Reference Interval of Thyroidal Function of Women in the Early,Middle and Late Pregnancy in Jingzhou City,Hubei Province

[Objectives]To study the reference value of thyroid function in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City.[Methods]362 healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)were selected as the study group,and 360 non-pregnant women were selected as the control group.Serum thyroid hormone levels in the two groups were detected,and the reference value was expressed as the median(M)and 95%confidence interval(CI).On this basis,the chart of changing trend of thyroid hormone in the early,middle and late pregnancy were plotted.[Results]Compared with the control group,FT3,TT4,TT3,FT4and TSH in the early,middle and late pregnancy were significantly different in the study group(P<0.05).In the study group,there were significant differences in the early,middle and late pregnancy(P<0.05).[Conclusions]This trend chart has certain reference value in the screening,diagnosis and treatment of thyroid diseases in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City of Hubei Province.

Intracontinental Collisional Orogeny During Late Permian-Middle Triassic in South China: Sedimentary Records of the Shiwandashan Basin

Sedimentary response to an orogenic process is important for determining whether South China had compressional or extensional orogeny during the period from the Late Permian to the Middle Triassic besides the tectonic and magmatologic evidence. An intracontinental collision event took place between the Yangtze and Cathaysia blocks in the Late Permian. Beginning at the Late Triassic, the tectonic movement was completely changed in nature and entered a post-collisional extensional orogenic and basin-making process. This paper presents sedimentological evidence from the Late Permian to the Middle Triassic in the Shiwandashan basin at the southwestern end of the junction zone between the Yangtze and Cathaysia blocks.

Middle and Late Carboniferous Tetracoral Assemblages and Biogeography of China

China is rich in Middle and Carboniferous fossil corals. The coral faunas in different regions have varying characteristics and can be divided into distinct assemblages. The coral fauna in South China is dominated by the order Caninida and contains numerous endemic elements; that in North China has a lot of Middle Carboniferous corals which are monotonous in species, with Late Carboniferous solitary corals being predominant. The coral fauna in Junggar mainly contains large bi-zoned solitary caninids, while that in southern Khingan is similar to that in South China due to the presence of abundant tri-zoned compound corals. In northern Tibet the coral fauna is also similar to that in South China, but in southern Tibet it is of a cold-water type. Therefore, the Middle and Late Carboniferous coral geography of China can be divided into the Tethys, Boreal and Gondwana Realms.

Prevention and Control Effects of New Biological Formulations Sprayed by Different Methods on Proceras venosatus (Walker) and Tryporyza intacta Snellen in Middle and Late Stages

To screen new biological formulations, accurate and efficient application technology, field test was conducted with 72% Bacillus thuringiensis(Bt)·monosultap WP, 8% lambda-cyhalothrin·emamectin benzoate SA and 3.6% lambda-cyhalothrin·Bt SA through manual spraying and unmanned aerial vehicle spraying. Test results and comprehensive evaluation analysis demonstrated that 72% Bt·monosultap WP and 8%lambda-cyhalothrin·emamectin benzoate SA by manual spraying and unmanned aerial vehicle spraying had good prevention and control effect on strains and internodes damaged by Tryporyza intacta Snellen in middle and late stage, which were ideal new biological formulations with high effi-ciency and low risk for prevention and control of T. intacta in middle and late stage, and could be popularized in sugarcane area. 72% Bt·monosultap WP at the dose of 3 000 g/hectare and 8% lambda-cyhalothrin·emamectin benzoate SA at the dose of 750 mL/hectare could be sprayed in mid September at the peak occurrence period of the forth and fifth generations of T. intacta and Proceras venosatus. Agents were diluted with 900 kg water per hectare, and manually sprayed with electric knapsack sprayer; or agents were diluted with 15 kg of Haoyang aerial control special addi-tives and water per hectare, and sprayed with unmanned aerial vehicle. The control effect against borer-damaged strain rate was above 81.3% and that against borer-damaged internode rate was above 88.6%.

