Effect of minimally invasive intracranial hematoma drainage on inflammatory factors, serum ferritin and serum P substance in patients with hypertensive cerebral hemorrhage

Objective:To study the effect of minimally invasive intracranial hematoma drainage on inflammatory factors, serum ferritin and serum P substance in patients with hypertensive cerebral hemorrhage.Methods:92 cases of hypertensive cerebral hemorrhage patients in our hospital were selected and randomly divided into 2 groups: minimally invasive group (51 cases) and routine group (41 cases). Minimally invasive intracranial hematoma drainage was performed on the minimally invasive group. Bone flap decompression or small bone window craniotomy were used in the routine group. Tumor necrosis factorα (TNF-α), interleukin-6 (IL-6), high sensitive C reactive protein (hs-CRP) and serum protein (SF), serum substance P (SP) in the 2 groups were detected before treatment and 2 weeks after treatment.Results: The comparison of TNF-α, IL-6, hs-CRP, SP, and SF in the two groups before treatment was not statistically significant (P>0.05). TNF-α, IL-6, hs-CRP and SF in both groups after treatment significantly decreased, compared with that before treatment (P<0.01,P<0.05). TNF-α, IL-6, and SF in minimally invasive group decreased more significantly than that in routine group (P<0.01);The comparison of SP in the two groups after treatment significantly increased compared with that before treatment (P<0.01,P<0.05). SP in minimally invasive group increased more significantly than that in routine group (P<0.05).Conclusions:Compared with bone flap decompression or small bone window craniotomy, minimally invasive intracranial hematoma drainage can inhibit inflammatory reaction, reduce the degree of nerve damage and alleviate clinical symptoms more effectively.

Therapeutic effect of minimally invasive intracranial hematoma evacuation in the treatment of hypertensive cerebral hemorrhage and TCD evaluation

Objective:To explore the therapeutic effect of minimally invasive intracranial hematoma evacuation in the treatment of hypertensive cerebral hemorrhage and the value of dynamic TCD monitoring in predicting the neurological function recovery.Methods: A total of 70 patients with hypertensive cerebral hemorrhage who were admitted in our hospital were included in the study and divided into the minimally invasive group and conservative group with 35 cases in each group according to different treatment protocols. The patients in the two groups were given drug conservative treatments. On this basis, the patients in the minimally invasive group were given urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle. TCD was performed before treatment, 1 d, 5 d, 10 d, and 21 d after treatment. The hematoma and edema volume was calculated. NIHSS was used to evaluate the neurological function recovery.Results: Vs, Vd, and Vm after treatment in the minimally invasive group were significantly elevated, while PI was significantly reduced. Vs, Vd, and Vm after treatment in the conservative group were reduced first and elevated later, while PI was elevated first and reduced later, and reached the lowest/peak 10d after treatment. Vs, Vd, and Vm 5 d, 10 d, and 21 d after treatment in the minimally invasive group were significantly higher than those in the conservative group, while PI was significantly lower than that in the conservative group. The hematoma and edema volume after treatment in the two groups was significantly reduced. The hematoma and edema volume at each timing point was significantly lower than that in the conservative group. NIHSS score after treatment in the minimally invasive group was significantly reduced. NIHSS score in the conservative group was elevated first and reduced later, reached the peak 10d after treatment, and at each timing point was higher than that in the minimally invasive group.Conclusions:The early minimally invasive operation can significantly improve the hematoma adjacent blood flow volume in patients with hypertensive cerebral hemorrhage, and contribute to the neurological function recovery. TCD not only can be applied in the dynamic monitoring of cerebral blood flow volume in patients with hypertensive cerebral hemorrhage, but also has a certain value in evaluating the prognosis of neurological function.

