Predictive value of CA-153,CA-125 and Apo A for ocular metastasis in menopausal female patients with breast cancer

AIM:To establish a meaningful standard for diagnosing ocular metastasis(OM)in menopausal breast cancer(BC)women,and explore the relationship between CA-153,CA-125,apolipoprotein A,and OM.METHODS:A total of 1362 menopausal female BC patients with OM volunteered to take part in this study between July 2012 and July 2022.Women with BC who are menopausal were found to have an OM incidence of 1.6%.Furthermore,CA-153,CA-125,and apolipoprotein A(Apo A)all contributed to OM in women with BC who are postmenopausal according to binary logistic regression.Receiver operating curve(ROC)analysis was used to assess the diagnostic value of OM in patients with BC.RESULTS:Both CA-153 and CA-153+CA-125 showed a higher sensitivity of 95.45%,whereas CA-153+Apo A illustrated the highest specificity of 99.02%.Moreover,CA-153 and CA-153+CA-125 had higher areas under the curve(AUC)of 0.973.CONCLUSION:The data indicate that the serum concentrations of CA-153 exhibited the most significant predictors of the diagnosis of OM in menopausal women with BC.The current study researches the utility of risk factors in predicting of OM in menopausal BC women and put forward the latest suggestions on their clinical application.

The Quality of Life of Chinese Middle-Aged Male Patients with Gastric Carcinoma After Total Gastrectomy and Nursing Intervention

OBJECTIVE The purpose of this study was to evaluate the quality of life （QOL） in Chinese middle-aged male patients with gastric carcinoma after total gastrectomy, to investigate the factors affecting their QOL, and to Study the effectiveness of nursing intervention.METHODS Structured questionnaire （EORTC QLQ-C30） was used among 162 middle-aged male patients after total gastrectomy （the patients finished the whole process of chemotherapy, and returned home, and society） for data collection and reevaluate the patients＇ aualitv of life with 2 months nursing intervention.RESULTS The patient＇s quality of life was related to their education level, economic condition, family support, and pathological staging. This study showed that patients got higher scores in Functional scales （except for CF）, and lower scores in Symptom scales and single items （except for FI） after receiving intervention than before it was received before.CONCLUSION The study revealed that the QOL in middleaged male patients after total gastrectomy was worse when there was inadequate attention. After implementing pertinent nursing intervention implementing, patients＇ mental attitude and negative behavior were improved, and their QOL was enhanced after returning home and into society.

Characteristics of management of reproductive endocrine problems in female patients

In 1956, my former Head and Professor of the Department of Obstetrics and Gynecology KT LIM, asked me to take the initiative to establish a reproductive endocrinology unit. As China is a developing country, we were then short of diagnostic facilities and therapeutic agents. We can learn basic knowledge and clinical experiences from the literature, but hormonal preparations were expensive and generally most of our patients were poor. We needed to find simpler, inexpensive and yet effective ways to treat our patients. In a word, we had to develop our own way.……

Correlation of three grades with carotid atherosclerotic plaque by the ultrasound in middle-aged patients with hypertension

Objective:To explore the correlation of different hypertension grades with carotid atherosclerotic plaque in middle-aged patients with hypertension.Methods:A total of 300 patients with primary hypertension who were admitted in the Cardiology Department and Neurology Department of our hospital from January, 2015 to September, 2016 were included in the study and divided into 3 groups with 100 cases in each group according to the hypertension grade criteria. Moreover, 100 normal individuals who came for physical examinations were served as the control group. TCD was used to detect MCA, ACA, PCA, VA1, and BA. CDFI was used to detect CCA, ICA, ECA, and VA2. EDV, PSV, PI, and RI were detected, respectively. The nitrate reductase colorimetric method was used to detect NO, MDA, and SOD.Results:PSV and EDV in the internal carotid artery system in patients with hypertension were significantly reduced (P<0.05), while PI and RI were significantly increased (P<0.05);moreover, with the increasing of hypertension grading, PSV and EDV were gradually reduced, while PI and RI were increased. PSV and EDV in the vertebral artery system in patients with hypertension were significantly reduced (P<0.05), while PI and RI were significantly increased (P<0.05);moreover, with the increasing of hypertension grading, PSV and EDV were gradually reduced, while PI and RI were increased. SOD and NO in patients with hypertension were significantly lower than those in the control group (P<0.05), while MDA was significantly higher than that in the control group (P<0.05);moreover, with the increasing of hypertension grading, SOD and NO were gradually reduced, while MDA was gradually increased.Conclusions: TCD in combined with CDFI can make a comprehensive evaluation of hemodynamic indicators of intracranial and extracranial vessels in patients with hypertension, and is of great significance in the early detection of intracranial and extracranial arteriosclerosis.

