This paper takes the assessment and evaluation of computational mechanics course as the background,and constructs a diversified course evaluation system that is student-centered and integrates both quantitative and qu...This paper takes the assessment and evaluation of computational mechanics course as the background,and constructs a diversified course evaluation system that is student-centered and integrates both quantitative and qualitative evaluation methods.The system not only pays attention to students’practical operation and theoretical knowledge mastery but also puts special emphasis on the cultivation of students’innovative abilities.In order to realize a comprehensive and objective evaluation,the assessment and evaluation method of the entropy weight model combining TOPSIS(Technique for Order Preference by Similarity to Ideal Solution)multi-attribute decision analysis and entropy weight theory is adopted,and its validity and practicability are verified through example analysis.This method can not only comprehensively and objectively evaluate students’learning outcomes,but also provide a scientific decision-making basis for curriculum teaching reform.The implementation of this diversified course evaluation system can better reflect the comprehensive ability of students and promote the continuous improvement of teaching quality.展开更多
Machine learning is currently one of the research hotspots in the field of landslide prediction.To clarify and evaluate the differences in characteristics and prediction effects of different machine learning models,Co...Machine learning is currently one of the research hotspots in the field of landslide prediction.To clarify and evaluate the differences in characteristics and prediction effects of different machine learning models,Conghua District,which is the most prone to landslide disasters in Guangzhou,was selected for landslide susceptibility evaluation.The evaluation factors were selected by using correlation analysis and variance expansion factor method.Applying four machine learning methods namely Logistic Regression(LR),Random Forest(RF),Support Vector Machines(SVM),and Extreme Gradient Boosting(XGB),landslide models were constructed.Comparative analysis and evaluation of the model were conducted through statistical indices and receiver operating characteristic(ROC)curves.The results showed that LR,RF,SVM,and XGB models have good predictive performance for landslide susceptibility,with the area under curve(AUC)values of 0.752,0.965,0.996,and 0.998,respectively.XGB model had the highest predictive ability,followed by RF model,SVM model,and LR model.The frequency ratio(FR)accuracy of LR,RF,SVM,and XGB models was 0.775,0.842,0.759,and 0.822,respectively.RF and XGB models were superior to LR and SVM models,indicating that the integrated algorithm has better predictive ability than a single classification algorithm in regional landslide classification problems.展开更多
Zambia like any other country in most African regions is still grappling with the dynamics of harnessing technology for the betterment of Higher Education. The onset of the Covid 19 pandemic brought a test for the pre...Zambia like any other country in most African regions is still grappling with the dynamics of harnessing technology for the betterment of Higher Education. The onset of the Covid 19 pandemic brought a test for the preparedness of the Zambian Higher Education Institutions (HEIs) in harnessing technology for pedagogical activities. As countries worldwide switched to electronic learning during the pandemic, the same could not be said for Zambian HEIs. Zambian HEIs struggled to conduct pedagogical activities on learning management platforms. This study investigated the factors affecting the implementation and assessment of learning Management systems in Zambia’s HEIs. With its focus on assessing: 1) system features, 2) compliance with regulatory standards, 3) quality of service and 4) technology acceptance as the four key assessment areas of an LMS, this article proposed a model for assessing learning management systems in Zambian HEIs. To test the proposed model, a software tool was also developed.展开更多
With the development of EMC technology, EMC assessment has become increasingly important in EMC design. Although numerous EMC assessment models are available today, few of them can provide a tradeoff between efficienc...With the development of EMC technology, EMC assessment has become increasingly important in EMC design. Although numerous EMC assessment models are available today, few of them can provide a tradeoff between efficiency and accuracy for the specific case of military vehicular communication systems. Face to this situation, a modified four-level assessment model is proposed in the paper. First, the development of EMC assessment technology is briefly reviewed, and the theoretical mechanism of EMI environment is introduced. Then, the architecture of the proposed model is outlined, and the assessment methods are explored. To demonstrate the application of it, an example involving a communication system in a military vehicle is presented. From the physical layer to the signal layer, a hierarchical assessment on the entire system is successfully performed based on the proposed model, and we can make a qualitative EMC assessment on the EMC performance of the system. Based on a comparison with the traditional model, we conclude that the proposed model is more accurate, more efficient and less time-consuming, which is suitable for the EMC assessment on militaryvehicular communication systems. We hope that the proposed model will serve as a useful reference for system-level EMC assessments for other systems.展开更多
The ecosystem is important because it is the life sustaining system for human survival.Three ecosystem characteristics are:regional particularities,ecosystem complexity and conventional cultural particularities.This p...The ecosystem is important because it is the life sustaining system for human survival.Three ecosystem characteristics are:regional particularities,ecosystem complexity and conventional cultural particularities.This paper develops a remote sensing based dynamic model to assess grassland ecosystem service values involving multidisciplinary knowledge.The ecological value of grassland ecosystems is focused on using a remote sensing technique in the model,and setting up the framework for a dynamic assessing model.The grassland ecological services condition and value in 1985 is used as the benchmark.The dynamic model has two adjusting indicators:biomass and price index.The biomass is simulated using the CASA(Carnegie-Ames-Stanford Approach) model.The price index was obtained from statistics data published by the statistical bureau.Results show that the grassland ecosystem value in Gansu Province was 28.36 billion Chinese Yuan in 1985,140.37 billion in 1999 and 130.86 billion in 2002.展开更多
