Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma

Hepatocellular carcinoma(HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective,especially for the advanced forms of the disease. In the last year,short double stranded RNA molecules termed small interfering RNAs(si RNAs) and micro interfering RNAs(mi RNA),emerged as interesting molecules with potential therapeutic value for HCC. The practical use of these molecules is however limited by the identification of optimal molecular targets and especially by the lack of effective and targeted HCC delivery systems. Here we focus our discussion on the most recent advances in the identification of si RNAs/mi RNAs molecular targets and on the development of suitable si RNA/mi RNAs delivery systems.

High-efficiency Approach for Fabricating MTE Rotor by Micro-EDM and Micro-extrusion

Micro-gas turbine engine（MTE） rotor is an important indicator of its property, therefore, the manufacturing technology of the microminiature rotor has become a hot area of research at home and abroad. At present, the main manufacturing technologies of the MTE rotor are directed forming fabrication technologies. However, these technologies have a series of problems, such as complex processing technology high manufacturing cost, and low processing efficiency, and so on. This paper takes advantage of micro electric discharge machining（micro-EDM） in the field of microminiature molds manufacturing, organizes many processing technologies of micro-EDM reasonably to improve processing accuracy, presents an integrated micro-EDM technology and its process flow to fabricate MTE rotor die, and conducts a series of experiments to verify efficiency of this integrated micro-EDM. The experiments results show that the MTE rotor die has sharp outline and ensure the good consistency of MTE rotor blades. Meanwhile, the MTE rotor die is applied to micro extrusion equipment, and technologies of micro-EDM and micro forming machining are combined based on the idea of the molds manufacturing, so the MTE rotor with higher aspect ratio and better consistency of blades can be manufactured efficiently. This research presents an integrated micro-EDM technology and its process flow, which promotes the practical process of MTE effectively.

Micro electrical discharge machining of small hole in TC4 alloy

Aiming at machining deeply small holes in TC4 alloy,a series of experiments were carried out on a self-developed multi-axis micro electrical discharge machining(micro-EDM)machine tool.To improve machining efficiency and decrease relative wear of electrode in machining deeply small hole in TC4 alloy,many factors in micro-EDM,such as polarity,electrical parameters and supplying ways of working fluid were studied.Experimental results show that positive polarity machining is far superior to negative polarity machining;it is more optimal when open-circuit voltage,pulse width and pulse interval are 130 V,5μs and 15μs respectively on the self developed multi-axis micro-EDM machine tool;when flushing method is applied in micro-EDM,the machining efficiency is higher and relative wear of electrode is smaller.

Empirical Research on the Credit Demand and Credit Behavior of Small and Micro Enterprises

This article uses discriminant sampling method to select 1062 small and micro enterprises from 25 provinces in China. Researches were conducted on their credit demand and credit behavior, with the Probit model to carry out metrologic tests on influential factors of these enterprises' credit demand and credit behavior.The metrologic analysis shows: Literacy level of leader, asset size, annual revenue of the enterprises have significantly positive effects on the credit demand of these small and micro enterprises. Annual revenue has significantly negative influence on overall credit behavior and the occurrence of informal financial behavior, but significantly positive influence on the occurrence of formal financial behavior. Literacy level of staff and asset size of enterprises have significantly positive influence on the occurrence of the overall credit behavior of small and micro enterprises.

H _ index based fault estimation for micro quad-rotor

Taking the attitude control system of micro quad-rotor as a research object, a design scheme of fault estimator based on generalized Kalman-Yakubovic-Popov （GKYP） lemma is put forward to deal with the problem of estimating multiple actuators malfunctions with couplings. Using an H_index and an appropriate algorithm, the goal of weakening the coupling can be achieved by limiting the fault frequency to a certain range, then different kinds of actuator faults can be estimated correctly. The simulations demonstrate the reliability and validity of the proposed method.

