Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

Objective The association of metabolic syndrome （MetS） with cardiovascular diseases （CVD） has not been adequately explored in middle-aged and elderly Chinese. This study aimed to investigate MetS＇ prevalence and its impact on the CVD incidence in this specific population group. Methods A data set of a community-based prospective cohort study was analyzed. A total of 2300 subjects aged 40-94 years were followed up for the CVD events. MetS defined according to the JCDCG criteria was assessed at baseline, and the middle-aged and elderly groups were classified by the WHO definition. Results As compared with the middle-aged group, the prevalence of MetS increased by 0.6 times （34.6% vs. 21.3%） and the incidence density of CVD increased by 4.9 times in the elderly group （52.3/1000 person-year vs. 8.9/1000 person-year）. Furthermore, the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group （HR=2.23, P〈0.01） and to elevated blood glucose in the elderly group （HR=1.39, P〈O.01）. Conclusion MetS was highly prevalent in middle-aged and elderly Chinese. MetS significantly increased the risk to OdD incidence in the elderly. All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD.

Public Square Dancing Intervention on Subjective Well-Being of Middle-Aged and Elderly People:A Meta-Analysis

Objective:To understand the influence of public square dancing on the subjective well-being of middle-aged and elderly people.Methods:According to the principle of Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,we search Chinese databases,such as CNKI,Wanfang Data,and VIP,and English databases,such as Proquest,Web of Science,Pubmed,Cochrane,and ScienceDirect,and collect relevant articles at home and abroad from 2006 to December 2019 for meta-analysis in January 2020.Result:A total of 10 articles were included.The meta-analysis results showed that the well-being of middle-aged and elderly people in the public square dancing intervention group was significantly higher than that of the other exercise group and control group(both P<0.01).The results of the subgroup analysis showed the following:Different durations of intervention significantly influence the intervention effect(P<0.01).No difference was found between the effect of the mixed-gender intervention and the individual female intervention(P>0.05).No significant difference was found between the groups with weekly intervention frequency(P>0.05).Conclusion:Public square dancing intervention is effective for middle-aged and elderly people’s subjective well-being.Neither mixed intervention nor the times of weekly intervention have an impact on the intervention effect.However,the length of duration of intervention influences the intervention effect.

Relationship between platelet-lymphocyte ratio and carotid atherosclerosis in middle-aged and elderly patients with type 2 diabetes mellitus

Objective:To investigate the relationship between platelet-lymphocyte ratio(PLR)and carotid atherosclerosis(CAS)in middle-aged and elderly patients with T2DM.Methods:A total of 420 middle-aged and elderly patients with T2DM who were hospitalized in the Endocrinology Department of our hospital from September 2018 to September 2020 and were examined by ultrasound were selected as the subjects.The carotid artery intima-media thickness(CIMT)was examined by color Doppler ultrasonography,including normal CIMT group(n=111),CIMT thickening group(n=103)and CAS plaque group(n=206).The differences of serum PLR levels among the three groups were compared.Multivariate Logistic regression was used to analyze the relationship between PLR and CAS plaque formation.The receiver operating curve(ROC)was used to evaluate the value of multivariate Logistic regression model(Logit P)in the diagnosis of CAS lesions.Results:The mean value of PLR in CAS plaque group(127.86±48.54)was significantly higher than that in CIMT normal group(109.15±48.35).Multivariate Logistic regression analysis showed that after adjusting for other confounding factors,the increase of PLR was an independent risk factor for the occurrence of CAS plaque.ROC showed that the efficacy of multivariate Logit P model in the diagnosis of CAS plaque was(AUC=0.807,95%CI=0.759-0.858).Conclusions:PLR is one of the important risk factors for the occurrence of CAS lesions.At the same time,the multivariate Logistic regression model established in this study has clinical reference value in predicting CAS lesions in middle-aged and elderly patients with T2DM.

