Finding the superior mode basis for mode-division multiplexing:a comparison of spatial modes in air-core fiber

Diverse spatial mode bases can be exploited in mode-division multiplexing(MDM)to sustain the capacity growth in fiber-optic communications,such as linearly polarized(LP)modes,vector modes,LP orbital angular momentum(LP-OAM)modes,and circularly polarized OAM(CP-OAM)modes.Nevertheless,which kind of mode bases is more appropriate to be utilized in fiber still remains unclear.Here,we aim to find the superior mode basis in MDM fiber-optic communications via a system-level comparison in air-core fiber(ACF).We first investigate the walk-off effect of four spatial mode bases over 1-km ACF,where LP and LP-OAM modes show intrinsic mode walk-off,while it is negligible for vector and CP-OAM modes.We then study the mode coupling effect of degenerate vector and CP-OAM modes over 1-km ACF under fiber perturbations,where degenerate even and odd vector modes suffer severe mode cross talk,while negligible for highorder degenerate CP-OAM modes based on the laws of angular momentum conservation.Moreover,we comprehensively evaluate the system-level performance for data-carrying single-channel and two-channel MDM transmission with different spatial mode bases under various kinds of fiber perturbations(bending,twisting,pressing,winding,and out-of-plane moving).The obtained results indicate that the CP-OAM mode basis shows superiority compared to other mode bases in MDM fiber-optic communications without using multiple-input multiple-output digital signal processing.Our findings may pave the way for robust shortreach MDM optical interconnects for data centers and high-performance computing.

On-chip metamaterial-enabled high-order mode-division multiplexing

Mode-division multiplexing(MDM)technology enables high-bandwidth data transmission using orthogonal waveguide modes to construct parallel data streams.However,few demonstrations have been realized for generating and supporting high-order modes,mainly due to the intrinsic large material groupvelocity dispersion(GVD),which make it challenging to selectively couple different-order spatial modes.We show the feasibility of on-chip GVD engineering by introducing a gradient-index metamaterial structure,which enables a robust and fully scalable MDM process.We demonstrate a record-high-order MDM device that supports TE_(0)–TE_(15)modes simultaneously.40-GBaud 16-ary quadrature amplitude modulation signals encoded on 16 mode channels contribute to a 2.162 Tbit∕s net data rate,which is the highest data rate ever reported for an on-chip single-wavelength transmission.Our method can effectively expand the number of channels provided by MDM technology and promote the emerging research fields with great demand for parallelism,such as high-capacity optical interconnects,high-dimensional quantum communications,and large-scale neural networks.

Multi-dimensional multiplexing optical secret sharing framework with cascaded liquid crystal holograms

Secret sharing is a promising technology for information encryption by splitting the secret information into different shares.However,the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is limited.Herein,we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal(LC)holograms.The LC holograms are used as spatially separated shares to carry secret images.The polarization of the incident light and the distance between different shares are served as secret keys,which can significantly improve the information security and capacity.Besides,the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency,which further increases the information security.In implementation,an artificial neural network(ANN)model is developed to carefully design the phase distribution of each LC hologram.With the advantage of high security,high capacity and simple configuration,our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display.

Mode demultiplexing hybrids for mode-division multiplexing coherent receivers

We propose a mode demultiplexing hybrid(MDH) that integrates mode demultiplexing, local oscillator power splitting, and optical 90-deg mixing using multi-plane light conversion(MPLC). We demonstrate the realization of a three-mode MDH using four phase plates, one more than what is required for an MPLC-based mode demultiplexer, via numerical simulations. The performance of the three-mode MDH is comparable to that of commercial single-mode 90-deg hybrids. This multiple-functionality device enables simplification of the coherent optical front end of mode-division multiplexing receivers.

From first fibers to mode-division multiplexing(Invited Paper)

This Review focuses on optical transmission fibers and the high-capacity systems operating thereon. It attempts to combine key lessons learned from the 50-year history of low-loss optical fibers with views on future fiber and systems requirements, discussing likely evolution paths and potential pitfalls in resolving the optical network capacity crunch.