Individual idea about the micro-invasive aspiration and drainage of intracranial hematoma

AIM： This study aimed to expound the individual idea of micro-invasive surgery from pre-operative preparation, intra-operative processing and post-operative management. METHODS： Pre-operative preparation was improved by analyzing pathological factors and hematoma property, and considering patients＇ age, basic disease, blood pressure control, with persistent haemorrhagia/rehaemorrhagia or not, operative occasion choice, positioning and other procedures. In the surgery, positioner was used. Initial aspiration volume was cautiously controlled. After operation, vital signs of patients were kept stable by cautiously using hematoma liquefacient and combining with free radical scavenger. RESULTS： The core content of individual micro-invasive surgery was mainly to relieve intracranial pressure. Under the condition of sufficient pre-operative preparation known by patients＇ family members, precise positioning was determined and individual therapeutic regimen was made. Meanwhile, caution should be taken in hematoma aspiration. Liquefaction and drainage should be paid more attention, and complications were processed actively. CONCLUSION： During the process of micro-invasive evacuation of intracranial hematoma for treating cerebral hemorrhage, attention should be paid to analyzing cerebral hematoma etiology and pathophysiological mechanism, and individual idea should be considered in surgical treatment aiming at patients＇ concrete disease condition.

Effect of minimally invasive evacuation of hematoma combined with Xingnaojing therapy on neurological function injury and cytokine level in patients with hypertensive cerebral hemorrhagen

Objective:To study the effect of minimally invasive evacuation of hematoma combined with Xingnaojing therapy on neurological function damage and cytokine level in patients with hypertensive cerebral hemorrhage.Methods:A total of 80 patients with hypertensive cerebral hemorrhage treated in our hospital between June 2010 and September 2015 were selected as the research subjects, the treatment methods and test results were reviewed, and then they were divided into the control group (n=45) who accepted minimally invasive evacuation of hematoma alone and the observation group (n=35) who accepted minimally invasive evacuation of hematoma combined with Xingnaojing therapy. Before and after treatment, cerebral blood flow detector was used to detect cerebral blood flow parameters;ELISA method was used to detect serum levels of neurological function indexes and inflammatory cytokines;high performance liquid chromatograph was used to detect serum neurotransmitter levels. Results: Before treatment, the differences in cerebral blood flow parameters, neurological function indexes, inflammatory cytokines and neurotransmitters were not statistically significant between two groups of patients. After treatment, cerebral blood flow parameters Q and V levels of observation group were higher than those of control group while R level was lower than that of control group;serum NSE, NPY, IL-1β, IL-4, IL-6, TNF-α, Glu and Asp contents of observation group were lower than those of control group while BDNF and Gly contents were higher than those of control group.Conclusion: Minimally invasive evacuation of hematoma combined with Xingnaojing therapy can improve the neurological function and regulate the synthesis of inflammatory cytokines and neurotransmitters in patients with hypertension cerebral hemorrhage.

Minimally invasive thalamic hematoma drainage can improve the six-month outcome of thalamic hemorrhage

Objective To explore predictors of the 6-month clinical outcome ofthalamic hemorrhage, and evaluate if minimally invasive thalamic hematoma drainage （THD） could improve its prognosis. Methods A total of 54 patients with spontaneous thalamic hemorrhage were evaluated retrospectively. Clinical data, including demographics, stroke risk factors, neuroimaging variables, Glasgow Coma Score （GCS） on admission, surgical strategy, and outcome, were collected. Clinical outcome was assessed using a modified Rankin Scale, six months after onset. Univariate analysis and multivariate logistic regression analysis were performed to determine predictors of a poor outcome. Results Conservative treatnaent was performed for five patients （9.3%）, external ventricular drainage （EVD） for 20 patients （37.0%）, THD for four patients （7.4%）, and EVD combined with THD for 25 patients （46.3%）. At six months after onset, 21 （38.9%） patients achieved a favorable outcome, while 33 （61.1%） had a poor outcome. In the univariate analysis, predictors of poor 6-month outcome were lower GCS on admis- sion （P = 0.001）, larger hematoma volume （P 〈 0.001）, midline shift （P = 0.035）, acute hydrocephalus （P = 0.039）, and no THD （P = 0.037）. The independent predictors of poor outcome, according to the multivariate logistic regression analysis, were no THD and larger hematoma volume. Conclusions Minimally invasive THD, which removes most of the hematoma within a few days, with limited damage to perihematomal brain tissue, improved the 6-month outcome of thalamic hemorrhage. Thus, THD can be widely applied to treat patients with thalamic hemorrhage.