Identification of late-onset hypogonadism in middle-aged and elderly men from a community of China

In this study, we investigated the essential criteria for late-onset hypogonadism （LOH） syndrome based on the presence of symptoms associated with low testosterone levels in Han Chinese men. Blood tests for total testosterone （TT） and sex hormone-binding globulin （SHBG） were performed, and the aging male symptoms （AMS） questionnaire was conducted in a randomly selected cohort composed of 944 Chinese men aged 40 to 79 years from nine urban communities. Three sexual symptoms （decreased ability/frequency of sexual activity, decreased number of morning erections, and decreased libido） were confirmed to be related to the total and free testosterone levels. The thresholds for TT were approximately 12.55 nmol l^-1 for a decreased ability/frequency to perform sex, 12.55 nmol l^-1 for decreased frequency of morning erections, and 14.35 nmol l^-1 for decreased sexual desire. The calculated free testosterone （CFT） thresholds for these three sexual symptoms were 281.14, 264.90, and 287.21 pmol l^-1, respectively. TT 〈13.21 nmol l^-1 （OR =1.4, 95%Ch 1.0-1.9, P= 0.037） or CFT 〈268.89 pmol l^-1 （OR - 1.5, 95%Ch 1.1-20, P=0.020） was associated with an increase in the aforementioned three sexual symptoms. The prevalence of LOH was 9.1% under the criteria, including all three sexual symptoms with TT levels 〈13.21 nmol l^-1 and CFT levels 〈268.89 pmol l^-1. Our results may improve the diagnostic accuracy of LOH in older men.

Prevalence of late-onset hypogonadism among middle-aged and elderly males in China:results from a national survey

This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in China.A population-based sample of 6296 men aged 40 years-79 years old was enrolled from six representative provinces in China.Serum total testosterone(TT),sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were measured and free testosterone(cFT)was calculated.The Aging Males’Symptoms(AMS)scale was used to evaluate the LOH symptoms.Finally,5078 men were included in this analysis.The TT levels did not decrease with age(P=0.59),and had no relationship with AMS symptoms(P=0.87 for AMS total score,P=0.74 for≥3 sexual symptoms).The cFT levels decreased significantly with age(P<0.01)and showed a negative association with the presence of≥3 sexual symptoms(P=0.03).The overall estimated prevalence of LOH was 7.8%(395/5078)if a cFT level<210 pmol l−1 combined with the presence of≥3 sexual symptoms was used as the criterion of LOH.Among them,26.1%(103/395)and 73.9%(292/395)had primary and secondary hypogonadism,respectively.After adjustment for confounding factors,primary and secondary hypogonadism was positively related to age and comorbidities.Body mass index was an independent risk factor for secondary hypogonadism.The results suggest that the AMS total score is not an appropriate indicator for decreased testosterone,and that the cFT level is more reliable than TT for LOH diagnosis.Secondary hypogonadism is the most common form of LOH.

Prevalence and influence factors of self-medication in Chinese middle-aged and elderly people: evidence from 2011, 2013 and 2015 CHARLS panel data

Self-medication is an increasingly frequent phenomenon worldwide and has an important influence on health.In this study,we analyzed the self-medication prevalence rate in Chinese middle-aged and elderly people,and explored the influence factors.The data from China Health and Retirement Longitudinal Study(CHARLS)in 2011,2013 and 2015 were used.Self-medication prevalence was calculated as the number of whole people divided by the number of people taking self-medication.The influence factors of self-medication were analyzed by panel data random effect model.We excluded observations with missing values in our analysis,leaving 16 962,17 876 and 19 572 observations in 2011,2013 and 2015,respectively.The average 3-year self-medication prevalence was 45.52%.Moreover,11.70%of respondents practiced self-medication with prescription medicine in 2011,2013 and 2015.Respondents living in non-rural areas(P=0.009)and western region(P=0.000)took more self-medication.Self-medication was a common phenomenon among middle-aged and elderly population in China.The government should strengthen the guidance for the middle-aged and elderly people who took more self-medication,such as those living in urban and western region.