Towards integrated mode-division demultiplexing spectrometer by deep learning

Miniaturized spectrometers have been widely researched in recent years,but few studies are conducted with on-chip multimode schemes for mode-division multiplexing(MDM)systems.Here we propose an ultracompact mode-division demultiplexing spectrometer that includes branched waveguide structures and graphene-based photodetectors,which realizes simultaneously spectral dispersing and light fields detecting.In the bandwidth of 1500-1600 nm,the designed spectrometer achieves the single-mode spectral resolution of 7 nm for each mode of TE_(1)-TE_(4) by Tikhonov regularization optimization.Empowered by deep learning algorithms,the 15-nm resolution of parallel reconstruction for TE_(1)-TE_(4) is achieved by a single-shot measurement.Moreover,by stacking the multimode response in TE_(1)-TE_(4) to the single spectra,the 3-nm spectral resolution is realized.This design reveals an effective solution for on-chip MDM spectroscopy,and may find applications in multimode sensing,interconnecting and processing.

Time-sequential color code division multiplexing holographic display with metasurface

Color metasurface holograms are powerful and versatile platforms for modulating the amplitude,phase,polarization,and other properties of light at multiple operating wavelengths.However,the current color metasurface holography can only realize static manipulation.In this study,we propose and demonstrate a multiplexing metasurface technique combined with multiwavelength code-division multiplexing(CDM)to realize dynamic manipulation.Multicolor code references are utilized to record information within a single metasurface and increase the information capacity and security for anticracks.A total of 48 monochrome images consisting of pure color characters and multilevel color video frames were reconstructed in dual polarization channels of the birefringent metasurface to exhibit high information density,and a video was displayed via sequential illumination of the corresponding code patterns to verify the ability of dynamic manipulation.Our approach demonstrates significant application potential in optical data storage,optical encryption,multiwavelengthversatile diffractive optical elements,and stimulated emission depletion microscopy.

Flat multifunctional liquid crystal elements through multi-dimensional information multiplexing

Flat optical elements have attracted enormous attentions and act as promising candidates for the next generation of optical components.As one of the most outstanding representatives,liquid crystal(LC)has been widely applied in flat panel display industries and inspires the wavefront modulation with the development of LC alignment techniques.However,most LC elements perform only one type of optical manipulation and are difficult to realize the multifunctionality and light integration.Here,flat multifunctional liquid crystal elements(FMLCEs),merely composed of anisotropic LC molecules with space-variant orientations,are presented for multichannel information manipulation by means of polarization,space and wavelength multiplexing.Specifically,benefiting from the unique light response with the change of the incident polarization,observation plane,and working wavelength,a series of FMLCEs are demonstrated to achieve distinct near-and far-field display functions.The proposed strategy takes full advantage of basic optical parameters as the decrypted keys to improve the information capacity and security,and we expect it to find potential applications in information encryption,optical anti-counterfeiting,virtual/augmented reality,etc.

Planar peristrophic multiplexing metasurfaces

As a promising counterpart of two-dimensional metamaterials,metasurfaces enable to arbitrarily control the wavefront of light at subwavelength scale and hold promise for planar holography and applicable multiplexing devices.Nevertheless,the degrees of freedom(DoF)to orthogonally multiplex data have been almost exhausted.Compared with state-of-theart methods that extensively employ the orthogonal basis such as wavelength,polarization or orbital angular momentum,we propose an unprecedented method of peristrophic multiplexing by combining the spatial frequency orthogonality with the subwavelength detour phase principle.The orthogonal relationship between the spatial frequency of incident light and the locally shifted building blocks of metasurfaces can be regarded as an additional DoF.We experimentally demonstrate the viability of the multiplexed holograms.Moreover,this newly-explored orthogonality is compatible with conventional DoFs.Our findings will contribute to the development of multiplexing metasurfaces and provide a novel solution to nanophotonics,such as large-capacity chip-scale devices and highly integrated communication.