Short-term effect and long-term prognosis of neuroendoscopic minimally invasive surgery for hypertensive int-racerebral hemorrhage

BACKGROUND Hypertensive intracerebral hemorrhage is a common critical disease of the nervous system,comprising one fifth of all acute cerebrovascular diseases and has a high disability and mortality rate.It severely affects the patients’quality of life.AIM To analyze the short-term effect and long-term prognosis of neuroendoscopic minimally invasive surgery for hypertensive intracerebral hemorrhage.METHODS From March 2018 to May 2020,118 patients with hypertensive intracerebral hemorrhage were enrolled in our study and divided into a control group and observation group according to the surgical plan.The control group used a hard-channel minimally invasive puncture and drainage procedure.The observation group underwent minimally invasive neuroendoscopic surgery.The changes in the levels of serum P substances(SP),inflammatory factors[tumor necrosis factor-α,interleukin-6(IL-6),IL-10],and the National Hospital Stroke Scale(NIHSS)and Barthel index scores were recorded.Surgery related indicators and prognosis were compared between the two groups.RESULTS The operation time(105.26±28.35)of the observation group was min longer than that of the control group,and the volume of intraoperative bleeding was 45.36±10.17 mL more than that of the control group.The hematoma clearance rates were 88.58%±4.69%and 94.47%±4.02%higher than those of the control group at 48 h and 72 h,respectively.Good prognosis rate(86.44%)was higher in the observation group than in the control group,and complication rate(5.08%)was not significantly different from that of the control group(P>0.05).The SP level and Barthel index score of the two groups increased(P<0.05)and the inflam-matory factors and NIHSS score decreased(P<0.05).The cytokine levels,NIHSS score,and Barthel index score were better in the observation group than in the control group(P<0.05).CONCLUSION Neuroendoscopic minimally invasive surgery is more complicated than hard channel minimally invasive puncture drainage in the treatment of hypertensive intracerebral hemorrhage;however,hematoma clearance is more thorough,and the short-term effect and long-term prognosis are better than hard channel minimally invasive puncture drainage.

注射体积对老年患者中等量基底节区脑出血微创穿刺术后临床疗效的影响

目的探讨药物总量控制下注射体积对老年患者中等量基底节区脑出血微创穿刺术后临床疗效的影响。方法以血肿最大层面长轴中心点为穿刺点,CT引导穿刺,穿刺成功后抽吸液态血肿,控制血肿腔内单次尿激酶总量4.0×10^(4)U,注射体积分别为2 mL和4 mL,根据术后CT结果调整针体深度,并根据血肿清除情况拔针。比较两组术后血肿清除率、颅内压、血肿周围水肿体积、总死亡率、并发症发生率、神经功能缺失评分(neurological deficit score,NDS)和日常生活能力评定(activities of daily living,ADL)结果。结果两组患者术后首次血肿清除率(31.17%±1.46%vs.30.50%±1.69%)、术后颅内压、总死亡率无明显差异(P均>0.05)。大体积组术后1 d(77.30%±3.75%vs.62.77%±3.89%),2 d(91.43%±4.05%vs.80.12%±4.15%),拔针前(92.35%±4.83%vs.85.9%±3.59%)血肿清除率明显高于小体积组(P<0.05)。大体积组留针时间(1.8 d±0.2 d vs.3.1 d±0.4 d,P<0.05)、尿激酶总用量(24.3×10^(4)U±2.3×10^(4)U vs.36.5×10^(4)U±4.7×10^(4)U,P<0.05)均少于小体积组(P<0.05)。大体积组术后3 d(11.33 mL±2.32 mL vs.16.45 mL±1.97 mL)、5 d(14.59 mL±2.11 mL vs.21.37 mL±2.43 mL)、7 d(22.79 mL±3.15 mL vs.30.15 mL±4.04 mL)、14 d(12.41 mL±1.95 mL vs.19.38 mL±2.47 mL)血肿周围水肿体积少于小体积组(P<0.05)。大体积组术后28 d、3个月、6个月NDS[分别为(22.35±2.49 vs.28.14±2.95)、(16.43±2.17 vs.23.81±2.56)、(11.39±1.87 vs.17.74±2.03)]及ADL评分[分别为(44.76±4.22 vs.36.15±2.36)、(62.55±3.81 vs.51.39±2.45)、(77.53±3.76 vs.60.81±4.35)]优于小体积组(P<0.05)。大体积组术后并发症发生率低于小体积组(P<0.05)。结论大体积注射法能更有效引流血肿,缩短留针时间,减少尿激酶用量,降低术后并发症发生率,改善患者预后,是老年中等量基底节区脑出血微创穿刺术后提高疗效的有效方法。

