Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering behaviors.Traditional ground improvement techniques require enormous mechanical effort or synthetic...Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering behaviors.Traditional ground improvement techniques require enormous mechanical effort or synthetic chemicals.Sustainable stabilization technique such as microbially induced calcite precipitation(MICP)utilizes bacterial metabolic processes to precipitate cementitious calcium carbonate.The reactive transport of biochemical species in the soil mass initiates the precipitation of biocement during the MICP process.The precipitated biocement alters the hydro-mechanical performance of the soil mass.Usually,the flow,deformation,and transport phenomena regulate the biocementation technique via coupled bio-chemo-hydro-mechanical(BCHM)processes.Among all,one crucial phenomenon controlling the precipitation mechanism is the encapsulation of biomass by calcium carbonate.Biomass encapsulation can potentially reduce the biochemical reaction rate and decelerate biocementation.Laboratory examination of the encapsulation process demands a thorough analysis of associated coupled effects.Despite this,a numerical model can assist in capturing the coupled processes influencing encapsulation during the MICP treatment.However,most numerical models did not consider biochemical reaction rate kinetics accounting for the influence of bacterial encapsulation.Given this,the current study developed a coupled BCHM model to evaluate the effect of encapsulation on the precipitated calcite content using a micro-scale semiempirical relationship.Firstly,the developed BCHM model was verified and validated using numerical and experimental observations of soil column tests.Later,the encapsulation phenomenon was investigated in the soil columns of variable maximum calcite crystal sizes.The results depict altered reaction rates due to the encapsulation phenomenon and an observable change in the precipitated calcite content for each maximum crystal size.Furthermore,the permeability and deformation of the soil mass were affected by the simultaneous precipitation of calcium carbonate.Overall,the present study comprehended the influence of the encapsulation of bacteria on cement morphology-induced permeability,biocement-induced stresses and displacements.展开更多
BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have ...BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no research.AIM To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic intervention.METHODS A cross-sectional survey was disseminated among ophthalmologists all over India.The survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up patterns.RESULTS A total of 180 ophthalmologists responded to the survey.Most practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was advised.The most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid surgeries.Sixty-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease patients.CONCLUSION Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular conditions.Many ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract surgery.Eyelid conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.展开更多
A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication pr...A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication processes,while forming a high pressure gas film between two sealing faces due to the deceleration of the gas pumped in or out.There is little research into the effects and the influence on seal performance,if the grooves and the gas film are at the micro-scale.This paper investigates the micro-scale effects on spiral-groove dry-gas seal performance in a numerical solution of a corrected Reynolds equation.The Reynolds equation is discretized by means of the finite difference method with the second order scheme and solved by the successive-over-relaxation(SOR) iterative method.The Knudsen number of the flow in the sealing gas film is changed from 0.005 to 0.120 with a variation of film depth and sealing pressure.The numerical results show that the average pressure in the gas film and the sealed gas leakage increase due to micro-scale effects.The open force is enlarged,while the gas film stiffness is significantly decreased due to micro-scale effects.The friction torque and power consumption remain constant,even in low sealing pressure and spin speed conditions.In this paper,the seal performance at different rotor face spin speeds is also described.The proposed research clarifies the micro-scale effects in a spiral-groove dry-gas seal and their influence on seal performance,which is expected to be useful for the improvement of the design of dry-gas seal systems operating in the slip flow regime.展开更多
To understand the discharge characteristics under a gap of micrometers,the breakdown voltage and current–voltage curve are measured experimentally in a needle-to-plate electrode at a microscale gap of 3–50 μm in ai...To understand the discharge characteristics under a gap of micrometers,the breakdown voltage and current–voltage curve are measured experimentally in a needle-to-plate electrode at a microscale gap of 3–50 μm in air.The effect of the needle radius and the gas pressure on the discharge characteristics are tested.The results show that when the gap is larger than 10 μm,the relation between the breakdown voltage and the gap looks like the Paschen curve;while below 10 μm,the breakdown voltage is nearly constant in the range of the tested gap.However,at the same gap distance,the breakdown voltage is still affected by the pressure and shows a trend similar to Paschen's law.The current–voltage characteristic in all the gaps is similar and follows the trend of a typical Townsend-to-glow discharge.A simple model is used to explain the non-normality of breakdown in the micro-gaps.The Townsend mechanism is suggested to control the breakdown process in this configuration before the gap reduces much smaller in air.展开更多
Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics (CFD) method has played a dominant r...Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics (CFD) method has played a dominant role in studying and simulating transport phenomena involving fluid flow and heat and mass transfers, in recent years, other numerical methods for the simulations at meso- and micro-scales have also been actively applied to solve the physics of complex flow and fluid-interface interactions. This paper presents a review of recent advances in multi-scale computational simulation of biomimetics related fluid flow problems. The state-of-the-art numerical techniques, such as lattice Boltzmann method (LBM), molecular dynamics (MD), and conventional CFD, applied to different problems such as fish flow, electro-osmosis effect of earthworm motion, and self-cleaning hydrophobic surface, and the numerical approaches are introduced. The new challenging of modelling biomimetics problems in developing the physical conditions of self-clean hydrophobic surfaces is discussed.展开更多
