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Depressive Symptom Endorsement among Alzheimer’s Disease, Vascular Dementia and Mild Cognitive Impairment 被引量:1
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作者 James R. Hall Leigh Johnson +2 位作者 April Wiechmann Robert C. Barber Sid O’Bryant 《Open Journal of Medical Psychology》 2012年第3期32-37,共6页
Background: The Geriatric Depression Scale (GDS) is widely used to assess depressive symptoms in clinical and research settings. This study utilized a 4 factor solution for the 30-item GDS to explore differences in th... Background: The Geriatric Depression Scale (GDS) is widely used to assess depressive symptoms in clinical and research settings. This study utilized a 4 factor solution for the 30-item GDS to explore differences in the presentation of depressive symptoms in various types of cognitive impairment. Method: Retrospective chart review was conducted on 254 consecutive cases of community dwelling elderly newly diagnosed with mild Alzheimer’s Dementia (AD) n = 122, mild Vascular Dementia (VaD) n = 71 or Amnestic Mild Cognitive Impairment (aMCI) n = 32 and Non-Amnestic MCI (nMCI) n = 29. Results: Analysis revealed no significant differences (p 05). No statistically significant differences were found between VaD and nMCI or between the MCI groups. Conclusions: Support is provided for the use of GDS subscales in a wide range of cognitively impaired elderly. This study suggests in mild dementia the number and type of depressive symptoms vary significantly between AD and VaD. There are indications that aMCI patients are similar in their symptom endorsement to AD and nMCI are similar to VaD which is consistent with some of the notions regarding likely trajectories of the respective MCI groups. 展开更多
关键词 Depression COGNITIVE IMPAIRMENT Alzheimer’s Vascular dementia mild COGNITIVE IMPAIRMENT
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Usefulness of the Japanese version of Rapid Dementia Screening Test for mild cognitive impairment in older patients with cardiovascular disease:a cross-sectional study 被引量:1
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作者 Takuji Adachi Yuki Tsunekawa +1 位作者 Akihito Matsuoka Daisuke Tanimura 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2021年第4期245-251,共7页
BACKGROUND Cognitive decline is common among older patients with cardiovascular disease(CVD) and can decrease their self-management abilities. However, the instruments for identifying mild cognitive impairment(MCI) ar... BACKGROUND Cognitive decline is common among older patients with cardiovascular disease(CVD) and can decrease their self-management abilities. However, the instruments for identifying mild cognitive impairment(MCI) are not always feasible in clinical practice. Therefore, this study evaluated whether MCI could be detected using the Japanese version of the Rapid Dementia Screening Test(RDST-J), which is a simple screening tool for identifying cognitive decline.METHODS This retrospective single-center study included patients who were ≥ 65 years old and hospitalized because of CVD.Patients with a pre-hospitalization diagnosis of dementia were excluded. Each patient's cognitive function had been measured at discharge using the RDST-J and the Japanese version of the Montreal Cognitive Assessment(Mo CA-J), which is a standard tool for MCI screening. The correlation between the two