微创血肿清除术与传统开颅手术在脑出血治疗中的疗效及安全性比较

目的对比微创血肿清除术和传统开颅手术治疗脑出血的疗效及安全性差异。方法选取67例经传统开颅手术治疗的脑出血患者作为对照组,另外将经微创血肿清除术治疗的66例脑出血患者作为观察组。对比两组患者的临床疗效、手术指标(手术时间、术中出血量、术后引流时间、术后清醒时间、住院时间)、康复指标[美国国立卫生研究院卒中量表(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分]、并发症发生率。结果观察组的临床疗效明显优于对照组,差异有统计学意义(Z=2.7311,P<0.05)。观察组的手术时间、术后引流时间、术后清醒时间、住院时间分别为(5.54±1.05)h、(2.19±0.42)d、(5.76±1.09)d、(21.63±4.11)d,明显比对照组的(6.94±1.32)h、(3.58±0.68)d、(6.94±1.32)d、(23.95±4.55)d短,术中出血量(23.85±4.53)ml明显比对照组的(57.85±10.99)ml少,差异有统计学意义(P<0.05)。治疗后3个月,两组的NIHSS评分、GCS评分均低于治疗后1周,且观察组的NIHSS评分(6.62±1.29)分、GCS评分(3.18±0.62)分比对照组的(7.24±1.40)、(3.92±0.76)分低,差异有统计学意义(P<0.05)。观察组的并发症发生率(7.58%)明显比对照组(23.88%)低,差异有统计学意义(P<0.05)。结论相比传统开颅手术,对脑出血患者通过微创血肿清除术治疗能在确保安全的基础上提升疗效,优化手术指标,提升康复质量,值得推荐。

两种手术方式治疗高血压脑出血患者的临床效果及复发因素探讨

目的 探讨微创穿刺血肿引流术(MIPHD)与开颅血肿清除术治疗高血压脑出血(HICH)的效果以及复发的危险因素。方法 80例HICH患者根据治疗方案的不同分为MIPHD组和开颅手术组,比较两组的治疗效果和临床指标,分析影响HICH患者复发的危险因素。结果 治疗后,两组的NIHSS评分均显著低于治疗前(P <0.05)。Logistic回归分析显示,入院SBP、出血量、凝血机制异常是影响HICH患者术后复发的危险因素(P <0.05)。结论 微创穿刺血肿引流术和开颅血肿清除术均可改善HICH患者的神经缺损程度,对于术前SBP过高、出血量偏大、凝血机制异常的患者,应警惕术后HICH的复发。

