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Migration pattern of a population of Barn Swallows(Hirundo rustica)breeding in East Asian tropical region
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作者 Li Tian Yu Liu +3 位作者 Yang Wu Zimei Feng Dan Hu Zhengwang Zhang 《Avian Research》 SCIE CSCD 2024年第3期299-307,共9页
Birds exhibit a high degree of migratory diversity,which is influenced by various ecological factors and life history strategies.Conducting studies on tropical bird migration,of which research is scarce,and comparing ... Birds exhibit a high degree of migratory diversity,which is influenced by various ecological factors and life history strategies.Conducting studies on tropical bird migration,of which research is scarce,and comparing it with temperate birds can enhance our understanding of bird migration behaviour and its underlying mecha-nisms.In this study,we explored the migration behaviour of a breeding population of the Barn Swallow(Hirundo rustica)in Zhanjiang,southern China,a region located in the northern tropics,using light-level geolocators.From 2021 to 2023,we deployed geolocators on 92 breeding swallows and retrieved geolocators successfully from 23 individuals.These swallows all exhibited migratory behaviour,and wintering on various islands in Southeast Asia.They displayed sex differences in their wintering locations.All males concentrated in Borneo,while females primarily chose Borneo but also dispersed to the Philippines,South China Sea,and Vietnam for wintering.The studied swallow population adopted a seasonal migration pattern of“indirect in autumn,direct in spring”,bypassing the ecological barrier of the South China Sea in autumn and tending to directly cross it in spring migration.Moreover,the distance and duration of autumn migration was significantly longer than those of the spring migration.Compared to temperate Barn Swallows,the Barn Swallow population breeding in Zhanjiang adopts a pattern of“intra-tropical migration”and initiates autumn migration earlier.The formation of their migration pattern may be limited by ecological and physiological factors. 展开更多
关键词 ASIA Chain migration Light-level geolocators migration Northern tropics
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The roles of macrophage migration inhibitory factor in retinal diseases
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作者 Hongbing Zhang Xianjiao Zhang +3 位作者 Hongsong Li Bing Wang Pei Chen Jiamin Meng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期309-315,共7页
Macrophage migration inhibitory factor(MIF),a multifunctional cytokine,is secreted by various cells and participates in inflammatory reactions,including innate and adaptive immunity.There are some evidences that MIF i... Macrophage migration inhibitory factor(MIF),a multifunctional cytokine,is secreted by various cells and participates in inflammatory reactions,including innate and adaptive immunity.There are some evidences that MIF is involved in many vitreoretinal diseases.For example,MIF can exacerbate many types of uveitis;measurements of MIF levels can be used to monitor the effectiveness of uveitis treatment.MIF also alleviates trauma-induced and glaucoma-induced optic nerve damage.Furthermore,MIF is critical for retinal/choroidal neovascularization,especially complex neovascularization.MIF exacerbates retinal degeneration;thus,anti-MIF therapy may help to mitigate retinal degeneration.MIF protects uveal melanoma from attacks by natural killer cells.The mechanism underlying the effects of MIF in these diseases has been demonstrated:it binds to cluster of differentiation 74,inhibits the c-Jun N-terminal kinase pathway,and triggers mitogen-activated protein kinases,extracellular signal-regulated kinase-1/2,and the phosphoinositide-3-kinase/Akt pathway.MIF also upregulates Toll-like receptor 4 and activates the nuclear factor kappa-B signaling pathway.This review focuses on the structure and function of MIF and its receptors,including the effects of MIF on uveal inflammation,retinal degeneration,optic neuropathy,retinal/choroidal neovascularization,and uveal melanoma. 展开更多
关键词 diabetic retinopathy GLAUCOMA macrophage migration inhibitory factor migration inhibitory factor receptor optic neuropathy retinal degeneration retinal neovascular uveal melanoma UVEITIS
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The Impact of Hula Project (1993-2018) on Nutrient Migrations
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作者 Moshe Gophen 《Open Journal of Ecology》 2024年第3期215-227,共13页
During the 1950s the Hula wetlands and old lake were drained and the land converted utilization to agriculture and ecotourism. As a result of the drainage, the Peat Soil was exposed to atmospheric oxygen. The geochemi... During the 1950s the Hula wetlands and old lake were drained and the land converted utilization to agriculture and ecotourism. As a result of the drainage, the Peat Soil was exposed to atmospheric oxygen. The geochemical environment was modified from reductive to oxidative and the Nitrogen in it was converted from Ammonium to Nitrate. Intensive migration of Nitrate from the Hula Valley induced a national concern of water quality deterioration in the lake which was dissipated when Nitrogen deficiency was developed in Lake Kinneret. Forty years after drainage the ecosystem structure was renovated (Hula Project, HP) aimed at agricultural management and nutrient migration reduction. The paper examines through evaluation of the ecological data record (1993-2018) the impact of hydrological changes, attributed to the HP implementation on nutrient dynamics within surface waters in the Hula Valley. It is suggested that soil moisture elevation by irrigation in summer reduced Phosphorus and enhanced Nitrate concentrations. 展开更多