scores was evaluated using Spearman's rank correlation coefficient. Receiver operating characteristic(ROC) analysis was also to evaluate whether the RDST-J could identify MCI, which was defined as a Mo CA-J score of ≤ 25 points.RESULTS The study included 78 patients(mean age: 77.2 ± 8.9 years). The RDST-J and Mo CA-J scores were strongly correlated(r = 0.835, P < 0.001). The ROC analysis revealed that an RDST-J score of ≤ 9 points provided 75.4% sensitivity and 95.2% specificity for identifying MCI, with an area under the curve of 0.899(95% CI: 0.835-0.964). The same cut-off value was identified when excluding patients with a high probability of dementia(RDST-J score of ≤ 4 points).CONCLUSIONS The RDST-J may be a simple and effective tool for identifying MCI in older patients with CVD. 展开更多
关键词 CVD MCI Usefulness of the Japanese version of Rapid dementia Screening Test for mild cognitive impairment in older patients with cardiovascular disease:a cross-sectional study
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Jian Nao Ning for Treatment of Memory Impairment in Patients with Mild or Moderate Multi-infarct Dementia
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作者 田金洲 尹军祥 +2 位作者 刘峘 杨承芝 王永炎 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2002年第4期247-251,共5页
Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at... Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia. 展开更多
关键词 Jian Nao Ning for Treatment of Memory Impairment in Patients with mild or Moderate Multi-infarct dementia
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Evaluation of the Clinical Efficacy of Acupuncture and Moxibustion Combined with Repetitive Transcranial Magnetic Stimulation on Cognitive Function and Sleep Disorders in Patients with Mild Vascular Dementia
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作者 Ningyao Wang Guohui Xu +2 位作者 Nan Wang Wuying Piao Guanghui Gao 《Journal of Clinical and Nursing Research》 2021年第5期75-80,共6页
Objective:To explore the clinical effects of acupuncture and repeated transcranial magnetic stimulation in patients with mild vascular dementia.Method:From May 2020 to May 2021,40 patients with mild vascular dementia ... Objective:To explore the clinical effects of acupuncture and repeated transcranial magnetic stimulation in patients with mild vascular dementia.Method:From May 2020 to May 2021,40 patients with mild vascular dementia in Harbin Fourth Hospital(our hospital)were divided into the experimental group(20 cases,using conventional drugs+acupuncture+repeated transcranial magnetic stimulation)and the control group(20 cases,for example,the application of conventional medication).The improvement of cognitive function score,sleep quality score,quality of life score,and cerebral hemodynamics before and after treatment were compared between the two groups.Result:Before treatment,the difference in cognitive function score,sleep quality score,quality of life score,and cerebral hemodynamic index between the two groups of patients did not form,that is,p>0.05;after treatment,the experimental group5s cognitive function score was(19.45±2.47)points,Sleep quality score(12.18±2.09),quality of life score(33.29±4.08),left cerebral blood flow velocity(65.76±3.32)cm/s,right cerebral blood flow velocity(64.32±3.25)cm/s,more For the control group,P<0.05・Conclusion:In the clinical treatment of patients with mild vascular dementia,based on conventional drugs,combined with acupuncture and repetitive transcranial magnetic stimulation,the patients?cognitive function can be improved,and the quality of sleep and quality of life can be improved.Comprehensive clinical promotion. 展开更多