清震汤加减联合微创血肿清除术治疗高血压脑出血临床研究

目的:观察清震汤加减联合微创血肿清除术治疗高血压脑出血的治疗效果。方法:抽取98例高血压脑出血患者为研究对象,按照随机数字表法分为试验组和对照组各49例。对照组行微创血肿清除术,术后给予西医常规治疗,试验组在对照组基础上联合清震汤加减治疗。比较2组颅内压(ICP)、美国国立卫生院卒中量表(NIHSS)评分与格拉斯哥昏迷指数(GCS),脑水肿体积和持续时间,血清肿瘤坏死因子-α(TNF-α)、神经生长因子(NGF)、基质金属蛋白酶-9(MMP-9)水平及中医证候评分。结果:术前,2组ICP值比较,差异无统计学意义(P>0.05);术后即刻及24 h、72 h、1周,试验组相同时间点的ICP值均低于对照组(P<0.05)。术前,2组NIHSS、GCS指数评分比较,差异无统计学意义(P>0.05);术后14 d,试验组NIHSS评分低于对照组(P<0.05),GCS指数高于对照组(P<0.05)。术后,试验组脑水肿体积、脑水肿持续时间低于对照组,差异有统计学意义(P<0.05)。术前,2组血清TNF-α、MMP-9、NGF水平比较,差异无统计学意义(P>0.05)。术后14 d,2组血清TNF-α、MMP-9水平较术前下降(P<0.05),血清NGF水平较术前上升(P<0.05);且试验组血清TNF-α、MMP-9水平低于对照组(P<0.05),NGF水平高于对照组(P<0.05)。术前,2组半身不遂、口眼歪斜、神志昏蒙等中医证候评分比较,差异无统计学意义(P>0.05);术后14 d,试验组上述各项中医证候评分均低于对照组(P<0.05)。结论:微创血肿清除术联合清震汤加减治疗高血压脑出血可降低ICP,减轻卒中症状和昏迷指数,减轻脑水肿,改善中医证候及炎症反应。

TRAIL及CD64表达与脑出血微创血肿穿刺引流术后颅内感染的相关性

目的探讨脑出血微创血肿穿刺引流术后患者血清和脑脊液中的肿瘤坏死因子相关的诱导凋亡的配体(TRAIL)及IgGFc受体Ⅰ(CD64)表达水平与术后颅内感染的相关性。方法回顾性分析2019年1月至2020年12月在信阳市人民医院神经外科接受脑出血微创血肿穿刺引流术治疗的70例患者的临床资料,根据术后是否发生颅内感染分为感染组(n=25)和非感染组(n=45)。比较两组患者的一般资料、临床特征、手术方式、手术时间、住院时间等。采用酶联免疫吸附法(ELISA)检测并比较两组患者术前、术后24h、48h、72h的血清和脑脊液中TRAIL及CD64的表达水平。采用Spearman相关系数法分析TRAIL及CD64的表达水平与各观察指标间的相关性。结果两组患者的一般资料比较差异均无统计学意义(P>0.05);感染组患者的手术时间和住院时间分别为(62.4±15.3)min、(18.6±4.7)d,明显长于非感染组的(54.8±12.6)min、(15.3±3.8)d,差异均有统计学意义(P<0.05);两组患者术后24 h、48 h、72 h血清和脑脊液中的TRAIL和CD64表达水平随着时间的延长呈上升趋势,且观察组明显高于非感染组,差异均有统计学意义(P<0.05);Spearman相关系数法分析结果显示,RAIL及CD64的表达水平与NIHSS评分、手术时间、引流管留置时间、住院时间、Hunt-Hess评分均呈正相关(r>0.4,P<0.05)。结论脑出血微创血肿穿刺引流术后患者血清和脑脊液中TRAIL及CD64的表达水平与NIHSS评分、手术时间、引流管留置时间、住院时间、Hunt-Hess评分密切相关,TRAIL及CD64可能作为颅内感染的早期预警和监测指标,为颅内感染的防治提供依据。

