AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plas...AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis.展开更多
The clinical efficacy was compared between 3D navigation-assisted percutaneous iliosacral screw(3DPS)and minimally invasive reconstruction plate(MIRP)in treating sacroiliac complex injury and the surgical procedures o...The clinical efficacy was compared between 3D navigation-assisted percutaneous iliosacral screw(3DPS)and minimally invasive reconstruction plate(MIRP)in treating sacroiliac complex injury and the surgical procedures of 3DPS were introduced.A retrospective analysis was performed on 49 patients with sacroiliac complex injury from March 2013 to May 2017.Twenty-one cases were treated by 3DPS,and 28 cases by MIRP.Intraoperative indexes as operative time,blood loss,incision length,length of hospital stay and postoperative complications were respectively documented.Quality of reduction was postoperatively evaluated by Matta radiological criteria,and clinical effect was assessed by Majeed scoring criteria at the last followup.Operative time and hospital stay were significantly shortened,and blood loss,and incision length were significantly reduced in 3DPS group as compared with those in MIRP group(P<0.05).No statistically significant difference was found between 3DPS group and MIRP group in the assessment of reduction and function(P>0.05).It was concluded that both 3DPS and MIRP can effectively treat the sacroiliac complex injury,and 3DPS can provide an accurate,safe and minimally invasive fixation with shorter operative time and hospital stay.展开更多
Two new metal-organic frameworks（MOFs）, namely, [Co_2（L_1）（bix）（μ_3-OH）]·2H_2O（1） and [Co_2（L_2）（bix）（μ_3-OH）]·2.5H_2O（2）（H_3L_1 = 5-oxyacetate isophthalic acid, H_3L_2 = 3,5-bis-oxyacet...Two new metal-organic frameworks（MOFs）, namely, [Co_2（L_1）（bix）（μ_3-OH）]·2H_2O（1） and [Co_2（L_2）（bix）（μ_3-OH）]·2.5H_2O（2）（H_3L_1 = 5-oxyacetate isophthalic acid, H_3L_2 = 3,5-bis-oxyacetate-benzoic acid, bix = 1,4-bis（imidazol-1-ylmethyl）benzene）, have been synthesized under hydrothermal conditions. Their structures were determined by single-crystal X-ray diffraction analysis and further characterized by elemental analysis, IR spectra, and powder X-ray diffraction（PXRD） analysis. Both complexes 1 and 2 demonstrate identical three-dimensional（3D）（3,8）-connected tfz-d nets with（4~3）_2（4~6·6^（18）·8~4） topologies, where the tetranuclear [Co_4（μ_3-OH）_2] clusters act as 8-connected nodes and aromatic multicarboxylic ligands as 3-connected nodes. The results show that the ligands with different geometrical conformations can form products with the same topological structures. Their thermal and magnetic properties were also investigated.展开更多
In colon cancer surgery,ensuring the complete removal of the primary tumor and draining lymph nodes is crucial.Lymphatic drainage in the colon follows the vascular supply,typically progressing from pericolic to paraao...In colon cancer surgery,ensuring the complete removal of the primary tumor and draining lymph nodes is crucial.Lymphatic drainage in the colon follows the vascular supply,typically progressing from pericolic to paraaortic lymph nodes.While NCCN guidelines recommend the removal of 10-12 lymph nodes for ade-quate oncological resection,achieving complete oncological resection involves more than just meeting these numerical targets.Various techniques have been developed and studied over time to attain optimal oncological outcomes.A key technique central to this goal is identifying the ileocolic vessels at their origin from the superior mesenteric vessels.Complete excision of the visceral and parietal mesocolon ensures the intact removal of the specimen,while D3 lymphade-nectomy targets all draining regional lymph nodes.Although these principles emphasize different aspects,they ultimately converge to achieve the same goal of complete oncological resection.This article aims to simplify the surgical steps that align with the principle of central vascular ligation and mesocolon mobilization while ensuring adequate D3 dissection.展开更多
We give a local analytic characterization that a minimal surface in the 3-sphere S3 C R4 defined by an irreducible cubic polynomial is one of the Lawson＇s minimal tori. This provides an alternative proof of the resul...We give a local analytic characterization that a minimal surface in the 3-sphere S3 C R4 defined by an irreducible cubic polynomial is one of the Lawson＇s minimal tori. This provides an alternative proof of the result by Perdomo （Characterization of order 3 algebraic immersed minimal surfaces of S3, Geom. Dedicata 129 （2007）, 23 34）.展开更多