Novel biallelic compound heterozygous mutations in FDXR cause optic atrophy in a young female patient: a case report

Dear Editor,I write to present a case of novel biallelic compound heterozygous mutations in FDXR cause optic atrophy in a young female patient.This is a rare genetic mutation with new site mutation.Auditory neuropathy and optic atrophy(ANOA,OMIM:617717)is an autosomal recessive disease that is caused by ferredoxin reductase(FDXR,OMIM:103270)gene mutation.

Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report

Coronary artery vasospasm is an infrequent cause of acute coronary syndrome (ACS). A 50-year-old female developed persistent chest discomfort related to anterior STEMI. After an unsuccessful thrombolysis attempt, due to delay concern, the patient was then sent to the catheterization laboratory for rescue PCI. The coronary angiogram revealed a TIMI 3 flow proximal LAD significant stenosis with spastic appearance of the coronary arteries which has improved after intracoronary nitrates administration. Optical Coherence Tomography (OCT) excluded coronary artery dissection and haematoma also revealed thrombus on moderate atherosclerotic plaque. The patient was then pain-free;she was managed medically and discharged after few days of monitoring. Three weeks later, she developed transient chest pain with ST segment elevation while cycling during rehabilitation program. Provocation test by Ergonovine was positive with complete occlusion of proximal RCA (right coronary artery) complicated by transient complete heart block and shock. She was stabilized with 7 mg of intracoronary nitrates injection. She was discharged after close monitoring with calcium channel blocker and tobacco cessation. ACS may complicate prolonged coronary artery vasospasm making the diagnosis challenging. OCT may help understand ACS mechanism and exclude spontaneous coronary artery dissection. Provocation test is crucial for confirmation.

Knowledge and Attitude towards Cervical Cancer Screening among Females Attending out Patient Department in Health Centre IIIs in Oyam District

Cervical cancer is a serious health concern in Uganda. Early screening and detection certainly improves chances of survival and treatment outcome. Sound knowledge and positive attitudes highly influence acceptability and uptake of screening methods. This descriptive cross-sectional study determines knowledge and attitudes towards Cervical Cancer screening amongst female out-patients aged 15 - 49 years, attending Health Centre IIIs in Oyam District, Northern Uganda. A systematically obtained sample of 445 respondents was interviewed using semi-structured questionnaires and focused group discussions. Quantitative data was analyzed using SPSS 16.0. Directed content analysis of themes of transcribed qualitative data was conducted manually. Of the 445 respondents, only 62.7% (n = 279) had heard of cervical cancer amongst which only 35.1% (n = 85) had been screened;13.7% (n = 34) did not know what screening was;3.7% (n = 9) were not sure and 5.8% (n = 14) knew it as removal of the cervix. Only 39.1% (n = 174) believed that cervical cancer can be prevented. There is still limited knowledge and lots of misconceptions about cervical cancer screening in the communities, which requires massive sensitization of the population at risk to change negative attitudes and maximize acceptability to screening methods.

