The stability constants of some ternary mixed-ligand complexes, Pt(Phen)(CA)+, where Phen=1,10-phenanthroline and CA- =carboxylate, were determined by means of potentiometric pH titration in aqueous solutions(I=0.1 mo...The stability constants of some ternary mixed-ligand complexes, Pt(Phen)(CA)+, where Phen=1,10-phenanthroline and CA- =carboxylate, were determined by means of potentiometric pH titration in aqueous solutions(I=0.1 mol/L, KNO 3; 25 ℃), and the stability of them was compared with that of the corresponding binary complexes. It was revealed that the ternary complexes containing phenylalkane carboxylates ligands(PCA-) are much more stable than those formed with formate and acetate. The results indicate that there exist the intramolecular aromatic-ring interactions between the phenanthroline ring of Phen and the phenyl moiety of ligand PCA- in the ternary mixed-ligand Pt(Phen)(PCA)- complexes. The extent of the stacking interactions, which depends on the number of methylene groups between the phenyl moieties and the coordinated phenylalkane carboxylate groups, was calculated. The best-fitted stack was obtained for the complexes with 2-phenylacetate and 3-phenylpropionate as the ligands.展开更多
The complexes [Pt2L2（μ-dppm）]（ClO4）2 （1） and {[Pt2L2（μ-dppm）Li（CH3CN）2]（ClO4）3}n （2）, where HL is 6-[4-（diethoxyphosphorylmethyl）phenyl]-2,2′-bipyridinyl and dppm is bis（diphenylphosphino）methane,...The complexes [Pt2L2（μ-dppm）]（ClO4）2 （1） and {[Pt2L2（μ-dppm）Li（CH3CN）2]（ClO4）3}n （2）, where HL is 6-[4-（diethoxyphosphorylmethyl）phenyl]-2,2′-bipyridinyl and dppm is bis（diphenylphosphino）methane, have been synthesized and characterized. In complex 1 the platinum（Ⅱ） center adopts a distorted square planar coordination geometry. The polymer 2 exhibits a ＂stairstep＂ configuration with one-dimensional Pt（Ⅱ）N^N^CPO- Li（Ⅰ）-OPC^N^ NPt（Ⅱ） mixed-metal units which are linked through dppm. Both complexes have metal-metal interaction with Pt- Pt distances of 3.325（2） and 3.1432（9） A, respectively, and display strong metal-metal-to-ligand charge-transfer （MMLCT） triplet state emission. The density-functional-theory calculation was used to interpret the absorption spectra of the complexes.展开更多
Complexes of the type [Pt? (CH3NH2)(NH3){(OOC)2(CH2)n}] (Ⅰ～Ⅲ )(n=0,1,2) have been synthesized for the first time. At the same time, the three precursor complexes also have been synthesized. They were characterized ...Complexes of the type [Pt? (CH3NH2)(NH3){(OOC)2(CH2)n}] (Ⅰ～Ⅲ )(n=0,1,2) have been synthesized for the first time. At the same time, the three precursor complexes also have been synthesized. They were characterized by elemental analyses, molar conductance, differential thermal analyses and spectral (IR, UV, 1H NMR) studies. In vitro antitumor activity results indicated that these complexes have activity against HL 60 and U937, but show poor activity against K562.展开更多
The stability constants of the ternary mixed ligand complexes Pt(Phen)(CA) +(Phen=1,10 Phenanathroline,CA=carboxylate Ligands) were determined by potentiometric pH titration in aqueous solution and in 30～90%(V/V) aqu...The stability constants of the ternary mixed ligand complexes Pt(Phen)(CA) +(Phen=1,10 Phenanathroline,CA=carboxylate Ligands) were determined by potentiometric pH titration in aqueous solution and in 30～90%(V/V) aqueous ethanal(I=0.1mol·L -1 ,KNO 3;25℃).The difference of stability among the different complexes was compared and discussed,and the percentages of the stacked isomers in the ternary mixed ligand complexes Pt(Phen)(PCA) +(PCA=2 phenylacetate and 3 phenylpropionate) was calculated.The experimental results indicate that the extent of the intramolecular aromatic ring stacking interaction in the ternary mixed ligand Pt(Phen)(PCA) + complexes depends on the polarity of the solution.The weaker the polarity of the solution,the more notable the intramolecular aromatic ring stacking interaction,the larger the percentage of the stacked isomers in the ternary complexes,and the more stable the ternary mixed ligand complexes.展开更多
