A simple experiment of rat gastric ulcer was carried out to study the medical effect of Chinese Medical Stone which is a kind of Mineral Medicine of mines in China on gastric ulcer in rats.The purpose of this study wa...A simple experiment of rat gastric ulcer was carried out to study the medical effect of Chinese Medical Stone which is a kind of Mineral Medicine of mines in China on gastric ulcer in rats.The purpose of this study was to investigate the effect of the Chinese Medical Stone on the prevention and treatment of experimental gastrointestinal disease,especially gastric ulcer.展开更多
Copper mineral medicines are widely used in clinical practice.There are 11 kinds of copper-bearing minerals used in the treatment of diseases in Tibetan medicine:bjarosite,silane malachite,brass,malachite,turquoise,br...Copper mineral medicines are widely used in clinical practice.There are 11 kinds of copper-bearing minerals used in the treatment of diseases in Tibetan medicine:bjarosite,silane malachite,brass,malachite,turquoise,bronze,ring copper,turquoise,red copper,chlorite,copper.In this paper,the main components,processing methods,clinical uses and modern pharmacological research progress of copper-bearing minerals in Tibetan medicines were summarized by referring to the Tibetan medicine books,modern ethnic medicine monographs,current quality standards and recent literature,providing reference for the sustainable development and effective utilization of Tibetan medicine resources.展开更多
About 100 crude Chinese mineral drug samples were investigated with M&’ssbauer spectroscopy, X-ray diffraction analysis and atomic absorption spectroscopy. The classifications, species and components of Chinese m...About 100 crude Chinese mineral drug samples were investigated with M&’ssbauer spectroscopy, X-ray diffraction analysis and atomic absorption spectroscopy. The classifications, species and components of Chinese mineral drugs are elucidated. The pharmaceutic and curative mechanisms of these mineral drugs are discussed.展开更多
In order to change for the good flavor in green tea of middle or low grade,roast naked barley(miner ingredient) was added to it.To make tea having functional property,mixed roast naked barley-green tea with one medici...In order to change for the good flavor in green tea of middle or low grade,roast naked barley(miner ingredient) was added to it.To make tea having functional property,mixed roast naked barley-green tea with one medicinal herb(MH,miner ingredient).This study was performed to investigate the effect of drinking extracts of naked barley- MH- green tea(A group) and adlay- Angelica gigas Nakai- green tea(B group) on the body weights of rats,and volatile flavor components of best effective extract on weight reduction.Forty-eight male Sprague-Dawley rats divided into six groups were fed five different green tea extracts for 8 weeks.The result obtained in the experiment indicated that the change of body weights of rats was affected by A group,B group and others.A group showed highest reduction rate of body weights(36.40%).Reduction rate of body weights on the B group(10.10%) was much lower than A group(36.40%).Aroma compounds were extracted by the SDE method.The concentrated aroma extracts were analyzed and identified by GC and GC-MS.The main aroma components of the green tea blended with naked barley and MH were 12 pyrazines having roasty note,methyl butanals having sweet note,hexanal having briskness greenish note,and nerolidol and β-ionone having floral note.展开更多