Micro-scale Al-Zn-Mg/Fe composite powders (MAF) with high reactivity and good storage properties were prepared by reducing iron onto the surface of Al-Zn-Mg alloy powders. Experimental results show that MAF as advance...Micro-scale Al-Zn-Mg/Fe composite powders (MAF) with high reactivity and good storage properties were prepared by reducing iron onto the surface of Al-Zn-Mg alloy powders. Experimental results show that MAF as advanced zero-valent iron are highly effective for degradation of chlorinated organic compounds. The efficiency of degradation for carbon tetrachloride and perchloroethylene is higher than 99% within a period of 2 h. The efficiency of degradation for trichloroethylene by MAF after storing for one month is equivalent to that by freshly prepared nano-size zero-valent iron particles.展开更多
Micro-scale functionally graded material(FGM)pipes conveying fluid have many significant applications in engineering fields.In this work,the thermoelastic vibration of FGM fluid-conveying tubes in elastic medium is st...Micro-scale functionally graded material(FGM)pipes conveying fluid have many significant applications in engineering fields.In this work,the thermoelastic vibration of FGM fluid-conveying tubes in elastic medium is studied.Based on modified couple stress theory and Hamilton’s principle,the governing equation and boundary conditions are obtained.The differential quadrature method(DQM)is applied to investigating the thermoelastic vibration of the FGM pipes.The effect of temperature variation,scale effect of the microtubule,micro-fluid effect,material properties,elastic coefficient of elastic medium and outer radius on thermoelastic vibration of the FGM pipes conveying fluid are studied.The results show that in the condition of considering the scale effect and micro-fluid of the microtubule,the critical dimensionless velocity of the system is higher than that of the system which calculated using classical macroscopic model.The results also show that the variations of temperature,material properties,elastic coefficient and outer radius have significant influences on the first-order dimensionless natural frequency.展开更多
Fabrication of micro gratings using a femtosecond laser exposure system is experimentally investigated for the electron moire method. Micro holes and lines are firstly etched for parameter study. Grating profile is th...Fabrication of micro gratings using a femtosecond laser exposure system is experimentally investigated for the electron moire method. Micro holes and lines are firstly etched for parameter study. Grating profile is theoretically optimized to form high quality moire patterns. For a demonstration, a parallel grating is fabricated on a specimen of quartz glass. The minimum line width and the distance between two adjacent lines are both set to be 1 μm, and the frequency of grating is 500 lines/ram. The experimental results indicate that the quality of gratings is good and the relative error of the gratings pitch is about 1.5%. Based on molte method, scanning electron microscope (SEM) moire patterns are observed clearly, which manifests that gratings fabricated with the femtosecond laser exposure is suitable for micro scale deformation measurement.展开更多
The dispersion is mainly governed by wind field and depends on the planetary boundary layer (PBL) dynamics. Accurate representation of the meteorological weather fields would improve the dispersion assessments. In urb...The dispersion is mainly governed by wind field and depends on the planetary boundary layer (PBL) dynamics. Accurate representation of the meteorological weather fields would improve the dispersion assessments. In urban areas representation of wind around the obstacles is not possible for the pollution dispersion studies using Gaussian based modeling studies. It is widely accepted that computational fluid dynamics (CFD) tools would provide reasonably good solution to produce the wind fields around the complex structures and other land scale elements. By keeping in view of the requirement for the micro-scale dispersion, a commercial CFD model PANACHE with PANEPR developed by Fluidyn is implemented to study the micro-scale dispersion of air pollution over an urban setup at Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam a coastal station in the east coast of India under stable atmospheric conditions. Meso-scale module of the PANACHE model is integrated with the data generated at the site by IGCAR under RRE (Round Robin Exercise) program to develop the flow fields. Using this flow fields, CFD model is integrated to study the micro-scale dispersion. Various pollution dispersion scenarios are developed using hypothetical emission inventory during stably stratified conditions to understand the micro-scale dispersion over different locations of coastal urban set up in the IGCAR region of Kalpakkam.展开更多
The main aim of this research is to get a better knowledge and understanding of the micro-scale oscillatory networks behavior in the solid propellants reactionary zones. Fundamental understanding of the micro-and nano...The main aim of this research is to get a better knowledge and understanding of the micro-scale oscillatory networks behavior in the solid propellants reactionary zones. Fundamental understanding of the micro-and nano-scale combustion mechanisms is essential to the development and further improvement of the next-generation technologies for extreme control of the solid propellant thrust. Both experiments and theory confirm that the micro-and nano-scale oscillatory networks excitation in the solid propellants reactionary zones is a rather universal phenomenon. In accordance with our concept,the micro-and nano-scale structures form both the fractal and self-organized wave patterns in the solid propellants reactionary zones. Control by the shape, the sizes and spacial orientation of the wave patterns allows manipulate by the energy exchange and release in the reactionary zones. A novel strategy for enhanced extreme thrust control in solid propulsion systems are based on manipulation by selforganization of the micro-and nano-scale oscillatory networks and self-organized patterns formation in the reactionary zones with use of the system of acoustic waves and electro-magnetic fields, generated by special kind of ring-shaped electric discharges along with resonance laser radiation. Application of special kind of the ring-shaped electric discharges demands the minimum expenses of energy and opens prospects for almost inertia-free control by combustion processes. Nano-sized additives will enhance self-organizing and self-synchronization of the micro-and nano-scale oscillatory networks on the nanometer scale. Suggested novel strategy opens the door for completely new ways for enhanced extreme thrust control of the solid propulsion systems.展开更多
