A 68-years old woman presented with ahistory of recurrent fever of 38-39°ac-companied by chills and weakness over the past month.Her physical examination was unremarkable except for an audible 3/6 ejection murmur...A 68-years old woman presented with ahistory of recurrent fever of 38-39°ac-companied by chills and weakness over the past month.Her physical examination was unremarkable except for an audible 3/6 ejection murmur at the 2nd right intercostal space.Her vital signs were normal with no fever at presentation.Laboratory tests showed elevated white blood count of 11,800cells/mm3 with a remarkable neutrophilia and elevated C-reactive protein of 14 mg/dL.Blood glucose,renal and liver function tests were all normal.展开更多
Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters accordi...Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems.展开更多
During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the s...During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis results.To elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget analysis.The findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern Pacific.This increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective instability.Such a process is pivotal in amplifying intraseasonal convection anomalies.The observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.展开更多
Researchers in computer science and computer engineering devote a significant part of their efforts on communication and interaction between man and machine. Indeed, with the advent of multimedia and multimodal proces...Researchers in computer science and computer engineering devote a significant part of their efforts on communication and interaction between man and machine. Indeed, with the advent of multimedia and multimodal processing in real time, the computer is no longer considered only as a computational tool, but as a machine for processing, communication, collection and control. Many machines assist and support many activities in daily life. The main objective of this paper is to propose a new methodological solution by modeling an architecture that facilitates the work of multimodal system especially for a fission module. To realize such systems, we rely on ontology to integrate data semantically. Ontologies provide a structured vocabulary usedas support for data representation. This paper provides a better understanding of the fission system and multimodal interaction. We present our architecture and the description of the detection of optimal modalities. This is done by using an ontological model that contains different applicable scenarios and describes the environment where a multimodal system exists.展开更多
A self-normalized statistic the modified modal scintillation index MMSI is proposed and defined as the variance of the modulus of modal excitation normalized by the square of its expected value over some observation i...A self-normalized statistic the modified modal scintillation index MMSI is proposed and defined as the variance of the modulus of modal excitation normalized by the square of its expected value over some observation intervals.It is proved in an analytical form that the MMSI is a depth dependent signature and independent of the source level and the source range under the condition of the ideal waveguide while the classical modal scintillation index MSI depends on both the source level and the source range.The MSI and the MMSI in the Pekeris waveguide at 70 Hz are simulated with different source levels and source ranges by the Kraken normal mode model.The simulation results are consistent with the theoretical deduction.The MMSI probability density functions PDFs of different normal modes for surface and submerged sources are calculated using the mode filtering methods with the same variations of vertical motions.It is indicated that the PDFs can be used to separate the submerged and the surface sources except for the fourth mode.展开更多
This paper aims at examing how modality values are realized in native and non-native English news reporting and comparing the values they each take.By analyzing,the writer hopes to contribute to the awareness of forei...This paper aims at examing how modality values are realized in native and non-native English news reporting and comparing the values they each take.By analyzing,the writer hopes to contribute to the awareness of foreign language learners in terms of the importance of modality values in news analysis and make readers benefit from their reading,writing.展开更多
Modality is used to express subjective judgment as well as the speaker’s opinions and attitudes.This paper aims to analyze the reporters’orientation reflected by linguistic modal expressions in English news reports ...Modality is used to express subjective judgment as well as the speaker’s opinions and attitudes.This paper aims to analyze the reporters’orientation reflected by linguistic modal expressions in English news reports from the perspective of Systemic-Functional Grammar,especially from the perspective of type,value,orientation and polarity.展开更多