关键词 ACUPUNCTURE Transcranial magnetic stimulation mild vascular dementia Cognitive function Sleep disorder
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Recent research about mild cognitive impairment in China 被引量:10
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作者 Yan CHENG Shifu XIAO 《上海精神医学》 2014年第1期4-14,共11页
关键词 认知功能障碍 中国人口 老年痴呆症 MCI 认知障碍 流行病学 心理特征 生理变化
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Effectiveness of Traditional Chinese Medicine (TCM) treatments on the cognitive functioning of elderly persons with mild cognitive impairment associated with white matter lesions 被引量:9
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作者 Songming HE Lijun LI +2 位作者 Juying HU Qiaoli CHEN Weiqun SHU 《上海精神医学》 CSCD 2015年第5期289-295,共7页
关键词 认知功能障碍 中医药疗法 老年人 患者 老年痴呆症 中医治疗 疗效 认知障碍
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A meta-analysis of Chinese herbal medicines for vascular dementia 被引量:7
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作者 Xiude Qin Yu Liu +6 位作者 Yanqing Wu Shuo Wang Dandan Wang Jinqiang Zhu Qiaofeng Ye Wei Mou Liyuan Kang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第18期1685-1692,共8页
OBJECTIVE: To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL: We retrieved publications from Cochrane Library (2004 to July 2011... OBJECTIVE: To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL: We retrieved publications from Cochrane Library (2004 to July 2011), PubMed (1966 to July 2011), the Chinese Science and Technique Journals Database (1977 to July 2011), the China National Knowledge Infrastructure (1979 to July 2011), Google Scholar (July 2011), and the Chinese Biomedical Database (1977 to July 2011) using the key words "Chinese medicine OR Chinese herbal medicine" and "vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia". SELECTION CRITERIA: Randomized controlled trials comparing Chinese herbal medicines with placebo/western medicine in the treatment of patients with vascular dementia were included. Diagnostic standards included Diagnostic and Statistical Manual of Mental Disorders-IV, and National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et I'Enseignement en Neurosciences. Two participants independently conducted literature screening, quality evaluation and data extraction. The quality of each trial was assessed according to the Cochrane Reviewers' Handbook 5.0. MAIN OUTCOME MEASURES: Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions. RESULTS: We identified 1 143 articles discussing the effects of Chinese medicine on vascular dementia. Thirty-one of these were included in the analysis. These studies involved a total of 2 868 participants (1 605 patients took Chinese medicine decoctions (treatment group); 1 263 patients took western medicine or placebo). The results of our meta-analysis revealed that Chinese herbal remedies in the treatment group were more efficacious than the control intervention (relative risk (RR) = 1.27; 95% confidence interval (C/): 1.18-1.38, P 〈 0.01). Mini-Mental State Examination scores were higher in patients taking Chinese herbal medicines than in those in the control group (weighted mean