基于颅内压和血脑屏障指数评估软通道微创穿刺血肿清除术治疗高血压脑出血的疗效

目的 基于颅内压和血脑屏障指数评估软通道微创穿刺血肿清除术治疗高血压脑出血的疗效。方法 选取2019年2月至2021年9月联勤保障部队第九○四医院收治的78例高血压脑出血患者,按不同治疗方式分为对照组(n=35)与观察组(n=43)。对照组实施开颅血肿清除手术,观察组实施软通道微创穿刺血肿清除术。比较观察组和对照组手术相关指标(手术时间、术中出血量、引流时间)、颅内压变化、血脑屏障指数及疗效。结果 观察组手术时间和引流时间短于对照组,术中出血量少于对照组(P<0.05)。相对于手术结束时,术后24 h观察组和对照组颅内压均有所下降(P<0.05),且观察组手术结束时及术后24 h的颅内压均低于对照组(P<0.05)。术后观察组和对照组血脑屏障指数下降,且观察组低于对照组(P<0.05)。观察组患者有效率(93.02%)高于对照组(74.29%),差异有统计学意义(P<0.05)。结论 软通道微创穿刺血肿清除术可有效降低高血压脑出血患者颅内压水平与血脑屏障指数,疗效佳,且手术时间缩短、术中出血量减少,可作为临床高血压脑出血患者治疗的首选手段之一。

手术导航定位系统在高血压脑出血穿刺引流中的应用

目的:探讨老年高血压脑出血(HICH)患者应用神经外科手术导航定位系统辅助定位微创软通道血肿穿刺引流术治疗的临床价值,分析其安全性。方法:回顾性分析2023年1—10月黔西南州人民医院收治的86例老年(年龄≥60岁)HICH患者的临床资料,所有病例均有明确手术指征,且采用微创软通道血肿穿刺引流术。根据辅助定位方式进行分组,采用常规CT检查定位法的43例患者为对照组,采用RM-200型神经外科手术导航定位系统辅助定位的43例患者为观察组。比较两组手术时间、术中失血量、引流管拔除时间、血肿清除情况、美国国立卫生研究院卒中量表(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分、并发症发生情况。结果:观察组手术时间短于对照组,引流管拔除时间早于对照组,术中失血量少于对照组,差异均有统计学意义(P<0.05)。观察组NIHSS评分低于对照组,GCS评分高于对照组,并发症总发生率低于对照组,差异均有统计学意义(P<0.05)。术后1、3 d,观察组血肿清除率均高于对照组,差异均有统计学意义(P<0.05);术后5d,两组血肿清除率差异无统计学意义(P>0.05)。结论:在老年HICH患者行微创软通道血肿穿刺引流术治疗中,采用手术导航定位系统辅助定位能够提高手术效率,改善短期内血肿清除情况,降低术中失血量与术后并发症发生风险,且对患者昏迷症状、神经功能损伤的早期改善也有积极影响。

重症脑出血微创颅内血肿清除引流手术的护理配合及结局观察

目的:探析重症脑出血患者行微创颅内血肿清除引流术的护理配合方法。方法:选取2022—2023年聊城市人民医院收治的150例行微创颅内血肿清除引流手术的重症脑出血患者,采用随机数表法将其分为对照组和研究组,每组各75例。对照组患者术中予以常规护理配合,研究组患者术中在常规护理配合基础上予以加强护理配合,对比两组患者症状改善时间、ICU入住时间和并发症发生情况。结果:研究组患者症状改善时间为(4.01±1.09)d、ICU入住时间为(8.42±0.43)d,低于对照组患者的(6.38±1.70)d、(10.38±2.90)d,组间比较差异均有统计学意义(t值分别为10.164、5.790,P<0.05);研究组患者并发症发生率为2.67%,低于对照组(12.00%),差异有统计学意义(χ^(2)=4.807,P<0.05)。结论:在重症脑出血患者行微创颅内血肿清除引流手术过程中,加强护理配合,能够促进患者身体恢复,减少并发症发生。

