Objective： This article provides an overview of characteristics of phospholipids, the characteristics and influential factors of liposome and microemulsion as carriers for skin delivery of drugs, and the latest advan...Objective： This article provides an overview of characteristics of phospholipids, the characteristics and influential factors of liposome and microemulsion as carriers for skin delivery of drugs, and the latest advances of the phospholipids carriers in transdermal delivery systems. The perspective is that phospholipids carriers may be capable of a wide range of applications in the transdermal delivery system.展开更多
The vitamin C（VC） in crops was successfully determined using ascorbate oxidase（AO） electrochemical biosensor based on the biocompatible poly（3,4-ethylenedioxythiophene）（PEDOT） matrices,which was easily prepare...The vitamin C（VC） in crops was successfully determined using ascorbate oxidase（AO） electrochemical biosensor based on the biocompatible poly（3,4-ethylenedioxythiophene）（PEDOT） matrices,which was easily prepared by one-step electrodeposition technique in ionic liquid microemulsions.The fabricated biosensor displayed excellent bioelectrocatalytic performance to the oxidation of VC,wide linear range,low detection limit,fast response time,good operational and storage stability,the good results of the determination of VC in vegetable crops indicated that the fabricated biosensor will be a good candidate for the physiological and biochemical studies of crops in near future.展开更多
Smart flexible electronics with underwater motion detection have become a promising research aspect in intelligent perception.Inspired by the strong adaptability of marine creatures to complex underwater environments,...Smart flexible electronics with underwater motion detection have become a promising research aspect in intelligent perception.Inspired by the strong adaptability of marine creatures to complex underwater environments,conventional biocompatible hydrogels are worth developing into organogels with preferred underwater adhesive properties,hydrophobic and antiswelling performance,and motion perception ability.Herein,a highly sensitive organogel sensor exhibiting good hydrophobicity,electromechanical properties,and adhesion properties was prepared for underwater utilization by regulating the chemical components and internal interactions.The synergistic effect of massive reversible noncovalent bonds ensures the organogel’s excellent underwater adhesion to multifarious substrates.Meanwhile,the interactions of hydrophobic conductive fillers and the dynamic hydrophobic associations in the organogel endow it with satisfactory hydrophobic performance(contact angle of111.8°)and antiswelling property(equilibrium swelling ratio of-31%after 15-day immersion).The fabricated flexible organogel strain sensor exhibits high sensitivity(gauge factor of1.96),ultrafast response rate(79.1 ms),low limit of detection(0.45 Pa),and excellent cyclic stability(1044 tensile cycles followed by 3981 compressive cycles).Results demonstrate the proposed organogel’s precise perception of sophisticated human motions in air and underwater,which expands its application scenarios.展开更多
Self-microemulsion drug delivery systems(SMEDDS)have great potential for use in food applications,but their adoption has been limited due to the high proportion of non-edible surfactants.To address this limitation,we ...Self-microemulsion drug delivery systems(SMEDDS)have great potential for use in food applications,but their adoption has been limited due to the high proportion of non-edible surfactants.To address this limitation,we developed a novel surfactant-free SMEDDS by utilizing phospholipids(40.4%)and triglycerides(54.7%)from Antarctic krill oil(KO)as the intrinsic surfactant and oil phase,respectively,and incorporating glycerol as an edible co-surfactant.The formation mechanism of the KO-based SMEDDS and their potential to deliver curcumin were investigated.The results demonstrated that glycerol facilitated the formation of organogels by the phos-pholipids in krill oil,and homogenization effectively disrupted the organogels to form SMEDDS.The resulting microemulsion was stable under various conditions and significantly improved the bioaccessibility of curcumin in vitro,increasing it by 13.96-fold compared to curcumin powder.Our approach of using marine lipid-based SMEDDS provides insights into their formation and expands their application in foods that contain hydropho-bic active ingredients.This sustainable and potentially healthier option offers a promising solution for enhancing the bioavailability of active ingredients in food applications.展开更多
基金This study was supported by Chongqing Tackle Key Prob-lems in Science and Technology Project(CSTC,2006AB5011)
文摘Objective： This article provides an overview of characteristics of phospholipids, the characteristics and influential factors of liposome and microemulsion as carriers for skin delivery of drugs, and the latest advances of the phospholipids carriers in transdermal delivery systems. The perspective is that phospholipids carriers may be capable of a wide range of applications in the transdermal delivery system.