Middle and Late Tertiary Palaeogeography and Palaeoenvironment on the Northern Continental Margin of the South China Sea

Based essentially on research results of calcareous nannofossils, combined with some other microfossil da-ta and several secondary depositional breaks, this paper discusses the criteria of division and comparison of themiddle and late Tertiary marine sediments, palaeogeographical and palaeoenvironmental evolution andpalaeoclimates on the northern continental margin of the South China Sea, comprising the Tainan basin, PearlRiver Mouth basin. Southeast Hainan basin and Beibu Gulf basin. Study shows that the upper Oligocene toPliocene strata in the whole area consist essentially of marine sediments except in the Beibu Gulf basin. Theyinclude littoral. neritic and deltaic sediments as well as carbonate rock-bioherm limestone. The sea advancedfrom southeast to northwest. During the transgression there appeared three culminations coinciding to thestages of deposition of nannofossil zones NN4-5, NN11 and 13-15.

On the Rural Revitalization in the Middle and Late Stages of Modernization

China’s rural revitalization,which was initiated in the middle and late stages of modernization,features distinct characteristics of the times.It is necessary to approach rural revitalization in China from the aspects of industrial-agricultural coordination,urban-rural integration,and regional balance.Industrial-agricultural coordination concerns forging the“world’s factory”and,more importantly,developing into the“world’s farm”through rural revitalization.Urban-rural integration is not just about urban modernization,but also about rural modernization through rural revitalization.Regional balance requires the promotion of characteristic development in peripheral regions with targeted measures of rural revitalization,as well as the building of highly developed city clusters.

A combination of castration with(125)~I brachtherapy in middle and late period prostate cancer

Objective To investigate the therapeutic efficacy of castration with 125 I brachtherapy in middle and late stage prostate cancer. Methods Sixty-six patients with prostate cancer from 2004 to 2009 were analyzed,40 were at clinical stage C and 26 were at clinical stage D,

Occurrence of Middle Miocene Fossil Cyprinid Fish in the Northern Qaidam Basin and its Paleoenvironmental Implications

With a thick sequence of early Eocene to Pleistocene terrestrial records, the Qaidam Basin on the northern Tibetan Plateau provides an important sedimentary archive for understanding the paleoenvironmental evolution of the northeast Tibetan Plateau. In this study, specimens of fossil fish remains are collected from the late Middle Miocene（Serravallian, -12 Ma） of the middle member of the Shang Youshashan Formation, Dahonggou（DHG） section, in the northern Qaidam Basin. Based on a systematic study of these materials, the remains have assigned to Cyprinidae, with typical pharyngeal teeth and dorsal fin spines with serrations on the posterior edge. Our discovery improves understanding of the cyprinid fish distribution characteristics in the Qaidam Basin during the Cenozoic. Cooccurrences of terrestrial brackish ostracod species Cyprideis and long chain alkenonesin the layer indicate that the studied cyprinid fish lived in a generally large brackish to saline water body during the late middle Miocene（Serravallian）, when the climate of Qaidam Basin was still not sufficiently dry to form an extreme saline water lake.

Palynoflora and climatic dynamics of the Laizhou Bay of Bohai Sea,North China Plain,since the late middle Pleistocene

The coastal plain of Laizhou Bay in Bohai Sea is a transitional area of land-sea interaction.Sediments in this area can bear significant information of sea-level fluctuation,climate change,as well as regional geological setting.Here,in this study,new sporopollen data from three boreholes(GK138,GK111 and GK95)in the coastal plain of Laizhou Bay,Bohai Sea were investigated,and the pollen spectrum since the late middle Pleistocene was established as six sporopollen assemblage zones(Ⅰ-Ⅵ),i.e.,Pinus-Quercus-Artemisia,Gramineae-Artemisia-Chenopodiaceae,Picea-Pinus-QuercusArtemisia,Picea-Pinus-Betula-Gramineae-Artemisia,Picea-Pinus-Cupressaceae-Chenopodiaceae and Pinus-Quercus-Gramineae-Artemisia-Chenopodiaceae.Combining with existing sedimentary successions and detailed radiocarbon dating results of the sediments from the three boreholes,paleovegetation and climatic evolution since the late middle Pleistocene were reconstructed.The findings revealed that climatic changes in this area since the late middle Pleistocene were characterized by alternating cold-arid and warmhumid conditions,which were well correlated with marine isotopic stages(MIS).The present study offers specific insight into the climatic dynamics in the North China Plain since the late middle Pleistocene and provides evidence of a clear link among the palynoflora in the area,the glacial-interglacial period climatedriven sea-level changes,and the marineδ^(18)O records.