早期颅内血肿微创清除术治疗轻中度基底核区高血压脑出血的临床效果分析

目的分析早期颅内血肿微创清除术应用在轻中度基底核区高血压脑出血(HICH)中的临床效果。方法80例轻中度的基底核区HICH患者,依据随机数字表法划分为研究组和对照组,每组40例。对照组采取保守方式治疗,研究组实施早期颅内血肿微创清除术治疗。对比两组治疗效果、神经功能评分、认知功能评分及并发症发生情况。结果研究组总有效率为95.00%,与对照组77.50%相比更优,差异具有统计学意义(P<0.05)。治疗前,两组神经功能评分对比,差异无统计学意义(P>0.05);治疗后,研究组神经功能评分(13.64±2.12)分比对照组的(19.74±5.26)分低,差异具有统计学意义(P<0.05)。研究组注意评分(5.71±0.43)分、命名评分(2.76±0.24)分、语言流畅评分(1.99±0.37)分、定向力评分(5.97±0.45)分、延迟记忆评分(2.96±0.33)分、抽象思维评分(1.65±0.33)分、视空间的执行能力评分(4.79±0.53)分、总分(23.85±5.47)分与对照组的(4.12±0.49)、(2.04±0.03)、(1.52±0.08)、(4.06±0.32)、(1.76±0.14)、(1.14±0.21)、(4.02±0.46)、(17.28±2.35)分相比更高,差异具有统计学意义(P<0.05)。研究组并发症发生率7.50%与对照组25.00%相比较低,差异具有统计学意义(P<0.05)。结论早期颅内血肿微创清除术应用在轻中度的基底核区HICH患者效果较好,可帮助患者更好地恢复其神经功能,帮助患者提升认知功能,降低术后并发症,能有效促进其早日康复,临床上值得推广使用。

微创血肿穿刺引流术与传统开颅血肿清除术用于治疗高血压脑出血的临床疗效对比分析

目的探讨微创血肿穿刺引流术与传统开颅血肿清除术用于治疗高血压脑出血的临床价值。方法选取2017年1月—2022年12月进行微创血肿穿刺引流术治疗的41例高血压脑出血患者作为微创组,选取同期进行传统开颅血肿清除术治疗的46例高血压脑出血患者作为开颅组,对两组患者血肿清除率、神经损伤情况、生活自理能力、生存质量及不良反应发生情况进行对比分析。结果两组间血肿清除率比较,差异无统计学意义(P>0.05),微创组不良反应发生率显著低于开颅组(P<0.05)。两组患者术前美国国立卫生研究院卒中量表(NIHSS)、日常生活活动能力(ADL)、健康调查简表(SF-36)评分比较,差异无统计学意义(P>0.05),术后NIHSS、ADL、SF-36评分均较术前显著改善(P<0.05),且术后各时间点微创组患者NIHSS、ADL、SF-36评分均显著优于开颅组(P<0.05)。结论与传统开颅血肿清除术相比,微创血肿穿刺引流术用于治疗高血压脑出血可显著降低术后并发症的发生,同时还可提升患者远期预后。