difference (WMD) = 2.83; 95%CI: 2.55-3.12, P 〈 0.01). Patients in the treatment group showed better disease amelioration than those in the control group (Hasegawa Dementia Scale scores; WMD = 2.41, 95%CI: 1.48-3.34, P 〈 0.01). There were also considerably fewer adverse reactions among those in the treatment group compared with those in the control group (RR = 0.20, 95%CI: 0.08-0.47, P 〈 0.01). CONCLUSION: Chinese herbal medicine appears to be safer and more effective than control measures in the treatment of vascular dementia. However, the included trials were generally low in quality. More well-designed, high-quality trials are needed to provide better evidence for the assessment of the efficacy and safety of Chinese medicines for vascular dementia. 展开更多
关键词 neural regeneration Chinese herbal medicine META-ANALYSIS vascular dementia mild cognitiveimpairment DECOCTION efficacy Mini-Mental State Examination Hasegawa dementia Scale adverse reaction neurodegenerative disease grants-supported paper NEUROREGENERATION
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Progression of Cognitive Deficit in Older People with Mild Cognitive Impairment Treated with Cerebrolysin 被引量:1
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作者 Irina S. Boksha Svetlana I. Gavrilova +6 位作者 Igor V. Kolykhalov Iana B. Fedorova Iaroslav B. Kalyn Natalia D. Selezneva Andrei V. Samorodov Serge N. Miasoedov Elizabeta B. Mukaetova-Ladinska 《Health》 2014年第19期2581-2591,共11页
Objectives: Although people with amnestic mild cognitive impairment (aMCI) benefit from cerebrolysin treatment, some still develop dementia. The aim of the current study was to identify most informative clinical asses... Objectives: Although people with amnestic mild cognitive impairment (aMCI) benefit from cerebrolysin treatment, some still develop dementia. The aim of the current study was to identify most informative clinical assessment tests to predict the therapy efficacy in aMCI subjects treated with cerebrolysin. Methods: We studied patients with amnestic mild cognitive impairment (aMCI;n = 53) who had regular neurocognitive and clinical psychiatric assessments and were treated with cerebrolysin i.v. infusions 20 × 30 ml twice a year over three years period. Data were analyzed using non-parametric statistics, cluster and linear discriminant analyses. Results: Combined mathematical modeling enabled to predict cognitive decline from aMCI to dementia in the cerebrolysin-treated patients based on their initial neurocognitive assessment scores. We identified a “dementia risk group” with fast cognitive decline (i.e. low efficacy of the treatment). Lower baseline scores in the Mattis Dementia Rating Scale Memory subtest, Mini-Mental State Examination (MMSE), 10 word list immediate recall, and Frontal Assessment Battery tests when accompanied by higher depression score (Hamilton Depression Rating Scale) suggest poor prognosis for aMCI patients treated with cerebrolysin. Changes in scores on the MMSE, Boston naming test, Digit span forward, and Wechsler scale subtest “Categorical associations” during the treatment course are more characteristic for patients who convert to dementia than their initial scores. Conclusions: aMCI subjects treated with cerebrolysin with lower baseline cognitive functioning and subclinical depression have poor prognosis in terms of converting to dementia. Changes in the MMSE, Boston naming test, Digit span forward, and Wechsler scale subtest “Categorical associations” scores during the treatment course are more informative to identify patients who will develop dementia than their initial scores. 展开更多