A micro-scale finite element method(FEM) was proposed to precisely calculate the heat conduction between mortar and aggregate, and thus to accurately predict the non-uniformity of concrete pouring temperature. The con...A micro-scale finite element method(FEM) was proposed to precisely calculate the heat conduction between mortar and aggregate, and thus to accurately predict the non-uniformity of concrete pouring temperature. The concrete temperature field during vibration was also precisely calculated by accurate description of heat absorption characteristics of different parts of concrete when vibration. Based on the above method, the prediction model was used to predict the pouring temperature of a practical engineering. The comparison between actual results and simulated values shows that this method can be adopted to accurately predict the non-uniformity of concrete pouring temperature and the influence of mechanized vibration on concrete pouring temperature, and thus accurately predict pouring temperature. The control of casting temperature is crucial for preventing concrete fracture. The study provides a new method for predicting the pouring temperature of concrete structures, which has great practical value in engineering application.展开更多
A new 6-DOF micro-manipulation robot based on 3-PPTTRS parallel mechanisms in combination with flexure hinges is proposed. The design principle of the mechanism is introduced, and the kinematics analysis method based ...A new 6-DOF micro-manipulation robot based on 3-PPTTRS parallel mechanisms in combination with flexure hinges is proposed. The design principle of the mechanism is introduced, and the kinematics analysis method based on differentiation is used to get the (inverse) kinematics equations. Then a micro-scale motion precision simulation method is proposed according to finite element analysis (FEA), and the prediction of robot’s motion precision in design phase is realized. The simulation result indicates that the 6-DOF micro-manipulation robot can meet the design specification.展开更多
BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To ex...BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in China.METHODS We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology.Patients and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.RESULTS Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included.Epigastric pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting symptoms.Gastritis was classified as chronic non-atrophic in 69.9%of patients.Among those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat lesions.In patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more effective.For those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more promising.CONCLUSION CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms.Gastroscopy may play a major role in its detection and diagnosis.Treatment should be individualized based on symptom profile.展开更多
The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of resea...The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of research on revegetation stability.However,it is unclear how meso-and micro-scale revegetation activity has responded to climatic change over the past decades.To evaluate the relative influence of climatic variables on revegetation activities in a restored desert ecosystem,we analysed the trend of revegetation change from 2002 to 2015 using a satellite-derived normalized difference vegetation index(NDVI)dataset.The time series of the NDVI data were decomposed into trend,seasonal,and random components using a segmented regression method.The results of the segmented regression model indicate a changing trend in the NDVI in the VPS,changing from a decrease(−7×10−3/month)before 2005 to an increase(0.3×10−3/month)after 2005.We found that precipitation was the most important climatic factor influencing the growing season NDVI(P<0.05),while vegetation growth sensitivity to water and heat varied significantly in different seasons.In the case of precipitation reduction and warming in the study area,the NDVI of the VPS could still maintain an overall slow upward trend(0.04×10−3/month),indicating that the ecosystem is sustainable.Our findings suggest that the VPS has been successful in maintaining stability and sustainability under current climate change conditions and that it is possible to introduce the VPS in similar areas as a template for resistance to sand and drought hazards.展开更多
Objective: Plant-based diets have multiple health benefits for cancers;however, little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation...Objective: Plant-based diets have multiple health benefits for cancers;however, little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation of the prospective associations among three predefined indices of plant-based dietary patterns and the risk of EC.Methods: We performed endoscopic screening for 15,709 participants aged 40-69 years from two high-risk areas of China from January 2005 to December 2009 and followed the cohort until December 31, 2022. The overall plant-based diet index(PDI), healthful plant-based diet index(h PDI), and unhealthful plant-based diet index(u PDI), were calculated using survey responses to assess dietary patterns. We applied Cox proportional hazard regression to estimate the multivariable hazard ratios(HRs) and 95% confidence intervals(95% CIs) of EC across 3plant-based diet indices and further stratified the analysis by subgroups.Results: The final study sample included 15,184 participants in the cohort. During a follow-up of 219,365person-years, 176 patients with EC were identified. When the highest quartile was compared with the lowest quartile, the pooled multivariable-adjusted HR of EC was 0.50(95% CI, 0.32-0.77) for h PDI. In addition, the HR per 10-point increase in the h PDI score was 0.42(95% CI, 0.27-0.66) for ECs. Conversely, u PDI was positively associated with the risk of EC, and the HR was 1.80(95% CI, 1.16-2.82). The HR per 10-point increase in the u PDI score was 1.90(95% CI, 1.26-2.88) for ECs. The associations between these scores and the risk of EC were consistent in most subgroups. These results remained robust in sensitivity analyses.Conclusions: A healthy plant-based dietary pattern was associated with a reduced risk of EC. Emphasizing the healthiness and quality of plant-based diets may be important for preventing the development of EC.展开更多