Performance of phase-matching quantum key distribution based on wavelength division multiplexing technology

Quantum key distribution(QKD) generates information-theoretical secure keys between two parties based on the physical laws of quantum mechanics. The phase-matching(PM) QKD protocol allows the key rate to break the quantum channel secret key capacity limit without quantum repeaters, and the security of the protocol is demonstrated by using equivalent entanglement. In this paper, the wavelength division multiplexing(WDM) technique is applied to the PM-QKD protocol considering the effect of crosstalk noise on the secret key rate. The performance of PM-QKD protocol based on WDM with the influence of adjacent classical channels and Raman scattering is analyzed by numerical simulations to maximize the total secret key rate of the QKD, providing a reference for future implementations of QKD based on WDM techniques.

Research on Weighted Directed Dynamic Multiplexing Network of World Grain Trade Based on Improved MLP Framework

As the main food source for humans, the global movement of the three major grains significantly impacts human survival and development. To investigate the evolution of the world cereal trade network and its development trend, a weighted directed dynamic multiplexed network was established using historical data on cereal trade, cereal import dependency ratio, and arable land per capita. Inspired by the MLP framework, we redefined the weight determination method for computing layer weights and edge weights of the target layer, modified the CN, RA, AA, and PA indicators, and proposed the node similarity indicator for weighted directed networks. The AUC metric, which measures the accuracy of the algorithm, has also been improved in order to finally obtain the link prediction results for the grain trading network. The prediction results were processed, such as web-based presentation and community partition. It was found that the number of generalized trade agreements does not have a decisive impact on inter-country cereal trade. The former large grain exporters continue to play an important role in this trade network. In the future, the world trade in cereals will develop in the direction of more frequent intercontinental trade and gradually weaken the intracontinental cereal trade.

A 220 GHz Frequency-Division Multiplexing Wireless Link with High Data Rate

With the development of wireless communication,the 6G mobile communication technology has received wide attention.As one of the key technologies of 6G,terahertz(THz)communication technology has the characteristics of ultra-high bandwidth,high security and low environmental noise.In this paper,a THz duplexer with a half-wavelength coupling structure and a sub-harmonic mixer operating at 216 GHz and 204 GHz are designed and measured.Based on these key devices,a 220 GHz frequency-division multiplexing communication system is proposed,with a real-time data rate of 10.4 Gbit/s for one channel and a transmission distance of 15 m.The measured constellation diagram of two receivers is clearly visible,the signal-to-noise ratio(SNR)is higher than 22 dB,and the bit error ratio(BER)is less than 10^(−8).Furthermore,the high definition(HD)4K video can also be transmitted in real time without stutter.

Study on Distribution of Four Pseudomonas Species in Living Environment Using Multiplex PCR

Purpose: The genus Pseudomonas is a ubiquitous microorganism frequently detected from immunocompromised patients. The inherent resistance to numerous antimicrobial agents contributes to the opportunistic character of this pathogen exhaustive monitoring of this pathogen is considered of critical importance to public health organizations. The reliable identification method able to distinguish genetic close Pseudomonas species is needed, because these organisms are difficult to differentiate by phenotypic or biochemical methods. The purpose of the present study was to design species-specific primers in order to identify and detect four Pseudomonas species which are frequently detected from the human oral cavities, and to investigate the distribution of these organisms in the living environment using a multiplex PCR. Methods: Polymerase chain reaction (PCR) primers were designed based on partial sequences of the rpoD gene of four Pseudomonas species. Swab samples were collected from fifty washstands, and the distribution of Pseudomonas species was investigated using a conventional PCR at genus level and a multiplex PCR at species level. Results: Multiplex PCR method developed in this study was able to distinguish four Pseudomonas species clearly. The genus Pseudomonas was detected from all samples (100%), whereas P. putida, P, aeruginosa, P. stutzeri and P. fluorescens were detected at 44%, 8%, 4% and 2% in fifty swab samples, respectively. Conclusion: Our developed one-step multiplex PCR method is accurate, specific, cost-effective, time-saving, and works without requiring DNA extraction. It was indicated that washstands were the uninhabitable environment for P. putida, P, aeruginosa, P. stutzeri and P. fluorescens.