关键词 mild Cognitive IMPAIRMENT CEREBROLYSIN dementia Cluster ANALYSIS Linear DISCRIMINANT ANALYSIS
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5种认知功能筛查量表在老年人中的应用效果分析 被引量:5
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作者 张晓静 孙佶英 +3 位作者 肖卫忠 张丽丽 任宁 杨振华 《护理研究》 北大核心 2024年第7期1162-1167,共6页
目的:评价三级甲等综合医院记忆门诊常用的5种认知筛查量表的应用效果,以期为临床医护人员进行神经认知障碍的评估和诊断提供参考依据。方法:选取2020年10月—2022年5月就诊于记忆门诊且主诉记忆减退的155例病人,经神经内科医生初诊,在... 目的:评价三级甲等综合医院记忆门诊常用的5种认知筛查量表的应用效果,以期为临床医护人员进行神经认知障碍的评估和诊断提供参考依据。方法:选取2020年10月—2022年5月就诊于记忆门诊且主诉记忆减退的155例病人,经神经内科医生初诊,在征得病人同意后,开具认知障碍筛查处方,病人预约后由具有认知筛查培训资质的护士依次对病人及家属完成中文版认知功能检查量表-Ⅲ(ACE-Ⅲ)、简易智力状态检查量表(MMSE)、画钟测试4分法(CDT4)、蒙特利尔认知评估量表(MoCA)、认知障碍自评量表(AD8)和日常生活能力(ADL)量表的筛查,病人携带认知筛查结果、相关实验室及影像学检查结果到神经内科初诊专家处进行诊疗。结果:155例病人中,正常对照组72人,认知障碍组38例,痴呆组45例。5种认知筛查量表与相关因素间相关性比较结果显示,年龄、教育年限、认知障碍程度与中文版ACE-Ⅲ、MoCA相关性更为显著;认知障碍组病人中文版ACE-Ⅲ、MMSE、MoCA和AD8的受试者工作特征曲线下面积为0.698~0.788,MoCA、中文版ACE-Ⅲ和AD8对轻度认知障碍诊断的特异性分别为78.9%、76.3%和73.7%,敏感性分别为70.8%、58.3%和56.9%;痴呆组病人的中文版ACE-Ⅲ、MMSE、MoCA量表的受试者工作特征曲线下面积为0.915~0.931,其中MMSE、中文版ACE-Ⅲ和MoCA对痴呆诊断的敏感性分别为91.7%,84.7%和83.3%,特异性分别为86.7%、84.4%和84.4%。结论:对于具有记忆力减退、高龄、具有一定学历的病人宜选用MoCA、中文版ACE-Ⅲ在三级甲等综合医院记忆门诊筛查使用;认知筛查量表对轻度认知障碍筛查的准确性依次为MoCA>中文版ACE-Ⅲ>AD8,对痴呆筛查的准确性MMSE>中文版ACE-Ⅲ>MoCA。 展开更多
关键词 认知功能 评估工具 老年人 轻度认知障碍 痴呆 量表
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Cognitive and Functional Profiles in Mild-to-Moderate Alzheimer’s Disease and Mild Cognitive Impairment Compared to Healthy Elderly
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作者 Mark Marsico Celeste A. de Jager +3 位作者 April Grant Xingshu Zhu Arwen Markwick Julie Chandler 《Advances in Alzheimer's Disease》 2014年第4期168-186,共19页
Background: Amnestic mild cognitive impairment (aMCI) and mild-to-moderate Alzheimer’s disease (AD) are clinically distinct but impact cognitive and functional ability similarly. Comprehensive assessment of cognitive... Background: Amnestic mild cognitive impairment (aMCI) and mild-to-moderate Alzheimer’s disease (AD) are clinically distinct but impact cognitive and functional ability similarly. Comprehensive assessment of cognitive and functional deficits may prove useful in informing differential diagnosis in early stages of dementia and in informing endpoint selection in therapeutic AD trials. Objective: The objective of this study was to characterize patterns of cognitive and functional impairment in aMCI and mild-to-moderate AD subjects compared to cognitively intact healthy elderly (HE). Methods: Thirty-one healthy elderly, 20 aMCI and 19 AD participants were administered a cognitive test battery that included the ADAS-Cog and functional assessments. Z-scores were calculated for all endpoints based on the HE reference group. Results: Cognitive deficits were observed in AD and aMCI participants relative to the referent group. On average, aMCI participants performed 1 - 2 standard deviations below HE on cognitive tests, and AD participants performed 2 - 3 standard deviations below HE. Domain-specific functional deficits among AD participants (z- score -0.4 to -6.4) were consistently greater than those of aMCI participants (z-score 0 to -1.7). Conclusion: This study provides further support for comprehensive assessment