The traditional spheroidal kernel results in the spectrum leakage,and the utilization rate of the removed degrees of the measured data is low.Hence,a kind of spheroidal kernel whose high-and low-degrees are both modif...The traditional spheroidal kernel results in the spectrum leakage,and the utilization rate of the removed degrees of the measured data is low.Hence,a kind of spheroidal kernel whose high-and low-degrees are both modified is introduced in this research,which is exampled by the Hotine kernel.In addition,the low-degree modified spheroidal kernel is proposed.Either cosine or linear modification factors can be utilized.The modified kernel functions can effectively control the spectrum leakage compared with the traditional spheroidal kernel.Furthermore,the modified kernel augments the contribution rate of the measured data to height anomaly in the modified frequency domain.The experimental results show that the accuracy of the quasi-geoid by the cosine or linear low-degree modified kernel is higher than that by the traditional spheroidal kernel.And the accuracy equals the accuracy of the quasi-geoid using the spheroidal kernel with high-and low-degrees modified approximately when the low-degree modification bandwidths of these two kinds of kernels are the same.Since the computational efficiency of the low-degree modified kernel is much higher,the low-degree modified kernel behaves better in constructing the(quasi-)geoid based on Stokes-Helmert or Hotine-Helmert boundary-value theory.展开更多
This study is one of the first to focus on the unexpected drug leakage from discoidal recombinant high-density lipoproteins(d-rHDLs)as a consequence of remodeling process,mainly associated with lecithin-cholesterol ac...This study is one of the first to focus on the unexpected drug leakage from discoidal recombinant high-density lipoproteins(d-rHDLs)as a consequence of remodeling process,mainly associated with lecithin-cholesterol acyltransferase(LCAT)during their metabolic process.Here,a newly monocholesterylsuccinate(CHS)modified paclitaxel-loaded drHDLs(cP-d-rHDLs)were constructed successfully through structural modification,thus aiming to improve the performance of d-rHDLs.And next their in vitro physiochemical properties and pharmacokinetics in SpragueeDawley rats were elaborately investigated.Collectively our studies demonstrated that cP-d-rHDLs,whose remodeling behaviors were restrained effectively after structural modification,exhibited more excellent and promising properties as novel delivery vehicles for anti-cancer agents.展开更多
基金National Natural Science Foundation of China(Nos.41674025,41674082)Open Research Foundation of State Key Laboratory of Geo-information Engineering(Nos.SKLGIE2016-M-1-5,SKLGIE2018-ZZ-10)。
文摘The traditional spheroidal kernel results in the spectrum leakage,and the utilization rate of the removed degrees of the measured data is low.Hence,a kind of spheroidal kernel whose high-and low-degrees are both modified is introduced in this research,which is exampled by the Hotine kernel.In addition,the low-degree modified spheroidal kernel is proposed.Either cosine or linear modification factors can be utilized.The modified kernel functions can effectively control the spectrum leakage compared with the traditional spheroidal kernel.Furthermore,the modified kernel augments the contribution rate of the measured data to height anomaly in the modified frequency domain.The experimental results show that the accuracy of the quasi-geoid by the cosine or linear low-degree modified kernel is higher than that by the traditional spheroidal kernel.And the accuracy equals the accuracy of the quasi-geoid using the spheroidal kernel with high-and low-degrees modified approximately when the low-degree modification bandwidths of these two kinds of kernels are the same.Since the computational efficiency of the low-degree modified kernel is much higher,the low-degree modified kernel behaves better in constructing the(quasi-)geoid based on Stokes-Helmert or Hotine-Helmert boundary-value theory.
基金This study is financially supported by National Science Foundation Grant of China(No.81072587)Jiangsu Province Ordinary College and University Innovative Research Programs(No.CXZZ110805)+1 种基金the Major Project of National Science and Technology of China for New Drugs Development(No.2009ZX09310-004)the Special Found Project of Universities’Basic Scientific Research of Central Authorities(No.ZJ11253).
文摘This study is one of the first to focus on the unexpected drug leakage from discoidal recombinant high-density lipoproteins(d-rHDLs)as a consequence of remodeling process,mainly associated with lecithin-cholesterol acyltransferase(LCAT)during their metabolic process.Here,a newly monocholesterylsuccinate(CHS)modified paclitaxel-loaded drHDLs(cP-d-rHDLs)were constructed successfully through structural modification,thus aiming to improve the performance of d-rHDLs.And next their in vitro physiochemical properties and pharmacokinetics in SpragueeDawley rats were elaborately investigated.Collectively our studies demonstrated that cP-d-rHDLs,whose remodeling behaviors were restrained effectively after structural modification,exhibited more excellent and promising properties as novel delivery vehicles for anti-cancer agents.