A simple and efficient CRISPR/Cas9 system permits ultra-multiplex genome editing in plants

The development and maturation of the CRISPR/Cas genome editing system provides a valuable tool for plant functional genomics and genetic improvement.Currently available genome-editing tools have a limited number of targets,restricting their application in genetic research.In this study,we developed a novel CRISPR/Cas9 plant ultra-multiplex genome editing system consisting of two template vectors,eight donor vectors,four destination vectors,and one primer-design software package.By combining the advantages of Golden Gate cloning to assemble multiple repetitive fragments and Gateway recombination to assemble large fragments and by changing the structure of the amplicons used to assemble sg RNA expression cassettes,the plant ultra-multiplex genome editing system can assemble a single binary vector targeting more than 40 genomic loci.A rice knockout vector containing 49 sg RNA expression cassettes was assembled and a high co-editing efficiency was observed.This plant ultra-multiplex genome editing system advances synthetic biology and plant genetic engineering.

Multiplex Rapid Test with Acceptable Diagnosis Performance as a Solution to Increase Diagnosis of Hepatitis B and C Viruses in Pregnant Women in an Area of High Prevalence of Both Hepatitis Viruses Associated with HIV

Background and Objective: HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) are very widespread in the world, however, less than 20% of the people affected are diagnosed and treated. This study aimed to determine the prevalence of HIV, HCV and HBV co-infections in pregnant women at Bangui Community University Hospital and the cost of screening. Methods: A cross-sectional study involving consenting pregnant women who came for antenatal care was performed. HIV, HCV antibodies and HBV antigens were detected using Exacto Triplex? HIV/HCV/HBsAg rapid test, cross-validated by ELISA tests. Sociodemographic and professional data, the modes of transmission and prevention of HIV and both hepatitis viruses were collected in a standard sheet and analyzed using the Epi-Info software version 7. Results: Pregnant women aged 15 to 24 were the most affected (45.3%);high school girls (46.0%), and pregnant women living in cohabitation (65.3%) were the most represented. Twenty-five (16.7%) worked in the formal sector, 12.7% were unemployed housewives and the remainder in the informal sector. The prevalence of HIV, HBV, and HCV viruses was 11.8%, 21.9% and 22.2%, respectively. The prevalence of co-infections was 8.6% for HIV-HBV, 10.2% for HIV-HCV, 14.7% for HBV-HCV and 6.5% for HIV-HBV-HCV. All positive results and 10% of negative results by the rapid test were confirmed by ELISA tests. The serology of the three viruses costs 39,000 FCFA (60 Euros) by ELISA compared to 10,000 FCFA (15.00 Euros) with Exacto Triplex? HIV/HCV/AgHBs (BioSynex, Strasbourg, France). Conclusion: The low level of education and awareness of hepatitis are barriers to development and indicate the importance of improving the literacy rate of women in the Central African Republic (CAR). Likewise, the high prevalence of the three viruses shows the need for the urgent establishment of a national program to combat viral hepatitis in the CAR.

Semi-implantable device based on multiplexed microfilament electrode cluster for continuous monitoring of physiological ions

Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical indicators.Ion sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological subjects.Current semi-implantable devices are mainly based on single-parameter detection.Miniaturized semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode sensitivity.This study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)concentrations.The electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric sensing.The MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above ions.In vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex environments.This work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

Real-Time 4-Mode MDM Transmission Using Commercial 400G OTN Transceivers and All-Fiber Mode Multiplexers

Weakly-coupled mode division multiplexing(MDM)technique is considered a promising candidate to enhance the capacity of an optical transmission system,in which mode multiplexers/demultiplexers(MMUX/MDEMUX)with low insertion loss and modal crosstalk are the key components.In this paper,a low-modal-crosstalk 4-mode MMUX/MDEMUX for the weakly-coupled triple-ring-core few-mode fiber(TRC-FMF)is designed and fabricated with side-polishing processing.The measurement results show that a pair of MMUX/MDEMUX and 25 km weakly-coupled TRC-FMF MDM link achieve low modal crosstalk of lower than−17.5 dB and insertion loss of lower than 11.56 dB for all the four modes.Based on the TRC-FMF and all-fiber MMUX/MDEMUX,an experiment for 25 km real-time 4-mode 3-λwavelength division multiplexing(WDM)-MDM transmission is conducted using commercial 400G optical transport network(OTN)transceivers.The experimental results prove weakly-coupled MDM techniques facilitate a smooth upgrade of the optical transmission system.