Although the current standard treatment for hepatocellular carcinoma(HCC) with portal vein tumor thrombosis(PVTT) is sorafenib, many previous studies have established the need for a reliable local modality for PVTT co...Although the current standard treatment for hepatocellular carcinoma(HCC) with portal vein tumor thrombosis(PVTT) is sorafenib, many previous studies have established the need for a reliable local modality for PVTT control, which is a major cause of liver function deterioration and metastasis. Additionally, there is growing evidence for the prognostic significance of PVTT classification according to the location of tumor thrombosis. Favorable outcomes can be obtained by applying local modalities, including surgery or transarterial chemoembolization, especially in second-order or distal branch PVTT. Rapid control of PVTT could maintain or improve liver function and reduce intrahepatic as well as distant metastasis. Radiotherapy(RT) is one of the main locoregional treatment modalities in oncologic fields, but has rarely been used in HCC because of concerns regarding hepatic toxicity. However, with the development of advanced techniques, RT has been increasingly applied in HCC management. Randomized studies have yet to definitively prove the benefit of RT, but several comparative studies have justified the application of RT in HCC. The value of RT is especially noticeable in HCC with PVTT; several prospective and retrospective studies have reported favorable outcomes, including a 40% to 60% objective response rate and median overall survival of 15 mo to 20 mo in responders. In this review, we evaluate the role of RT as an alternative local modality in HCC with PVTT.展开更多
AIM: To compare the therapeutic effect and significances of multimodality treatment for hepatocellular carcinoma (HCC) with tumor thrombi in portal vein (PVTT). METHODS: HCC patients (n=147) with tumor thrombi in the ...AIM: To compare the therapeutic effect and significances of multimodality treatment for hepatocellular carcinoma (HCC) with tumor thrombi in portal vein (PVTT). METHODS: HCC patients (n=147) with tumor thrombi in the main portal vein or the first branch of portal vein were divided into four groups by the several therapeutic methods. There were conservative treatment group in 18 out of patients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAI) group in 18 patients (group B), in whom postoperative chemoembolization was done periodically; group of removal of HCC with PVTT in 79 (group C) and group of transcatheter hepatic arterial chemoembolization (TACE) or HAI and/or portal vein infusion (PVI) after operation in 32 (group D). RESULTS: The median survival period was 12 months in our series and the 1-,3-, and 5-year survival rates were 44.3%, 24.5% and 15.2%, respectively. The median survival times were 2, 5, 12 and 16 months in group A, B, C and D, respectively. The 1-, 3- and 5-year survival rates were 5.6%, 0% and 0% in group A; 22.2%, 5.6% and 0% in group B; 53.9%, 26.9% and 16.6% in group C; 79.3%, 38.9% and 26.8% in group D, respectively. Significant difference appeared in the survival rates among the groups (P 【 0.05). CONCLUSION: Hepatic resection with removal of tumor thrombi and HCC should increase the curative effects and be encouraged for the prolongation of life span and quality of life for HCC patients with PVTT, whereas the best therapeutic method for HCC with PVTT is with regional hepatic chemotherapy or chemoembolization after hepatic resection with removal of tumor thrombi.展开更多
The ChatGPT,a lite and conversational variant of Generative Pretrained Transformer 4(GPT-4)developed by OpenAI,is one of the milestone Large Language Models(LLMs)with billions of parameters.LLMs have stirred up much i...The ChatGPT,a lite and conversational variant of Generative Pretrained Transformer 4(GPT-4)developed by OpenAI,is one of the milestone Large Language Models(LLMs)with billions of parameters.LLMs have stirred up much interest among researchers and practitioners in their impressive skills in natural language processing tasks,which profoundly impact various fields.This paper mainly discusses the future applications of LLMs in dentistry.We introduce two primary LLM deployment methods in dentistry,including automated dental diagnosis and cross-modal dental diagnosis,and examine their potential applications.Especially,equipped with a cross-modal encoder,a single LLM can manage multi-source data and conduct advanced natural language reasoning to perform complex clinical operations.We also present cases to demonstrate the potential of a fully automatic Multi-Modal LLM AI system for dentistry clinical application.While LLMs offer significant potential benefits,the challenges,such as data privacy,data quality,and model bias,need further study.Overall,LLMs have the potential to revolutionize dental diagnosis and treatment,which indicates a promising avenue for clinical application and research in dentistry.展开更多
The characteristics of the photonic crystal vertical cavity surface emitting lasers(PhC-VCSELs) were investigated by using the full vector finite-difference time-domain(FDTD) method through the transverse mode los...The characteristics of the photonic crystal vertical cavity surface emitting lasers(PhC-VCSELs) were investigated by using the full vector finite-difference time-domain(FDTD) method through the transverse mode loss analysis. PhC-VCSELs with different photonic crystal structures were analyzed theoretically and experimentally. Through combining the dual mode confinement of oxide aperture and seven-point-defect photonic crystal structure, the PhC-VCSELs with low threshold current of 0.9 mA and maximum output power of 3.1 mW operating in single fundamental mode were demonstrated. Mode loss analysis method was proven as a reliable and useful way to analyze and optimize the PhC-VCSELs.展开更多
