Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product development.Previous efforts of digital twinning neglect the decisive con...Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product development.Previous efforts of digital twinning neglect the decisive consumer feedback in product development stages,failing to cover the gap between physical and digital spaces.This work mines real-world consumer feedbacks through social media topics,which is significant to product development.We specifically analyze the prevalent time of a product topic,giving an insight into both consumer attention and the widely-discussed time of a product.The primary body of current studies regards the prevalent time prediction as an accompanying task or assumes the existence of a preset distribution.Therefore,these proposed solutions are either biased in focused objectives and underlying patterns or weak in the capability of generalization towards diverse topics.To this end,this work combines deep learning and survival analysis to predict the prevalent time of topics.We propose a specialized deep survival model which consists of two modules.The first module enriches input covariates by incorporating latent features of the time-varying text,and the second module fully captures the temporal pattern of a rumor by a recurrent network structure.Moreover,a specific loss function different from regular survival models is proposed to achieve a more reasonable prediction.Extensive experiments on real-world datasets demonstrate that our model significantly outperforms the state-of-the-art methods.展开更多
In the video captioning methods based on an encoder-decoder,limited visual features are extracted by an encoder,and a natural sentence of the video content is generated using a decoder.However,this kind ofmethod is de...In the video captioning methods based on an encoder-decoder,limited visual features are extracted by an encoder,and a natural sentence of the video content is generated using a decoder.However,this kind ofmethod is dependent on a single video input source and few visual labels,and there is a problem with semantic alignment between video contents and generated natural sentences,which are not suitable for accurately comprehending and describing the video contents.To address this issue,this paper proposes a video captioning method by semantic topic-guided generation.First,a 3D convolutional neural network is utilized to extract the spatiotemporal features of videos during the encoding.Then,the semantic topics of video data are extracted using the visual labels retrieved from similar video data.In the decoding,a decoder is constructed by combining a novel Enhance-TopK sampling algorithm with a Generative Pre-trained Transformer-2 deep neural network,which decreases the influence of“deviation”in the semantic mapping process between videos and texts by jointly decoding a baseline and semantic topics of video contents.During this process,the designed Enhance-TopK sampling algorithm can alleviate a long-tail problem by dynamically adjusting the probability distribution of the predicted words.Finally,the experiments are conducted on two publicly used Microsoft Research Video Description andMicrosoft Research-Video to Text datasets.The experimental results demonstrate that the proposed method outperforms several state-of-art approaches.Specifically,the performance indicators Bilingual Evaluation Understudy,Metric for Evaluation of Translation with Explicit Ordering,Recall Oriented Understudy for Gisting Evaluation-longest common subsequence,and Consensus-based Image Description Evaluation of the proposed method are improved by 1.2%,0.1%,0.3%,and 2.4% on the Microsoft Research Video Description dataset,and 0.1%,1.0%,0.1%,and 2.8% on the Microsoft Research-Video to Text dataset,respectively,compared with the existing video captioning methods.As a result,the proposed method can generate video captioning that is more closely aligned with human natural language expression habits.展开更多
Cataract is the main cause of visual impairment and blindness worldwide while the only effective cure for cataract is still surgery.Consecutive phacoemulsification under topical anesthesia has been the routine procedu...Cataract is the main cause of visual impairment and blindness worldwide while the only effective cure for cataract is still surgery.Consecutive phacoemulsification under topical anesthesia has been the routine procedure for cataract surgery.However,patients often grumbled that they felt more painful during the second-eye surgery compared to the first-eye surgery.The intraoperative pain experience has negative influence on satisfaction and willingness for second-eye cataract surgery of patients with bilateral cataracts.Intraoperative ocular pain is a complicated process induced by the nociceptors activation in the peripheral nervous system.Immunological,neuropsychological,and pharmacological factors work together in the enhancement of intraoperative pain.Accumulating published literatures have focused on the pain enhancement during the secondeye phacoemulsification surgeries.In this review,we searched PubMed database for articles associated with pain perception differences between consecutive cataract surgeries published up to Feb.1,2024.We summarized the recent research progress in mechanisms and interventions for pain perception enhancement in consecutive secondeye phacoemulsification cataract surgeries.This review aimed to provide novel insights into strategies for improving patients’intraoperative experience in second-eye cataract surgeries.展开更多