Study on Prevention and Treatment of Kidney Deficiency and Bone Mineral Loss in Middle-Aged and Elderly Female Diabetes Patients

In this study, 48 cases of middle-aged and elderly female diabetes patients were dividedrandomly into two groups, and treated separately by western medicine alone ( glibenclamide) in group A, andby traditional Chinese medicine (herbs that replenish the Kidney and activate blood circulation ) and gliben-clamide in group B. Before treatment, the patients of both groups had elevated glycosylated hemoglobin(HbAlc) and fast blood glucose (FBG) levels, decreased serum estradiol (E2 ) and testosterone/estradiol(E2/T) ratio, and the loss of bone mineral (elevated urinary calcium,phosphorus levels) . Most ot the pa-tients in the two groups had the symptoms of soreness and weakness of the loins and knees, general weak-ness ,dizziness,decreased sexual libido , palpitation and frequent urination , etc. These symptoms in traditionalChinese medicine belong to the deficiency of the Kidney. After treatment in both groups. the patients' serumHbAlc, FBG, and urinary Beta-2-microglobulin (B2M) got reduced, the concentration of serum sex hormone(E2 , E2/T ratio) elevated, and the elimination of urinary calcium, phosphorus levels cut down. But , the ther-apeutic effect in group B is apparently better than that in group A. The symptoms of deficiency of the Kidneywas apparently improved in group B. So, The authors think the medicinal herbs(reinforcing Kidney and acti-vating blood circulation) have an important role in the prevention and treatment of the 'Kidney deficiency'and bone mineral loss in middle-aged and elderly female diabetes patients.

Long term recurrence,pain and patient satisfaction after ventral hernia mesh repair

AIM: To compare long term outcomes of laparoscopic and open ventral hernia mesh repair with respect to recurrence, pain and satisfaction.METHODS: We conducted a single-centre follow-up study of 194 consecutive patients after laparoscopic and open ventral hernia mesh repair between March 2000 and June 2010. Of these, 27 patients(13.9%) died and 12(6.2%) failed to attend their follow-up appointment. One hundred and fifty-three(78.9%) patients attended for follow-up and two patients(1.0%) were interviewed by telephone. Of those who attended the follow-up appointment, 82(52.9%) patients had received laparoscopic ventral hernia mesh repair(LVHR) while 73(47.1%) patients had undergone open ventral hernia mesh repair(OVHR), including 11 conversions. The follow-up study included analyses of medical records, clinical interviews, examination of hernia recurrence and assessment of pain using a 100 mm visual analogue scale(VAS) ruler anchored by word descriptors. Overall patient satisfaction was also determined. Patients with signs of recurrence were examined by magnetic resonance imaging or computed tomography scan.RESULTS: Median time from hernia mesh repair to follow-up was 48 and 52 mo after LVHR and OVHR respectively. Overall recurrence rates were 17.1% after LVHR and 23.3% after OVHR. Recurrence after LVHR was associated with higher body mass index. Smoking was associated with recurrence after OVHR. Chronic pain(VAS > 30 mm) was reported by 23.5% in the laparoscopic cohort and by 27.8% in the open surgery cohort. Recurrence and late complications were predictors of chronic pain after LVHR. Smoking was associated with chronic pain after OVHR. Sixty point five percent were satisfied with the outcome after LVHR and 49.3% after OVHR. Predictors for satisfaction were absence of chronic pain and recurrence. Old age and short time to follow-up also predicted satisfaction after LVHR.CONCLUSION: LVHR and OVHR give similar long term results for recurrence, pain and overall satisfaction. Chronic pain is frequent and is therefore important for explaining dissatisfaction.

Correction to:Better survival in female SOD1-mutant patients with ALS: a study of SOD1-related natural history

In the original publication of this article[1],a numerical value in the sentence“The mean(SD)AAO was 43.92 years(9.24)for all subjects,with a significant difference between patients carrying mutations in exon 2(n=24,46.83,8.31)and exon 4(n=18,37.75,7.67)(p=0.002).”is wrong.The true value in the parenthesis of exon 2 should be(n=24,46.63,8.31).