and monitoring of cognitive and functional domain scores in the diagnosis and treatment of aMCI and mild AD. Domain-specific cognitive scores may be more useful than composite scores in characterizing impairment and decline. Measuring domains such as attention, processing speed and executive function may increase the sensitivity of detecting disease progression and therapeutic effects, particularly in mild-moderate AD where memory decline may be too slow to detect drug effects during a typical clinical trial. 展开更多
关键词 Alzheimer’s Disease Amnestic mild COGNITIVE IMPAIRMENT dementia Cognition
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Cognitive Profiles and Subtypes of Patients with Mild Cognitive Impairment: Data from a Clinical Follow-Up Study
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作者 Kyung Won Park Eun-Joo Kim +5 位作者 Hwan Joo Sung-Man Jeon Seong-Ho Choi Jay C. Kwon Byoung Gwon Kim Jae Woo Kim 《International Journal of Clinical Medicine》 2012年第5期352-360,共9页
Background: Mild cognitive impairment (MCI) is a heterogeneous condition with a variety of clinical outcomes, the presence of which correlates with risk of Alzheimer’s disease as well as pre-clinical stages of other ... Background: Mild cognitive impairment (MCI) is a heterogeneous condition with a variety of clinical outcomes, the presence of which correlates with risk of Alzheimer’s disease as well as pre-clinical stages of other dementia subtypes. The aims of this study were to assess the specific patterns of cognitive profiles and to identify changes from baseline to 24 weeks in patients with MCI using detailed neuropsychological testing. Methods: We consecutively recruited 120 MCI patients at baseline according to the Petersen’s clinical diagnostic criteria, who were admitted to the Dementia and Memory Clinics. We analyzed patients who fulfilled both inclusion and exclusion criteria for MCI and classified them into four subtypes according to deficits in major cognitive domains;amnestic MCI single domain (aMCI-s), amnestic multiple domain MCI (aMCI-m), non-amnestic single domain MCI (naMCI-s) and non-amnestic multiple domain MCI (naMCI-m). Four groups of MCI were evaluated by a detailed neuropsychological battery test. Results: 83 patients with MCI at the 24-week follow-up were classified into four subtypes. The most frequent subtype was amnestic multi-domain MCI, with the frequency of MCI subtypes as follows: aMCI-s (n = 21, 25.3%), aMCI-m (n = 53, 63.9%), naMCI-s (n = 5, 6.0%) and naMCI-m (n = 4, 4.8%). In the major cognitive items of the SNSB-D, there were significant changes between the initial and follow-up tests in the domains of language, memory and the fron-tal/executive function (p < 0.05), except for attention, in all MCI patient subtypes. At 24-weeks follow-up, the conversion rate to Alzheimer’s disease was 2.4% (n = 2) from a subtype of amnestic multi-domain MCI. Conclusions: Our study revealed the most frequent subtype of MCI to be multiple domain amnestic MCI, with this subtype having a higher tendency of conversion to Alzheimer’s disease. 展开更多
关键词 mild Cognitive IMPAIRMENT Alzheimer’s dementia NEUROPSYCHOLOGY Conversion
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日本公共图书馆的轻度老年认知症读者服务探析 被引量:1
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作者 陈婧 印雪 陈卓 《图书馆杂志》 CSSCI 北大核心 2024年第5期68-77,共10页