基于NIHSS评分探讨2种清除术治疗急性脑出血的临床效果

目的探讨软通道微创穿刺血肿清除术与开颅血肿清除术治疗急性脑出血的临床效果及对美国国立卫生研究院卒中量表(NIHSS)评分、术后并发症发生率的影响。方法回顾性分析75例急性脑出血患者的临床资料,按不同手术方式分为A组(行软通道微创穿刺血肿清除术,n=40)、B组(行开颅血肿清除术,n=35)。比较2组手术相关指标(住院时间、手术时间、出血量)、手术前后脑部血流动力学[动脉搏动指数(PI)、动脉平均流速(Vm)]、神经功能[中枢神经系统的特异性蛋白(S100β蛋白)、可溶性髓系细胞触发受体-1(sTREM-1)、神经特异性烯醇化酶(NSE)]、NIHSS和简易智能状态量表(MMSE)评分及术后并发症发生率。结果A组住院时间和手术时间短于B组,出血量少于B组(均P<0.001)。术后1、3个月,A组PI指数和NIHSS评分低于B组,Vm指标和MMSE评分高于B组(P<0.01或P<0.001)。术后1周,A组血清S100β蛋白、sTREM-1、NSE水平较B组低(P<0.05或P<0.001)。2组术后并发症发生率比较差异无统计学意义(2.50%比8.57%,P>0.05)。结论急性脑出血患者行软通道微创穿刺血肿清除术能加快脑部血流流速,改善认知能力,降低对神经功能损伤,缩短住院时间,促进患者早日康复。

高血压性脑出血患者微创颅内血肿清除术后发生再出血的影响因素分析

目的分析高血压性脑出血(HICH)患者微创颅内血肿清除术后发生再出血的相关影响因素。方法回顾性分析80例行微创颅内血肿清除术的HICH患者的临床资料,统计再出血发生率,采用单因素和多因素分析探讨术后再出血的危险因素。结果80例HICH患者术后再出血发生率为16.25%。单因素和多因素Logistic回归分析显示,术前舒张压>120 mm Hg、术前收缩压>200 mm Hg、术前GCS评分≤8分、合并糖尿病、术前血肿量≥60 mL是HICH患者微创颅内血肿清除术后发生再出血的独立危险因素(P<0.05)。结论术前舒张压>120 mm Hg、术前收缩压>200 mm Hg、术前GCS评分≤8分、合并糖尿病、术前血肿量≥60 mL是HICH患者微创颅内血肿清除术后发生再出血的独立危险因素。

微创颅内血肿清除术在高血压性脑出血患者中的应用及对机体炎症、术后恢复的影响

目的研讨微创颅内血肿清除术(Minimally Invasive Removal of Intracranial Hematoma,MPST)对高血压性脑出血患者机体炎症、术后功能恢复的影响。方法方便选取2021年10月-2023年3月漳州正兴医院收治的84例高血压性脑出血患者为研究对象,采用随机对照原则分为对照组与观察组(42例/组)。对照组予以传统开颅手术处理,观察组予以MPST处理,比较两组手术基础性评估指标、机体炎症指标及术后恢复状况。结果观察组各项围术期基础指标较对照组均更优,差异有统计学意义(P均<0.05)。术后7 d,观察组机体3项炎症水平相较于对照组均更低,差异有统计学意义(P均<0.05)。术后6个月,观察组日常生活能力得分较对照组明显更高,差异有统计学意义(P<0.05)。术后6个月,观察组神经缺损状况得分为(10.21±2.05)分较对照组的(14.29±2.87)分更低,差异有统计学意义(t=7.496,P<0.001)。结论对高血压性脑出血患者实施MPST治疗效果显著,并可促进机体炎症清除,加快术后功能恢复。

医护一体化护理干预在早期微创钻孔引流术治疗硬膜下血肿中的应用

目的探讨医护一体化护理干预对早期微创钻孔引流术治疗硬膜下血肿的意义。方法随机选取2020年6月—2023年6月于扬州大学医学院附属兴化市人民医院就诊的硬膜下血肿接受微创钻孔引流术治疗的患者60例,利用随机数表法分为对照组和观察组,每组30例。对照组采取常规护理干预,观察组采取医护一体化护理干预。对比两组患者负面情绪和护理满意率。结果护理后,两组患者负面情绪分数均降低,且观察组各项评分均低于对照组,差异有统计学意义(P<0.05)。护理后观察组患者满意率为96.67%,显著高于对照组的76.67%,差异有统计学意义(χ^(2)=5.192,P<0.05)。结论医护一体化护理干预对改善微创钻孔引流术治疗硬膜下血肿患者的负面情绪效果显著,可促进患者术后恢复,安全性更高。