The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially im...The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially impede the practical application of rechargeable aqueous Zn metal batteries(ZMBs).Herein,we present a strategy for achieving a high-rate and long-cycle-life Zn metal anode by patterning Zn foil surfaces and endowing a Zn-Indium(Zn-In)interface in the microchannels.The accumulation of electrons in the microchannel and the zincophilicity of the Zn-In interface promote preferential heteroepitaxial Zn deposition in the microchannel region and enhance the tolerance of the electrode at high current densities.Meanwhile,electron aggregation accelerates the dissolution of non-(002)plane Zn atoms on the array surface,thereby directing the subsequent homoepitaxial Zn deposition on the array surface.Consequently,the planar dendrite-free Zn deposition and long-term cycling stability are achieved(5,050 h at 10.0 mA cm^(−2) and 27,000 cycles at 20.0 mA cm^(−2)).Furthermore,a Zn/I_(2) full cell assembled by pairing with such an anode can maintain good stability for 3,500 cycles at 5.0 C,demonstrating the application potential of the as-prepared ZnIn anode for high-performance aqueous ZMBs.展开更多
Background:Foot kinematics,such as excessive eversion and malalignment of the hindfoot,are believed to be associated with running-related injuries.The maj ority of studies to date show that different foot strike patte...Background:Foot kinematics,such as excessive eversion and malalignment of the hindfoot,are believed to be associated with running-related injuries.The maj ority of studies to date show that different foot strike patterns influence these specific foot and ankle kinematics.However,technical deficiencies in traditional motion capture approaches limit knowledge of in vivo joint kinematics with respect to rearfoot and forefoot strike patterns(RFS and FFS,respectively).This study uses a high-speed dual fluoroscopic imaging system(DFIS)to determine the effects of different foot strike patterns on 3D in vivo tibiotalar and subtalar joints kinematics.Methods:Fifteen healthy male recreational runners underwent foot computed tomography scanning for the construction of 3-dimensional models.A high-speed DFIS(100 Hz)was used to collect 6 degrees of freedom kinematics for participants’tibiotalar and subtalar joints when they adopted RFS and FFS in barefoot condition.Results:Compared with RFS,FFS exhibited greater internal rotation at 0%-20%of the stance phase in the tibiotalar joint.The peak internal rotation angle of the tibiotalar joint under FFS was greater than under RFS(p<0.001,Cohen’s d=0.92).RFS showed more dorsiflexion at 0%-20%of the stance phase in the tibiotalar joint than FFS.RFS also presented a larger anterior translation(p<0.001,Cohen’s d=1.28)in the subtalar joint at i nitial contact than FFS.Conclusion:Running with acute barefoot FFS increases the internal rotation of the tibiotalar joint in the early stance.The use of high-speed DFIS to quantify the movement of the tibiotalar and subtalar joint was critical to revealing the effects of RF S and FFS during running.展开更多
To explore the effects of freeze‒thaw cycles on the mechanical properties and crack evolution of fissured sandstone,biaxial compression experiments were carried out on sandstone subjected to freeze‒thaw cycles to char...To explore the effects of freeze‒thaw cycles on the mechanical properties and crack evolution of fissured sandstone,biaxial compression experiments were carried out on sandstone subjected to freeze‒thaw cycles to characterize the changes in the physical and mechanical properties of fissured sandstone caused by freeze‒thaw cycles.The crack evolution and crack change process on the surface of the fissured sandstone were recorded and analysed in detail via digital image technology(DIC).Numerical simulation was used to reveal the expansion process and damage mode of fine-scale cracks under the action of freeze‒thaw cycles,and the simulation results were compared and analysed with the experimental data to verify the reliability of the numerical model.The results show that the mass loss,porosity,peak stress and elastic modulus all increase with increasing number of freeze‒thaw cycles.With an increase in the number of freeze‒thaw cycles,a substantial change in displacement occurs around the prefabricated cracks,and a stress concentration appears at the crack tip.As new cracks continue to sprout at the tips of the prefabricated cracks until the microcracks gradually penetrate into the main cracks,the displacement cloud becomes obviously discontinuous,and the contours of the displacement field in the crack fracture damage area simply intersect with the prefabricated cracks to form an obvious fracture.The damage patterns of the fractured sandstone after freeze‒thaw cycles clearly differ,forming a symmetrical"L"-shaped damage pattern at zero freeze‒thaw cycles,a symmetrical"V"-shaped damage pattern at 10 freeze‒thaw cycles,and a"V"-shaped damage pattern at 20 freeze‒thaw cycles.After 20 freeze‒thaw cycles,a"V"-shaped destruction pattern and"L"-shaped destruction pattern are formed;after 30 freeze‒thaw cycles,an"N"-shaped destruction pattern is formed.This shows that the failure mode of fractured sandstone gradually becomes more complicated with an increasing number of freeze‒thaw cycles.The effects of freeze‒thaw cycles on the direction and rate of crack propagation are revealed through a temperature‒load coupled model,which provides an important reference for an in-depth understanding of the freeze‒thaw failure mechanisms of fractured rock masses.展开更多
The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted...The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted that venous congestion is an important clinical feature worthy of investigation.Evaluating venous Doppler profile abnormalities at multiple sites could suggest adequate treatment and monitor its efficacy.Renal dysfunction could trigger or worsen fluid overload in heart disease,and cardio-renal syndrome is a well-characterized spectrum of disorders describing the complex interactions between heart and kidney diseases.Fluid overload and venous congestion,including renal venous hypertension,are major determinants of acute and chronic renal dysfunction arising in heart disease.Organ congestion from venous hypertension could be involved in the development of organ injury in several clinical situations,such as critical diseases,congestive heart failure,and chronic kidney disease.Ultrasonography and abnormal Doppler flow patterns diagnose clinically significant systemic venous congestion.Cardiologists and nephrologists might use this valuable,noninvasive,bedside diagnostic tool to establish fluid status and guide clinical choices.展开更多
基金the funding support from the Ministry of Education,Government of India,under the Prime Minister Research Fellowship programme(Grant Nos.SB21221901CEPMRF008347 and SB22230217CEPMRF008347).