A contact bolt model is proposed as a new modeling technique to investigate the complex structure with bolted joints for modal analysis and compared with the coupled bolt model, and the test results are given. Among t...A contact bolt model is proposed as a new modeling technique to investigate the complex structure with bolted joints for modal analysis and compared with the coupled bolt model, and the test results are given. Among these models, the coupled bolt model provides the best accurate responses compared with the experimental results. The contact bolt model shows the best effectiveness and usefulness in view of operational time. The bolt models proposed in this study are adopted for a dynamic characteristic analysis of a large diesel engine consisting of several parts which are connected by many bolts. The dynamic behavior of the entire engine structure was investigated by experiment. The coupled bolt model and the contact bolt model were applied to model the assembly of engine with high preload. The experimental results are in good agreement with the finite element method (FEM) results. Compared with the other models, the contact bolt model presented in this paper is more effective and useful in view of operational time and experience of analysts.展开更多
Stress-induced birefringence and modal birefringence of single-mode specialty optical fibers with three stress regions are numerically analyzed by the vector finite element method. Stress distribution and stress-induc...Stress-induced birefringence and modal birefringence of single-mode specialty optical fibers with three stress regions are numerically analyzed by the vector finite element method. Stress distribution and stress-induced birefringence distribution of three kinds of optical fibers with different cross structures are presented and compared, and the influence on the stress- induced birefringence by temperature change are analyzed as well. The results show that the fibers with three-stress regions have a lower linear birefringence, which is very important for the fabrication of the circular polaxization-maintalning fiber with high performance drawn from the same fiber preform by using the spinning method.展开更多
On the basis of a nonhydrostatic numerical model, the interaction of internal solitary wave with slope - shelf was studied. The breaking and polarity transformation were analyzed. A "kink" structure, due to shoaling...On the basis of a nonhydrostatic numerical model, the interaction of internal solitary wave with slope - shelf was studied. The breaking and polarity transformation were analyzed. A "kink" structure, due to shoaling topography and higher nonlinear effect, was found to be generated by the leading wave before breaking. Coherent vortex shedding behind the leading wave was presented. The evolution characteristics of the modal structure were analyzed based on the empirical orthogonal function method. The modal structure was complicated due to the effect of the variable topography, especially when breaking occurred. In the performed experiments, the contributions to the total variance from higher mode jumped from no more than 20% to over 40%.展开更多
There is a problem of unfairness in allocation of radio resources among heterogeneous mobile terminals in heterogeneous wireless networks. Low-capability mobile terminals (such as single-mode terminals) suffer high ca...There is a problem of unfairness in allocation of radio resources among heterogeneous mobile terminals in heterogeneous wireless networks. Low-capability mobile terminals (such as single-mode terminals) suffer high call blocking probability whereas high-capability mobile terminals (such as quad-mode terminals) experience very low call blocking probability, in the same heterogeneous wireless network. This paper proposes a Terminal-Modality-Based Joint Call Admission Control (TJCAC) algorithm to reduce this problem of unfairness. The proposed TJCAC algorithm makes call admission decisions based on mobile terminal modality (capability), network load, and radio access technology (RAT) terminal support index. The objectives of the proposed TJCAC algorithm are to reduce call blocking/dropping probability, and ensure fairness in allocation of radio resources among heterogeneous mobile terminals in heterogeneous networks. An analytical model is developed to evaluate the performance of the proposed TJCAC scheme in terms of call blocking/dropping probability in a heterogeneous wireless network. The performance of the proposed TJCAC algorithm is compared with that of other JCAC algorithms. Results show that the proposed algorithm reduces call blocking/dropping probability in the networks, and ensure fairness in allocation of radio resources among heterogeneous terminals.展开更多
BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI...BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI), iScan] facilitate the detection and classification of colonic polyps during endoscopic sessions. However, there are no comprehensive studies so far that analyze which endoscopic imaging modalities facilitate the automated classification of colonic polyps. In this work, we investigate the impact of endoscopic imaging modalities on the results of computer-assisted diagnosis systems for colonic polyp staging.AIM To assess which endoscopic imaging modalities are best suited for the computerassisted staging of colonic polyps.METHODS In our experiments, we apply twelve state-of-the-art feature extraction methods for the classification of colonic polyps to five endoscopic image databases of colonic lesions. For this purpose, we employ a specifically designed experimental setup to avoid biases in the outcomes caused by differing numbers of images per image database. The image databases were obtained using different imaging modalities. Two databases were obtained by high-definition endoscopy in combination with i-Scan technology(one with chromoendoscopy and one without chromoendoscopy). Three databases were obtained by highmagnification endoscopy(two databases using narrow band imaging and one using chromoendoscopy). The lesions are categorized into non-neoplastic and neoplastic according to the histological diagnosis.RESULTS Generally, it is feature-dependent which imaging modalities achieve high results and which do not. For the high-definition image databases, we achieved overall classification rates of up to 79.2% with chromoendoscopy and 88.9% without chromoendoscopy. In the case of the database obtained by high-magnification chromoendoscopy, the classification rates were up to 81.4%. For the combination of high-magnification endoscopy with NBI, results of up to 97.4% for one database and up to 84% for the other were achieved. Non-neoplastic lesions were classified more accurately in general than non-neoplastic lesions. It was shown that the image recording conditions highly affect the performance of automated diagnosis systems and partly contribute to a stronger effect on the staging results than the used imaging modality.CONCLUSION Chromoendoscopy has a negative impact on the results of the methods. NBI is better suited than chromoendoscopy. High-definition and high-magnification endoscopy are equally suited.展开更多
A technique to extract real modes from the identified complex modes is presented in this paper, which enables the normalized real mode shapes, modal masses, and full or reduced mass and stiffness matrices to be obtain...A technique to extract real modes from the identified complex modes is presented in this paper, which enables the normalized real mode shapes, modal masses, and full or reduced mass and stiffness matrices to be obtained. The theoretical derivation of the method is provided in detail. An 11-DOF vibration system is used to validate the algorithm, and to analyze the effects of the number of modes utilized and measurement DOFs on the extraction results. Finally, the method is used to extract real modes from both experimental modal analysis and operational modal analysis.展开更多
The effect of tire repeated root modal(RRM)on tire modeling with an experimental modal is studied.Firstly,a radial tire with radial and tangential RRMs is tested and analyzed.By multi-point exciting of the radial ti...The effect of tire repeated root modal(RRM)on tire modeling with an experimental modal is studied.Firstly,a radial tire with radial and tangential RRMs is tested and analyzed.By multi-point exciting of the radial tire,a multiple reference frequency domain method based on a least squares(LMS PolyMAX)algorithm is used to identify modal parameters.Then,modal stability diagram(MSD),modal indication function(MIF)and modal assurance criteria(Auto-MAC)matrix are utilized to induce multiple inputs multiple outputs(MIMO)frequency response function(FRF)matrixes.The tests reveal that notable repeated roots exist in both radial and tangential response modes.Their modal frequencies and damping factors are approximately the same,the amplitudes of modal vectors are in the same order of magnitude,and the mode shapes are orthogonal.Based on the works mentioned,the method of trigonometric series modal shapes fitting is adopted,the effects of RRM model on tire modeling with a vertical experimental modal are discussed.The final results show that the effects of considering the RRM shapes are equivalent to the tire mode shapes depended on rotating the tire’s different exciting points during tire modeling,and since considering the RRM,the tire mode shapes can be unified and fixed during tire modeling.展开更多
Modalclust is an R package which performs Hierarchical Mode Association Clustering (HMAC) along with its parallel implementation over several processors. Modal clustering techniques are especially designed to efficien...Modalclust is an R package which performs Hierarchical Mode Association Clustering (HMAC) along with its parallel implementation over several processors. Modal clustering techniques are especially designed to efficiently extract clusters in high dimensions with arbitrary density shapes. Further, clustering is performed over several resolutions and the results are summarized as a hierarchical tree, thus providing a model based multi resolution cluster analysis. Finally we implement a novel parallel implementation of HMAC which performs the clustering job over several processors thereby dramatically increasing the speed of clustering procedure especially for large data sets. This package also provides a number of functions for visualizing clusters in high dimensions, which can also be used with other clustering softwares.展开更多
文摘A 68-years old woman presented with ahistory of recurrent fever of 38-39°ac-companied by chills and weakness over the past month.Her physical examination was unremarkable except for an audible 3/6 ejection murmur at the 2nd right intercostal space.Her vital signs were normal with no fever at presentation.Laboratory tests showed elevated white blood count of 11,800cells/mm3 with a remarkable neutrophilia and elevated C-reactive protein of 14 mg/dL.Blood glucose,renal and liver function tests were all normal.