Effect of Atorvastatin on the levels of adiponectin and leptin and adiponectin-leptin ratio in the elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia

Objective To evaluate effects of Atorvastatin on the levels of adiponectin and leptin and adiponectin-leptin ratio in the elderly and middle-aged patients with type 2diabetes and combined hyperlipidemia.Methods Totally80 elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia were treated with Atorvastatin(10 mg/d)for 12 weeks.Fasting plasma levels

The study of the correlation between serum uric acid and insulin resistance in middle-aged and elderly hospitalized patients with type 2 diabetes

Objective To study the relationship between serum uric acid and insulin resistance in type 2 diabetic patients.Methods A total of 728 middle-aged and elderly type 2 diabetic patients were recruited and the anthropometric,clinical and biochemical parameters and

生殖系统超声参数与性早熟女性患儿内分泌激素表达的关系及对治疗效果的评估

目的:探讨性早熟(PP)女性患儿的生殖系统超声参数与内分泌激素表达的关系以及对治疗效果的评估。方法:选取2021年1-12月在北京京煤集团总医院就诊的160例疑似PP女性患儿,依据PP诊断将其分为阳性组和正常组,每组80例。对两组患儿进行子宫、卵巢及乳腺的超声检查,测量相关参数,并检测血清中的内分泌激素水平。对阳性组患儿进行治疗后,再次行超声检查和内分泌激素检测,评估治疗效果。比较两组间的超声参数与内分泌激素差异及相关性,以及对治疗效果的影响因素。结果:阳性组患儿的子宫长径、厚径、宫体与宫颈长度之比,以及宫内膜厚度、卵巢大小、卵泡数量、乳腺低回声区宽径和厚度均显著大于正常组,差异有统计学意义(t=16.8、12.6、12.4、14.7、11.5、15.8、10.9、10.2,P<0.05);阳性组子宫动脉阻力指数(RI)为0.58±0.07,显著小于正常组(0.67±0.06),差异有统计学意义(t=-7.9,P<0.05)。阳性组患儿的血清雌二醇(E2)、促性腺激素(GnRH)、促卵泡激素(FSH)、黄体生成素(LH)、孕酮(P)及生长激素(GH)水平均显著高于正常组,差异有统计学意义(t=20.6、19.8、15.4、17.6、15.2、8.9,P<0.05)。阳性组患儿经过治疗后,上述超声参数和内分泌激素水平均有明显改善。相关分析显示,超声参数与内分泌激素水平呈正相关,是内分泌激素水平的重要影响因素,治疗效果与超声参数(OR=0.78~1.28,P<0.05)、内分泌激素水平(OR=0.73~0.77,P<0.05)、年龄、身高、体重、体质量指数(BMI)等因素有关(OR=0.70~0.72,P<0.05)。结论:PP女性患儿的生殖系统超声参数与内分泌激素表达有密切的关系,内分泌激素水平可以作为PP女性患儿的病情和预后的重要指标。

肌肉减少和平衡不良对女性类风湿性关节炎患者并发脊柱骨质疏松性骨折的影响

目的探讨肌肉减少和平衡不良对女性类风湿性关节炎(RA)患者并发脊柱骨质疏松性骨折的影响。方法选择2021年1月至2024年2月在该院就诊的RA并发脊柱骨质疏松性骨折患者43例作为观察组,按照1:2比例抽取同期在该院就诊的86例RA非脊柱骨质疏松性骨折患者作为对照组。评估患者的肌肉减少症和平衡控制不良发生率,采用Logistic回归分析观察肌肉减少症和平衡控制不良对脊柱骨质疏松性骨折的影响。结果观察组患者肌肉减少症和平衡控制不良发生率明显高于对照组,差异均有统计学意义(P<0.05)。两组患者年龄、病程、RA疾病活动度(DAS28)、C反应蛋白(CRP)、类风湿因子(RF)、血沉(ESR)、糖皮质激素应用等资料比较,差异存在统计学意义(P<0.05)。多因素Logistic回归分析结果显示,在剔除协变量影响后,肌肉减少症和平衡控制不良均是脊柱骨质疏松性骨折的风险因素(P<0.05)。结论RA女性患者脊柱骨质疏松性骨折受肌肉减少症和平衡控制不良影响,临床工作中应关注RA患者的肌肉质量和平衡能力,以减少脊柱骨质疏松性骨折的发生。