文摘Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering behaviors.Traditional ground improvement techniques require enormous mechanical effort or synthetic chemicals.Sustainable stabilization technique such as microbially induced calcite precipitation(MICP)utilizes bacterial metabolic processes to precipitate cementitious calcium carbonate.The reactive transport of biochemical species in the soil mass initiates the precipitation of biocement during the MICP process.The precipitated biocement alters the hydro-mechanical performance of the soil mass.Usually,the flow,deformation,and transport phenomena regulate the biocementation technique via coupled bio-chemo-hydro-mechanical(BCHM)processes.Among all,one crucial phenomenon controlling the precipitation mechanism is the encapsulation of biomass by calcium carbonate.Biomass encapsulation can potentially reduce the biochemical reaction rate and decelerate biocementation.Laboratory examination of the encapsulation process demands a thorough analysis of associated coupled effects.Despite this,a numerical model can assist in capturing the coupled processes influencing encapsulation during the MICP treatment.However,most numerical models did not consider biochemical reaction rate kinetics accounting for the influence of bacterial encapsulation.Given this,the current study developed a coupled BCHM model to evaluate the effect of encapsulation on the precipitated calcite content using a micro-scale semiempirical relationship.Firstly,the developed BCHM model was verified and validated using numerical and experimental observations of soil column tests.Later,the encapsulation phenomenon was investigated in the soil columns of variable maximum calcite crystal sizes.The results depict altered reaction rates due to the encapsulation phenomenon and an observable change in the precipitated calcite content for each maximum crystal size.Furthermore,the permeability and deformation of the soil mass were affected by the simultaneous precipitation of calcium carbonate.Overall,the present study comprehended the influence of the encapsulation of bacteria on cement morphology-induced permeability,biocement-induced stresses and displacements.
文摘BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no research.AIM To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic intervention.METHODS A cross-sectional survey was disseminated among ophthalmologists all over India.The survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up patterns.RESULTS A total of 180 ophthalmologists responded to the survey.Most practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was advised.The most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid surgeries.Sixty-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease patients.CONCLUSION Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular conditions.Many ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract surgery.Eyelid conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.
基金supported by Scientific Research Foundation for Returned Scholars of Ministry of Education of China
文摘A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication processes,while forming a high pressure gas film between two sealing faces due to the deceleration of the gas pumped in or out.There is little research into the effects and the influence on seal performance,if the grooves and the gas film are at the micro-scale.This paper investigates the micro-scale effects on spiral-groove dry-gas seal performance in a numerical solution of a corrected Reynolds equation.The Reynolds equation is discretized by means of the finite difference method with the second order scheme and solved by the successive-over-relaxation(SOR) iterative method.The Knudsen number of the flow in the sealing gas film is changed from 0.005 to 0.120 with a variation of film depth and sealing pressure.The numerical results show that the average pressure in the gas film and the sealed gas leakage increase due to micro-scale effects.The open force is enlarged,while the gas film stiffness is significantly decreased due to micro-scale effects.The friction torque and power consumption remain constant,even in low sealing pressure and spin speed conditions.In this paper,the seal performance at different rotor face spin speeds is also described.The proposed research clarifies the micro-scale effects in a spiral-groove dry-gas seal and their influence on seal performance,which is expected to be useful for the improvement of the design of dry-gas seal systems operating in the slip flow regime.
基金supported by National Natural Science Foundation of China(11475019)the Electrostatic Research Foundation of Liu Shanghe Academicians and Experts Workstation,Beijing Orient Institute of Measurement and Test(BOIMTLSHJD20161002)
文摘To understand the discharge characteristics under a gap of micrometers,the breakdown voltage and current–voltage curve are measured experimentally in a needle-to-plate electrode at a microscale gap of 3–50 μm in air.The effect of the needle radius and the gas pressure on the discharge characteristics are tested.The results show that when the gap is larger than 10 μm,the relation between the breakdown voltage and the gap looks like the Paschen curve;while below 10 μm,the breakdown voltage is nearly constant in the range of the tested gap.However,at the same gap distance,the breakdown voltage is still affected by the pressure and shows a trend similar to Paschen's law.The current–voltage characteristic in all the gaps is similar and follows the trend of a typical Townsend-to-glow discharge.A simple model is used to explain the non-normality of breakdown in the micro-gaps.The Townsend mechanism is suggested to control the breakdown process in this configuration before the gap reduces much smaller in air.
文摘Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics (CFD) method has played a dominant role in studying and simulating transport phenomena involving fluid flow and heat and mass transfers, in recent years, other numerical methods for the simulations at meso- and micro-scales have also been actively applied to solve the physics of complex flow and fluid-interface interactions. This paper presents a review of recent advances in multi-scale computational simulation of biomimetics related fluid flow problems. The state-of-the-art numerical techniques, such as lattice Boltzmann method (LBM), molecular dynamics (MD), and conventional CFD, applied to different problems such as fish flow, electro-osmosis effect of earthworm motion, and self-cleaning hydrophobic surface, and the numerical approaches are introduced. The new challenging of modelling biomimetics problems in developing the physical conditions of self-clean hydrophobic surfaces is discussed.
文摘Micro-scale Al-Zn-Mg/Fe composite powders (MAF) with high reactivity and good storage properties were prepared by reducing iron onto the surface of Al-Zn-Mg alloy powders. Experimental results show that MAF as advanced zero-valent iron are highly effective for degradation of chlorinated organic compounds. The efficiency of degradation for carbon tetrachloride and perchloroethylene is higher than 99% within a period of 2 h. The efficiency of degradation for trichloroethylene by MAF after storing for one month is equivalent to that by freshly prepared nano-size zero-valent iron particles.