In this study, 48 cases of middle-aged and elderly female diabetes patients were dividedrandomly into two groups, and treated separately by western medicine alone ( glibenclamide) in group A, andby traditional Chinese...In this study, 48 cases of middle-aged and elderly female diabetes patients were dividedrandomly into two groups, and treated separately by western medicine alone ( glibenclamide) in group A, andby traditional Chinese medicine (herbs that replenish the Kidney and activate blood circulation ) and gliben-clamide in group B. Before treatment, the patients of both groups had elevated glycosylated hemoglobin(HbAlc) and fast blood glucose (FBG) levels, decreased serum estradiol (E2 ) and testosterone/estradiol(E2/T) ratio, and the loss of bone mineral (elevated urinary calcium,phosphorus levels) . Most ot the pa-tients in the two groups had the symptoms of soreness and weakness of the loins and knees, general weak-ness ,dizziness,decreased sexual libido , palpitation and frequent urination , etc. These symptoms in traditionalChinese medicine belong to the deficiency of the Kidney. After treatment in both groups. the patients' serumHbAlc, FBG, and urinary Beta-2-microglobulin (B2M) got reduced, the concentration of serum sex hormone(E2 , E2/T ratio) elevated, and the elimination of urinary calcium, phosphorus levels cut down. But , the ther-apeutic effect in group B is apparently better than that in group A. The symptoms of deficiency of the Kidneywas apparently improved in group B. So, The authors think the medicinal herbs(reinforcing Kidney and acti-vating blood circulation) have an important role in the prevention and treatment of the 'Kidney deficiency'and bone mineral loss in middle-aged and elderly female diabetes patients.展开更多
目的由Hedgehog信号通路探讨补肾方药左归丸对卵巢切除所致骨质疏松症(osteoporosis,OP)大鼠的作用机理。方法选用雌性SD大鼠,随机分为空白对照组、假手术组、造模组。造模组切除双侧卵巢,假手术组不切除卵巢,仅切除卵巢周围少量脂肪组...目的由Hedgehog信号通路探讨补肾方药左归丸对卵巢切除所致骨质疏松症(osteoporosis,OP)大鼠的作用机理。方法选用雌性SD大鼠,随机分为空白对照组、假手术组、造模组。造模组切除双侧卵巢,假手术组不切除卵巢,仅切除卵巢周围少量脂肪组织。12周后,将造模组随机分为卵巢切除组(OVX组)、阳性对照组和左归丸组。阳性对照组灌服戊酸雌二醇混悬液,左归丸组灌服左归丸水煎液,OVX组灌服等体积纯水,给药13周后取材。通过Micro-CT检测各组骨密度(bone mineral density,BMD),免疫组化法(immunohistochemistry,IHC)检测各组胫骨骨髓基质细胞中Ihh、Ptch、Smo、Gli1、OPG、RANKL的蛋白表达。结果假手术组骨密度(bone mineral density,BMD)高于OVX组、阳性对照组、左归丸组,且OVX组BMD较阳性对照组、左归丸组更低;OVX组Hedgehog信号通路关键因子Ihh、Ptch、Smo、GLi1蛋白表达水平以及RANKL/OPG比值较假手术组明显增高;阳性对照组和左归丸组Ihh、Ptch、Smo、GLi1蛋白表达水平及RANKL/OPG比值均低于OVX组,但仍高于假手术组。结论左归丸可抑制卵巢切除所致的Hedgehog信号通路异常活跃,使其关键因子Ihh、Ptch、Smo、GLi1蛋白表达水平明显降低;进而降低RANKL/OPG比值,抑制破骨细胞(osteoclast,OC)活性,减少骨量流失。展开更多
文摘A simple experiment of rat gastric ulcer was carried out to study the medical effect of Chinese Medical Stone which is a kind of Mineral Medicine of mines in China on gastric ulcer in rats.The purpose of this study was to investigate the effect of the Chinese Medical Stone on the prevention and treatment of experimental gastrointestinal disease,especially gastric ulcer.
基金Supported by National Natural Science Foundation of China(81300107)Fundamental Research Funds for the Central Universities in Southwest Minzu University(2018NQN08).
文摘Copper mineral medicines are widely used in clinical practice.There are 11 kinds of copper-bearing minerals used in the treatment of diseases in Tibetan medicine:bjarosite,silane malachite,brass,malachite,turquoise,bronze,ring copper,turquoise,red copper,chlorite,copper.In this paper,the main components,processing methods,clinical uses and modern pharmacological research progress of copper-bearing minerals in Tibetan medicines were summarized by referring to the Tibetan medicine books,modern ethnic medicine monographs,current quality standards and recent literature,providing reference for the sustainable development and effective utilization of Tibetan medicine resources.
基金The Project Supported by National Natural Science Foundation of China
文摘About 100 crude Chinese mineral drug samples were investigated with M&’ssbauer spectroscopy, X-ray diffraction analysis and atomic absorption spectroscopy. The classifications, species and components of Chinese mineral drugs are elucidated. The pharmaceutic and curative mechanisms of these mineral drugs are discussed.
