Microwave Solvothermal Synthesis, Crystal Structures and in Vitro Antitumor Activities of Di-n-butyltin Piperonylate with a Sn4O4 Ladder Framework

A two-dimensional supramolecular compound di-n-butyltin piperonylate, {（μ3-O）（μ2-OMe）（n-Bu2Sn）2[O2CAr（C2H4O）]}2 constructed by hydrogen bonds with a Sn4O4 ladder-like framework, was obtained by the microwave-assisted solvothermal reaction of di-n-butyltin oxide precursor with the piperonylic acid in methanol environments. The composite was characterized by elemental analysis and IR（~1H, ^（13）C and ^（119）Sn） NMR spectra. The compound crystallizes in monoclinic system, space group P21/n with a = 13.3690（12）, b = 14.1442（14）, c = 16.4022（16） A, β = 107.191（6）°, V = 2963.0（5） A^3, Z = 2, Dc = 1.520 g/cm^3, F（000） = 1368, μ = 1.719 mm^（-1）, Mo Kα radiation（λ = 0.71073 A）, the final R = 0.0495 and w R = 0.1260 for 6780 observed reflections with I 〉 2σ（I）. Its X-ray crystallography diffraction analyses show a Sn4O4 ladder-like skeleton, in which two endocyclic tin and one exo tin atoms are bonded to the μ3-O atom. In addition, one endocyclic tin and one exo tin atoms are respectively bonded to the μ2-O atom from methanol. The ladder-like molecule has a three-ring fused skeleton, which is almost coplanar. The endocyclic and exocyclic tin atoms were all five-coordinated with distorted trigonal bipyramidal geometry. The antitumor activity showed that the compound had higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro.

Two Novel Dibutyltin Complexes with Trimers and Hexanuclear Based on the Bis(5-Cl/Me-salicylaldehyde) Carbohydrazide: Syntheses, Structures, Fluorescent Properties and Herbicidal Activity

Two novel bis(2-hydroxy-5-R-benzylidene)carbohydrazide dibutyltin complexes(R:Cl(T1),Me(T2))with hexanuclear and triangular frame structures were obtained by microwave-assisted solvothermal reaction of dibutyltin oxide precursor with the ligands in methanol environments,However,their structures are characterized by elemental analysis,IR,(1H,13C)NMR spectra,and the molecular structures of T1 and T2 were confirmed by X-ray diffraction.The crystal of T1 belongs to triclinic system,space group P1,and T2 is of monoclinic system,space group C2/c.Five-coordinated distorted triangular bipyramids and six-coordinated distorted octahedral configurations were formed by the coordination of oxygen and nitrogen atoms of ligands with two dibutyltins,respectively,and trimer hexanuclear dibutyltin complexes were constructed by the cross-coordination of enol imines.The two complexes exhibit fluorescence emission in DMF solvents and DMF-water mixtures.When the volume fraction of water content is between 0 and 10%(V/V),the aggregation fluorescence enhancement effect is good,and fluorescence quenching occurs when the water content is more than 10%(V/V).The T1 can inhibit the growth of target plants,such as Portulaca oleracea,Cassia tora L.,Brassica campestris L.ssp.chinensis var.utilis Tsen et Lee and Amaranthus tricolor L.The T2 can selectively inhibit the growth of Portulaca oleracea L.,Amaranthus spinosus L.and Amaranthus tricolor L.It can be used as a candidate herbicide for Portulaca oleracea L.,Amaranthus spinosus L.and Amaranthus tricolor L.