Immigrants,Citizenship and Social Integration in French Urban Society in the Late Middle Ages:A Case Study of Avignon

An important feature of the urban demographic structure in France in the late Middle Ages was the significant increase in immigrants as a proportion of the population.The influx of immigrants and their successful assimilation were necessary for urban society to cope with the crisis of the late Middle Ages.There were two principal pathways for integration.Firstly,the municipal authority granted citizenship to some selected immigrants,accepting them legally into the citizen community.Secondly,immigrants constructed spontaneous and autonomously diversified social relationships and interacted with other residents through religious-based confraternities.The two routes were mutually complimentary and promoted the absorption of multiple immigrants into urban society achieving a revival in early modern times.That said,social participation was the only way for all immigrants to integrate into urban society and reveals the initiative and autonomy of the newcomers.

The Most Complete Pistosauroid Skeleton from the Triassic of Yunnan,China

A new specimen discovered from the Falang Formation in northeastern Yunnan represents the most complete skeleton of Triassic pistosauroids. The new specimen is referred to Yunguisaurus Cheng et al., 2006 on the basis of the skull features, such as the presence of a separated nasal entering the external naris, a large pineal foramen located at the frontal/parietal suture and an interpterygoid vacuity with a narrow anterior extension. The new specimen differs from the type species of Yunguisaurus liae Cheng et al., 2006 in some aspects. Most of these differences can be attributed to ontogenetic variations. The new specimen is provisionally considered as Yunguisaurus cf. liae although its relatively short snout of the skull and slenderer hyoid may not be explained ontogenetically. Whether or not the new specimen represents a different taxon has to wait for a detailed study of the whole skeleton.

Yuzhou Flora——A hidden gem of the Middle and Late Cathaysian Flora

The Yuzhou Flora of the southern North China Platform possesses the typical regional features of the Middle and Late Cathaysian Flora.For a long time during the Permian,this area was located on shoreline marine tidal flats and deltas at low latitudes with a warm and humid climate.Consequently,many successive layers with abundant well-preserved plant fossils and a complete evolutionary sequence were developed.This is a unique and ideal place to study the Middle and Late Cathaysian Flora.We have recognized 111 genera and 307 species from this flora.The rapid morphological evolution and uninterrupted stratigraphic succession of Lobatannularia(Sphenophytes) make this group one of the bases for biostratigraphic divisions of the Permian System of the North China Platform.Ninety percent of Pteridophytes belong to the order Marattiales,which are well developed during the early and middle stages of the Yuzhou Flora but experience a sudden decline during the late stage.Ancient Pteridospermatophytes only flourished during the Middle Permian whereas advanced Peltaspermales are extremely well developed at the end of the early Late Permian.Among them Shenzhouphyllum is one of characteristic elements in the late stage of the Yuzhou Flora.The Cycadophytes evolved relatively early in this area and they differentiated and proliferated during the late Middle to early Late Permian.The number of species of Ginkgophytes is small but this group is extremely abundant,especially in the early Late Permian.The Gigantopteridales(preangiosperms) is a very important and unique group in the Yuzhou Flora.Based upon their venation and leaf architecture,this group can be divided into three evolutionary stages,i.e.,appearance and differentiation,first flourishing,and second flourishing and sudden disappearance,which form the basis for biostratigraphic division and correlation of the Permian System of the North China Platform.Based upon the evolutionary trend of venation pattern and leaf architecture,we propose some taxonomic changes at the generic level.The Yuzhou Flora emerged at the middle Early Permian(Zisongian) and suddenly disappeared at the early Late Permian(Wujiapingian).It is later replaced by the Euro-American Zechstein flora in the late Late Permian.The Yuzhou Flora is divided into three(early,middle and late) stages based upon the cyclic development of its plant groups.Five fossil plant assemblage zones are recognized from the Yuzhou Flora based upon the succession of each group and their combined characters in different layers.