Prevalence of stroke and metabolic disorders in the middle-aged and elderly Chinese with type 2 diabetes

Background Stroke is now the most prevalent and debilitating disease affecting diabetic population in China. The study aimed to investigate the prevalence of stroke and metabolic disorders in the middle-aged and elderly Chinese with type 2 diabetes. Methods A total of 4 629 subjects with type 2 diabetes （males： 1 917; females： 2 712） aged ≥ 40 years from Shijingshan district, Beijing, China from November 2011 to August 2012 were included in the study. Data on demographic information, lifestyle, history of diabetes mellitus, stroke, coronary heart disease, hypertension, and dyslipidemia were collected. The oral glucose tolerance test or a standard meal test was performed. Non-fatal stroke was reported by the subjects. The 2-tailed test was used, and P 〈0.05 was regarded as statistically significant. Results Prevalence of stroke in the subjects with type 2 diabetes was 5.5%. The prevalence of smoking, overweight or obesity, hypertension, and dyslipidemia was 41.0%, 65.8%, 67.4%, and 52.0% in males, and 2.2%, 65.5%, 69.5%, and 57.6% in females. Multivariate Logistic regression analysis showed that increased age, hypertension, diabetic duration, and overweight or obesity were positively correlated with stroke in the population with type 2 diabetes, whereas high- density lipoprotein cholesterol level was negatively correlated with stroke. After adjustment for age and gender, the odds ratio values of stroke in subjects having 1,2 or ≥3 of 4 risk factors, including smoking, overweight or obesity, hypertension and dyslipidemia, were 2.302 （95% CI： 0.789-6.712）, 4.089 （95% CI： 1.470-11.373）, 6.023 （95% CI： 2.176-16.666）, compared with subjects without any of the above 4 risk factors. Conclusions The prevalence of stroke was higher in middle-aged and eldedy Chinese with type 2 diabetes than that in the general population. With the aggregation of risk factors, the prevalence of stroke increased.

The Association between Interpersonal Relationship and Erectile Dysfunction of Middle-Aged and Elderly Men in a Rural Area of Zhejiang,China

Objective:To explore the association between interpersonal relationship and erectile dysfunction(ED)of middle-aged and elderly men.Methods:A population-based cross-sectional research was conducted in the rural area of Jiashan County,Zhejiang Province,in 2016.Middle-aged and elderly men(aged 40-80)were selected as study participants.The face-to-face questionnaire was collected,including basic information,lifestyles,interpersonal relationship,and sexual function.The interpersonal relationship was evaluated based on marital relationship,neighborhood relationship,and relatives/friends relationship.According to the International index of erectile function,the study participants were divided into ED group(mild ED,moderate-to-severe ED),and non-ED group.Correlations were evaluated between interpersonal relationship indices and the prevalence or the severity of ED.Potential confounders were adjusted by the logistical regression model.Results:There were 674 study participants with average age of 60.4±8.5 years,and 489 ED patients with prevalence of 72.6%.With age increasing,the prevalence and the severity of ED increased significantly.The men who could get help from spouse when an emergency occurred or who were more cared about by their neighbors had lower ED risk,and odds ratios(ORs)(95%confidence intervals[CIs])were 0.23(0.13-0.42)and 0.58(0.46-0.75),respectively.After the adjustment of the covariates(age,education degree,household income,smoking,and drinking),the ORs(95%CIs)were 0.29(0.14-0.60)and 0.54(0.39-0.74),respectively.Good marital relationship and good neighborhood relationship were associated with a less severity of ED.

Study on Prevention and Treatment of Kidney Deficiency and Bone Mineral Loss in Middle-Aged and Elderly Female Diabetes Patients

In this study, 48 cases of middle-aged and elderly female diabetes patients were dividedrandomly into two groups, and treated separately by western medicine alone ( glibenclamide) in group A, andby traditional Chinese medicine (herbs that replenish the Kidney and activate blood circulation ) and gliben-clamide in group B. Before treatment, the patients of both groups had elevated glycosylated hemoglobin(HbAlc) and fast blood glucose (FBG) levels, decreased serum estradiol (E2 ) and testosterone/estradiol(E2/T) ratio, and the loss of bone mineral (elevated urinary calcium,phosphorus levels) . Most ot the pa-tients in the two groups had the symptoms of soreness and weakness of the loins and knees, general weak-ness ,dizziness,decreased sexual libido , palpitation and frequent urination , etc. These symptoms in traditionalChinese medicine belong to the deficiency of the Kidney. After treatment in both groups. the patients' serumHbAlc, FBG, and urinary Beta-2-microglobulin (B2M) got reduced, the concentration of serum sex hormone(E2 , E2/T ratio) elevated, and the elimination of urinary calcium, phosphorus levels cut down. But , the ther-apeutic effect in group B is apparently better than that in group A. The symptoms of deficiency of the Kidneywas apparently improved in group B. So, The authors think the medicinal herbs(reinforcing Kidney and acti-vating blood circulation) have an important role in the prevention and treatment of the 'Kidney deficiency'and bone mineral loss in middle-aged and elderly female diabetes patients.