The Importance of Cultural Intelligence for Leader to Communicate Effectively: Case Study in Micro Small Medium Enterprises

Micro Small Medium Enterprises (MSMEs) in Indonesia play huge part of national economic development because MSMEs can reduce unemployment rate. But, it is not easy to manage MSMEs well so it can be sustainable. There are some reasons why MSMEs are difficult to sustain, i.e., good management people by communicate effectively. Authors believe that one of important ability that owners, as a leader, must have in order to communicate effectively is cultural intelligence. Even in MSMEs, cultural intelligence plays important part because employees in MSMEs are diverse. They come from different region (mean having different tradition) and have different level of education. Methodology that is used in this article is qualitative method, and techniques of data collection are interview and observation. Technique of choosing informant is purposive and convenience while data analysis is using content analysis. The result of this study shows that leaders in MSMEs already have cultural intelligence to communicate with their employee. Leaders who have cultural intelligence can choose right method to communicate effectively with their employee.

Measuring the Degree of Innovation in Retail and Services Micro and Small Enterprises

Micro and small enterprises （MSEs） are considered the most dynamic and flexible arrangement of activity. In the economy, the foundation and development of these features is important for the creation of the so-called ＂normal＂ economic environment. The main objective of this research is to present a research model of innovation in MSEs to analyse： first, the degree of innovation of MSEs, and second, how the innovation is handled by existing MSEs as a result of its business environment. The research made is based on a sample of 550 MSEs distributed over six cities across the Brazilian State of Piaui. The data were collected using the Innovation Radar application, which is owned by the SEBRAE Local Innovation Agents program. Statistical techniques of descriptive, exploratory, and inferential nature were used for corresponding data treatment and results validation. The results obtained suggest that MSEs have innovation capacity between the ＂Little Innovative＂ and ＂Occasional Innovative＂ range, and also that the average and the distribution of innovation levels are similar amongst MSEs analyzed.

Opto propeller effect on Micro–Rotors with different handedness

Manipulating biomacromolecules and micro-devices with light is highly appealing.Opto driving torque can propel micro-rotors to translational motion in viscous liquid,and then separate microsystems according to their handedness.We study the torque of dielectric loss generated by circular polarized lasers.The unwanted axial force which causes the handedness independent translational motion is cancelled by the counter propagating reflection beams.The propelling efficiency and the friction torque of water are obtained by solving the Navier-Stokes equation.In the interesting range of parameters,the numerical friction torque is found to be linear to the angular velocity with a slope depending on the radius of rotor as r^3.The time-dependent distribution of angular velocity is obtained as a solution of the Fokker-Planck equation,with which the thermal fluctuation is accounted.The results shed light on the micro-torque measurement and suggest a controllable micro-carrier.

Countermeasures of Financing Difficulties of Small and Micro Enterprises in China

Financing difficult problem has seriously restricted the further development of small and micro enterprises in our country. This paper analyzes and discusses the Countermeasures of the financing difficulties of small and micro enterprises in our country from two aspects of the external environment and internal self.

Research on the Influence Degree and Effect of Support on Innovation Incentives for R&D Personnel in Micro and Small Enterprises:An Empirical Study based on the China Micro and Small Enterprise Survey(CMES)

In this study,the influence degree and effect of support on innovation incentives for research and development(R&D)personnel in micro and small enterprises(MSEs)were explored based on the CMES data.We found that government support will increase the R&D wage and widen the gap between R&D wage and staff wage,especially for small,non-high-tech enterprises with strict financing constraints.Furthermore,taking the wage gap as a mediator,we concluded that support would widen the wage gap and increase management innovation rather than technological innovation in MSEs because the wage premium of R&D personnel is the main driver for the increase of management innovation.The findings of this study provide useful enlightenment for China to implement an innovation-driven strategy and build an innovative country.

Financing of small and micro enterprises based on P2B net loan mode

Small and micro enterprises play an extremely important role in the realization of employment, independent innovation,increasing taxes and so on, It is an important part of national economic development in China. Although the government has introduced a series of supportive policies, but small and micro enterprises arc still faced with many development problems, small and micro enterprises face an important problem is financing difficulty, which relates to its health, sustainable and stable development. This paper analyzes the financing problem of small and micro enterprises from the new net loan mode of P2B, hoping to benefit the development of small and micro enterprises.