基金supported by the Innovation Foundation of Provincial Education Department of Gansu(2024B-005)the Gansu Province National Science Foundation(22YF7GA182)the Fundamental Research Funds for the Central Universities(No.lzujbky2022-kb01)。
文摘Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems.
基金supported by the National Natural Science Foundation of China [grant number 42088101]。
文摘During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis results.To elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget analysis.The findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern Pacific.This increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective instability.Such a process is pivotal in amplifying intraseasonal convection anomalies.The observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.
文摘Researchers in computer science and computer engineering devote a significant part of their efforts on communication and interaction between man and machine. Indeed, with the advent of multimedia and multimodal processing in real time, the computer is no longer considered only as a computational tool, but as a machine for processing, communication, collection and control. Many machines assist and support many activities in daily life. The main objective of this paper is to propose a new methodological solution by modeling an architecture that facilitates the work of multimodal system especially for a fission module. To realize such systems, we rely on ontology to integrate data semantically. Ontologies provide a structured vocabulary usedas support for data representation. This paper provides a better understanding of the fission system and multimodal interaction. We present our architecture and the description of the detection of optimal modalities. This is done by using an ontological model that contains different applicable scenarios and describes the environment where a multimodal system exists.
基金The National Natural Science Foundation of China(No.11104029)
文摘A self-normalized statistic the modified modal scintillation index MMSI is proposed and defined as the variance of the modulus of modal excitation normalized by the square of its expected value over some observation intervals.It is proved in an analytical form that the MMSI is a depth dependent signature and independent of the source level and the source range under the condition of the ideal waveguide while the classical modal scintillation index MSI depends on both the source level and the source range.The MSI and the MMSI in the Pekeris waveguide at 70 Hz are simulated with different source levels and source ranges by the Kraken normal mode model.The simulation results are consistent with the theoretical deduction.The MMSI probability density functions PDFs of different normal modes for surface and submerged sources are calculated using the mode filtering methods with the same variations of vertical motions.It is indicated that the PDFs can be used to separate the submerged and the surface sources except for the fourth mode.
文摘This paper aims at examing how modality values are realized in native and non-native English news reporting and comparing the values they each take.By analyzing,the writer hopes to contribute to the awareness of foreign language learners in terms of the importance of modality values in news analysis and make readers benefit from their reading,writing.
文摘Modality is used to express subjective judgment as well as the speaker’s opinions and attitudes.This paper aims to analyze the reporters’orientation reflected by linguistic modal expressions in English news reports from the perspective of Systemic-Functional Grammar,especially from the perspective of type,value,orientation and polarity.