Prevailing tissue degeneration caused by musculoskeletal maladies poses a great demand on bioscaffolds,which are artificial,biocompatible structures implanted into human bodies with appropriate mechanical properties.R...Prevailing tissue degeneration caused by musculoskeletal maladies poses a great demand on bioscaffolds,which are artificial,biocompatible structures implanted into human bodies with appropriate mechanical properties.Recent advances in additive manufacturing,i.e.,3D printing,facilitated the fabrication of bioscaffolds with unprecedented geometrical complexity and size flexibility and allowed for the fabrication of topologies that would not have been achieved otherwise.In our work,we explored the effect of porosity on themechanical properties of a periodic cellular structure.The structure was derived from the mathematically created triply periodic minimal surface(TPMS),namely the Sheet-Diamond topology.First,we employed a series of software including MathMod,Meshmixer,Netfabb and Cura to design the model.Then,we utilized additive manufacturing technology to fabricate the cellular structures with designated scale.Finally,we performed compressive testing to deduce the mechanical properties of each cellular structure.Results showed that,in comparison with the highporosity group,the yield strength of the low-porosity group was 3 times higher,and the modulus was 2.5 times larger.Our experiments revealed a specific relationship between porosity and Young’s modulus of PLA-made Sheet-Diamond TPMS structure.Moreover,it was observed that the high-and low-porosity structures failed through distinctive mechanisms,with the former breaking down via buckling and the latter via micro-fracturing.展开更多
Associated with an immersion φ : S^3→ ■, we can define a canonical bundle endomorphism F : TS^3→ TS^3 by the pull back of the K?hler form of ■. In this article,related to F we study equivariant minimal immersions...Associated with an immersion φ : S^3→ ■, we can define a canonical bundle endomorphism F : TS^3→ TS^3 by the pull back of the K?hler form of ■. In this article,related to F we study equivariant minimal immersions from S^3 into ■ under the additional condition(?_XF)X = 0 for all X ∈ ker(F). As main result, we give a complete classification of such kinds of immersions. Moreover, we also construct a typical example of equivariant non-minimal immersion φ : S^3→ ■ satisfying(?_XF)X = 0 for all X ∈ ker(F), which is neither Lagrangian nor of CR type.展开更多
Minimally invasive surgery is an important technique used for cytopathological examination.Recently,multiple studies have been conducted on a three-dimensional(3D)puncture simulation model as it can reveal the interna...Minimally invasive surgery is an important technique used for cytopathological examination.Recently,multiple studies have been conducted on a three-dimensional(3D)puncture simulation model as it can reveal the internal deformation state of the tissue at the micro level.In this study,a viscoelastic constitutive equation suitable for muscle tissue was derived.Additionally,a method was developed to define the fracture characteristics of muscle tissue material during the simulation process.The fracture of the muscle tissue in contact with the puncture needle was simulated using the cohesive zone model and a 3D puncture finite element model was established to analyze the deformation of the muscle tissue.The stress nephogram and reaction force under different parameters were compared and analyzed to study the deformation of the biological soft tissue and guide the actual operation process and reduce pain.展开更多
In this paper, we prove that if any set of ｜E（G）｜- ｜V（G）｜ ＋ 1 facial cycles of a 3-connected planar graph G embedded in the plane doesn＇t form a minimum cycle base of G, then any minimum cycle base of G cont...In this paper, we prove that if any set of ｜E（G）｜- ｜V（G）｜ ＋ 1 facial cycles of a 3-connected planar graph G embedded in the plane doesn＇t form a minimum cycle base of G, then any minimum cycle base of G contains a separating cycle, and G has a minor isomorphic to T6, where T6 is the graph obtained from the complete graph K6 by deleting a path with four edges.展开更多
基金Supported by Mr.Wade Thompson and family donation funds to the Divisions of Colon and Rectal surgery,Department of Surgery,Mount Sinai West Hospital,New York,NY 10019
文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis.
文摘The clinical efficacy was compared between 3D navigation-assisted percutaneous iliosacral screw(3DPS)and minimally invasive reconstruction plate(MIRP)in treating sacroiliac complex injury and the surgical procedures of 3DPS were introduced.A retrospective analysis was performed on 49 patients with sacroiliac complex injury from March 2013 to May 2017.Twenty-one cases were treated by 3DPS,and 28 cases by MIRP.Intraoperative indexes as operative time,blood loss,incision length,length of hospital stay and postoperative complications were respectively documented.Quality of reduction was postoperatively evaluated by Matta radiological criteria,and clinical effect was assessed by Majeed scoring criteria at the last followup.Operative time and hospital stay were significantly shortened,and blood loss,and incision length were significantly reduced in 3DPS group as compared with those in MIRP group(P<0.05).No statistically significant difference was found between 3DPS group and MIRP group in the assessment of reduction and function(P>0.05).It was concluded that both 3DPS and MIRP can effectively treat the sacroiliac complex injury,and 3DPS can provide an accurate,safe and minimally invasive fixation with shorter operative time and hospital stay.
