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Neuronal signal detecting and stimulating circuit array for monolithic integrated MEA
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作者 谢书珊 王志功 +1 位作者 潘海仙 吕晓迎 《Journal of Southeast University(English Edition)》 EI CAS 2009年第2期175-179,共5页
A neuronal signal detecting circuit and a neuronal signal stimulating circuit designed for a monolithic integrated MEA(micro-electrode array) system are described. As a basic cell of the circuits, an OPA( operation... A neuronal signal detecting circuit and a neuronal signal stimulating circuit designed for a monolithic integrated MEA(micro-electrode array) system are described. As a basic cell of the circuits, an OPA( operational amplifier) is designed with low power, low noise, small size and high gain. The detecting circuit has a chip area of 290 μm × 400 μm, a power dissipation of 2.02 mW, an equivalent input noise of 17.72 nV/ Hz, a gain of 60. 5 dB, and an output voltage from - 2. 48 to + 2. 5 V. The stimulating circuit has a chip area of 130 μm × 290 μm, a power dissipation of 740 μW, and an output voltage from - 2. 5 to 2. 04 V. The parameters show that two circuits are suitable for a monolithic integrated MEA system. The detecting circuit and MEA have been fabricated. The test results show that the detecting circuit works well. 展开更多
关键词 neuronal signal detecting noise micro-electrode array mea complementary metal-oxide-semiconductor transistor (CMOS) technology
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Microelectrode Recording of Tissue Neural Oscillations for a Bionic Olfactory Biosensor 被引量:2
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作者 Qingjun Liu Fenni Zhang +3 位作者 Ning Hu Hua Wang Kuen Jimmy Hsia Ping Wang 《Journal of Bionic Engineering》 SCIE EI CSCD 2012年第4期494-500,共7页
In olfactory research, neural oscillations exhibit excellent temporal regularity, which are functional and necessary at thephysiological and cognitive levels. In this paper, we employed a bionic tissue biosensor which... In olfactory research, neural oscillations exhibit excellent temporal regularity, which are functional and necessary at thephysiological and cognitive levels. In this paper, we employed a bionic tissue biosensor which treats intact epithelium as sensing element to record the olfactory oscillations extracellularly. After being stimulated by odorant of butanedione, the olfactory receptor neurons generated different kinds of oscillations, which can be described as pulse firing oscillation, transient firing oscillation, superposed firing oscillation, and sustained firing oscillation, according to their temporal appearances respectively. With a time-frequency analysis of sonogram, the oscillations also demonstrated different frequency properties, such as δ, θ, α, β and γ oscillations. The results suggest that the bionic biosensor cooperated with sonogram analysis can well improve the in- vestigation of olfactory oscillations, and provide a novel model for artificial olfaetion sensor design. 展开更多
关键词 bionic sensor olfactory epithelium microelectrode array mea neural oscillation olfactory bioscnsor
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