为优化公共图书馆的轻度老年认知症读者服务,通过网络调研与邮件访谈对日本公共图书馆的轻度老年认知症读者服务情况进行调查,并从政策、文献资源、空间与设施、服务团队以及服务方法5个方面总结建设经验,最后提出我国公共图书馆开展轻... 为优化公共图书馆的轻度老年认知症读者服务,通过网络调研与邮件访谈对日本公共图书馆的轻度老年认知症读者服务情况进行调查,并从政策、文献资源、空间与设施、服务团队以及服务方法5个方面总结建设经验,最后提出我国公共图书馆开展轻度老年认知症读者服务的建议。 展开更多
关键词 公共图书馆 阿尔茨海默病 轻度老年认知症
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针刺飞腾八法穴位联合多奈哌齐治疗轻中度老年痴呆的疗效分析
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作者 李天实 黄靖宇 +1 位作者 王南卜 庄礼兴 《世界复合医学(中英文)》 2024年第9期93-96,共4页
目的分析轻中度老年痴呆患者采用针刺飞腾八法穴位联合多奈哌齐治疗的效果。方法选取2022年12月—2023年12月广州中医药大学第一附属医院收治的100例轻中度老年痴呆患者,按治疗方法不同分为多奈哌齐组(50例,多奈哌齐治疗)和针刺飞腾组(5... 目的分析轻中度老年痴呆患者采用针刺飞腾八法穴位联合多奈哌齐治疗的效果。方法选取2022年12月—2023年12月广州中医药大学第一附属医院收治的100例轻中度老年痴呆患者,按治疗方法不同分为多奈哌齐组(50例,多奈哌齐治疗)和针刺飞腾组(50例,多奈哌齐联合针刺飞腾八法穴位治疗)。比较两组中医证候积分、简易智能精神状态检查量表(Mini-mental State Examination,MMES)评分、巴塞尔指数、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、同型半胱氨酸(homocysteine,Hcy)。结果治疗后,针刺飞腾组中医证候积分、MMES评分、巴塞尔指数均高于多奈哌齐组,差异有统计学意义(P均<0.05)。治疗后,针刺飞腾组血清BDNF及Hcy水平[(15.55±0.24)pg/mL,(15.48±0.16)μmol/L]显著优于多奈哌齐组[(13.92±0.16)pg/mL、(19.74±0.33)μmol/L],差异有统计学意义(t=18.534、82.136,P均<0.05)。结论与单纯多奈哌齐治疗比较,对轻中度老年痴呆患者施行针刺飞腾八法穴位联合多奈哌齐治疗效果明显,能够改善患者的中医证候积分、MMES评分、巴塞尔指数、血清BDNF及Hcy。 展开更多
关键词 针刺飞腾八法穴位 多奈哌齐 轻中度老年痴呆
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听觉词汇学习测验对于轻度认知障碍转归的预测价值研究
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作者 秦虹云 赵欣欣 +2 位作者 张雷 王强 胡承平 《同济大学学报(医学版)》 2024年第3期354-358,共5页
目的研究听觉词汇学习测验(auditory vocabulary learning test,AVLT)对轻度认知障碍(mild cognitive impairment,MCI)进展为痴呆的预测能力。方法对257例MCI患者进行纵向随访,然后根据临床结果将其分为痴呆进展组和非痴呆进展组。比较... 目的研究听觉词汇学习测验(auditory vocabulary learning test,AVLT)对轻度认知障碍(mild cognitive impairment,MCI)进展为痴呆的预测能力。方法对257例MCI患者进行纵向随访,然后根据临床结果将其分为痴呆进展组和非痴呆进展组。比较这些组的基线人口统计学信息和AVLT评分。构建受试者工作特征(receiver operating characteristic,ROC)曲线以评估AVLT评分对MCI转归的区分值。结果在6年后的随访中,有45例受试者进展为痴呆,归为痴呆进展组(MCI progression,MCIp),3例受试者恢复正常认知,209例受试者维持MCI,一同归为非痴呆进展组(MCI non-progression,MCInp)。在基线时,MCIp组的AVLT评分明显低于MCInp,差异有统计学意义(P<0.05)。ROC曲线分析显示,AVLT延迟回忆(delayed recall,AVLT-DR)在区分MCI患者进展为痴呆方面有最大的曲线下面积(largest area under the curve,AUC),是重要预测指标。结论AVLT,尤其是AVLT-DR评分较低能较好预测MCI进展为痴呆,但由于其特异度偏低,需要联合其他特异度高的量表综合使用来运用于临床工作。 展开更多
关键词 听觉词汇学习测验 轻度认知障碍 社区调查 进展为痴呆
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ApoE基因多态性与老年人群认知功能障碍的相关性
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作者 柳军凡 严钢莉 吴磊 《医学研究与战创伤救治》 CAS 北大核心 2024年第6期588-592,共5页
目的 分析载脂蛋白E(ApoE)基因多态性与老年人群认知功能障碍的相关性。方法 回顾性分析2020年1月至2022年6月武汉科技大学附属普仁医院收治的106例认知功能障碍老年患者临床资料为认知障碍组,另收集84例同期入院的老年健康体检者作为... 目的 分析载脂蛋白E(ApoE)基因多态性与老年人群认知功能障碍的相关性。方法 回顾性分析2020年1月至2022年6月武汉科技大学附属普仁医院收治的106例认知功能障碍老年患者临床资料为认知障碍组,另收集84例同期入院的老年健康体检者作为对照组,比较两组血清β淀粉样蛋白1-42(Aβ1-42)、Aβ1-40及微管相关蛋白Tau、磷酸化Tau181(pTau181)水平等基线资料、ApoE基因型及等位基因频率分布情况,并分析ApoE基因多态性与观察组认知功能障碍类型的关系。结果 认知障碍组简易精神状态评估量表(MMSE)评分及蒙特利尔认知评估量表(MoCA)评分低于对照组(P<0.05),血清Aβ1-42、Aβ1-40及Tau、p-Tau181水平高于对照组(P<0.05)。两组ApoE基因型及等位基因频率比较,差异具有统计学意义(P<0.05),Logistic回归分析校正混杂因素后,携带ε4等位基因者患认知功能障碍相对风险度(OR)=2.701,95%CI(1.239~5.861),P<0.05。认知障碍组中,痴呆者ApoE ε4等位基因频率明显高于轻度认知功能障碍者(P<0.05),Logistic回归分析校正混杂因素后,携带ε4等位基因者发生痴呆的OR=2.779,95%CI(1.475~5.234),P<0.05。结论 ApoE ε4等位基因可增加本地区老年人群认知功能障碍发生风险,对促进认知功能障碍进展也有积极作用。。 展开更多
关键词 认知功能障碍 老年 载脂蛋白E 基因多态性 轻度认知功能障碍 痴呆
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针药联合对血管性轻度认知障碍大鼠行为学、抗氧化反应及α-Syn的影响
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作者 欧梦宁 吴明娟 蒙艳丽 《中国中医药现代远程教育》 2024年第9期147-150,共4页