Objective:This paper aims to study the application of flipped classroom teaching model based on micro-course in the practical training teaching of contact lens fitting technology.Methods:From September 21 to July 23,1...Objective:This paper aims to study the application of flipped classroom teaching model based on micro-course in the practical training teaching of contact lens fitting technology.Methods:From September 21 to July 23,120 students majoring in ophthalmology and optometry were selected and randomly divided into groups.The control group adopted the traditional teaching mode,and the study group adopted the flipped classroom teaching mode based on micro-course.Teaching scores and the skills,observation and judgment,adaptability,and communication skills were compared between the groups.Results:Statistical comparison of teaching scores under different management methods showed that the clinical thinking score and practice work quality in the study group were higher than those of the control group,and the effect of the study group was better(P<0.05).The overall scores of skills,observation and judgment,adaptability,and communication skills of the study group were better than those in the control group,and the comprehensive ability scores in the two groups were significantly different(P<0.05).Conclusion:In practical training teaching of contact lens fitting technology,the application of flipped classroom teaching based on micro-course can improve the skill scores of personnel,and the overall effect is good.This can lay the foundation for advanced ophthalmology and optometry talents with profound theoretical knowledge and professional skills.展开更多
目的分析2009~2024年间国际延时现场救护领域的文献,探究主要研究主题及其发展趋势,以期为未来救护策略提供理论支持。方法系统检索PubMed、Embase、Web of Science和中国知网等数据库,筛选并纳入283篇相关文献。运用BERTopic主题建模...目的分析2009~2024年间国际延时现场救护领域的文献,探究主要研究主题及其发展趋势,以期为未来救护策略提供理论支持。方法系统检索PubMed、Embase、Web of Science和中国知网等数据库,筛选并纳入283篇相关文献。运用BERTopic主题建模技术对文献进行主题识别和关键词分析,并进行可视化展示。结果当前研究主要聚焦在“急救策略研究”“智能技术与信息管理”“实战应用”与“政策与理论研究”等4个方面,预测这些领域将持续成为研究热点。结论国际延时现场救护研究正处于快速发展阶段,建议未来研究深入重点领域,开发有效的救护策略,以提升救治效率和伤员生存率。展开更多
With the extensive integration of the Internet,social networks and the internet of things,the social internet of things has increasingly become a significant research issue.In the social internet of things application...With the extensive integration of the Internet,social networks and the internet of things,the social internet of things has increasingly become a significant research issue.In the social internet of things application scenario,one of the greatest challenges is how to accurately recommend or match smart objects for users with massive resources.Although a variety of recommendation algorithms have been employed in this field,they ignore the massive text resources in the social internet of things,which can effectively improve the effect of recommendation.In this paper,a smart object recommendation approach named object recommendation based on topic learning and joint features is proposed.The proposed approach extracts and calculates topics and service relevant features of texts related to smart objects and introduces the“thing-thing”relationship information in the internet of things to improve the effect of recommendation.Experiments show that the proposed approach enables higher accuracy compared to the existing recommendation methods.展开更多
Recently,automation is considered vital in most fields since computing methods have a significant role in facilitating work such as automatic text summarization.However,most of the computing methods that are used in r...Recently,automation is considered vital in most fields since computing methods have a significant role in facilitating work such as automatic text summarization.However,most of the computing methods that are used in real systems are based on graph models,which are characterized by their simplicity and stability.Thus,this paper proposes an improved extractive text summarization algorithm based on both topic and graph models.The methodology of this work consists of two stages.First,the well-known TextRank algorithm is analyzed and its shortcomings are investigated.Then,an improved method is proposed with a new computational model of sentence weights.The experimental results were carried out on standard DUC2004 and DUC2006 datasets and compared to four text summarization methods.Finally,through experiments on the DUC2004 and DUC2006 datasets,our proposed improved graph model algorithm TG-SMR(Topic Graph-Summarizer)is compared to other text summarization systems.The experimental results prove that the proposed TG-SMR algorithm achieves higher ROUGE scores.It is foreseen that the TG-SMR algorithm will open a new horizon that concerns the performance of ROUGE evaluation indicators.展开更多