结直肠癌术后女性患者盆底康复管理的最佳证据总结

目的 检索并总结结直肠癌术后女性患者盆底康复管理的最佳证据,为医护人员进行科学有效的盆底康复管理提供循证依据。方法 计算机检索2010年1月至2023年2月国内外有关指南网站和数据库中结直肠癌术后女性患者盆底康复管理的文献,对所纳入文献进行方法学质量评价后,对证据进行汇总、分级并归纳主题。结果 最终纳入22篇文献,其中指南4篇、临床决策5篇、专家共识2篇、系统评价8篇、随机对照试验3篇,提炼出11个方面、共55条最佳证据主题。结论 总结的结直肠癌术后女性患者盆底康复管理的最佳证据切实可行,医护人员可在多学科合作和循证基础上为结直肠癌术后女性患者提供标准化的结直肠癌术后盆底康复的管理与护理。

女性先天性心脏病患者生育体验的Meta整合

目的了解先天性心脏病女性患者生育体验,为先天性心脏病女性患者生育管理提供参考。方法系统检索中英文数据库中关于先天性心脏病女性患者生育相关体验的质性研究,检索时限为建库至2024年5月。根据澳大利亚JBI循证卫生保健中心质性研究质量评价工具对文献进行质量评价,并对结果进行Meta整合。结果共纳入6篇文献,提取21个研究结果,归纳为10个研究类别,4个整合结果:生育决策影响因素复杂;与生育相关的多重忧虑;生育相关管理经验不足及专业指导需求较高;与生育相关的成长与收获。结论先天性心脏病女性患者的生育决策受到多重因素影响,患者面对生育问题存在多方面的担忧与需求。医护人员应关注患者与生育相关的需求,为其提供专业的生育辅助决策,加强先天性心脏病生育相关的风险评估与宣教。

耳穴疗法联合八段锦对女性强制戒毒人员稽延性戒断综合征睡眠质量的影响

目的观察耳穴疗法联合八段锦对女性强制戒毒人员稽延性戒断综合征睡眠质量的影响。方法选取2022年1月至8月福建省女子司法强制隔离戒毒所康复期的女性强制戒毒人员90例,采用随机数字表法分为对照组、八段锦组及耳穴+八段锦组(每组30例),最终完成研究82例(对照组27例、八段锦组27例、耳穴+八段锦组28例)。3组均进行包括行为教育、戒毒教育和心理咨询等常规教育。对照组采用广播体操锻炼,90 min/d,每周5 d;八段锦组采用八段锦锻炼,90 min/d,每周5 d;耳穴+八段锦组采用耳穴疗法(神门、心、皮质下+配穴)联合八段锦锻炼,八段锦锻炼90 min/d,每周5 d,耳穴疗法每穴单侧耳郭贴压,3 min/次,于八段锦休息时间段进行,每隔2 d更换至对侧耳穴交替进行。共治疗12周。观察3组治疗前及治疗6、12周后匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)及其睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍等各项评分变化,并观察临床疗效、不良反应发生情况。结果与治疗前比较,3组在治疗6、12周后PSQI总分均降低(P<0.05);与对照组比较,耳穴+八段锦组在治疗6、12周后PSQI总分均降低(P<0.05),且在治疗12周后睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物和日间功能障碍评分均降低(P<0.05);与八段锦组比较,耳穴+八段锦组在治疗6、12周后PSQI总分均降低(P<0.05),在治疗12周后睡眠质量、入睡时间、睡眠效率、睡眠障碍和日间功能障碍评分均降低(P<0.05)。治疗后,八段锦组显效率高于对照组(P<0.05),耳穴+八段锦组显效率高于对照组和八段锦组(P<0.05)。治疗期间,3组均未见肌肉酸痛和耳部皮肤青紫、红斑、破损、疼痛等不良反应。结论在治疗女性强制戒毒人员稽延性戒断综合征的睡眠障碍上,相较于广播体操、八段锦锻炼,耳穴疗法联合八段锦可更快改善睡眠质量,尤其在降低入睡时间、睡眠效率、睡眠障碍和日间功能障碍评分上,值得推广应用。

