The interaction of cationic gemini surfactants(alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug(chlorpromazine hydrochloride(CPZ)) has been investigated. Various micellar and interfacia...The interaction of cationic gemini surfactants(alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug(chlorpromazine hydrochloride(CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures.The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV–visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.展开更多
Among the popular mixed drugs in China,the oral solution shenxianshui and the floury drug milk tea have recently emerged.In 2014,123 bags of milk tea included in 14 cases were tested qualitatively and quantitatively,a...Among the popular mixed drugs in China,the oral solution shenxianshui and the floury drug milk tea have recently emerged.In 2014,123 bags of milk tea included in 14 cases were tested qualitatively and quantitatively,and the test results provided a basis for drug detection,prosecution,and sentencing.More than two drug components were detected in milk tea,which was characterized as a fragrant beige,yellow,or brown powder.The detection rates of methylamphetamine(MA),3,4-methylenedioxymethamphetamine(MDMA),and ketamine in milk tea were 36.6%,50.4%,and 76.4%,respectively,and the concentrations of MA,MDMA,and ketamine were 0.2-5.1,3.2-30.1,and 0.8-176.3 mg/g,respectively,in quantitative testing.展开更多
基金Chemistry Department and Centre of Excellence for Advanced Materials Research, King Abdulaziz University
文摘The interaction of cationic gemini surfactants(alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug(chlorpromazine hydrochloride(CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures.The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV–visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.
文摘Among the popular mixed drugs in China,the oral solution shenxianshui and the floury drug milk tea have recently emerged.In 2014,123 bags of milk tea included in 14 cases were tested qualitatively and quantitatively,and the test results provided a basis for drug detection,prosecution,and sentencing.More than two drug components were detected in milk tea,which was characterized as a fragrant beige,yellow,or brown powder.The detection rates of methylamphetamine(MA),3,4-methylenedioxymethamphetamine(MDMA),and ketamine in milk tea were 36.6%,50.4%,and 76.4%,respectively,and the concentrations of MA,MDMA,and ketamine were 0.2-5.1,3.2-30.1,and 0.8-176.3 mg/g,respectively,in quantitative testing.