Effect of Atorvastatin on the levels of adiponectin and leptin and adiponectin-leptin ratio in the elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia

Objective To evaluate effects of Atorvastatin on the levels of adiponectin and leptin and adiponectin-leptin ratio in the elderly and middle-aged patients with type 2diabetes and combined hyperlipidemia.Methods Totally80 elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia were treated with Atorvastatin(10 mg/d)for 12 weeks.Fasting plasma levels

The study of the correlation between serum uric acid and insulin resistance in middle-aged and elderly hospitalized patients with type 2 diabetes

Objective To study the relationship between serum uric acid and insulin resistance in type 2 diabetic patients.Methods A total of 728 middle-aged and elderly type 2 diabetic patients were recruited and the anthropometric,clinical and biochemical parameters and

Analysis of the impact of exercise education interventions on middle-aged and elderly people in Central-western rural China

This study aims to analyze the impact of health education effort that promote exercise activities have had on middle-aged and older people in central-western rural China.The Project for Family Health Care(PFHC)of the population in central and western China used questionnaires completed anonymously to survey 4217 randomly selected respondents in the baseline year of 2011,and 4529 in the end-line year of 2015.We used bivariate and multivariate analyses to examine the associations between several factors and regular exercise activities.The 2011 baseline year sample indicated that 90.5%of respondents knew the functions of regular exercise,but that only 45.4%participated in regular exercise activities.In the baseline multivariate model,a number of factors were positively associated with the prevalence of participation in regular exercise activities.Respondents who were women,older,retired,lived with children,had chronic diseases,and self-reported better health were more likely to participate in regular exercise.The proportion of those participating in regular exercise increased to 75.9%among the end-line year respondents after health education.This study revealed that health education interventions effectively encouraged rural middle-aged and elderly people to participate in regular exercise activities.Health education efforts of this sort for rural middle-aged and older adults should be further strengthened,and more public facilities for exercise should be provided.

METABONOMICS CHARACTERISTICS OF MIDDLE-AGED AND ELDERLY CHINESE PEOPLE WITH QI-INSUFFICIENCY CONSTITUTION

The aim of the work was to investigate the metabonomic characteristics of qi-insufficiency constitution among middle-aged and elderly healthy Chinese people.All healthy Chinese participants were screened from 2012annual health check-up for middle-aged and elderly community residents(=50 years old)at Chajiao community,

桂林中老年群体智慧医疗服务使用意愿调查:基于技术采纳与应用整合理论模型

目的对中老年群体智慧医疗服务使用情况及其影响因素进行调查分析,为医疗机构优化智慧医疗服务、推动中老年群体数字鸿沟治理提供参考。方法在广西壮族自治区桂林市采用线下问卷调查、访谈等方法收集数据,结合技术采纳与应用整合理论模型,使用SPSS 26.0和AMOS 24.0进行不同变量描述统计、单因素分析、不同维度相关分析和结构方程模型路径分析,研究中老年群体在使用智慧医疗服务过程中的影响因素。结果桂林市中老年群体对智慧医疗服务的使用意愿得分为(3.14±0.76)分,除了性别,不同变量对中老年群体的使用意愿差异分别有统计学意义(P<0.05)。中老年群体的绩效期望、社群影响、配合情况对中老年群体使用智慧医疗服务意愿有正向影响,努力期望对于使用意愿的影响不明显。结论桂林市中老年群体智慧医疗服务使用意愿还有很大的提升空间,要从各维度入手提高中老年群体的使用意愿,多方共同努力推进智慧医疗服务的使用。