关键词 Nitrogen PHOSPHORUS migration RUNOFF Peat Land HEADWATERS
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Migration of a Progestin Implant into a Pulmonary Artery: Observation of a Case at the Reference Health Center of Commune III of the District of Bamako in Mali
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作者 Hamady Sissoko Souma Kodio +20 位作者 Hamidou Albachar Cheickna Sylla Salif Diarra Sidy Moctar Diakité Mohamed Traoré Souleymane Traoré Ibrahim Fomba Ouncoumba Diarra Nana Bah Drissa Diarra Mahamoudou Coulibaly Bocary Sidi Koné Hawa Samaké Ahmadou Coulibaly Mamadou Traoré Seydou Z. Dao Sitapha Dembélé Samou Diarra Konimba Koné Alou Samaké Sanogo Siaka Amara 《Open Journal of Obstetrics and Gynecology》 2024年第9期1431-1436,共6页
It was a 36-year-old patient, 5th Pregnancy, 5th Delivery, 4 live children, and I deceased, had a consultation in the department for the removal of implants. Questioning revealed that she had had the implant three yea... It was a 36-year-old patient, 5th Pregnancy, 5th Delivery, 4 live children, and I deceased, had a consultation in the department for the removal of implants. Questioning revealed that she had had the implant three years ago without medical follow-up. It was in view of the difficulties in extracting the capsule that the chest X-ray and CT scan carried out concluded that the implant had migrated into a branch of the left pulmonary artery. Therapeutic abstention has been the attitude of cardiovascular surgeons. 展开更多
关键词 migration IMPLANT Pulmonary Artery BAMAKO
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GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling
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作者 TINGTING LI WEI ZHONG +10 位作者 LIU YANG ZHIYU ZHAO LI WANG CONG LIU WANYUN LI HAIYAN LV SHENGYU WANG JIANGHUA YAN TING WU GANG SONG FANGHONG LUO 《Oncology Research》 SCIE 2024年第2期361-371,共11页
The high mortality rate associated with gastric cancer(GC)has resulted in an urgent need to identify novel therapeutic targets for GC.This study aimed to investigate whether GAIP interacting protein,C terminus 1(GIPC1... The high mortality rate associated with gastric cancer(GC)has resulted in an urgent need to identify novel therapeutic targets for GC.This study aimed to investigate whether GAIP interacting protein,C terminus 1(GIPC1)represents a therapeutic target and its regulating mechanism in GC.GIPC1 expression was elevated in GC tissues,liver metastasis tissues,and lymph node metastases.GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor(PDGFR)/PI3K/AKT signaling pathway,and inhibited the proliferation and migration of GC cells.Conversely,GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway,and promoted GC cell proliferation and migration.Furthermore,platelet-derived growth factor subunit BB(PDGF-BB)cytokines and the AKT inhibitor attenuated the effect of differential GIPC1 expression.Moreover,GIPC1 silencing decreased tumor growth and migration in BALB/c nude mice,while GIPC1 overexpression had contrasting effects.Taken together,our findings suggest that GIPC1 functions as an oncogene in GC and plays a central role in regulating cell proliferation and migration via the PDGFR/PI3K/AKT signaling pathway. 展开更多
关键词 GIPC1 PDGFR Gastric cancer Proliferation migration
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Phase-stable wide-bandgap perovskites enabled by suppressed ion migration
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作者 Zhiyu Gao Yu Zhu +20 位作者 Jingwei Zhu Cong Chen Zongjin Yi Yi Luo Yuliang Xu Kai Wu Tianshu Ma Fangfang Cao Zijun Chen Fang Yao Juncheng Wang Wenwu Wang Chuanxiao Xiao Hao Huang Hongxiang Li Qianqian Lin Pei Cheng Changlei Wang Xia Hao Guanggen Zeng Dewei Zhao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第9期120-128,共9页
Wide-bandgap(>1.7 eV)perovskites suffer from severe light-induced phase segregation due to high bromine content,causing irreversible damage to devices stability.However,the strategies of suppressing photoinduced ph... Wide-bandgap(>1.7 eV)perovskites suffer from severe light-induced phase segregation due to high bromine content,causing irreversible damage to devices stability.However,the strategies of suppressing photoinduced phase segregation and related mechanisms have not been fully disclosed.Here,we report a new passivation agent 4-aminotetrahydrothiopyran hydrochloride(4-ATpHCl)with multifunctional groups for the interface treatment of a 1.77-eV wide-bandgap perovskite film.4-ATpH^(+)impeded halogen ion migration by anchoring on the perovskite surface,leading to the inhibition of phase segregation and thus the passivation of defects,which is ascribed to the interaction of 4-ATpH^(+)with perovskite and the formation of low-dimensional perovskites.Finally,the champion device achieved an efficiency of 19.32%with an open-circuit voltage(V_(OC))of 1.314 V and a fill factor of 83.32%.Moreover,4-ATpHCl modified device exhibited significant improved stability as compared with control one.The target device maintained 80%of its initial efficiency after 519 h of maximum power output(MPP)tracking under 1 sun illumination,however,the control device showed a rapid decrease in efficiency after 267 h.Finally,an efficiency of 27.38%of the champion 4-terminal all-perovskite tandem solar cell was achieved by mechanically stacking this wide-bandgap top subcell with a 1.25-eV low-bandgap perovskite bottom subcell. 展开更多
