AIM: To investigate the role of claudin 1 in the regulation of genes involved in cell migration and tumor necrosis factor alpha (TNF-α)-induced gene expression in human gastric adenocarcinoma cells.
Objective:To investigate the expression of HIP/PAP in hepatocellular carcinoma(HCC)patients and explore its role in migration and invasion of HCC.Methods:The expression of HIP/PAP in HCC tissue and corresponding adjac...Objective:To investigate the expression of HIP/PAP in hepatocellular carcinoma(HCC)patients and explore its role in migration and invasion of HCC.Methods:The expression of HIP/PAP in HCC tissue and corresponding adjacent noncancerous tissue was assessed by IHC,RT-PCR and Western blot.The correlation between clinicopathological features and HIP/PAP expression was analyzed.The role of HIP/PAP on invasion and migration of HCC cells was observed by RNA interference,wound healing and Transwell assay.Results:Both mRNA and protein expression of HIP/PAP was upregulated in HCC tissues compared to tumor-adjacent tissue and correlated with poor tumor differentiation,advanced tumor stage and vascular invasion.HIP/PAP expression was also upregulated in HCC cells,and silencing its expression by specific siRNA could inhibit the invasion and migration of HCC cells.Conclusions:HIP/APA is overexpressed in HCC and contributes to the migration and invasion of HCC cells.展开更多
20131683 Lin Wenjing(Institute of Hydrogeology and Environmental Geology,Chinese Academy of Geological Sciences,Shijiazhuang050061,China);Liu Zhiming An Estimation of HDR Resources in China’s Mainland(Acta Geoscienti...20131683 Lin Wenjing(Institute of Hydrogeology and Environmental Geology,Chinese Academy of Geological Sciences,Shijiazhuang050061,China);Liu Zhiming An Estimation of HDR Resources in China’s Mainland(Acta Geoscientica Sinica,ISSN1006-3021,CN11-3474/P,33(5),2012,p.807-811,2illus.,2tables,14refs.)展开更多
基金Supported by Grants-in-Aid for Young Scientists(B)No.22791295,No.23791557 and No.24791440Grant-in-Aid for Scientific Research(C)from the Japan Society for the Promotion of Science,No.22591464 and No.24591957
文摘AIM: To investigate the role of claudin 1 in the regulation of genes involved in cell migration and tumor necrosis factor alpha (TNF-α)-induced gene expression in human gastric adenocarcinoma cells.
基金supported by grant from Program for Science and Technology Development of Jiangsu Province(YG201503)
文摘Objective:To investigate the expression of HIP/PAP in hepatocellular carcinoma(HCC)patients and explore its role in migration and invasion of HCC.Methods:The expression of HIP/PAP in HCC tissue and corresponding adjacent noncancerous tissue was assessed by IHC,RT-PCR and Western blot.The correlation between clinicopathological features and HIP/PAP expression was analyzed.The role of HIP/PAP on invasion and migration of HCC cells was observed by RNA interference,wound healing and Transwell assay.Results:Both mRNA and protein expression of HIP/PAP was upregulated in HCC tissues compared to tumor-adjacent tissue and correlated with poor tumor differentiation,advanced tumor stage and vascular invasion.HIP/PAP expression was also upregulated in HCC cells,and silencing its expression by specific siRNA could inhibit the invasion and migration of HCC cells.Conclusions:HIP/APA is overexpressed in HCC and contributes to the migration and invasion of HCC cells.
文摘20131683 Lin Wenjing(Institute of Hydrogeology and Environmental Geology,Chinese Academy of Geological Sciences,Shijiazhuang050061,China);Liu Zhiming An Estimation of HDR Resources in China’s Mainland(Acta Geoscientica Sinica,ISSN1006-3021,CN11-3474/P,33(5),2012,p.807-811,2illus.,2tables,14refs.)