某部老干部药品需求满意度调查

目的了解2009年《军队合理医疗药品目录》颁布以来,军队老干部患慢性病、合理用药、药品需求等状况。方法采取问卷调查的方法,设计调查表对门诊老干部进行现场调研,利用Excel表格功能进行统计。结果老干部随着年龄增长,慢性病发病率处于较高水平。老干部用药品种多,多药合用和中西药联用比较普遍。老干部认为药品需求得到基本满足以上的占80.61%,大多数人认为药品需求基本得到满足,不需要自费购买药品。结论 2009年《军队合理医疗药品目录》极大提升了药品保障水平,基本满足了军队老干部日益增长的药品需求。

天津市1359名离退休老年人血脂倾向分析

目的研究天津市离退休老年人高血脂的分布情况。方法以2002年天津市老年人健康查体人群为研究对象,选择60岁以上老年人1359人进行血脂分析。用氧化酶法测定血清总胆固醇(TC)和三酰甘油(TG),用聚乙二醇沉淀法测定高密度脂蛋白(HDL-C)。结果老年人高脂血症发病率及血脂水平随增龄而下降,高峰期在60～69岁,以高TG血症为主。结论血脂异常已经成为老年医学领域不可忽视的重要研究课题,为减少老年人冠心病、糖尿病、高血压、脑血管病的患病率和死亡率,预防高脂血症是至关重要的。天津市离退休老年人血脂控制情况较好,另外,应加强对高TG血症的监测,社区全科医生有必要加强对相关知识的宣教。

干部病房老年患者护理安全隐患与对策

目的分析干部病房老年患者护理安全管理中存在的隐患,提出相应对策,为老年干部提供更好的护理服务。方法选取我院干部病房598例老年住院患者,结合其自身特点及临床护理工作中可能存在的安全隐患进行分析。结果干部病房老年患者的自身因素、环境因素、陪护人员因素及护理人员等因素,都有可能造成护理过程中发生安全隐患,针对这些因素提出相应的对策。结论护理过程中加强患者的入院评估、加强护患沟通、改善病房环境、加强护理人员知识培训,同时构建积极的护理安全文化,能够有效降低护理中不安全隐患,提高护理质量。

做好新形势下离退休干部工作之管见

离退休干部工作在部门工作和发展中不是中心和全局 ,但与中心工作和发展紧密相连。离退休干部工作部门及其工作人员要按照党和政府的各项政策规定 ,结合离退休干部的特点 ,充分利用现有条件 ,努力做好离退休干部工作。

打造养老文化品牌,共筑和谐温馨家园——天津石化公司敬老文化、养老文化建设形成“三六三”工作模式

养老文化建设是广大离退休工作人员肩负的重要责任和使命。中国石化股份有限公司天津分公司认真贯彻落实习近平总书记对老干部、离退休工作的重要论述和要求,牢固树立"尊老敬老,为老爱老"理念,不断拓宽离退休工作内涵,始终秉承"以子女之心,做精准服务之事"原则,倾心服务于离退休人员各类群体,着力在打造敬老文化、养老文化机制上下功夫,逐步形成了富有天津石化特色的"三六三"工作模式,营造了"老有所养、老有所乐、老有所学"的浓郁氛围。

老年干部病房患者医院感染的调查分析

目的了解老年干部病房患者医院感染发病率、危险因素及病原菌的分布,探讨其控制措施。方法采用回顾性调查方法,对784例>60岁老年患者进行调查。结果老年干部病房患者发生医院感染76例,感染发生率为9.7%,感染部位以呼吸道为主(47.4%),其次为泌尿系统(21.1%);菌群分布以革兰阴性杆菌为主(52.9%),革兰阳性球菌次之(30.5%);感染因素包括年龄、住院时间、侵入性操作、使用广谱抗菌药物及基础疾病等。结论老年患者易发生医院感染,积极治疗基础疾病,减少危险因素,增加机体免疫力,才能降低医院感染发生。