关键词 Wide-bandgap perovskite Phase segregation lon migration Interface post-treatment All-perovskite tandems
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Migration Networks Pattern of China’s Floating Population from the Perspective of Complex Network
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作者 LIU Wangbao CHEN Ranran 《Chinese Geographical Science》 SCIE CSCD 2024年第2期327-341,共15页
Since China’s reform and opening-up,the growing disparity between urban and rural areas and regions has led to massive migration.With China’s Rural Revitalization Strategy and the industrial transfer from the easter... Since China’s reform and opening-up,the growing disparity between urban and rural areas and regions has led to massive migration.With China’s Rural Revitalization Strategy and the industrial transfer from the eastern coastal areas to the inland,the migration direction and pattern of the floating population have undergone certain changes.Using the 2017 China Migrants Dynamic Survey(CMDS),excluding Hong Kong,Macao,and Taiwan regions of China,organized by China’s National Health Commission,the relationship matrix of the floating population is constructed according to the inflow place of the interviewees and their outflow place(the location of the registered residence)in the questionnaire survey.We then apply the complex network model to analyze the migration direction and network pattern of China’s floating population from the city scale.The migration network shows an obvious hierarchical agglomeration.The first-,second-,third-and fourth-tier distribution cities are municipalities directly under the central government,provincial capital cities,major cities in the central and western regions and ordinary cities in all provinces,respectively.The migration trend is from the central and western regions to the eastern coastal areas.The migration network has‘small world’characteristics,forming nine communities.It shows that most node cities in the same community are closely linked and geographically close,indicating that the migration network of floating population is still affected by geographical proximity.Narrowing the urban-rural and regional differences will promote the rational distribution this population.It is necessary to strengthen the reform of the registered residence system,so that the floating population can enjoy urban public services comparable to other populations,and allow migrants to live and work in peace. 展开更多
关键词 complex network floating population migration network spatial pattern community structure
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Application of Gaussian Beam Summation Migration in Reflected In-seam Wave Imaging
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作者 HAN Jianguang LÜQingtian +2 位作者 ZHANG Zhiheng YANG Shun WANG Shuo 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第1期276-284,共9页
The geological conditions for coal mining in China are complex,with various structural issues such as faults and collapsed columns seriously compromising the safety of coal mine production.In-seam wave exploration is ... The geological conditions for coal mining in China are complex,with various structural issues such as faults and collapsed columns seriously compromising the safety of coal mine production.In-seam wave exploration is an effective technique for acquiring detailed information on geological structures in coal seam working faces.However,the existing reflected in-seam wave imaging technique can no longer meet the exploration precision requirements,making it imperative to develop a new reflected in-seam wave imaging technique.This study applies the Gaussian beam summation(GBS)migration method to imaging coal seams'reflected in-seam wave data.Firstly,with regard to the characteristics of the reflected in-seam wave data,methods such as wavefield removal and enveloped superposition are employed for the corresponding wavefield separation,wave train compression and other processing of reflected in-seam waves.Thereafter,imaging is performed using the GBS migration technique.The feasibility and effectiveness of the proposed method for reflected in-seam wave imaging are validated by conducting GBS migration tests on 3D coal-seam fault models with different dip angles and throws.By applying the method to reflected in-seam wave data for an actual coal seam working face,accurate imaging of a fault structure is obtained,thereby validating its practicality. 展开更多
