Secondary metabolites in microorganisms represent a resource for drug discovery and development.In particular,microbial-derived antitumor agents are in clinical use worldwide.Herein,we provide an overview of the devel...Secondary metabolites in microorganisms represent a resource for drug discovery and development.In particular,microbial-derived antitumor agents are in clinical use worldwide.Herein,we provide an overview of the devel-opment of classical antitumor drugs derived from microorganisms.Currently used drugs and drug candidates are comprehensively described in terms of pharmacological activities,mechanisms of action,microbial sources,and biosynthesis.We further discuss recent studies that have demonstrated the utility of gene-editing technologies and synthetic biology tools for the identification of new gene clusters,expansion of natural products,and eluci-dation of biosynthetic pathways.This review summarizes recent progress in the discovery and development of microbial-derived anticancer compounds with emphasis on biosynthesis.展开更多
基金supported by the Shandong Provincial Natural Sci-ence Foundation(ZR2020QB158)the Guangdong Basic and Applied Basic Research Foundation(2020A1515110284).
文摘Secondary metabolites in microorganisms represent a resource for drug discovery and development.In particular,microbial-derived antitumor agents are in clinical use worldwide.Herein,we provide an overview of the devel-opment of classical antitumor drugs derived from microorganisms.Currently used drugs and drug candidates are comprehensively described in terms of pharmacological activities,mechanisms of action,microbial sources,and biosynthesis.We further discuss recent studies that have demonstrated the utility of gene-editing technologies and synthetic biology tools for the identification of new gene clusters,expansion of natural products,and eluci-dation of biosynthetic pathways.This review summarizes recent progress in the discovery and development of microbial-derived anticancer compounds with emphasis on biosynthesis.