文摘Micro-scale functionally graded material(FGM)pipes conveying fluid have many significant applications in engineering fields.In this work,the thermoelastic vibration of FGM fluid-conveying tubes in elastic medium is studied.Based on modified couple stress theory and Hamilton’s principle,the governing equation and boundary conditions are obtained.The differential quadrature method(DQM)is applied to investigating the thermoelastic vibration of the FGM pipes.The effect of temperature variation,scale effect of the microtubule,micro-fluid effect,material properties,elastic coefficient of elastic medium and outer radius on thermoelastic vibration of the FGM pipes conveying fluid are studied.The results show that in the condition of considering the scale effect and micro-fluid of the microtubule,the critical dimensionless velocity of the system is higher than that of the system which calculated using classical macroscopic model.The results also show that the variations of temperature,material properties,elastic coefficient and outer radius have significant influences on the first-order dimensionless natural frequency.
基金support from the National Natural Science Foundation of China (11372118 and 11302082)
文摘Fabrication of micro gratings using a femtosecond laser exposure system is experimentally investigated for the electron moire method. Micro holes and lines are firstly etched for parameter study. Grating profile is theoretically optimized to form high quality moire patterns. For a demonstration, a parallel grating is fabricated on a specimen of quartz glass. The minimum line width and the distance between two adjacent lines are both set to be 1 μm, and the frequency of grating is 500 lines/ram. The experimental results indicate that the quality of gratings is good and the relative error of the gratings pitch is about 1.5%. Based on molte method, scanning electron microscope (SEM) moire patterns are observed clearly, which manifests that gratings fabricated with the femtosecond laser exposure is suitable for micro scale deformation measurement.
文摘The dispersion is mainly governed by wind field and depends on the planetary boundary layer (PBL) dynamics. Accurate representation of the meteorological weather fields would improve the dispersion assessments. In urban areas representation of wind around the obstacles is not possible for the pollution dispersion studies using Gaussian based modeling studies. It is widely accepted that computational fluid dynamics (CFD) tools would provide reasonably good solution to produce the wind fields around the complex structures and other land scale elements. By keeping in view of the requirement for the micro-scale dispersion, a commercial CFD model PANACHE with PANEPR developed by Fluidyn is implemented to study the micro-scale dispersion of air pollution over an urban setup at Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam a coastal station in the east coast of India under stable atmospheric conditions. Meso-scale module of the PANACHE model is integrated with the data generated at the site by IGCAR under RRE (Round Robin Exercise) program to develop the flow fields. Using this flow fields, CFD model is integrated to study the micro-scale dispersion. Various pollution dispersion scenarios are developed using hypothetical emission inventory during stably stratified conditions to understand the micro-scale dispersion over different locations of coastal urban set up in the IGCAR region of Kalpakkam.
基金supported by the Western-Caucasus Research Center
文摘The main aim of this research is to get a better knowledge and understanding of the micro-scale oscillatory networks behavior in the solid propellants reactionary zones. Fundamental understanding of the micro-and nano-scale combustion mechanisms is essential to the development and further improvement of the next-generation technologies for extreme control of the solid propellant thrust. Both experiments and theory confirm that the micro-and nano-scale oscillatory networks excitation in the solid propellants reactionary zones is a rather universal phenomenon. In accordance with our concept,the micro-and nano-scale structures form both the fractal and self-organized wave patterns in the solid propellants reactionary zones. Control by the shape, the sizes and spacial orientation of the wave patterns allows manipulate by the energy exchange and release in the reactionary zones. A novel strategy for enhanced extreme thrust control in solid propulsion systems are based on manipulation by selforganization of the micro-and nano-scale oscillatory networks and self-organized patterns formation in the reactionary zones with use of the system of acoustic waves and electro-magnetic fields, generated by special kind of ring-shaped electric discharges along with resonance laser radiation. Application of special kind of the ring-shaped electric discharges demands the minimum expenses of energy and opens prospects for almost inertia-free control by combustion processes. Nano-sized additives will enhance self-organizing and self-synchronization of the micro-and nano-scale oscillatory networks on the nanometer scale. Suggested novel strategy opens the door for completely new ways for enhanced extreme thrust control of the solid propulsion systems.
基金Supported by the National Key Research and Development Project of China(No.2018YFC0406703)the National Natural Science Foundation of China(Nos.51779277,51579252,51439005)+2 种基金the Special Scientific Research Project of the State Key Laboratory of Simulation and Regulation of Water Cycles in River Basins(No.2016ZY10)a Special Scientific Research Project of the China Institute of Water Resources and Hydropower Research(Nos.SS0145B392016,SS0145B612017)the Special Scientific Research Project of the China Institute of Water Resources and Hydropower Research(No.KY1799).
文摘A micro-scale finite element method(FEM) was proposed to precisely calculate the heat conduction between mortar and aggregate, and thus to accurately predict the non-uniformity of concrete pouring temperature. The concrete temperature field during vibration was also precisely calculated by accurate description of heat absorption characteristics of different parts of concrete when vibration. Based on the above method, the prediction model was used to predict the pouring temperature of a practical engineering. The comparison between actual results and simulated values shows that this method can be adopted to accurately predict the non-uniformity of concrete pouring temperature and the influence of mechanized vibration on concrete pouring temperature, and thus accurately predict pouring temperature. The control of casting temperature is crucial for preventing concrete fracture. The study provides a new method for predicting the pouring temperature of concrete structures, which has great practical value in engineering application.