关键词 reflected in-seam wave Gaussian beam summation migration numerical tests fault
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Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination
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作者 Rong Hu Xinpeng Dun +1 位作者 Lolita Singh Matthew C.Banton 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1575-1583,共9页
Runx2 is a major regulator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea r.Here,we analyzed Runx2expression following injury and found that it was specifical... Runx2 is a major regulator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea r.Here,we analyzed Runx2expression following injury and found that it was specifically up-regulated in Schwann cells.Furthermore,using Schwann cell-specific Runx2 knocko ut mice,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration process following sciatic nerve injury were Runx2-dependent.Changes observed in Runx2 knoc kout mice include increased prolife ration of Schwann cells,impaired Schwann cell migration and axonal regrowth,reduced re-myelination of axo ns,and a block in macrophage clearance in the late stage of regeneration.Taken together,our findings indicate that Runx2 is a key regulator of Schwann cell plasticity,and therefore peripheral nerve repair.Thus,our study shows that Runx2 plays a major role in Schwann cell migration,re-myelination,and peripheral nerve functional recovery following injury. 展开更多
关键词 macrophage clearance migration peripheral nerve injury regeneration re-myelination RUNX2 Schwann cells
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LFM Radar Source Passive Localization Algorithm Based on Range Migration
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作者 Dandan Li Deyi Wang Hao Huan 《Journal of Beijing Institute of Technology》 EI CAS 2024年第2期130-140,共11页
Traditional single-satellite passive localization algorithms are influenced by frequency and angle measurement accuracies,resulting in error estimation of emitter position on the order of kilometers.Subsequently,a sin... Traditional single-satellite passive localization algorithms are influenced by frequency and angle measurement accuracies,resulting in error estimation of emitter position on the order of kilometers.Subsequently,a single-satellite localization algorithm based on passive synthetic aper-ture(PSA)was introduced,enabling high-precision positioning.However,its estimation of azimuth and range distance is considerably affected by the residual frequency offset(RFO)of uncoopera-tive system transceivers.Furthermore,it requires data containing a satellite flying over the radia-tion source for RFO search.After estimating the RFO,an accurate estimation of azimuth and range distance can be carried out,which is difficult to achieve in practical situations.An LFM radar source passive localization algorithm based on range migration is proposed to address the dif-ficulty in estimating frequency offset.The algorithm first provides a rough estimate of the pulse repetition time(PRT).It processes intercepted signals through range compression,range interpola-tion,and polynomial fitting to obtain range migration observations.Subsequently,it uses the changing information of range migration and an accurate PRT to formulate a system of nonlinear equations,obtaining the emitter position and a more accurate PRT through a two-step localization algorithm.Frequency offset only induces a fixed offset in range migration,which does not affect the changing information.This algorithm can also achieve high-precision localization in squint scenar-ios.Finally,the effectiveness of this algorithm is verified through simulations. 展开更多
关键词 passive localization range migration residual frequency offset
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Clogging caused by coupled grain migration and compaction effect during groundwater recharge for unconsolidated sandstone reservoir in groundwater-source heat pump
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作者 Fujian Yang Jing Luo +3 位作者 Guiling Wang Hejuan Liu Dawei Hu Hui Zhou 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期2947-2959,共13页
In unconsolidated sandstone reservoirs,presence of numerous movable grains and a complex grain size composition necessitates a clear understanding of the physical clogging process for effective groundwater recharge in... In unconsolidated sandstone reservoirs,presence of numerous movable grains and a complex grain size composition necessitates a clear understanding of the physical clogging process for effective groundwater recharge in groundwater-source heat pump systems.To investigate this,a series of seepage experiments was conducted under in situ stress conditions using unconsolidated sandstone samples with varying grain compositions.The clogging phenomenon arises from the combined effects of grain migration and compaction,wherein the migration of both original and secondary crushed fine-grain particles blocks the seepage channels.Notably,grain composition influences the migration and transport properties of the grains.For samples composed of smaller grains,the apparent permeability demonstrates a transition from stability to decrease.In contrast,samples with larger grains experience a skip at the stability stage and directly enter the decrease stage,with a minor exception of a slight increase observed.Furthermore,a unique failure mode characterized by diameter shrinkage in the upper part of the sample is observed due to the combined effects of grain migration and in situ stress-induced compaction.These testing results contribute to a better understanding of the clogging mechanism caused by the coupled effects of grain migration and compaction during groundwater recharge in unconsolidated sandstone reservoirs used in groundwater-source heat pump systems. 展开更多
