In order to explore internal factors for adsorption kinetic effect of miglitol by D001 resin, a batch adsorption operation for miglitol kinetic adsorption at different concentrations, temperatures and vibrating rates ...In order to explore internal factors for adsorption kinetic effect of miglitol by D001 resin, a batch adsorption operation for miglitol kinetic adsorption at different concentrations, temperatures and vibrating rates was investigated in oscillator (SHZ-A), respectively. The different kinetic mathematical model, Webber-Morris kinetic equation, film diffusion coefficient equation and kinetic boundary model were all applied to discuss the adsorption process. The results showed that Type 1 pseudo-second order kinetic equation can be all used to describe miglitol adsorbed by D001 resin at different concentrations, temperatures and vibrating rates. Moreover, the total activation energy (Ea) can be calculated and its value is 9.7 kJ/mol, and then calculated values of the process film diffusion coefficient and pore diffusion coefficient, it may be inferred from these gotten values that the ion exchange process is all mainly controlled by film diffusion. Therefore, the results also suggest that the external adsorption factors such as solute concentration, temperature and vibrating rate for effect of mass transfer diffusion process control of miglitol onto D001 resin are relatively weak.展开更多
目的探讨急进高原后高原环境对米格列醇在Wistar大鼠体内药代动力学参数的影响。方法将12只大鼠随机分为平原组与高原组,两组大鼠分别给予5.25 mg/kg米格列醇灌胃,并分别于给药后5、10、15、30、60、90、120、240 min眼眶静脉丛采集血...目的探讨急进高原后高原环境对米格列醇在Wistar大鼠体内药代动力学参数的影响。方法将12只大鼠随机分为平原组与高原组,两组大鼠分别给予5.25 mg/kg米格列醇灌胃,并分别于给药后5、10、15、30、60、90、120、240 min眼眶静脉丛采集血样。液相色谱-串联质谱法(liquid chromatography tandem mass spectrometry,LC-MS/MS)测定大鼠血浆中米格列醇浓度,采用WinNonlin 8.1软件计算药代动力学参数。结果LC-MS/MS测定米格列醇血浆浓度在一定浓度范围内线性关系良好(r=0.996),日内精密度和日间精密度均小于10%且稳定性良好。与平原组大鼠相比,米格列醇在高原组大鼠体内的达峰血药浓度增加、平均滞留时间延长、半衰期延长、清除率减小、曲线下面积(area under the curve,AUC)增加(P均<0.05)。结论急进高原后,米格列醇在大鼠体内吸收增加、代谢减慢,为进一步研究糖尿病患者高原环境下合理用药提供参考。展开更多
文摘In order to explore internal factors for adsorption kinetic effect of miglitol by D001 resin, a batch adsorption operation for miglitol kinetic adsorption at different concentrations, temperatures and vibrating rates was investigated in oscillator (SHZ-A), respectively. The different kinetic mathematical model, Webber-Morris kinetic equation, film diffusion coefficient equation and kinetic boundary model were all applied to discuss the adsorption process. The results showed that Type 1 pseudo-second order kinetic equation can be all used to describe miglitol adsorbed by D001 resin at different concentrations, temperatures and vibrating rates. Moreover, the total activation energy (Ea) can be calculated and its value is 9.7 kJ/mol, and then calculated values of the process film diffusion coefficient and pore diffusion coefficient, it may be inferred from these gotten values that the ion exchange process is all mainly controlled by film diffusion. Therefore, the results also suggest that the external adsorption factors such as solute concentration, temperature and vibrating rate for effect of mass transfer diffusion process control of miglitol onto D001 resin are relatively weak.
文摘目的探讨急进高原后高原环境对米格列醇在Wistar大鼠体内药代动力学参数的影响。方法将12只大鼠随机分为平原组与高原组,两组大鼠分别给予5.25 mg/kg米格列醇灌胃,并分别于给药后5、10、15、30、60、90、120、240 min眼眶静脉丛采集血样。液相色谱-串联质谱法(liquid chromatography tandem mass spectrometry,LC-MS/MS)测定大鼠血浆中米格列醇浓度,采用WinNonlin 8.1软件计算药代动力学参数。结果LC-MS/MS测定米格列醇血浆浓度在一定浓度范围内线性关系良好(r=0.996),日内精密度和日间精密度均小于10%且稳定性良好。与平原组大鼠相比,米格列醇在高原组大鼠体内的达峰血药浓度增加、平均滞留时间延长、半衰期延长、清除率减小、曲线下面积(area under the curve,AUC)增加(P均<0.05)。结论急进高原后,米格列醇在大鼠体内吸收增加、代谢减慢,为进一步研究糖尿病患者高原环境下合理用药提供参考。