Untethered Micro/Nanorobots for Remote Sensing:Toward Intelligent Platform

Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and diverse functionalities.Researchers are developing micro/nanorobots as innovative tools to improve sensing performance and miniaturize sensing systems,enabling in situ detection of substances that traditional sensing methods struggle to achieve.Over the past decade of development,significant research progress has been made in designing sensing strategies based on micro/nanorobots,employing various coordinated control and sensing approaches.This review summarizes the latest developments on micro/nanorobots for remote sensing applications by utilizing the self-generated signals of the robots,robot behavior,microrobotic manipulation,and robot-environment interactions.Providing recent studies and relevant applications in remote sensing,we also discuss the challenges and future perspectives facing micro/nanorobots-based intelligent sensing platforms to achieve sensing in complex environments,translating lab research achievements into widespread real applications.

Internal Flow Condition between Front and Rear Rotor of Contra-Rotating Small-Sized Axial Fan at Low Flow Rate

Contra-rotating small-sized fans are used as cooling fans for electric equipment. The internal flow condition between the front and rear rotors of the contra-rotating small-sized fan is not known well especially at the low flow rate. Furthermore, the blade row distance between the front and rear rotors is an important parameter for the contra-rotating small-sized fan and its influence on the internal flow condition is not clarified at the low flow rate. Therefore, the internal flow condition of the contra-rotating small-sized fan at the low flow rate is investigated by the numerical analysis in this research. The numerical analysis results are validated by comparing the fan static pressure curves of the numerical results to the experimental results. The internal flow condition at the low flow rate is clarified using the numerical models of the different blade row distance L = 10 mm and 30 mm. In the present paper, pressure fluctuations phase locked each front and rear rotor’s rotation are shown and the influences of the wake and the potential interference are discussed by the unsteady numerical analysis results at the low flow rate.

A Study on Improving the Financing Environment of Small and Micro Enterprises-Based on Taizhou Model

China’s small and micro enterprises have always had the typical characteristics of“five,six,seven,eight,nine,”which are important supports to expand employment and improve people’s livelihood.However,the current proportion of these enterprises in obtaining bank loans does not commensurate with the proportion of small,medium,and micro enterprises in the total economic aggregate.The financing dilemma of small and micro enterprises still exists.In consideration of the financing status of small and micro enterprises,this study analyzes the constraints of small and micro enterprises in financing,such as the difficulty in mortgage,difficulty in obtaining loans,and difficulty in guaranteeing.This study sorts out Taizhou’s practical experience and links its operation mechanism of“two platforms,one fund,and one index.”Finally,by learning from its successful experience,how to utilize the environment and the trend of big data will be further discussed,so as to form a scalable and sustainable financing method and path.This will provide a reference for improving the financing environment of small and micro enterprises.

离子造影剂增强Micro-CT扫描对大鼠关节软骨形态的定量分析

利用Micro-CT技术的较高分辨精度,探索一种新的测量小动物关节软骨形态的方法,为进一步利用小动物模型开展关节软骨的损伤和退变等研究提供基础。选择不同浓度的造影剂及Micro-CT扫描条件,通过造影剂对比增强Micro-CT扫描大鼠膝关节,对大鼠股骨远端关节软骨进行手动分割、重建,得到软骨3D模型,利用重建得到的3D模型,对软骨的厚度和体积等形态学参数进行无创定量分析。根据造影剂、软骨和软骨下骨对X射线吸收的平均相对衰减值差异,确定30%的离子造影剂浓度为最佳。利用该浓度对4个不同的正常大鼠关节软骨进行扫描和重建,分析获得关节软骨的体积和厚度,并求得关节软骨体积和厚度的变异系数均方根分别为7.3%和6.1%。结果提示,利用造影剂增强Micro-CT扫描能够对软骨形态重要参数厚度、体积等进行定量评价。