关键词 Groundwater-source heat pump CLOGGING Grain migration Compaction effect Groundwater recharge Unconsolidated sandstone
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Detour for the inexperienced? Migration count data suggest mostly juvenile Greater Spotted Eagles appear in coastal peninsulas in China
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作者 Xu Shi Xiaoping Wang +2 位作者 Qian Wei Qiwei Lin Lei Zhu 《Avian Research》 SCIE CSCD 2024年第2期249-254,共6页
Soaring bird migration often relies on suitable terrain and airflow;therefore,route selection is vital for successful migration.While age and experience have been identified as key factor influencing migration route s... Soaring bird migration often relies on suitable terrain and airflow;therefore,route selection is vital for successful migration.While age and experience have been identified as key factor influencing migration route selection among soaring raptors in the African-Eurasian Flyway,how they shape the migration route of soaring raptors in East Asia is still largely unknown.In this study,we investigated potential variations in the routes and timing in autumn migration of juvenile and older soaring birds,using count data of Greater Spotted Eagles(Clanga clanga)from two coastal sites and two inland sites in China.From 2020 to 2023,we recorded a total of 340 individuals,with the highest site averaging over 90 individuals per autumn,making it one of the world’s top single-season counts and thus a globally important site for this species.We found that 82% and 61% records from coastal sites were juveniles,significantly higher than inland sites(15% and 24%).Juveniles at all four sites exhibited markedly earlier median passage time than non-juveniles,with brief overlapping in their main migration periods.Both coastal sites are located on the tip of peninsulas stretching southwest,requiring long overwater flights if crossing the Bohai Bay or Beibu Gulf,which would be energetically demanding and increase mortality risk.Experienced individuals may have learned to avoid such terrain and subsequent detour,while juveniles are more prone to enter these peninsulas due to lack of experience and opportunities for social learning,or following other raptor species that are more capable of powered flight.Our findings highlight the importance of age and experience in migration route selection of large soaring birds. 展开更多
关键词 Clanga clanga East Asia Greater Spotted Eagle JUVENILE migration route Social learning
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Geometric regulation of collective cell tangential ordering migration
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作者 Hao Dong Yuming Zhou +8 位作者 Xuehe Ma Junfang Liu Fulin Xing Jianyu Yang Qiushuo Sun Qingsong Hu Fen Hu Leiting Pan Jingjun Xu 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第2期94-103,共10页
Collective cell migration is a coordinated movement of multi-cell systems essential for various processes throughout life.The collective motions often occur under spatial restrictions,hallmarked by the collective rota... Collective cell migration is a coordinated movement of multi-cell systems essential for various processes throughout life.The collective motions often occur under spatial restrictions,hallmarked by the collective rotation of epithelial cells confined in circular substrates.Here,we aim to explore how geometric shapes of confinement regulate this collective cell movement.We develop quantitative methods for cell velocity orientation analysis,and find that boundary cells exhibit stronger tangential ordering migration than inner cells in circular pattern.Furthermore,decreased tangential ordering movement capability of collective cells in triangular and square patterns are observed,due to the disturbance of cell motion at unsmooth corners of these patterns.On the other hand,the collective cell rotation is slightly affected by a convex defect of the circular pattern,while almost hindered with a concave defect,also resulting from different smoothness features of their boundaries.Numerical simulations employing cell Potts model well reproduce and extend experimental observations.Together,our results highlight the importance of boundary smoothness in the regulation of collective cell tangential ordering migration. 展开更多
关键词 Collective cell migration spatial restrictions tangential ordering geometric regula-tion cell Potts model
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Does Parental Migration Affect Left-Behind Children’s Social Anxiety?A Systematic Review and Meta-Analysis