The research of flipped class classroom teaching based on micro-course provides a new idea for the reform of classroom teaching in universities and colleges. This teaching concept of reversing the class and after-clas...The research of flipped class classroom teaching based on micro-course provides a new idea for the reform of classroom teaching in universities and colleges. This teaching concept of reversing the class and after-class activities can effectively solve the problems in the current Russian classroom teaching, which cultivates students’ ability to listen, speak, read and write, and meets the requirements and teaching purposes of Russian teaching in universities and colleges. This paper mainly explores and studies the current situation of Russian teaching in universities and colleges, and points out the specific way of using the flipped classroom concept to carry out education and teaching reform. It hopes to provide a certain reference for the reform of Russian teaching in universities and colleges.展开更多
As a new means and way of combining media convergence and ideological and political education,ideological and political micro-courses play an important role in the process of cultivating the socialist core values of c...As a new means and way of combining media convergence and ideological and political education,ideological and political micro-courses play an important role in the process of cultivating the socialist core values of college students and qualified successors of the socialist cause.For western economics as the core course of agricultural economics major,how to construct ideological and political micro-courses in the era of media convergence to give full play to the effective function of micro-courses in ideological and political education in western economics has good practical significance at present.展开更多
Objectives:Non-healing wounds have been one of the major challenges in health care because of increased morbidity,especially for those who have diabetes mellitus.Numerous regimens are being innovated to produce an evi...Objectives:Non-healing wounds have been one of the major challenges in health care because of increased morbidity,especially for those who have diabetes mellitus.Numerous regimens are being innovated to produce an evidence-based practice that would minimize complications and promote healing.Topical oxygen therapy is an innovation in wound care that has been considered influential in the wound healing process.This intervention aims to increase the oxygen concentration in the affected limb to promote wound healing.Methods:This research applied an experimental design that targeted a total of 60 adult patients aged 45–64 years with diabetic foot ulcers.A randomized systematic sampling technique was used to allow equal chances and prevent bias.In total,30 patients in the control group received usual care for diabetic foot ulcers,and the remaining 30 patients in the experimental group received topical oxygen therapy together with standard care for diabetic foot ulcers.Subjects were assessed using the Wagner-Meggitt Wound Classification System.Results:The result proved that there was a significant difference in the wound grade of patients in the experimental group after the application of the usual wound care plus the topical oxygen therapy using Friedman's test.The control and experimental groups were compared using Mann–Whitney statistical analyses,and the results showed that there was a significant difference between the control and experimental groups after the application of topical oxygen therapy.Conclusions:Topical oxygen therapy was demonstrated to be effective to aid in the wound healing process of patients with diabetic foot ulcers.Fur ther research was recommended to improve the application of topical oxygen therapy to patients with chronic wounds and promote the wound healing process.展开更多
Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been develope...Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been developed and explored for enhanced topical psoriasis treatment.However,these preparations usually have low viscosity and limited retention on the skin surface,resulting in low drug delivery efficiency and poor patient satisfaction.In this study,we developed the first water-responsive gel(WRG),which has a distinct water-triggered liquid-to-gel phase transition property.Specifically,WRG was kept in a solution state in the absence of water,and the addition of water induced an immediate phase transition and resulted in a high viscosity gel.Curcumin was used as a model drug to investigate the potential of WRG in topical drug delivery against psoriasis.In vitro and in vivo data showed that WRG formulation could not only extend skin retention but also facilitate the drug permeating across the skin.In a mouse model of psoriasis,curcumin loaded WRG(CUR-WRG)effectively ameliorated the symptoms of psoriasis and exerted a potent anti-psoriasis effect by extending drug retention and facilitating drug penetration.Further mechanism study demonstrated that the anti-hyperplasia,anti-inflammation,anti-angiogenesis,anti-oxidation,and immunomodulation properties of curcumin were amplified by enhanced topical drug delivery efficiency.Notably,neglectable local or systemic toxicity was observed for CUR-WRG application.This study suggests that WRG is a promising formulation for topically psoriasis treatment.展开更多
基金supported by Sichuan Science and Technology Program(Nos.2019YFG0507,2020YFG0328 and 2021YFG0018)by National Natural Science Foundation of China(NSFC)under Grant No.U19A2059+1 种基金by the Young Scientists Fund of the National Natural Science Foundation of China under Grant No.61802050by the Fundamental Research Funds for the Central Universities(No.ZYGX2021J019).
