findings suggest that mi RNAs deregulation in cancer is caused by genetic and/or epigenetic, transcriptional and post-transcriptional modifications resulting in abnormal expression and hallmarks of malignant transformation: aberrant cell growth, cell death, differentiation, angiogenesis, invasion and metástasis. The important role of mi RNAs in the development and progression of HCC has increased the efforts to understand and develop mechanisms of control overt this single-stranded RNAs. Several studies have analyzed tumoral response to the regulation and control of deregulated mi RNAs with good results in vitro and in vivo, proving that targeting aberrant expression of mi RNAs is a powerful anticancer therapeutic. Identification of up and/or down regulated mi RNAs related to HCC has led to the discovery of new potential application for detection of their presence in the affected organism. Mi RNAs represent a relevant new target for diagnosis, prognosis and treatment in a wide variety of pathologic entities, including HCC. This manuscript intends to summarize current knowledge regarding mi RNAs and their role in HCC development.展开更多
文摘The dynamic characteristics related to micro-motions, such as mechanical vibration or rotation, play an essential role in classifying and recognizing ballistic targets in the midcourse, and recent researches explore ways of extracting the micro-motion features from radar signals of ballistic targets. In this paper, we focus on how to investigate the micro-motion dynamic characteristics of the ballistic targets from the signals based on infrared (IR) detection, which is mainly achieved by analyzing the periodic fluctuation characteristics of the target IR irradiance intensity signatures. Simulation experiments demonstrate that the periodic characteristics of IR signatures can be used to distinguish different micro motion types and estimate related parameters. Consequently, this is possible to determine the micro-motion dynamics of ballistic targets based on IR detection.
文摘Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain,spinal cord and optic nerve leading to demyelination.Focal demyelination is associated with relapsing-remitting multiple sclerosis,while progressive forms of the disease show axonal degeneration and neuronal loss.The tests currently used in the clinical diagnosis and management of multiple sclerosis have limitations due to specificity and sensitivity.MicroRNAs(miRNAs)are dysregulated in many diseases and disorders including demyelinating and neuroinflammatory diseases.A review of recent studies with the experimental autoimmune encephalomyelitis animal model(mostly female mice 6–12 weeks of age)has confirmed miRNAs as biomarkers of experimental autoimmune encephalomyelitis disease and importantly at the pre-onset(asymptomatic)stage when assessed in blood plasma and urine exosomes,and spinal cord tissue.The expression of certain miRNAs was also dysregulated at the onset and peak of disease in blood plasma and urine exosomes,brain and spinal cord tissue,and at the post-peak(chronic)stage of experimental autoimmune encephalomyelitis disease in spinal cord tissue.Therapies using miRNA mimics or inhibitors were found to delay the induction and alleviate the severity of experimental autoimmune encephalomyelitis disease.Interestingly,experimental autoimmune encephalomyelitis disease severity was reduced by overexpression of miR-146a,miR-23b,miR-497,miR-26a,and miR-20b,or by suppression of miR-182,miR-181c,miR-223,miR-155,and miR-873.Further studies are warranted on determining more fully miRNA profiles in blood plasma and urine exosomes of experimental autoimmune encephalomyelitis animals since they could serve as biomarkers of asymptomatic multiple sclerosis and disease course.Additionally,studies should be performed with male mice of a similar age,and with aged male and female mice.
文摘The incidence of esophageal cancer is rising,mostly because the increasing incidence of esophageal adenocarcino main Western countries.Despit eimprovements in diagnosis and treatment,the overall5-year survival rates remain low.Micro RNAs(mi RNAs)are small non-coding RNA molecules that regulate the expression of target genes.Recently,disease specific mi RNAs have been identified,which act as tumor suppressors or oncogenes.In this review,we will summarize the current knowledge about the function of aberrantly expressed mi RNAs in esophageal cancer.We selected 5 mi RNAs(mi RNA-21,-143,-145,-196a and let-7)based on the available literature,and described their potential role in regulating pathways that are deregulated in esophageal cancer.Finally we will highlight the current achievements of using and targeting mi RNAs.Because these mi RNAs likely have important regulatory roles in cancer development,they open a therapeutic window for new treatment modalities.
文摘Hepatocellular carcinoma(HCC) is the leading primary liver cancer and its clinical outcome is still poor. MicroRNAs(mi RNAs) have demonstrated an interesting potential to regulate gene expression at post-transcriptional level. Current findings suggest that mi RNAs deregulation in cancer is caused by genetic and/or epigenetic, transcriptional and post-transcriptional modifications resulting in abnormal expression and hallmarks of malignant transformation: aberrant cell growth, cell death, differentiation, angiogenesis, invasion and metástasis. The important role of mi RNAs in the development and progression of HCC has increased the efforts to understand and develop mechanisms of control overt this single-stranded RNAs. Several studies have analyzed tumoral response to the regulation and control of deregulated mi RNAs with good results in vitro and in vivo, proving that targeting aberrant expression of mi RNAs is a powerful anticancer therapeutic. Identification of up and/or down regulated mi RNAs related to HCC has led to the discovery of new potential application for detection of their presence in the affected organism. Mi RNAs represent a relevant new target for diagnosis, prognosis and treatment in a wide variety of pathologic entities, including HCC. This manuscript intends to summarize current knowledge regarding mi RNAs and their role in HCC development.