目的探讨针药联合对血管性轻度认知障碍(VMCI)大鼠行为学、抗氧化反应及α-突触核蛋白(α-Syn)的影响。方法成模大鼠随机分为丹参川芎嗪注射液给药组(简称“给药组”)、头穴透刺联合注射液治疗组(简称“针药组”)和模型组,同时设立空白... 目的探讨针药联合对血管性轻度认知障碍(VMCI)大鼠行为学、抗氧化反应及α-突触核蛋白(α-Syn)的影响。方法成模大鼠随机分为丹参川芎嗪注射液给药组(简称“给药组”)、头穴透刺联合注射液治疗组(简称“针药组”)和模型组,同时设立空白组,每组9只;治疗3周后,观察大鼠认知功能变化,检测血清内超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量,检测α-Syn的表达。结果与模型组相比,针药组和给药组认知指数(CI)升高,SOD活性提高,MDA含量降低,α-Syn表达降低,且针药组改善效果均大于给药组(P<0.05)。结论头穴透刺联合丹参川芎嗪疗法可通过缓解氧化应激反应,减少α-Syn沉积来改善认知障碍,且治疗效果优于单独使用丹参川芎嗪注射液。 展开更多
关键词 痴呆 血管性轻度认知障碍 头穴透刺疗法
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脑小血管病磁共振成像总负荷与帕金森病认知障碍的相关性研究
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作者 蔡玉 徐成 《山西医药杂志》 CAS 2024年第16期1224-1230,共7页
目的帕金森病(PD)伴发脑小血管病(CSVD)可能会加重PD的认知障碍。本研究旨在探讨CSVD总负荷与PD认知功能的关系。方法回顾性比较了165例PD患者的临床和神经影像学特征,所有患者均接受脑部磁共振成像(MRI)检查,并通过假定血管源性的腔隙... 目的帕金森病(PD)伴发脑小血管病(CSVD)可能会加重PD的认知障碍。本研究旨在探讨CSVD总负荷与PD认知功能的关系。方法回顾性比较了165例PD患者的临床和神经影像学特征,所有患者均接受脑部磁共振成像(MRI)检查,并通过假定血管源性的腔隙、白质高信号(WMH)、脑微出血(CMB)和血管周围间隙扩大(EPVS)评估其CSVD总负荷。通过进行蒙特利尔认知评价量表(MoCA)来评估认知功能,将患者分为帕金森病伴轻度认知障碍(PD-MCI)组和帕金森病伴痴呆(PDD)组。运用多变量二元Logistic回归模型确定认知功能下降的独立危险因素。采用受试者工作特征曲线(ROC)分析方法量化腔隙、CSVD总负荷在区分PD-MCI和PDD的准确性。结果与PD-MCI患者相比,PDD患者的脑室周围高信号(PVH)、深部白质高信号(DWMH)、腔隙、基底节区血管周围间隙扩大(BG-EPVS)以及CSVD总负荷显著升高,且差异有统计学意义。多变量二元logistic回归显示,腔隙[OR值(95%CI)=2.418(1.088,5.371),P=0.030]和CSVD总负荷[OR值(95%CI)=1.572(1.138,2.171),P=0.006]与PD患者认知能力下降独立相关。此外,ROC曲线结果证实腔隙及CSVD总负荷在区分PD-MCI和PDD方面具有良好的准确性。结论CSVD总负荷与PD患者的认知障碍密切相关。腔隙及CSVD总负荷可以作为预测PD患者认知功能减退的关键指标。 展开更多
关键词 脑小血管病总负担 腔隙 帕金森病伴轻度认知障碍 帕金森病伴痴呆
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关于引入PRO理念评价中医药治疗轻度痴呆疗效的思考 被引量:17
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作者 金香兰 张允岭 +3 位作者 韩振蕴 陈宝鑫 高芳 刘保延 《天津中医药》 CAS 2008年第1期29-31,共3页
针对中医药治疗轻度痴呆,目前缺乏合理有效的疗效评价标准,临床多采用多个量表联合评分的方法对其进行评价,但不够全面。引入患者报告的临床结局(PRO)信息获取系统作为新的疗效指标来判定痴呆疗效,可以从患者及家属(亲密看护者)角度提... 针对中医药治疗轻度痴呆,目前缺乏合理有效的疗效评价标准,临床多采用多个量表联合评分的方法对其进行评价,但不够全面。引入患者报告的临床结局(PRO)信息获取系统作为新的疗效指标来判定痴呆疗效,可以从患者及家属(亲密看护者)角度提供对治疗效果的信息,从而较为全面的评价中医药疗效。 展开更多
关键词 PRO 轻度痴呆 疗效评定
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连线测验(中文修订版)在早期识别阿尔茨海默病中的作用 被引量:128
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作者 陆骏超 郭起浩 +2 位作者 洪震 史伟雄 吕传真 《中国临床心理学杂志》 CSCD 2006年第2期118-120,共3页
目的:中文修订版的连线测验(TMT)在识别轻度认知功能障碍(MCI)和轻度阿尔茨海默病(AD)中的作用。方法:对正常老人94名,遗忘型MCI组107例和轻度AD组54例进行MMSE、TMT在内的8种神经心理测验。结果:正常老人与MCI组TMT完成率均高于轻度AD... 目的:中文修订版的连线测验(TMT)在识别轻度认知功能障碍(MCI)和轻度阿尔茨海默病(AD)中的作用。方法:对正常老人94名,遗忘型MCI组107例和轻度AD组54例进行MMSE、TMT在内的8种神经心理测验。结果:正常老人与MCI组TMT完成率均高于轻度AD组。年龄与教育程度对TMT-B的影响比TMT-A更大。TMT-A、B与MMSE、CFT模仿、CWCR、CFT回忆、AVLT延迟回忆均有显著相关性。完成TMT-A、B测验,NC组、MCI组与轻度AD组两两比较均有显著差异,TMT可以清楚的区分三组。结论:TMT对MCI病人有一定的辅助识别作用,对轻度AD病人有较强的辅助识别作用.。 展开更多
关键词 连线测验 轻度认知功能障碍 轻度阿尔茨海默病
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多发腔隙性脑梗死与轻度认知功能障碍的关系 被引量:12
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作者 季芳 刘承延 +1 位作者 石华英 祁小娟 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2010年第3期165-167,共3页
目的探讨多发性腔隙性脑梗死(multiple lacunar infarction,MLI)对轻度认知功能损害(mild cognitive impairment,MCI)患者发展为痴呆的相关关系。方法采用国际通用标准从门诊和住院患者中筛选轻度认知功能障碍患者。通过MRI和CT扫描... 目的探讨多发性腔隙性脑梗死(multiple lacunar infarction,MLI)对轻度认知功能损害(mild cognitive impairment,MCI)患者发展为痴呆的相关关系。方法采用国际通用标准从门诊和住院患者中筛选轻度认知功能障碍患者。通过MRI和CT扫描,确定这些患者有否多发性腔隙性脑梗死。对轻度认知功能障碍患者进行随访,用Kapaln-Meier生存分析法评定MLI对MCI发展为痴呆的相关关系。结果经临床和神经心理学评估,有120例MCI患者入选,其中43例(35.8%)经影像学诊断为伴有MLI,77例(64.1%)不伴MLI。经6-24个月随访,伴有MLI的患者有27(62.8%)例进展为痴呆,不伴MLI的患者有15例(19.4%)进展为痴呆。随访期内伴有MLI的MCI患者进展为痴呆的比例显著高于不伴MLI的患者(P〈0.05)。结论伴有MLI的MCI患者更容易进展为痴呆。这类MCI患者必须尽早进行干预,去除可控危险因素,预防痴呆发生。 展开更多
关键词 多发腔隙性脑梗死 轻度认知功能障碍 痴呆
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