基金Supported by the Foundation of Academ y L eader of Zhejiang Gongshang U niversity(No.19972 0 0 2 )
文摘The stability constants of some ternary mixed-ligand complexes, Pt(Phen)(CA)+, where Phen=1,10-phenanthroline and CA- =carboxylate, were determined by means of potentiometric pH titration in aqueous solutions(I=0.1 mol/L, KNO 3; 25 ℃), and the stability of them was compared with that of the corresponding binary complexes. It was revealed that the ternary complexes containing phenylalkane carboxylates ligands(PCA-) are much more stable than those formed with formate and acetate. The results indicate that there exist the intramolecular aromatic-ring interactions between the phenanthroline ring of Phen and the phenyl moiety of ligand PCA- in the ternary mixed-ligand Pt(Phen)(PCA)- complexes. The extent of the stacking interactions, which depends on the number of methylene groups between the phenyl moieties and the coordinated phenylalkane carboxylate groups, was calculated. The best-fitted stack was obtained for the complexes with 2-phenylacetate and 3-phenylpropionate as the ligands.
文摘The complexes [Pt2L2（μ-dppm）]（ClO4）2 （1） and {[Pt2L2（μ-dppm）Li（CH3CN）2]（ClO4）3}n （2）, where HL is 6-[4-（diethoxyphosphorylmethyl）phenyl]-2,2′-bipyridinyl and dppm is bis（diphenylphosphino）methane, have been synthesized and characterized. In complex 1 the platinum（Ⅱ） center adopts a distorted square planar coordination geometry. The polymer 2 exhibits a ＂stairstep＂ configuration with one-dimensional Pt（Ⅱ）N^N^CPO- Li（Ⅰ）-OPC^N^ NPt（Ⅱ） mixed-metal units which are linked through dppm. Both complexes have metal-metal interaction with Pt- Pt distances of 3.325（2） and 3.1432（9） A, respectively, and display strong metal-metal-to-ligand charge-transfer （MMLCT） triplet state emission. The density-functional-theory calculation was used to interpret the absorption spectra of the complexes.
文摘Complexes of the type [Pt? (CH3NH2)(NH3){(OOC)2(CH2)n}] (Ⅰ～Ⅲ )(n=0,1,2) have been synthesized for the first time. At the same time, the three precursor complexes also have been synthesized. They were characterized by elemental analyses, molar conductance, differential thermal analyses and spectral (IR, UV, 1H NMR) studies. In vitro antitumor activity results indicated that these complexes have activity against HL 60 and U937, but show poor activity against K562.
文摘The stability constants of the ternary mixed ligand complexes Pt(Phen)(CA) +(Phen=1,10 Phenanathroline,CA=carboxylate Ligands) were determined by potentiometric pH titration in aqueous solution and in 30～90%(V/V) aqueous ethanal(I=0.1mol·L -1 ,KNO 3;25℃).The difference of stability among the different complexes was compared and discussed,and the percentages of the stacked isomers in the ternary mixed ligand complexes Pt(Phen)(PCA) +(PCA=2 phenylacetate and 3 phenylpropionate) was calculated.The experimental results indicate that the extent of the intramolecular aromatic ring stacking interaction in the ternary mixed ligand Pt(Phen)(PCA) + complexes depends on the polarity of the solution.The weaker the polarity of the solution,the more notable the intramolecular aromatic ring stacking interaction,the larger the percentage of the stacked isomers in the ternary complexes,and the more stable the ternary mixed ligand complexes.