高分辨率小动物Micro Insert PET系统的模拟研究

在西门子Micro PET小动物成像系统中接入高分辨率的Insert探测器环,组成了Micro Insert PET系统,可以进一步提高小动物PET系统的图像分辨率。本文采用蒙特卡罗模拟软件GATE定义Focus-220小动物PET和Micro Insert两种系统,在同步仿真运算中,给出了三种类型的符合数据,即PET Scanner和PET Scanner之间的符合、PET Scanner和Insert之间的符合、Insert和Insert之间的符合。用滤波反投影算法重建了Na-22单点源模型、多点源模型、LZU模型的PET图像。其中,多点源模型的径向图像分辨率的仿真结果与美国华盛顿大学的Micro Insert实验数据,在忽略正电子射程、非线性效应项以及噪声等的贡献下,两者符合得很好。研究表明,使用Micro Insert系统能够将小动物PET系统的图像分辨率提高到亚毫米水平。

MicroRNA在非小细胞肺癌的诊断、治疗和预后评估中的作用

肺癌是最常见的恶性肿瘤之一,居全球癌症死亡的首位。肺癌预后差的原因是缺乏有效的早期诊断方法及治疗手段。微小核糖核酸（Micro RNA,miRNA）是一种大小为18~23个碱基的非编码单链小分子RNA。近年研究发现,miRNA在肺癌的发生发展发挥着重要作用。本文对miRNA在非小细胞肺癌的诊断、治疗和预后判断中的作用做一综述。

隧道超挖超耗管控措施研究

隧道的超挖超耗管控是绿色低碳时代背景下工程界最关心的难题,对施工企业的成本控制和效益提升具有重要意义。以武两高速XFS隧道为背景,系统总结了隧道超挖超耗的10类影响因素和常见对策,包括围岩条件、施工参数、测量放样、爆破方案、钻孔质量、喷射混凝土回弹率、预留变形量、物资设备性能、作业人员水平和现场施工管控。分析了XFS隧道超挖超耗的原因,并制定了加强地质预报和超前支护施作,减小开挖进尺;动态调整爆破方案,严格炮孔质量检查;引入超细改性硅微粉优化配合比,提高喷射工艺水平;加强现场施工管控,制定超挖超耗管控办法,落实作业人员的激励奖惩等措施。措施执行后,XFS隧道平均超挖由30.1 cm降低至16.6 cm,综合超耗由173.7%降低至100.7%。

基于随机森林算法的小鼠micro-CT影像中骨骼关节特征点定位

随着小动物成像技术的发展,技术人员每天需要处理的小动物影像数量急剧增长,这使得自动化的小动物图像分析方法成为迫切的需求。在小鼠图像分析方面,小鼠灵活多变的身体姿态给自动化的图像分析带来困难。基于随机森林算法实现小鼠micro-CT图像中骨骼关节点的自动定位,为解决小鼠影像中身体姿态的自动识别打下基础。该算法主要分3步:先通过分类随机森林算法得到小鼠骨骼关节点的粗定位,再通过回归随机森林算法进一步减小定位误差,最后通过图匹配的方法在备选点中挑选正确位置上的关节点。对49例不同身体姿态的小鼠全身三维micro-CT图像进行测试,全身关节点定位的成功率为98.27%,定位误差的中值为0.68 mm。同时验证联合使用分类与回归随机森林的必要性,并探究训练数据的数量对不同骨关节的识别效果的影响。研究为小鼠micro-CT影像中身体姿态的识别提供一种新方法,为后续的自动化图像配准、图像分割以及自动化图像测量提供重要的定位信息。

Attitude control for part actuator failure of agile small satellite

The stability and singularity problem of agile small satellite （ASS） with actuator failure is discussed in this paper. Firstly, the three-axis stabilized controller of an ASS is designed, where micro control moment gyros （MCMG＇s） in pyramid configuration （PC） is used as the actuator. By using the same controller and steering law, the control results before and after one gyro fails are compared by simulation. The variation of singular momentum envelope before and after one gyro fails is also compared. The simulation results show that the failure intensively decreases the capacity of output torque, which leads to the emergence of more singular points and the rapid saturation of MCMG＇s. Finally, the parameters of system controller are changed to compare the control effect.