文摘Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product development.Previous efforts of digital twinning neglect the decisive consumer feedback in product development stages,failing to cover the gap between physical and digital spaces.This work mines real-world consumer feedbacks through social media topics,which is significant to product development.We specifically analyze the prevalent time of a product topic,giving an insight into both consumer attention and the widely-discussed time of a product.The primary body of current studies regards the prevalent time prediction as an accompanying task or assumes the existence of a preset distribution.Therefore,these proposed solutions are either biased in focused objectives and underlying patterns or weak in the capability of generalization towards diverse topics.To this end,this work combines deep learning and survival analysis to predict the prevalent time of topics.We propose a specialized deep survival model which consists of two modules.The first module enriches input covariates by incorporating latent features of the time-varying text,and the second module fully captures the temporal pattern of a rumor by a recurrent network structure.Moreover,a specific loss function different from regular survival models is proposed to achieve a more reasonable prediction.Extensive experiments on real-world datasets demonstrate that our model significantly outperforms the state-of-the-art methods.
基金supported in part by the National Natural Science Foundation of China under Grant 61873277in part by the Natural Science Basic Research Plan in Shaanxi Province of China underGrant 2020JQ-758in part by the Chinese Postdoctoral Science Foundation under Grant 2020M673446.
文摘In the video captioning methods based on an encoder-decoder,limited visual features are extracted by an encoder,and a natural sentence of the video content is generated using a decoder.However,this kind ofmethod is dependent on a single video input source and few visual labels,and there is a problem with semantic alignment between video contents and generated natural sentences,which are not suitable for accurately comprehending and describing the video contents.To address this issue,this paper proposes a video captioning method by semantic topic-guided generation.First,a 3D convolutional neural network is utilized to extract the spatiotemporal features of videos during the encoding.Then,the semantic topics of video data are extracted using the visual labels retrieved from similar video data.In the decoding,a decoder is constructed by combining a novel Enhance-TopK sampling algorithm with a Generative Pre-trained Transformer-2 deep neural network,which decreases the influence of“deviation”in the semantic mapping process between videos and texts by jointly decoding a baseline and semantic topics of video contents.During this process,the designed Enhance-TopK sampling algorithm can alleviate a long-tail problem by dynamically adjusting the probability distribution of the predicted words.Finally,the experiments are conducted on two publicly used Microsoft Research Video Description andMicrosoft Research-Video to Text datasets.The experimental results demonstrate that the proposed method outperforms several state-of-art approaches.Specifically,the performance indicators Bilingual Evaluation Understudy,Metric for Evaluation of Translation with Explicit Ordering,Recall Oriented Understudy for Gisting Evaluation-longest common subsequence,and Consensus-based Image Description Evaluation of the proposed method are improved by 1.2%,0.1%,0.3%,and 2.4% on the Microsoft Research Video Description dataset,and 0.1%,1.0%,0.1%,and 2.8% on the Microsoft Research-Video to Text dataset,respectively,compared with the existing video captioning methods.As a result,the proposed method can generate video captioning that is more closely aligned with human natural language expression habits.
基金Supported by the National Natural Science Foundation of China (No.82171038No.81974129)Jiangsu Provincial Medical Key Discipline (No.JSDW202245).
文摘Cataract is the main cause of visual impairment and blindness worldwide while the only effective cure for cataract is still surgery.Consecutive phacoemulsification under topical anesthesia has been the routine procedure for cataract surgery.However,patients often grumbled that they felt more painful during the second-eye surgery compared to the first-eye surgery.The intraoperative pain experience has negative influence on satisfaction and willingness for second-eye cataract surgery of patients with bilateral cataracts.Intraoperative ocular pain is a complicated process induced by the nociceptors activation in the peripheral nervous system.Immunological,neuropsychological,and pharmacological factors work together in the enhancement of intraoperative pain.Accumulating published literatures have focused on the pain enhancement during the secondeye phacoemulsification surgeries.In this review,we searched PubMed database for articles associated with pain perception differences between consecutive cataract surgeries published up to Feb.1,2024.We summarized the recent research progress in mechanisms and interventions for pain perception enhancement in consecutive secondeye phacoemulsification cataract surgeries.This review aimed to provide novel insights into strategies for improving patients’intraoperative experience in second-eye cataract surgeries.
