930904 A clinical study on determination ofplasma vasoactive intestinal peptide and its rela-tionship with bronchial responsiveness in asth-matics.LIU Ao(刘翱),et al.Dept Respir Med,Kunming General Hosp,Kunming Comman...930904 A clinical study on determination ofplasma vasoactive intestinal peptide and its rela-tionship with bronchial responsiveness in asth-matics.LIU Ao(刘翱),et al.Dept Respir Med,Kunming General Hosp,Kunming Command,Kunming,650032.Chin J Intern Med 1993;32(3):165-166.Vasoactive intestinal peptide(VIP),which islocalized in normal human lung,may play an im-portant role in regulating bronchial tone,pul-monary blood flow and mucus secretion.Thelevel of plasma VIP and bronchial responsivenesswere studied in patients with asthma,and chronicbronchitis and in the healthy subjects.The re-sults showed that the level of plasma VIP展开更多
10.1 Upper respiratory tract disease and bronchial asthma 2006357 Observation of airway hyperresponsiveness and inflammatory markers in induced sputum in elderly patients with stable late onset asthma during the remis...10.1 Upper respiratory tract disease and bronchial asthma 2006357 Observation of airway hyperresponsiveness and inflammatory markers in induced sputum in elderly patients with stable late onset asthma during the remission period. NIE Han-xiang, et al. Dept Respir Dis, Renmin Hosp, Wuhan Univ, Wuhan 430060. Chin J Geriatr 2006;25(5):328-331. Objective:To investigate the clinical significance of airway hyperresponsiveness, eosinophil (Eos) percentage, levels of eosinophil cationic protein (ECP) and interleukin-5 (IL-5) in induced sputum in elderly patients with late onset asthma (LOA)during the remission period. Methods: Fifty-eight elderly patients with LOA during the remission period were selected. Bronchial challenge test was performed and the percentage of Eos and levels of ECP and IL-5 in induced sputum were measured by Wrights′ stain, immuno-CAP system and ELISA, respectively. Twenty-five elderly patients with LOA during their exacerbation period and 15 healthy elderly subjects were selected as control. Results:In fifty-eight LOA patients during their remission period, 49 cases (84.5%) showed positive bronchial challenge test and 9 cases(15.5 %) negative. The percentage of Eos, levels of ECP and IL-5[(9.3± 3.1)%], [(144.2±68.1) μg/L] and [(20.3±6.3) μg/L], in induced sputum in patients with LOA during their remission period were lower than those[ (21.1±9.8)%, (399.3±172.5) μg/L] and[(50.6±10.7) μg/L, respectively]in LOA group during the exacerbation period, and higher than those[(1.3±0.7)%,(48. 7±21.9) μg/L and (10.3±3.2) μg/L]in healthy group(all P<0.01). The percentage of Eos, levels of ECP and IL-5 in induced sputum were all higher [(12.7±3.6)% ]vs [(3.1±1. 3)%], [(171.3±69.8) μg/L] vs [(52.7±21.1) μg/L] and [(23.6±8.5) μg/L]vs[(13.7±4.1) μg/L] (all P<0.01) in positive group than negative group of bronchial challenge test in LOA patients during remission period.展开更多
文摘930904 A clinical study on determination ofplasma vasoactive intestinal peptide and its rela-tionship with bronchial responsiveness in asth-matics.LIU Ao(刘翱),et al.Dept Respir Med,Kunming General Hosp,Kunming Command,Kunming,650032.Chin J Intern Med 1993;32(3):165-166.Vasoactive intestinal peptide(VIP),which islocalized in normal human lung,may play an im-portant role in regulating bronchial tone,pul-monary blood flow and mucus secretion.Thelevel of plasma VIP and bronchial responsivenesswere studied in patients with asthma,and chronicbronchitis and in the healthy subjects.The re-sults showed that the level of plasma VIP
文摘10.1 Upper respiratory tract disease and bronchial asthma 2006357 Observation of airway hyperresponsiveness and inflammatory markers in induced sputum in elderly patients with stable late onset asthma during the remission period. NIE Han-xiang, et al. Dept Respir Dis, Renmin Hosp, Wuhan Univ, Wuhan 430060. Chin J Geriatr 2006;25(5):328-331. Objective:To investigate the clinical significance of airway hyperresponsiveness, eosinophil (Eos) percentage, levels of eosinophil cationic protein (ECP) and interleukin-5 (IL-5) in induced sputum in elderly patients with late onset asthma (LOA)during the remission period. Methods: Fifty-eight elderly patients with LOA during the remission period were selected. Bronchial challenge test was performed and the percentage of Eos and levels of ECP and IL-5 in induced sputum were measured by Wrights′ stain, immuno-CAP system and ELISA, respectively. Twenty-five elderly patients with LOA during their exacerbation period and 15 healthy elderly subjects were selected as control. Results:In fifty-eight LOA patients during their remission period, 49 cases (84.5%) showed positive bronchial challenge test and 9 cases(15.5 %) negative. The percentage of Eos, levels of ECP and IL-5[(9.3± 3.1)%], [(144.2±68.1) μg/L] and [(20.3±6.3) μg/L], in induced sputum in patients with LOA during their remission period were lower than those[ (21.1±9.8)%, (399.3±172.5) μg/L] and[(50.6±10.7) μg/L, respectively]in LOA group during the exacerbation period, and higher than those[(1.3±0.7)%,(48. 7±21.9) μg/L and (10.3±3.2) μg/L]in healthy group(all P<0.01). The percentage of Eos, levels of ECP and IL-5 in induced sputum were all higher [(12.7±3.6)% ]vs [(3.1±1. 3)%], [(171.3±69.8) μg/L] vs [(52.7±21.1) μg/L] and [(23.6±8.5) μg/L]vs[(13.7±4.1) μg/L] (all P<0.01) in positive group than negative group of bronchial challenge test in LOA patients during remission period.