基金supported by NSFC(Nos50963002 and 51073074)Key Projects in the National Science& Technology Pillar Program in the Eleventh Five-year Plan Period of China(Nos2006BAD02A04 and 2006BAD01A01)Jiangxi Provincial Department of Education(NosGJJ11590 and GJJ10678)
文摘The vitamin C（VC） in crops was successfully determined using ascorbate oxidase（AO） electrochemical biosensor based on the biocompatible poly（3,4-ethylenedioxythiophene）（PEDOT） matrices,which was easily prepared by one-step electrodeposition technique in ionic liquid microemulsions.The fabricated biosensor displayed excellent bioelectrocatalytic performance to the oxidation of VC,wide linear range,low detection limit,fast response time,good operational and storage stability,the good results of the determination of VC in vegetable crops indicated that the fabricated biosensor will be a good candidate for the physiological and biochemical studies of crops in near future.
基金supported by the Natural Science Foundation of Jiangsu Province(BK20190688)the Natural Science Foundation of Jiangsu Higher Education Institutions(21KJB430039)Taishan Scholar Construction Special Fund of Shandong Province。
文摘Smart flexible electronics with underwater motion detection have become a promising research aspect in intelligent perception.Inspired by the strong adaptability of marine creatures to complex underwater environments,conventional biocompatible hydrogels are worth developing into organogels with preferred underwater adhesive properties,hydrophobic and antiswelling performance,and motion perception ability.Herein,a highly sensitive organogel sensor exhibiting good hydrophobicity,electromechanical properties,and adhesion properties was prepared for underwater utilization by regulating the chemical components and internal interactions.The synergistic effect of massive reversible noncovalent bonds ensures the organogel’s excellent underwater adhesion to multifarious substrates.Meanwhile,the interactions of hydrophobic conductive fillers and the dynamic hydrophobic associations in the organogel endow it with satisfactory hydrophobic performance(contact angle of111.8°)and antiswelling property(equilibrium swelling ratio of-31%after 15-day immersion).The fabricated flexible organogel strain sensor exhibits high sensitivity(gauge factor of1.96),ultrafast response rate(79.1 ms),low limit of detection(0.45 Pa),and excellent cyclic stability(1044 tensile cycles followed by 3981 compressive cycles).Results demonstrate the proposed organogel’s precise perception of sophisticated human motions in air and underwater,which expands its application scenarios.
基金financially supported by Key Program of National Natural Science Foundation of China(Grant No.32230080)Dalian Science and Technology Innovation Fund(Grant No.2022JJ11CG008)National Key R&D Program of China,grant number(Grant No.2018YFC1406806).
文摘Self-microemulsion drug delivery systems(SMEDDS)have great potential for use in food applications,but their adoption has been limited due to the high proportion of non-edible surfactants.To address this limitation,we developed a novel surfactant-free SMEDDS by utilizing phospholipids(40.4%)and triglycerides(54.7%)from Antarctic krill oil(KO)as the intrinsic surfactant and oil phase,respectively,and incorporating glycerol as an edible co-surfactant.The formation mechanism of the KO-based SMEDDS and their potential to deliver curcumin were investigated.The results demonstrated that glycerol facilitated the formation of organogels by the phos-pholipids in krill oil,and homogenization effectively disrupted the organogels to form SMEDDS.The resulting microemulsion was stable under various conditions and significantly improved the bioaccessibility of curcumin in vitro,increasing it by 13.96-fold compared to curcumin powder.Our approach of using marine lipid-based SMEDDS provides insights into their formation and expands their application in foods that contain hydropho-bic active ingredients.This sustainable and potentially healthier option offers a promising solution for enhancing the bioavailability of active ingredients in food applications.
