Objective To approach the effect of microgene pSVPoMcat modified Schwan n cell (SC) on the regeneration and repair of injured spinal cord.Method Spinal cord hemi－transection models were made with the cutting method i...Objective To approach the effect of microgene pSVPoMcat modified Schwan n cell (SC) on the regeneration and repair of injured spinal cord.Method Spinal cord hemi－transection models were made with the cutting method in healthy SD ra ts. Microgene pSVPoMcat modified SC(group A),highly purified SC(group B),and glu tin sponge (control group C)were randomly implanted into the cut. After 3 month living ,the host rats were scanned by MRI, and observed under EM. Result Spinal signals at the injury region nearly recovered to normal in group A.No recovery w as found in group B.Malacosis was found in group C.TEM findings: regeneration of large number of myelinated and nonmyelinated axons and SC proliferation in grou p A, myelinated axon regeneration and SC necrosis in group B, non myelinated and nonmyelinated axon in group C.Conclusion Implantation of microgene pSVPoMcat mo dified SC could promote the repair of injured spinal cord.展开更多
文摘Objective To approach the effect of microgene pSVPoMcat modified Schwan n cell (SC) on the regeneration and repair of injured spinal cord.Method Spinal cord hemi－transection models were made with the cutting method in healthy SD ra ts. Microgene pSVPoMcat modified SC(group A),highly purified SC(group B),and glu tin sponge (control group C)were randomly implanted into the cut. After 3 month living ,the host rats were scanned by MRI, and observed under EM. Result Spinal signals at the injury region nearly recovered to normal in group A.No recovery w as found in group B.Malacosis was found in group C.TEM findings: regeneration of large number of myelinated and nonmyelinated axons and SC proliferation in grou p A, myelinated axon regeneration and SC necrosis in group B, non myelinated and nonmyelinated axon in group C.Conclusion Implantation of microgene pSVPoMcat mo dified SC could promote the repair of injured spinal cord.
