Impacts of microenvironments on cell migration have been reported in various interaction modes.A rapid tumor metastasis occurs along topological interfaces in vivo,such as the interface between the blood vessels and n...Impacts of microenvironments on cell migration have been reported in various interaction modes.A rapid tumor metastasis occurs along topological interfaces in vivo,such as the interface between the blood vessels and nerves.In this work,we culture MDA-MB231 cells at dish-liquid,dish-hydrogel,and hydrogel-liquid interfaces,respectively,to study how these different interfaces influence cell dynamics and morphology.Our results show that the migration mode of cells changes from an amoeboid motion to a mesenchymal motion but their speed do not change obviously if the interface changes from hydrogel-liquid to dish-liquid.In contrast,the migration mode of cells at a dish-hydrogel interface maintains as a mesenchymal motion,whereas their speed increases significantly.展开更多
A theoretical investigation was conducted of laminar fully developed mixed convection of alumina-water nanofluid through a vertical annulus, to improve its heating/cooling performance. We focused on con- trolling the ...A theoretical investigation was conducted of laminar fully developed mixed convection of alumina-water nanofluid through a vertical annulus, to improve its heating/cooling performance. We focused on con- trolling the nanoparticle migration and studying how it affected the heat transfer rate and pressure drop. Because the nanoparticles have very small dimensions, we only considered Brownian motion and ther- mophoretic diffusivity as the main causes of nanoparticle migration. Because thermophoresis is very sensitive to temperature gradients, we imposed various temperature gradients using asymmetric heat- ing. Considering hydrodynamically and thermally fully developed flow, the governing equations were reduced to two-point ordinary boundary value differential equations and were solved numerically. The imposed thermal asymmetry changed the direction of nanoparticle migration and distorted the velocity, temperature, and nanoparticle concentration profiles. Moreover, we found optimum values for the radius ratio （ζ） and heat flux ratio （ε）; with these optimum values, the nanofluid enhanced the efficacy of the system.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11774394 and 11704404)the Chinese Academy of Sciences(CAS),and the Key Research Program of Frontier Sciences of CAS(Grant No.QYZDB-SSW-SYS003).
文摘Impacts of microenvironments on cell migration have been reported in various interaction modes.A rapid tumor metastasis occurs along topological interfaces in vivo,such as the interface between the blood vessels and nerves.In this work,we culture MDA-MB231 cells at dish-liquid,dish-hydrogel,and hydrogel-liquid interfaces,respectively,to study how these different interfaces influence cell dynamics and morphology.Our results show that the migration mode of cells changes from an amoeboid motion to a mesenchymal motion but their speed do not change obviously if the interface changes from hydrogel-liquid to dish-liquid.In contrast,the migration mode of cells at a dish-hydrogel interface maintains as a mesenchymal motion,whereas their speed increases significantly.
文摘A theoretical investigation was conducted of laminar fully developed mixed convection of alumina-water nanofluid through a vertical annulus, to improve its heating/cooling performance. We focused on con- trolling the nanoparticle migration and studying how it affected the heat transfer rate and pressure drop. Because the nanoparticles have very small dimensions, we only considered Brownian motion and ther- mophoretic diffusivity as the main causes of nanoparticle migration. Because thermophoresis is very sensitive to temperature gradients, we imposed various temperature gradients using asymmetric heat- ing. Considering hydrodynamically and thermally fully developed flow, the governing equations were reduced to two-point ordinary boundary value differential equations and were solved numerically. The imposed thermal asymmetry changed the direction of nanoparticle migration and distorted the velocity, temperature, and nanoparticle concentration profiles. Moreover, we found optimum values for the radius ratio （ζ） and heat flux ratio （ε）; with these optimum values, the nanofluid enhanced the efficacy of the system.