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作者 Yao Wang Xiaojiao Li +1 位作者 Panpan Yang Zengyan Yu 《International Journal of Mental Health Promotion》 2024年第5期335-343,共9页
Social anxiety is a common psychological problem among left-behind children(LBC)and has been a popular issue in recent years.Children with higher levels of social anxiety have more emotional and behavioral problems an... Social anxiety is a common psychological problem among left-behind children(LBC)and has been a popular issue in recent years.Children with higher levels of social anxiety have more emotional and behavioral problems and are prone to negative life events.Although several studies have explored the differences in social anxiety between LBC and non-left-behind children(N-LBC),the findings have not been consistent.In this study,a systematic review and meta-analysis method was used,with 411 papers retrieved on October 01,2023,from Pubmed,Embase,Web of Science,and Chinese databases(CNKI,VIP,and Wanfang)(PROSPERO registry number:CRD42023472463).Twenty-one studies met the research criteria and included 11,254 LBC and 13,096 N-LBC.LBC scored significantly higher for social anxiety([WMD(95%CI):0.35[0.23,0.48],p<0.001])and social avoidance and distress([WMD(95%CI):0.35[0.23,0.48],p<0.001]).Subgroup analyses showed significant differences in effect sizes for the overall proportion of children left behind(p=0.02).In addition,different types of parental migration may influence the social anxiety of LBC,double-parent migration was associated higher social anxiety than father migration(p<0.001).Future research should focus on treatments to decrease social anxiety of left-behind children.These findings suggest that due to the long-term absence of parental migration,LBC are more vulnerable to negative emotional experiences and behaviours such as anxiety,distress,and avoidance during social interaction,especially for those with both parents absent from the home.Future research should focus on treatments to reduce social anxiety in LBC. 展开更多
关键词 Parental migration left-behind children social anxiety META-ANALYSIS
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Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway
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作者 ZHI ZHANG XIAOSONG LI +7 位作者 YING ZHANG HAO ZHU ZHENGUO QIAO YANG LU XIUWEI MI HUIHUA CAO GENHAI SHEN SONGBING HE 《Oncology Research》 SCIE 2024年第2期353-360,共8页
Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally.Absent in melanoma 2(AIM2),a constituent of the interfe... Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally.Absent in melanoma 2(AIM2),a constituent of the interferoninducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family,contributes to both cancer progression and inflammasome activation.Despite this understanding,the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain elusive.Consequently,this study endeavors to assess AIM2’s expression levels,explore its potential antitumor effects,elucidate associated cancer-related processes,and decipher the underlying signaling pathways in CRC.Our findings showed a reduced AIM2 expression in most CRC cell lines.Elevation of AIM2 levels suppressed CRC cell proliferation and migration,altered cell cycle by inhibiting G1/S transition,and induced cell apoptosis.Further research uncovered the participation of P38 mitogen-activated protein kinase(P38MAPK)in AIM2-mediated modulation of CRC cell apoptosis and proliferation.Altogether,our achievements distinctly underscored AIM2’s antitumor role in CRC.AIM2 overexpression inhibited proliferation and migration and induced apoptosis of CRC cells via activating P38MAPK signaling pathway,indicating AIM2 as a prospective and novel therapeutic target for CRC. 展开更多
关键词 Absent in melanoma 2 PROLIFERATION migration Apoptosis P38MAPK Colorectal cancer
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Genetic source,migration and accumulation of helium under deep thermal fluid activities:A case study of Ledong diapir area in Yinggehai Basin,South China Sea
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作者 FENG Ziqi HAO Fang +7 位作者 HU Lin HU Gaowei ZHANG Yazhen LI Yangming WANG Wei LI Hao XIAO Junjie TIAN Jinqiang 《Petroleum Exploration and Development》 SCIE 2024年第3期753-766,共14页
Based on the geochemical parameters and analytical data,the heat conservation equation,mass balance law,Rayleigh fractionation model and other methods were used to quantify the in-situ yield and external flux of crust... Based on the geochemical parameters and analytical data,the heat conservation equation,mass balance law,Rayleigh fractionation model and other methods were used to quantify the in-situ yield and external flux of crust-derived helium,and the initial He concentration and thermal driving mechanism of mantle-derived helium,in the Ledong Diapir area,the Yinggehai Basin,in order to understand the genetic source,migration and accumulation mechanisms of helium under deep thermal fluid activities.The average content of mantle-derived He is only 0.0014%,the ^(3)He/^(4)He value is(0.002–2.190)×10^(−6),and the R/Ra value ranges from 0.01 to 1.52,indicating the contribution of mantle-derived He is 0.09%–19.84%,while the proportion of crust-derived