基金supported by the application basis research key project of Yunnan Province science and technology department(201401CB00299)the major project of Qujing Normal University(2012ZD002)
文摘Two new metal-organic frameworks（MOFs）, namely, [Co_2（L_1）（bix）（μ_3-OH）]·2H_2O（1） and [Co_2（L_2）（bix）（μ_3-OH）]·2.5H_2O（2）（H_3L_1 = 5-oxyacetate isophthalic acid, H_3L_2 = 3,5-bis-oxyacetate-benzoic acid, bix = 1,4-bis（imidazol-1-ylmethyl）benzene）, have been synthesized under hydrothermal conditions. Their structures were determined by single-crystal X-ray diffraction analysis and further characterized by elemental analysis, IR spectra, and powder X-ray diffraction（PXRD） analysis. Both complexes 1 and 2 demonstrate identical three-dimensional（3D）（3,8）-connected tfz-d nets with（4~3）_2（4~6·6^（18）·8~4） topologies, where the tetranuclear [Co_4（μ_3-OH）_2] clusters act as 8-connected nodes and aromatic multicarboxylic ligands as 3-connected nodes. The results show that the ligands with different geometrical conformations can form products with the same topological structures. Their thermal and magnetic properties were also investigated.
文摘In colon cancer surgery,ensuring the complete removal of the primary tumor and draining lymph nodes is crucial.Lymphatic drainage in the colon follows the vascular supply,typically progressing from pericolic to paraaortic lymph nodes.While NCCN guidelines recommend the removal of 10-12 lymph nodes for ade-quate oncological resection,achieving complete oncological resection involves more than just meeting these numerical targets.Various techniques have been developed and studied over time to attain optimal oncological outcomes.A key technique central to this goal is identifying the ileocolic vessels at their origin from the superior mesenteric vessels.Complete excision of the visceral and parietal mesocolon ensures the intact removal of the specimen,while D3 lymphade-nectomy targets all draining regional lymph nodes.Although these principles emphasize different aspects,they ultimately converge to achieve the same goal of complete oncological resection.This article aims to simplify the surgical steps that align with the principle of central vascular ligation and mesocolon mobilization while ensuring adequate D3 dissection.
文摘We give a local analytic characterization that a minimal surface in the 3-sphere S3 C R4 defined by an irreducible cubic polynomial is one of the Lawson＇s minimal tori. This provides an alternative proof of the result by Perdomo （Characterization of order 3 algebraic immersed minimal surfaces of S3, Geom. Dedicata 129 （2007）, 23 34）.
文摘Prevailing tissue degeneration caused by musculoskeletal maladies poses a great demand on bioscaffolds,which are artificial,biocompatible structures implanted into human bodies with appropriate mechanical properties.Recent advances in additive manufacturing,i.e.,3D printing,facilitated the fabrication of bioscaffolds with unprecedented geometrical complexity and size flexibility and allowed for the fabrication of topologies that would not have been achieved otherwise.In our work,we explored the effect of porosity on themechanical properties of a periodic cellular structure.The structure was derived from the mathematically created triply periodic minimal surface(TPMS),namely the Sheet-Diamond topology.First,we employed a series of software including MathMod,Meshmixer,Netfabb and Cura to design the model.Then,we utilized additive manufacturing technology to fabricate the cellular structures with designated scale.Finally,we performed compressive testing to deduce the mechanical properties of each cellular structure.Results showed that,in comparison with the highporosity group,the yield strength of the low-porosity group was 3 times higher,and the modulus was 2.5 times larger.Our experiments revealed a specific relationship between porosity and Young’s modulus of PLA-made Sheet-Diamond TPMS structure.Moreover,it was observed that the high-and low-porosity structures failed through distinctive mechanisms,with the former breaking down via buckling and the latter via micro-fracturing.
文摘Associated with an immersion φ : S^3→ ■, we can define a canonical bundle endomorphism F : TS^3→ TS^3 by the pull back of the K?hler form of ■. In this article,related to F we study equivariant minimal immersions from S^3 into ■ under the additional condition(?_XF)X = 0 for all X ∈ ker(F). As main result, we give a complete classification of such kinds of immersions. Moreover, we also construct a typical example of equivariant non-minimal immersion φ : S^3→ ■ satisfying(?_XF)X = 0 for all X ∈ ker(F), which is neither Lagrangian nor of CR type.
基金Natural Science Foundation of Shandong Province(Grant No.ZR2019JQ19)Interdisciplinary Research Project of Shandong University(Grant No.2017JC027)China Scholarship Council(CSC).
文摘Minimally invasive surgery is an important technique used for cytopathological examination.Recently,multiple studies have been conducted on a three-dimensional(3D)puncture simulation model as it can reveal the internal deformation state of the tissue at the micro level.In this study,a viscoelastic constitutive equation suitable for muscle tissue was derived.Additionally,a method was developed to define the fracture characteristics of muscle tissue material during the simulation process.The fracture of the muscle tissue in contact with the puncture needle was simulated using the cohesive zone model and a 3D puncture finite element model was established to analyze the deformation of the muscle tissue.The stress nephogram and reaction force under different parameters were compared and analyzed to study the deformation of the biological soft tissue and guide the actual operation process and reduce pain.
文摘In this paper, we prove that if any set of ｜E（G）｜- ｜V（G）｜ ＋ 1 facial cycles of a 3-connected planar graph G embedded in the plane doesn＇t form a minimum cycle base of G, then any minimum cycle base of G contains a separating cycle, and G has a minor isomorphic to T6, where T6 is the graph obtained from the complete graph K6 by deleting a path with four edges.