基金the Research Fund for the Doctoral Programof Higher Education(20060007023)
文摘A new 6-DOF micro-manipulation robot based on 3-PPTTRS parallel mechanisms in combination with flexure hinges is proposed. The design principle of the mechanism is introduced, and the kinematics analysis method based on differentiation is used to get the (inverse) kinematics equations. Then a micro-scale motion precision simulation method is proposed according to finite element analysis (FEA), and the prediction of robot’s motion precision in design phase is realized. The simulation result indicates that the 6-DOF micro-manipulation robot can meet the design specification.
基金the National Key Clinical Specialty Construction Project,No.ZK108000CAMS Innovation Fund for Medical Sciences,No.2021-I2M-C&T-A-001 and No.2022-I2M-C&T-B-012.
文摘BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in China.METHODS We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology.Patients and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.RESULTS Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included.Epigastric pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting symptoms.Gastritis was classified as chronic non-atrophic in 69.9%of patients.Among those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat lesions.In patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more effective.For those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more promising.CONCLUSION CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms.Gastroscopy may play a major role in its detection and diagnosis.Treatment should be individualized based on symptom profile.
基金The authors gratefully acknowledge the editor and two anonymous reviewers for valuable comments on the manuscript.We also acknowledge DingHai Zhang for their help in the data analysis.This work was supported by the Funds for Creative Research Groups of China(Grant No.41621001)the National Natural Science Foundation of China(Grant Nos.41530746+1 种基金41901064)the Foundation for Excellent Youth Scholars of NIEER,CAS.
文摘The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of research on revegetation stability.However,it is unclear how meso-and micro-scale revegetation activity has responded to climatic change over the past decades.To evaluate the relative influence of climatic variables on revegetation activities in a restored desert ecosystem,we analysed the trend of revegetation change from 2002 to 2015 using a satellite-derived normalized difference vegetation index(NDVI)dataset.The time series of the NDVI data were decomposed into trend,seasonal,and random components using a segmented regression method.The results of the segmented regression model indicate a changing trend in the NDVI in the VPS,changing from a decrease(−7×10−3/month)before 2005 to an increase(0.3×10−3/month)after 2005.We found that precipitation was the most important climatic factor influencing the growing season NDVI(P<0.05),while vegetation growth sensitivity to water and heat varied significantly in different seasons.In the case of precipitation reduction and warming in the study area,the NDVI of the VPS could still maintain an overall slow upward trend(0.04×10−3/month),indicating that the ecosystem is sustainable.Our findings suggest that the VPS has been successful in maintaining stability and sustainability under current climate change conditions and that it is possible to introduce the VPS in similar areas as a template for resistance to sand and drought hazards.
基金supported by grants from the Beijing Nova Program (No. Z201100006820069)CAMS Innovation Fund for Medical Sciences (CIFMS, No. 2021-I2M-1-023, 2021-I2M-1-010)Talent Incentive Program of Cancer Hospital Chinese Academy of Medical Sciences (Hope Star)。
文摘Objective: Plant-based diets have multiple health benefits for cancers;however, little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation of the prospective associations among three predefined indices of plant-based dietary patterns and the risk of EC.Methods: We performed endoscopic screening for 15,709 participants aged 40-69 years from two high-risk areas of China from January 2005 to December 2009 and followed the cohort until December 31, 2022. The overall plant-based diet index(PDI), healthful plant-based diet index(h PDI), and unhealthful plant-based diet index(u PDI), were calculated using survey responses to assess dietary patterns. We applied Cox proportional hazard regression to estimate the multivariable hazard ratios(HRs) and 95% confidence intervals(95% CIs) of EC across 3plant-based diet indices and further stratified the analysis by subgroups.Results: The final study sample included 15,184 participants in the cohort. During a follow-up of 219,365person-years, 176 patients with EC were identified. When the highest quartile was compared with the lowest quartile, the pooled multivariable-adjusted HR of EC was 0.50(95% CI, 0.32-0.77) for h PDI. In addition, the HR per 10-point increase in the h PDI score was 0.42(95% CI, 0.27-0.66) for ECs. Conversely, u PDI was positively associated with the risk of EC, and the HR was 1.80(95% CI, 1.16-2.82). The HR per 10-point increase in the u PDI score was 1.90(95% CI, 1.26-2.88) for ECs. The associations between these scores and the risk of EC were consistent in most subgroups. These results remained robust in sensitivity analyses.Conclusions: A healthy plant-based dietary pattern was associated with a reduced risk of EC. Emphasizing the healthiness and quality of plant-based diets may be important for preventing the development of EC.
基金supported by the National Research Foundation of Korea Grant funded by the Korean government(MSIP)(No.2018R1A6A1A03025708).