基金Supported by Samsung Medical Center,No.GF01130081Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education,No.NRF-2015R1D1A1A01060945Marine Biotechnology Program Funded by Ministry of Oceans and Fisheries,Korea,No.20150220
文摘Although the current standard treatment for hepatocellular carcinoma(HCC) with portal vein tumor thrombosis(PVTT) is sorafenib, many previous studies have established the need for a reliable local modality for PVTT control, which is a major cause of liver function deterioration and metastasis. Additionally, there is growing evidence for the prognostic significance of PVTT classification according to the location of tumor thrombosis. Favorable outcomes can be obtained by applying local modalities, including surgery or transarterial chemoembolization, especially in second-order or distal branch PVTT. Rapid control of PVTT could maintain or improve liver function and reduce intrahepatic as well as distant metastasis. Radiotherapy(RT) is one of the main locoregional treatment modalities in oncologic fields, but has rarely been used in HCC because of concerns regarding hepatic toxicity. However, with the development of advanced techniques, RT has been increasingly applied in HCC management. Randomized studies have yet to definitively prove the benefit of RT, but several comparative studies have justified the application of RT in HCC. The value of RT is especially noticeable in HCC with PVTT; several prospective and retrospective studies have reported favorable outcomes, including a 40% to 60% objective response rate and median overall survival of 15 mo to 20 mo in responders. In this review, we evaluate the role of RT as an alternative local modality in HCC with PVTT.
基金Surported by the Funds of Hundred Outsdanding Persons project of Shanghai(97BR029)Science and Technology Commission of Shanghai(984419067)
文摘AIM: To compare the therapeutic effect and significances of multimodality treatment for hepatocellular carcinoma (HCC) with tumor thrombi in portal vein (PVTT). METHODS: HCC patients (n=147) with tumor thrombi in the main portal vein or the first branch of portal vein were divided into four groups by the several therapeutic methods. There were conservative treatment group in 18 out of patients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAI) group in 18 patients (group B), in whom postoperative chemoembolization was done periodically; group of removal of HCC with PVTT in 79 (group C) and group of transcatheter hepatic arterial chemoembolization (TACE) or HAI and/or portal vein infusion (PVI) after operation in 32 (group D). RESULTS: The median survival period was 12 months in our series and the 1-,3-, and 5-year survival rates were 44.3%, 24.5% and 15.2%, respectively. The median survival times were 2, 5, 12 and 16 months in group A, B, C and D, respectively. The 1-, 3- and 5-year survival rates were 5.6%, 0% and 0% in group A; 22.2%, 5.6% and 0% in group B; 53.9%, 26.9% and 16.6% in group C; 79.3%, 38.9% and 26.8% in group D, respectively. Significant difference appeared in the survival rates among the groups (P 【 0.05). CONCLUSION: Hepatic resection with removal of tumor thrombi and HCC should increase the curative effects and be encouraged for the prolongation of life span and quality of life for HCC patients with PVTT, whereas the best therapeutic method for HCC with PVTT is with regional hepatic chemotherapy or chemoembolization after hepatic resection with removal of tumor thrombi.
基金supported by the Research and Development Program,West China Hospital of Stomatology,Sichuan University(RD-02-202107)Sichuan Province Science and Technology Support Program(2022NSFSC0743)Sichuan Postdoctoral Science Foundation(TB2022005)grant to H.Huang.
文摘The ChatGPT,a lite and conversational variant of Generative Pretrained Transformer 4(GPT-4)developed by OpenAI,is one of the milestone Large Language Models(LLMs)with billions of parameters.LLMs have stirred up much interest among researchers and practitioners in their impressive skills in natural language processing tasks,which profoundly impact various fields.This paper mainly discusses the future applications of LLMs in dentistry.We introduce two primary LLM deployment methods in dentistry,including automated dental diagnosis and cross-modal dental diagnosis,and examine their potential applications.Especially,equipped with a cross-modal encoder,a single LLM can manage multi-source data and conduct advanced natural language reasoning to perform complex clinical operations.We also present cases to demonstrate the potential of a fully automatic Multi-Modal LLM AI system for dentistry clinical application.While LLMs offer significant potential benefits,the challenges,such as data privacy,data quality,and model bias,need further study.Overall,LLMs have the potential to revolutionize dental diagnosis and treatment,which indicates a promising avenue for clinical application and research in dentistry.