helium can reach over 80%.Quantitative analysis indicates that the crust-derived helium is dominated by external input,followed by in-situ production,in the Ledong diapir area.The crust-derived helium exhibits an in-situ 4 He yield rate of(7.66–7.95)×10^(−13)cm^(3)/(a·g),an in-situ 4 He yield of(4.10–4.25)×10^(−4)cm^(3)/g,and an external 4 He influx of(5.84–9.06)×10^(−2)cm^(3)/g.These results may be related to atmospheric recharge into formation fluid and deep rock-water interactions.The ratio of initial mole volume of 3 He to enthalpy(W)is(0.004–0.018)×10^(−11) cm^(3)/J,and the heat contribution from the deep mantle(X_(M))accounts for 7.63%–36.18%,indicating that deep hot fluid activities drive the migration of mantle-derived 3 He.The primary helium migration depends on advection,while the secondary migration is controlled by hydrothermal degassing and gas-liquid separation.From deep to shallow layers,the CO_(2/3) He value rises from 1.34×10^(9)to 486×10^(9),indicating large amount of CO_(2)has escaped.Under the influence of deep thermal fluid,helium migration and accumulation mechanisms include:deep heat driven diffusion,advection release,vertical hydrothermal degassing,shallow lateral migration,accumulation in traps far from faults,partial pressure balance and sealing capability. 展开更多
关键词 deep thermal fluid HELIUM genetic source migration and accumulation mechanism Yinggehai Basin
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Rural labor migration and farmers’arrangements of rice production systems in Central China:Insight from the intergenerational division of labor
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作者 Xue Shen Quanyu Yang +1 位作者 Rongjun Ao Shengsheng Gong 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第9期3200-3214,共15页
Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied extensively.Labor migration in rural China has taken new forms in recent years.There has been a di... Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied extensively.Labor migration in rural China has taken new forms in recent years.There has been a discernible trend wherein adult children have started migrating to cities while their elderly parents return to villages to re-engage in on-farm work.The phenomenon has notably shaped the intergenerational division of labor(IDL)within households.However,it remains to be seen how farmers adjust their rice production systems in response to the IDL.The age of 60 years for employment injury insurance is the eligibility threshold for off-farm employment and is used to obtain a source of exogenous variation in the IDL.Based on a representative household survey of 1,752 rice farmers in the Hubei Province of Central China,our fuzzy regression discontinuity analysis reveals that farmers in IDL households are more likely to adopt ratoon rice(RR)than single cropping rice(SR)or double cropping rice(DR).The effect of the IDL varies under different levels of operational scales and specialized agricultural service availability.Further analysis suggests that farmers’arrangements are associated with two potential mechanisms of downward intergenerational transfer.Monetary transfer for urban housing purchases increases RR in IDL households,and time transfer for intergenerational childcare significantly promotes SR in IDL households.This study enhances the understanding of the relationship between rural labor migration and rice production in China,providing a reference for adjusting rice production systems to ensure food security. 展开更多
关键词 labor migration intergenerational division of labor rice production systems fuzzy regression discontinuity Central China
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An improved reverse time migration for subsurface imaging over complex geological structures:A numerical study
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作者 Alok Kumar Routa Priya Ranjan Monahty 《Energy Geoscience》 EI 2024年第2期290-297,共8页
In seismic exploration,it is a critical task to image and interpret different seismic signatures over complex geology due to strong lateral velocity contrast,steep reflectors,overburden strata and dipping flanks.To un... In seismic exploration,it is a critical task to image and interpret different seismic signatures over complex geology due to strong lateral velocity contrast,steep reflectors,overburden strata and dipping flanks.To understand the behavior of these seismic signatures,nowadays Reverse Time Migration(RTM)technique is used extensively by the oil&gas industries.During the extrapolation phase of RTM,the source wavefield needs to be saved,which needs high storage memory and large computing time.These two are the main obstacles of RTM for production use.In order to overcome these disadvantages,in this study,a second-generation improved RTM technique is proposed.In this improved form,a shift operator is introduced at the time of imaging condition of RTM algorithm which is performed automatically both in space and time domain.This effort is made to produce a better-quality image by minimizing the computational time as well as numerical artefacts.The proposed method is applied over various benchmark models and validated by implementing over one field data set from the Jaisalmer Basin,India.From the analysis,it is observed that the method consumes a minimum of 45%less storage space and reduce the execution time by 20%,as compared to conventional RTM.The proposed RTM is found to work efficiently in comparison to the conventional RTM both in terms of imaging quality and minimization of numerical artefacts for all the benchmark models as well as field data. 展开更多