Geochemistry of the Middle to Late Permian limestones from the marginal zone of an isolated platform(Laibin,South China)

Major, trace and rare earth elements were measured in 27 samples of the Middle to Late Permian limestones from the Tieqiao section located on the marginal zone of an isolated platform （Laibin, South China）. Shale-normalized REE＋Y patterns of all samples show notably negative Ce anomalies （0.21-0.66, average 0.33）, slightly positive Gd anomalies （1.08-1.30, average 1.20）, and positive Y anomalies with superchondritic Y/Ho ratios （36-91, average 55）, which are consistent with those of modern shallow seawater. Their relative LREEs enrichment with higher NdsN/YbsN ratios （0.58-1.80） than those of modern shallow seawater （0.21-0.50） suggests complicated sources of REEs for all samples. Compared with geochemical features of sediments influenced by terrigenous particles and hydrothermal fluids, it is concluded that ambient shallow seawater was the primary source of REEs in these limestones. Comparing the indicators of REE＋Y elements （ZREE, NdsN/YbsN, Ce/Ce＊, Gd/Gd＊, Eu/Eu＊ and Y/Ho） in limestones with those in bedded cherts from the Tieqiao section, we consider that limestone and bedded chert have similar sources of REE＋Y elements： ambient shallow seawater with more or less hydrothermal fluids. In addition, there is a completely negative correlation between CaCO3 and SiO2 contents in limestones and bedded cherts. These results imply that precipitation of CaCO3 was inhibited by that of SiO2 which was derived mainly from hydrothermal fluid, es- pecially in bedded cherts from the Tieqiao section.

Tectonic-lithofacies paleogeography,large-scale source-reservoir distribution and exploration zones of Cambrian subsalt formation,Tarim Basin,NW China

To predict the large-scale source rock and reservoir distribution in Cambrian subsalt formations(Upper Sinian to Mid-Cambrian)in the Tarim Basin,more than 502D seismic lines and 3D data volume acquired latest,22 wells and some out-crops around this area were used to study the tectonic-lithofacies paleogeography,define the distribution of large scale source rocks and reservoirs,and sort out favorable zones.(1)The basin experienced evolution from ramp to deep-water mud-rich ramp,low-gradient slope,weak rimmed to strong rimmed platform,and the differentiation in the platform was controlled by pre-Cambrian palaeo-rifts.(2)The Luonan-Yubei ancient rift controlled the distribution of source rocks in the Lower Cambrian Yuertusi Formation,and this rift together with the northern depression are the main source rock area.(3)There are three sets of large-scale reservoirs,the Upper Sinian Qigebulake Formation,the Lower Cambrian Xiaorbulake Formation and the Wu-songger Formation,and shoal-mounds,early dolomitization and multi-levels of unconformities controlled reservoir develop-ment.(4)Four favorable zones,the north slope of Tazhong,upper slope of Maigaiti area,Keping-Wensu periphery,and south slope of Tabei,were evaluated.Of them,the north slope of Tazhong is most likely to have exploration breakthrough;the south slope of Tabei is the best area for exploring the Upper Sinian large scale weathering crust dolomite;Maigaiti slope and Kep-ing-Wensu periphery area improved in exploration potentials significantly,and are worth prospecting faster.

Endu combined with concurrent chemotherapy and radiotherapy for stage IIB-IVA cervical squamous cell carcinoma patients