Development of a multiplex polymerase chain reaction assay for detection of hepatitis C virus,hepatitis B virus,and human immunodeficiency virus 1

BACKGROUND Hepatitis C virus(HCV),hepatitis B virus(HBV),and human immunodeficiency virus 1(HIV-1)are the most epidemic blood-borne viruses,posing threats to human health and causing economic losses to nations for combating the infection transmission.The diagnostic methodologies that depend on the detection of viral nucleic acids are much more expensive,but they are more accurate than sero-logical testing.AIM To develop a rapid,cost-effective,and accurate diagnostic multiplex polymerase chain reaction(PCR)assay for simultaneous detection of HCV,HBV,and HIV-1.METHODS The design of the proposed PCR assay targets the amplification of a short conserved region featured with a distinguishable melting profile and electro-phoretic molecular weight inside each viral genome.Therefore,this diagnostic method will be appropriate for application in both conventional(combined with electrophoresis)and real-time PCR facilities.Confirmatory in silico investigations were conducted to prove the capability of the approached PCR assay to detect variants of each virus.Then,Egyptian isolates of each virus were subjected to the wet lab examination using the given diagnostic assay.RESULTS The in silico investigations confirmed that the PCR primers can match many viral variants in a multiplex PCR assay.The wet lab experiment proved the efficiency of the assay in distinguishing each viral type through high-resolution melting analysis.Compared to related published assays,the proposed assay in the current study is more sensitive and competitive with many expensive PCR assays.CONCLUSION This study provides a simple,cost-effective,and sensitive diagnostic PCR assay facilitating the detection of the most epidemic blood-borne viruses;this makes the proposed assay promising to be substitutive for the mistakable and cheap serological-based assays.

Optical multiplexing techniques and their marriage for on-chip and optical fiber communication:a review

Herein,an attention-grabbing and up-to-date review related to major multiplexing techniques is presented which in-cludes wavelength division multiplexing(WDM),polarization division multiplexing(PDM),space division multiplexing(SDM),mode division multiplexing(MDM)and orbital angular momentum multiplexing(OAMM).Multiplexing is a mech-anism by which multiple signals are combined into a shared channel used to showcase the maximum capacity of the op-tical links.However,it is critical to develop hybrid multiplexing methods to allow enhanced channel numbers.In this re-view,we have also included hybrid multiplexing techniques such as WDM-PDM,WDM-MDM and PDM-MDM.It is prob-able to attain N×M channels by utilizing N wavelengths and M guided-modes by simply utilizing hybrid WDM-MDM(de)multiplexers.To the best of our knowledge,this review paper is one of its kind which has highlighted the most prom-inent and recent signs of progress in multiplexing techniques in one place.

High Speed Polarization-Division Multiplexing Transmissions Based on the Nonlinear Fourier Transform

Polarization-division multiplexing(PDM)with modulation in the nonlinear frequency domain consisting of the discrete and/or continuous spectrum has been recently regarded as a useful method to be utilized in optical fiber communication system.It can compensate the optical fiber nonlinearity based on the nonlinear Fourier transform(NFT).In this paper,we combine PDM with the method of nonlinear frequency division multiplexing(NFDM)and demonstrate the achievable transmission rate by increasing the number of multiplexing nonlinear channels.For the selected subcarriers(i.e.32,64,and 128),the transmission rates are 64 Gbit/s,76.8 Gbit/s,and 109.7 Gbit/s respectively by applying 64-quadrature amplitude modulation(64-QAM)on the nonlinear continuous spectrum.For the transmission distance shorter than 1200 km,the transmission rate of 128-NFDM PDM system can even reach up to 153.6 Gbit/s.