基金Baicheng Medical College 2020 school-based project.2020 General Topic“Practical Research on Project-Based Teaching in the Course of Contact Lens Fitting Technology”(Project number:BYZB2020031)。
文摘Objective:This paper aims to study the application of flipped classroom teaching model based on micro-course in the practical training teaching of contact lens fitting technology.Methods:From September 21 to July 23,120 students majoring in ophthalmology and optometry were selected and randomly divided into groups.The control group adopted the traditional teaching mode,and the study group adopted the flipped classroom teaching mode based on micro-course.Teaching scores and the skills,observation and judgment,adaptability,and communication skills were compared between the groups.Results:Statistical comparison of teaching scores under different management methods showed that the clinical thinking score and practice work quality in the study group were higher than those of the control group,and the effect of the study group was better(P<0.05).The overall scores of skills,observation and judgment,adaptability,and communication skills of the study group were better than those in the control group,and the comprehensive ability scores in the two groups were significantly different(P<0.05).Conclusion:In practical training teaching of contact lens fitting technology,the application of flipped classroom teaching based on micro-course can improve the skill scores of personnel,and the overall effect is good.This can lay the foundation for advanced ophthalmology and optometry talents with profound theoretical knowledge and professional skills.
文摘目的分析2009~2024年间国际延时现场救护领域的文献,探究主要研究主题及其发展趋势,以期为未来救护策略提供理论支持。方法系统检索PubMed、Embase、Web of Science和中国知网等数据库,筛选并纳入283篇相关文献。运用BERTopic主题建模技术对文献进行主题识别和关键词分析,并进行可视化展示。结果当前研究主要聚焦在“急救策略研究”“智能技术与信息管理”“实战应用”与“政策与理论研究”等4个方面,预测这些领域将持续成为研究热点。结论国际延时现场救护研究正处于快速发展阶段,建议未来研究深入重点领域,开发有效的救护策略,以提升救治效率和伤员生存率。
基金supported by National Key Research and Development Program of China (2019YFB2102500)China Postdoctoral Science Foundation (2021M700533)+1 种基金Natural Science Basic Research Program of Shaanxi Province of China (2021JQ-289,2020JQ-855)Social Science Fund of Shaanxi Province of China (2019S044).
文摘With the extensive integration of the Internet,social networks and the internet of things,the social internet of things has increasingly become a significant research issue.In the social internet of things application scenario,one of the greatest challenges is how to accurately recommend or match smart objects for users with massive resources.Although a variety of recommendation algorithms have been employed in this field,they ignore the massive text resources in the social internet of things,which can effectively improve the effect of recommendation.In this paper,a smart object recommendation approach named object recommendation based on topic learning and joint features is proposed.The proposed approach extracts and calculates topics and service relevant features of texts related to smart objects and introduces the“thing-thing”relationship information in the internet of things to improve the effect of recommendation.Experiments show that the proposed approach enables higher accuracy compared to the existing recommendation methods.
文摘Recently,automation is considered vital in most fields since computing methods have a significant role in facilitating work such as automatic text summarization.However,most of the computing methods that are used in real systems are based on graph models,which are characterized by their simplicity and stability.Thus,this paper proposes an improved extractive text summarization algorithm based on both topic and graph models.The methodology of this work consists of two stages.First,the well-known TextRank algorithm is analyzed and its shortcomings are investigated.Then,an improved method is proposed with a new computational model of sentence weights.The experimental results were carried out on standard DUC2004 and DUC2006 datasets and compared to four text summarization methods.Finally,through experiments on the DUC2004 and DUC2006 datasets,our proposed improved graph model algorithm TG-SMR(Topic Graph-Summarizer)is compared to other text summarization systems.The experimental results prove that the proposed TG-SMR algorithm achieves higher ROUGE scores.It is foreseen that the TG-SMR algorithm will open a new horizon that concerns the performance of ROUGE evaluation indicators.