文摘In order to change for the good flavor in green tea of middle or low grade,roast naked barley(miner ingredient) was added to it.To make tea having functional property,mixed roast naked barley-green tea with one medicinal herb(MH,miner ingredient).This study was performed to investigate the effect of drinking extracts of naked barley- MH- green tea(A group) and adlay- Angelica gigas Nakai- green tea(B group) on the body weights of rats,and volatile flavor components of best effective extract on weight reduction.Forty-eight male Sprague-Dawley rats divided into six groups were fed five different green tea extracts for 8 weeks.The result obtained in the experiment indicated that the change of body weights of rats was affected by A group,B group and others.A group showed highest reduction rate of body weights(36.40%).Reduction rate of body weights on the B group(10.10%) was much lower than A group(36.40%).Aroma compounds were extracted by the SDE method.The concentrated aroma extracts were analyzed and identified by GC and GC-MS.The main aroma components of the green tea blended with naked barley and MH were 12 pyrazines having roasty note,methyl butanals having sweet note,hexanal having briskness greenish note,and nerolidol and β-ionone having floral note.
文摘In this study, 48 cases of middle-aged and elderly female diabetes patients were dividedrandomly into two groups, and treated separately by western medicine alone ( glibenclamide) in group A, andby traditional Chinese medicine (herbs that replenish the Kidney and activate blood circulation ) and gliben-clamide in group B. Before treatment, the patients of both groups had elevated glycosylated hemoglobin(HbAlc) and fast blood glucose (FBG) levels, decreased serum estradiol (E2 ) and testosterone/estradiol(E2/T) ratio, and the loss of bone mineral (elevated urinary calcium,phosphorus levels) . Most ot the pa-tients in the two groups had the symptoms of soreness and weakness of the loins and knees, general weak-ness ,dizziness,decreased sexual libido , palpitation and frequent urination , etc. These symptoms in traditionalChinese medicine belong to the deficiency of the Kidney. After treatment in both groups. the patients' serumHbAlc, FBG, and urinary Beta-2-microglobulin (B2M) got reduced, the concentration of serum sex hormone(E2 , E2/T ratio) elevated, and the elimination of urinary calcium, phosphorus levels cut down. But , the ther-apeutic effect in group B is apparently better than that in group A. The symptoms of deficiency of the Kidneywas apparently improved in group B. So, The authors think the medicinal herbs(reinforcing Kidney and acti-vating blood circulation) have an important role in the prevention and treatment of the 'Kidney deficiency'and bone mineral loss in middle-aged and elderly female diabetes patients.
文摘目的由Hedgehog信号通路探讨补肾方药左归丸对卵巢切除所致骨质疏松症(osteoporosis,OP)大鼠的作用机理。方法选用雌性SD大鼠,随机分为空白对照组、假手术组、造模组。造模组切除双侧卵巢,假手术组不切除卵巢,仅切除卵巢周围少量脂肪组织。12周后,将造模组随机分为卵巢切除组(OVX组)、阳性对照组和左归丸组。阳性对照组灌服戊酸雌二醇混悬液,左归丸组灌服左归丸水煎液,OVX组灌服等体积纯水,给药13周后取材。通过Micro-CT检测各组骨密度(bone mineral density,BMD),免疫组化法(immunohistochemistry,IHC)检测各组胫骨骨髓基质细胞中Ihh、Ptch、Smo、Gli1、OPG、RANKL的蛋白表达。结果假手术组骨密度(bone mineral density,BMD)高于OVX组、阳性对照组、左归丸组,且OVX组BMD较阳性对照组、左归丸组更低;OVX组Hedgehog信号通路关键因子Ihh、Ptch、Smo、GLi1蛋白表达水平以及RANKL/OPG比值较假手术组明显增高;阳性对照组和左归丸组Ihh、Ptch、Smo、GLi1蛋白表达水平及RANKL/OPG比值均低于OVX组,但仍高于假手术组。结论左归丸可抑制卵巢切除所致的Hedgehog信号通路异常活跃,使其关键因子Ihh、Ptch、Smo、GLi1蛋白表达水平明显降低;进而降低RANKL/OPG比值,抑制破骨细胞(osteoclast,OC)活性,减少骨量流失。