BACKGROUND In recent years,the incidence of cervical cancer has increased with increasing life pressures and changes in women's social roles,posing a serious threat to women's physical and mental health.AIM To explore the clinical effect of Endo combined with concurrent radiotherapy and chemotherapy in the treatment of advanced cervical squamous cell carcinoma.METHODS A total of 120 patients admitted to the oncology department of our hospital were selected as the research subjects.They were equally divided into the test group and the control group(60 patients each)with a random number table.The test group was treated with Endo combined with concurrent radiotherapy and chemotherapy,and the control group was treated with concurrent radiotherapy and chemotherapy.We compared the serum thymidine kinase 1(TK1),human epididymis protein 4(HE4),vascular endothelial growth factor(VEGF),and squamous cell carcinoma-associated antigen(SCC-Ag)levels,the clinical effects and survival before and after radiotherapy and chemotherapy,the quality score,and the 3-year follow-up outcomes between the two groups.RESULTS After chemotherapy,the complete remission+partial remission rate was 85.00%in the test group and 68.33%in the control group;the difference was not statistically significant(P>0.05).Before chemotherapy,the serum TK1,HE4,VEGF,and SCC-Ag levels of the two groups were not significantly different(P>0.05).After chemotherapy,the levels of serum TK1(1.27±0.40 pmol/L),HE4(81.4±24.0 pmol/L),VEGF(235.1±38.0 pg/mL),and SCC-Ag(1.76±0.55 ng/mL)were lower than those in the control group[TK1(1.58±0.51 pmol/L),HE4(98.0±28.6)pmol/L,VEGF(284.2±54.1 pg/mL),and SCC-Ag(2.34±0.78 ng/mL)].The difference was statistically significant(P<0.05).Before chemotherapy,there were no significant differences in the physical,role,mood,cognition,social and symptom scale scores of the two groups(P>0.05).After chemotherapy,the physical,role,mood,cognitive and social scores were higher in the test group than in the control group,and the difference was statistically significant(P<0.05).The symptom scale scores of the test group were all lower than those of the control group,and the difference was statistically significant(P<0.05).The 3-year progression-free survival(PFS)rate was 43.33%in the test group and 26.67%in the control group;the overall survival(OS)rate was 48.33%in the test group and 33.33%in the control group;the differences were not statistically significant(P>0.05).The 3-year PFS time of the test group was 20.0 mo,which was longer than that of the control group(15.0 mo),and the difference was significant(P<0.05).The OS time of the test group was 30.0 mo,which was longer than that of the control group(18.0 mo),and the difference was significant(P<0.05).CONCLUSION Endo combined with concurrent radiotherapy and chemotherapy for the treatment of advanced cervical squamous cell carcinoma has a positive effect on reducing the level of tumor markers in patients,prolonging the PFS and OS times of patients,and improving the quality of life.

The relationship between species diversity and ecosystem function (productivity) of the late Middle Permian brachiopods community at the region of Hechuan,Chongqing,China

The relationship between species diversity and ecosystem function is a hot topic in ecology and environics. This paper investi- gates the evolution of diversity of the late Middle Permian brachiopods community in Hechuan, Chongqing, China, and dis- cusses the relationship between species diversity and community productivity in terms of the geohistorical development. This paper shows that the species diversity is externalized by several indexes, and the relationship between diversity and productiv- ity is too complex to be described by a single assumption. The relationship between species diversity and community produc- tivity is restricted by environment and community evolution. When the community succeeds normally, the relationship be- tween species richness index, species diversity index, and species evenness index to productivity is in linear dependence rela- tion to each other, which is met with the third assumption. But, when the environment interference surpasses the beating capa- bility of the community, not only the community succession will be terminated and be replaced by another one, but also the relationship between species richness index, species diversity index, and species evenness index to productivity is also in- versed to negative correlation by the interference from environment. Only the relationship between ecological dominance and productivity is in linear dependence relation to each other and approximately met with the third assumption. It is illustrated that the assumption that the productivity is in linear dependence relation with diversity should be established on the presupposition that the community succession is normal.

New records of Jurassic petrified wood in Jianchang of western Liaoning,China and their palaeoclimate implications

Diverse and rich fossil wood records have been documented from the Mesozoic of Liaoning Province, NE China. The Tiaojishan Formation(mainly distributed in Beipiao, Chaoyang, Fuxin and Jianchang regions) is one of the most significant horizons for the Jurassic petrified wood in Liaoning Province. Previously, wood fossils of this formation were mainly reported in Beipiao and Chaoyang regions, whereas fossil wood record was merely known in Jianchang region. Here we describe new fossil wood specimens from the Tiaojishan Formation in Jianchang County, western Liaoning. Two fossil wood taxa, i.e., Protaxodioxylon jianchangense Tian et Wang sp. nov. and Xenoxylon peidense Zheng et Zhang were recognized on the basis of anatomical features. These fossil wood records add new data for understanding the fossil wood diversity, floral composition and palaeoclimate of the Tiaojishan Formation. The occurrence of Xenoxylon and Protaxodioxylon implies a cool temperate, wet and seasonal climate condition with interannual variations during the Middle to Late Jurassic transition in western Liaoning region.