文摘The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially impede the practical application of rechargeable aqueous Zn metal batteries(ZMBs).Herein,we present a strategy for achieving a high-rate and long-cycle-life Zn metal anode by patterning Zn foil surfaces and endowing a Zn-Indium(Zn-In)interface in the microchannels.The accumulation of electrons in the microchannel and the zincophilicity of the Zn-In interface promote preferential heteroepitaxial Zn deposition in the microchannel region and enhance the tolerance of the electrode at high current densities.Meanwhile,electron aggregation accelerates the dissolution of non-(002)plane Zn atoms on the array surface,thereby directing the subsequent homoepitaxial Zn deposition on the array surface.Consequently,the planar dendrite-free Zn deposition and long-term cycling stability are achieved(5,050 h at 10.0 mA cm^(−2) and 27,000 cycles at 20.0 mA cm^(−2)).Furthermore,a Zn/I_(2) full cell assembled by pairing with such an anode can maintain good stability for 3,500 cycles at 5.0 C,demonstrating the application potential of the as-prepared ZnIn anode for high-performance aqueous ZMBs.
基金provided by the National Natural Science Foundation of China(Grants No.12272238 and No.11932013)the"Outstanding Young Scholar"Program of Shanghai Municipalthe"Dawn"Program of Shanghai Education Commission(Grant No.19SG47)。
文摘Background:Foot kinematics,such as excessive eversion and malalignment of the hindfoot,are believed to be associated with running-related injuries.The maj ority of studies to date show that different foot strike patterns influence these specific foot and ankle kinematics.However,technical deficiencies in traditional motion capture approaches limit knowledge of in vivo joint kinematics with respect to rearfoot and forefoot strike patterns(RFS and FFS,respectively).This study uses a high-speed dual fluoroscopic imaging system(DFIS)to determine the effects of different foot strike patterns on 3D in vivo tibiotalar and subtalar joints kinematics.Methods:Fifteen healthy male recreational runners underwent foot computed tomography scanning for the construction of 3-dimensional models.A high-speed DFIS(100 Hz)was used to collect 6 degrees of freedom kinematics for participants’tibiotalar and subtalar joints when they adopted RFS and FFS in barefoot condition.Results:Compared with RFS,FFS exhibited greater internal rotation at 0%-20%of the stance phase in the tibiotalar joint.The peak internal rotation angle of the tibiotalar joint under FFS was greater than under RFS(p<0.001,Cohen’s d=0.92).RFS showed more dorsiflexion at 0%-20%of the stance phase in the tibiotalar joint than FFS.RFS also presented a larger anterior translation(p<0.001,Cohen’s d=1.28)in the subtalar joint at i nitial contact than FFS.Conclusion:Running with acute barefoot FFS increases the internal rotation of the tibiotalar joint in the early stance.The use of high-speed DFIS to quantify the movement of the tibiotalar and subtalar joint was critical to revealing the effects of RF S and FFS during running.
基金supported by the National Natural Science Foundation of China(Project No.52074123).
文摘To explore the effects of freeze‒thaw cycles on the mechanical properties and crack evolution of fissured sandstone,biaxial compression experiments were carried out on sandstone subjected to freeze‒thaw cycles to characterize the changes in the physical and mechanical properties of fissured sandstone caused by freeze‒thaw cycles.The crack evolution and crack change process on the surface of the fissured sandstone were recorded and analysed in detail via digital image technology(DIC).Numerical simulation was used to reveal the expansion process and damage mode of fine-scale cracks under the action of freeze‒thaw cycles,and the simulation results were compared and analysed with the experimental data to verify the reliability of the numerical model.The results show that the mass loss,porosity,peak stress and elastic modulus all increase with increasing number of freeze‒thaw cycles.With an increase in the number of freeze‒thaw cycles,a substantial change in displacement occurs around the prefabricated cracks,and a stress concentration appears at the crack tip.As new cracks continue to sprout at the tips of the prefabricated cracks until the microcracks gradually penetrate into the main cracks,the displacement cloud becomes obviously discontinuous,and the contours of the displacement field in the crack fracture damage area simply intersect with the prefabricated cracks to form an obvious fracture.The damage patterns of the fractured sandstone after freeze‒thaw cycles clearly differ,forming a symmetrical"L"-shaped damage pattern at zero freeze‒thaw cycles,a symmetrical"V"-shaped damage pattern at 10 freeze‒thaw cycles,and a"V"-shaped damage pattern at 20 freeze‒thaw cycles.After 20 freeze‒thaw cycles,a"V"-shaped destruction pattern and"L"-shaped destruction pattern are formed;after 30 freeze‒thaw cycles,an"N"-shaped destruction pattern is formed.This shows that the failure mode of fractured sandstone gradually becomes more complicated with an increasing number of freeze‒thaw cycles.The effects of freeze‒thaw cycles on the direction and rate of crack propagation are revealed through a temperature‒load coupled model,which provides an important reference for an in-depth understanding of the freeze‒thaw failure mechanisms of fractured rock masses.
文摘The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted that venous congestion is an important clinical feature worthy of investigation.Evaluating venous Doppler profile abnormalities at multiple sites could suggest adequate treatment and monitor its efficacy.Renal dysfunction could trigger or worsen fluid overload in heart disease,and cardio-renal syndrome is a well-characterized spectrum of disorders describing the complex interactions between heart and kidney diseases.Fluid overload and venous congestion,including renal venous hypertension,are major determinants of acute and chronic renal dysfunction arising in heart disease.Organ congestion from venous hypertension could be involved in the development of organ injury in several clinical situations,such as critical diseases,congestive heart failure,and chronic kidney disease.Ultrasonography and abnormal Doppler flow patterns diagnose clinically significant systemic venous congestion.Cardiologists and nephrologists might use this valuable,noninvasive,bedside diagnostic tool to establish fluid status and guide clinical choices.