文摘The research of flipped class classroom teaching based on micro-course provides a new idea for the reform of classroom teaching in universities and colleges. This teaching concept of reversing the class and after-class activities can effectively solve the problems in the current Russian classroom teaching, which cultivates students’ ability to listen, speak, read and write, and meets the requirements and teaching purposes of Russian teaching in universities and colleges. This paper mainly explores and studies the current situation of Russian teaching in universities and colleges, and points out the specific way of using the flipped classroom concept to carry out education and teaching reform. It hopes to provide a certain reference for the reform of Russian teaching in universities and colleges.
基金Supported by the Ideological and Political Teaching Team of Excellent Courses in Western Economics of Jiangsu Second Normal University(2021).
文摘As a new means and way of combining media convergence and ideological and political education,ideological and political micro-courses play an important role in the process of cultivating the socialist core values of college students and qualified successors of the socialist cause.For western economics as the core course of agricultural economics major,how to construct ideological and political micro-courses in the era of media convergence to give full play to the effective function of micro-courses in ideological and political education in western economics has good practical significance at present.
文摘Objectives:Non-healing wounds have been one of the major challenges in health care because of increased morbidity,especially for those who have diabetes mellitus.Numerous regimens are being innovated to produce an evidence-based practice that would minimize complications and promote healing.Topical oxygen therapy is an innovation in wound care that has been considered influential in the wound healing process.This intervention aims to increase the oxygen concentration in the affected limb to promote wound healing.Methods:This research applied an experimental design that targeted a total of 60 adult patients aged 45–64 years with diabetic foot ulcers.A randomized systematic sampling technique was used to allow equal chances and prevent bias.In total,30 patients in the control group received usual care for diabetic foot ulcers,and the remaining 30 patients in the experimental group received topical oxygen therapy together with standard care for diabetic foot ulcers.Subjects were assessed using the Wagner-Meggitt Wound Classification System.Results:The result proved that there was a significant difference in the wound grade of patients in the experimental group after the application of the usual wound care plus the topical oxygen therapy using Friedman's test.The control and experimental groups were compared using Mann–Whitney statistical analyses,and the results showed that there was a significant difference between the control and experimental groups after the application of topical oxygen therapy.Conclusions:Topical oxygen therapy was demonstrated to be effective to aid in the wound healing process of patients with diabetic foot ulcers.Fur ther research was recommended to improve the application of topical oxygen therapy to patients with chronic wounds and promote the wound healing process.
基金This research was supported by National Natural Science Foundation of China(Grant No.81903551)Natural Science Foundation of Zhejiang Province(Grant No.LYY22H300001)+3 种基金Wenzhou Municipal Science and Technology Bureau(Grant No.ZY2019007)Zhejiang postdoctoral scientific research project(Grant No.ZJ2021024)Wenzhou Municipal Key Laboratory of Pediatric Pharmacy(Grant No.WZEY02)Excellent Young Scientist Training Program fund from Wenzhou Medical University.
文摘Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been developed and explored for enhanced topical psoriasis treatment.However,these preparations usually have low viscosity and limited retention on the skin surface,resulting in low drug delivery efficiency and poor patient satisfaction.In this study,we developed the first water-responsive gel(WRG),which has a distinct water-triggered liquid-to-gel phase transition property.Specifically,WRG was kept in a solution state in the absence of water,and the addition of water induced an immediate phase transition and resulted in a high viscosity gel.Curcumin was used as a model drug to investigate the potential of WRG in topical drug delivery against psoriasis.In vitro and in vivo data showed that WRG formulation could not only extend skin retention but also facilitate the drug permeating across the skin.In a mouse model of psoriasis,curcumin loaded WRG(CUR-WRG)effectively ameliorated the symptoms of psoriasis and exerted a potent anti-psoriasis effect by extending drug retention and facilitating drug penetration.Further mechanism study demonstrated that the anti-hyperplasia,anti-inflammation,anti-angiogenesis,anti-oxidation,and immunomodulation properties of curcumin were amplified by enhanced topical drug delivery efficiency.Notably,neglectable local or systemic toxicity was observed for CUR-WRG application.This study suggests that WRG is a promising formulation for topically psoriasis treatment.