关键词 Imaging condition Reverse time migration(RTM) Seismic imaging Velocity-depth model Wave propagation
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Sensitivity of Marine Controllable Source Electromagnetic Soundings for Identifying Plume Migration in Offshore CO_(2) Storage
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作者 Ning Qiu Chunwu Pan +3 位作者 Yongheng Zhang Bin Liu Zhen Sun Pengchun Li 《哈尔滨工程大学学报(英文版)》 CSCD 2024年第3期656-673,共18页
Offshore carbon dioxide(CO_(2)) storage is an effective method for reducing greenhouse gas emissions. However, when using traditional seismic wave methods to monitor the migration of sequestration CO_(2) plumes, the c... Offshore carbon dioxide(CO_(2)) storage is an effective method for reducing greenhouse gas emissions. However, when using traditional seismic wave methods to monitor the migration of sequestration CO_(2) plumes, the characteristics of wave velocity changes tend to become insignificant beyond a certain limit. In contrast, the controllable source electromagnetic method(CSEM) remains highly sensitive to resistivity changes. By simulating different CO_(2) plume migration conditions, we established the relevant models and calculated the corresponding electric field response characteristic curves, allowing us to analyze the CSEM's ability to monitor CO_(2) plumes. We considered potential scenarios for the migration and diffusion of offshore CO_(2) storage, including various burial depths, vertical extension diffusion, lateral extension diffusion,multiple combinations of lateral intervals, and electric field components. We also obtained differences in resistivity inversion imaging obtained by CSEM to evaluate its feasibility in monitoring and to analyze all the electric field(Ex, Ey, and Ez) response characteristics. CSEM has great potential in monitoring CO_(2) plume migration in offshore saltwater reservoirs due to its high sensitivity and accuracy. Furthermore, changes in electromagnetic field response reflect the transport status of CO_(2) plumes, providing an important basis for monitoring and evaluating CO_(2)transport behavior during storage processes. 展开更多
关键词 Offshore carbon dioxide storage Geophysics Resistivity inversion Monitoring Plume migration Marine controllable source electromagnetic method
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Simulation Study on the Migration Range of CO_(2) in the Offshore Saline Aquifer
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作者 Jiayi Wu Zhichao Sheng Jiudi Li 《哈尔滨工程大学学报(英文版)》 CSCD 2024年第3期599-607,共9页
The geological storage of carbon dioxide(CO_(2)) is a crucial technology for mitigating climate change. Offshore deep saline aquifers have elicited increased attention due to their remarkable potential for storing CO_... The geological storage of carbon dioxide(CO_(2)) is a crucial technology for mitigating climate change. Offshore deep saline aquifers have elicited increased attention due to their remarkable potential for storing CO_(2). During long-term storage, CO_(2) migration in a deep saline aquifer needs special attention to prevent it from reaching risk points and leading to security issues. In this paper, a mechanism model is established according to the geological characteristics of saline aquifers in an offshore sedimentary basin in China. The CO_(2) migration over 100 years is simulated considering geological changes such as permeability, dip angle, thickness, and salinity. The effects of injection conditions on the CO_(2) migration range are also investigated. Results reveal that the migration range of CO_(2) in the injection period exceeds 70%, even if the postinjection period's duration is five times longer than that of the injection period. As the values of the above geological parameters increase, the migration range of CO_(2) increases, and permeability has a particularly substantial influence. Moreover, the influences of injection rate and well type are considerable. At high injection rates, CO_(2) has a greater likelihood of displacing brine in a piston-like scheme. CO_(2) injected by long horizontal wells migrates farther compared with that injected by vertical wells. In general, the plane migration range is within 3 000 m, although variations in the reservoir and injection parameters of the studied offshore saline aquifers are considered. This paper can offer references for the site selection and injection well deployment of CO_(2) saline aquifer storage. According to the studied offshore aquifers, a distance of at least 3 000 m from potential leakage points, such as spill points, active faults, and old abandoned wells, must be maintained. 展开更多
关键词 Offshore saline aquifer Carbon dioxide(CO_(2)) Geological storage migration range Geological changes
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