基金supported by the National Basic Research Program of China(Grant Nos.2010CB934104,2009CB320300,and 2011CBA00608)the National Natural Foundation of China(Grant Nos.61604007,61378058,61376049,61575008,and 61574011)
文摘The characteristics of the photonic crystal vertical cavity surface emitting lasers(PhC-VCSELs) were investigated by using the full vector finite-difference time-domain(FDTD) method through the transverse mode loss analysis. PhC-VCSELs with different photonic crystal structures were analyzed theoretically and experimentally. Through combining the dual mode confinement of oxide aperture and seven-point-defect photonic crystal structure, the PhC-VCSELs with low threshold current of 0.9 mA and maximum output power of 3.1 mW operating in single fundamental mode were demonstrated. Mode loss analysis method was proven as a reliable and useful way to analyze and optimize the PhC-VCSELs.
基金Sponsored by the Ministerial Level Foundation(40402020105)
文摘A contact bolt model is proposed as a new modeling technique to investigate the complex structure with bolted joints for modal analysis and compared with the coupled bolt model, and the test results are given. Among these models, the coupled bolt model provides the best accurate responses compared with the experimental results. The contact bolt model shows the best effectiveness and usefulness in view of operational time. The bolt models proposed in this study are adopted for a dynamic characteristic analysis of a large diesel engine consisting of several parts which are connected by many bolts. The dynamic behavior of the entire engine structure was investigated by experiment. The coupled bolt model and the contact bolt model were applied to model the assembly of engine with high preload. The experimental results are in good agreement with the finite element method (FEM) results. Compared with the other models, the contact bolt model presented in this paper is more effective and useful in view of operational time and experience of analysts.
基金Project supported by the Shanghai Leading Academic Discipline Project (Grant No.S30108)the Science and Technology Commission of Shanghai Municipality (Grant No.08DZ2231100)
文摘Stress-induced birefringence and modal birefringence of single-mode specialty optical fibers with three stress regions are numerically analyzed by the vector finite element method. Stress distribution and stress-induced birefringence distribution of three kinds of optical fibers with different cross structures are presented and compared, and the influence on the stress- induced birefringence by temperature change are analyzed as well. The results show that the fibers with three-stress regions have a lower linear birefringence, which is very important for the fabrication of the circular polaxization-maintalning fiber with high performance drawn from the same fiber preform by using the spinning method.
基金This project was supported by the National Natural Science Foundation of China under contract No. 40576010.
文摘On the basis of a nonhydrostatic numerical model, the interaction of internal solitary wave with slope - shelf was studied. The breaking and polarity transformation were analyzed. A "kink" structure, due to shoaling topography and higher nonlinear effect, was found to be generated by the leading wave before breaking. Coherent vortex shedding behind the leading wave was presented. The evolution characteristics of the modal structure were analyzed based on the empirical orthogonal function method. The modal structure was complicated due to the effect of the variable topography, especially when breaking occurred. In the performed experiments, the contributions to the total variance from higher mode jumped from no more than 20% to over 40%.
文摘There is a problem of unfairness in allocation of radio resources among heterogeneous mobile terminals in heterogeneous wireless networks. Low-capability mobile terminals (such as single-mode terminals) suffer high call blocking probability whereas high-capability mobile terminals (such as quad-mode terminals) experience very low call blocking probability, in the same heterogeneous wireless network. This paper proposes a Terminal-Modality-Based Joint Call Admission Control (TJCAC) algorithm to reduce this problem of unfairness. The proposed TJCAC algorithm makes call admission decisions based on mobile terminal modality (capability), network load, and radio access technology (RAT) terminal support index. The objectives of the proposed TJCAC algorithm are to reduce call blocking/dropping probability, and ensure fairness in allocation of radio resources among heterogeneous mobile terminals in heterogeneous networks. An analytical model is developed to evaluate the performance of the proposed TJCAC scheme in terms of call blocking/dropping probability in a heterogeneous wireless network. The performance of the proposed TJCAC algorithm is compared with that of other JCAC algorithms. Results show that the proposed algorithm reduces call blocking/dropping probability in the networks, and ensure fairness in allocation of radio resources among heterogeneous terminals.