基于延续护理的心理护理干预对2型糖尿病肥胖女性患者血糖控制、负性情绪及生活质量的影响

目的分析基于延续护理的心理护理干预对2型糖尿病肥胖女性患者血糖控制、负性情绪及生活质量的影响。方法选择2021年10月—2023年10月山东省寿光市人民医院收治的146例2型糖尿病肥胖女性患者为研究对象,通过随机数表法分为参考组(n=73)和研究组(n=73)。参考组开展常规护理干预,研究组开展基于延续护理的心理护理干预,比较两组患者的血糖指标、体脂率、血脂指标、情绪评分、生活质量评分和护理满意度。结果研究组患者接受相关护理干预后,患者的血糖指标有所改善,且优于参考组,患者的焦虑评分、抑郁评分均有所下降,且低于参考组,生活质量评分和护理满意度均高于参考组,差异有统计学意义(P均<0.05)。结论基于延续护理的心理护理干预应用于2型糖尿病肥胖女性患者的效果确切,可显著改善患者的血糖,改善其负性情绪,提高生活质量。

系统化护理干预对女性双相情感障碍躁狂发作患者认知功能的影响

目的观察系统化护理干预对女性双相情感障碍躁狂发作患者认知功能的影响。方法选取2021年5月至2022年12月山东国欣颐养集团枣庄东郊医院收治的77例双相情感障碍女性患者为研究对象,以抛币法分为对照组(38例,常规护理)、观察组(39例,系统化护理),比较两组的护理效果。结果干预前,两组韦氏成人记忆量表(WMS-RC)各指标评分比较,差异无统计学意义(P>0.05)。两组干预后WMS-RC各指标评分均升高,且观察组WMS-RC各指标评分均高于对照组,差异有统计学意义(P<0.05)。干预前,两组韦氏成人智力量表(WAIS-RC)各指标评分比较,差异无统计学意义(P>0.05)。两组干预后WAIS-RC各指标评分均升高,且观察组WAIS-RC各指标评分均高于对照组,差异有统计学意义(P<0.05)。干预前,两组贝克-拉范森躁狂量表(BRMS)评分比较,差异无统计学意义(P>0.05)。两组干预后BRMS评分降低,且观察组BRMS评分低于对照组,差异有统计学意义(P<0.05)。结论系统化护理能够改善女性双相情感障碍躁狂发作患者的认知功能,值得推广应用。

女性戒毒人员社会排斥与复吸倾向的关系

目的:探讨社会排斥与女性戒毒人员复吸倾向的关系,以及自尊和积极心理资本在其中的调节或中介作用。方法:选取288名女性戒毒人员,采用社会排斥问卷(SEQ)评估戒毒人员所受社会排斥程度,复吸倾向量表(RPQ)评估戒毒人员当前对毒品的复吸倾向性,自尊量表(RSES)评估戒毒人员的自尊水平和积极心理资本问卷(PPCQ)评估戒毒人员的积极心理资本水平。结果:女性戒毒人员SEQ得分与RPQ得分正向关联(β=0.40,P<0.001);RSES得分在SEQ与RPQ得分之间起中介作用,中介作用大小为0.09(95%CI:0.04~0.15,占总效应20.6%);PPCQ得分在RSES得分与RPQ得分之间(β=-0.08,P<0.05)以及在SEQ得分与RPQ得分之间起调节作用(β=0.10,P<0.05)。结论:社会排斥可能直接作用于或通过自尊水平间接作用于复吸倾向,积极心理资本可调节自尊、社会排斥与复吸倾向的关系。