文摘BACKGROUND It was shown in previous studies that high definition endoscopy, high magnification endoscopy and image enhancement technologies, such as chromoendoscopy and digital chromoendoscopy [narrow-band imaging(NBI), iScan] facilitate the detection and classification of colonic polyps during endoscopic sessions. However, there are no comprehensive studies so far that analyze which endoscopic imaging modalities facilitate the automated classification of colonic polyps. In this work, we investigate the impact of endoscopic imaging modalities on the results of computer-assisted diagnosis systems for colonic polyp staging.AIM To assess which endoscopic imaging modalities are best suited for the computerassisted staging of colonic polyps.METHODS In our experiments, we apply twelve state-of-the-art feature extraction methods for the classification of colonic polyps to five endoscopic image databases of colonic lesions. For this purpose, we employ a specifically designed experimental setup to avoid biases in the outcomes caused by differing numbers of images per image database. The image databases were obtained using different imaging modalities. Two databases were obtained by high-definition endoscopy in combination with i-Scan technology(one with chromoendoscopy and one without chromoendoscopy). Three databases were obtained by highmagnification endoscopy(two databases using narrow band imaging and one using chromoendoscopy). The lesions are categorized into non-neoplastic and neoplastic according to the histological diagnosis.RESULTS Generally, it is feature-dependent which imaging modalities achieve high results and which do not. For the high-definition image databases, we achieved overall classification rates of up to 79.2% with chromoendoscopy and 88.9% without chromoendoscopy. In the case of the database obtained by high-magnification chromoendoscopy, the classification rates were up to 81.4%. For the combination of high-magnification endoscopy with NBI, results of up to 97.4% for one database and up to 84% for the other were achieved. Non-neoplastic lesions were classified more accurately in general than non-neoplastic lesions. It was shown that the image recording conditions highly affect the performance of automated diagnosis systems and partly contribute to a stronger effect on the staging results than the used imaging modality.CONCLUSION Chromoendoscopy has a negative impact on the results of the methods. NBI is better suited than chromoendoscopy. High-definition and high-magnification endoscopy are equally suited.
文摘A technique to extract real modes from the identified complex modes is presented in this paper, which enables the normalized real mode shapes, modal masses, and full or reduced mass and stiffness matrices to be obtained. The theoretical derivation of the method is provided in detail. An 11-DOF vibration system is used to validate the algorithm, and to analyze the effects of the number of modes utilized and measurement DOFs on the extraction results. Finally, the method is used to extract real modes from both experimental modal analysis and operational modal analysis.
文摘The effect of tire repeated root modal(RRM)on tire modeling with an experimental modal is studied.Firstly,a radial tire with radial and tangential RRMs is tested and analyzed.By multi-point exciting of the radial tire,a multiple reference frequency domain method based on a least squares(LMS PolyMAX)algorithm is used to identify modal parameters.Then,modal stability diagram(MSD),modal indication function(MIF)and modal assurance criteria(Auto-MAC)matrix are utilized to induce multiple inputs multiple outputs(MIMO)frequency response function(FRF)matrixes.The tests reveal that notable repeated roots exist in both radial and tangential response modes.Their modal frequencies and damping factors are approximately the same,the amplitudes of modal vectors are in the same order of magnitude,and the mode shapes are orthogonal.Based on the works mentioned,the method of trigonometric series modal shapes fitting is adopted,the effects of RRM model on tire modeling with a vertical experimental modal are discussed.The final results show that the effects of considering the RRM shapes are equivalent to the tire mode shapes depended on rotating the tire’s different exciting points during tire modeling,and since considering the RRM,the tire mode shapes can be unified and fixed during tire modeling.
文摘Modalclust is an R package which performs Hierarchical Mode Association Clustering (HMAC) along with its parallel implementation over several processors. Modal clustering techniques are especially designed to efficiently extract clusters in high dimensions with arbitrary density shapes. Further, clustering is performed over several resolutions and the results are summarized as a hierarchical tree, thus providing a model based multi resolution cluster analysis. Finally we implement a novel parallel implementation of HMAC which performs the clustering job over several processors thereby dramatically increasing the speed of clustering procedure especially for large data sets. This package also provides a number of functions for visualizing clusters in high dimensions, which can also be used with other clustering softwares.