This paper addresses the problem of assessing and optimizing the acoustic positioning system for underwater target localization with range measurement.We present a new three-dimensional assessment model to evaluate th...This paper addresses the problem of assessing and optimizing the acoustic positioning system for underwater target localization with range measurement.We present a new three-dimensional assessment model to evaluate the optimal geometric beacon formation whether meets user requirements.For mathematical tractability,it is assumed that the measurements of the range between the target and beacons are corrupted with white Gaussian noise with variance,which is distance-dependent.Then,the relationship between DOP parameters and positioning accuracy can be derived by adopting dilution of precision(DOP)parameters in the assessment model.In addition,the optimal geometric beacon formation yielding the best performance can be achieved via minimizing the values of geometric dilution of precision(GDOP)in the case where the target position is known and fixed.Next,in order to ensure that the estimated positioning accuracy on the region of interest satisfies the precision required by the user,geometric positioning accuracy(GPA),horizontal positioning accuracy(HPA)and vertical positioning accuracy(VPA)are utilized to assess the optimal geometric beacon formation.Simulation examples are designed to illustrate the exactness of the conclusion.Unlike other work that only uses GDOP to optimize the formation and cannot assess the performance of the specified size,this new three-dimensional assessment model can evaluate the optimal geometric beacon formation for each dimension of any point in three-dimensional space,which can provide guidance to optimize the performance of each specified dimension.展开更多
The diurnal temperature range(DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR varia...The diurnal temperature range(DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR variations over the Tibetan Plateau. It assesses 23 climate models from phase 6 of the Coupled Model Intercomparison Project(CMIP6) using CN05.1 observational data as validation, evaluating their ability to simulate DTR over the Tibetan Plateau. Then, the evolution of DTR over the Tibetan Plateau under different shared socioeconomic pathway(SSP) scenarios for the near,middle, and long term of future projection are analyzed using 11 selected robustly performing models. Key findings reveal:(1) Among the models examined, BCC-CSM2-MR, EC-Earth3, EC-Earth3-CC, EC-Earth3-Veg, EC-Earth3-Veg-LR,FGOALS-g3, FIO-ESM-2-0, GFDL-ESM4, MPI-ESM1-2-HR, MPI-ESM1-2-LR, and INM-CM5-0 exhibit superior integrated simulation capability for capturing the spatiotemporal variability of DTR over the Tibetan Plateau.(2) Projection indicates a slightly increasing trend in DTR on the Tibetan Plateau in the SSP1-2.6 scenario, and decreasing trends in the SSP2-4.5, SSP3-7.0, and SPP5-8.5 scenarios. In certain areas, such as the southeastern edge of the Tibetan Plateau, western hinterland of the Tibetan Plateau, southern Kunlun, and the Qaidam basins, the changes in DTR are relatively large.(3) Notably, the warming rate of maximum temperature under SSP2-4.5, SSP3-7.0, and SPP5-8.5 is slower compared to that of minimum temperature, and it emerges as the primary contributor to the projected decrease in DTR over the Tibetan Plateau in the future.展开更多
This study quantified the regional damages resulting from temperature and sea level changes using the Regional Integrated of Climate and Economy(RICE)model,as well as the effects of enabling and disabling the climate ...This study quantified the regional damages resulting from temperature and sea level changes using the Regional Integrated of Climate and Economy(RICE)model,as well as the effects of enabling and disabling the climate impact module on future emission pathways.Results highlight varied damages depending on regional economic development and locations.Specifically,China and Africa could suffer the most serious comprehensive damages caused by temperature change and sea level rise,followed by India,other developing Asian countries(OthAsia),and other high-income countries(OHI).The comprehensive damage fractions for China and Africa are projected to be 15.1%and 12.5%of gross domestic product(GDP)in 2195,with corresponding cumulative damages of 124.0 trillion and 87.3 trillion United States dollars(USD)from 2005 to 2195,respectively.Meanwhile,the comprehensive damage fractions in Japan,Eurasia,and Russia are smaller and projected to be lower than 5.6%of GDP in 2195,with cumulative damages of 6.8 trillion,4.2 trillion,and 3.3 trillion USD,respectively.Additionally,coastal regions like Africa,the European Union(EU),and OHI show comparable damages for sea level rise and temperature change.In China,however,sea level-induced damages are projected to exceed those from temperature changes.Moreover,this study indicates that switching the damage modules on or off affects the regional and global emission trajectories,but the magnitude is relatively small.By 2195,global emissions under the experiments with all of the damage modules switched off,only the sea level damage module switched on,and only the temperature damage module switched on,were 3.5%,2.3%and 1.2%higher than those with all of the damage modules switched on,respectively.展开更多
The public procurement system in Bangladesh has been running by traditional manual process under the flagship of Public Procurement Act (PPA 2006) and Public Procurement Rules (PPR 2008). Public procurement agencies h...The public procurement system in Bangladesh has been running by traditional manual process under the flagship of Public Procurement Act (PPA 2006) and Public Procurement Rules (PPR 2008). Public procurement agencies have been facing challenges in this manual tendering system. To overcome this problem and to bring reality to the “Digital Bangladesh” slogan, the Government of Bangladesh introduced the e-Procurement system under the e-GP (Electronic Government Procurement) guideline 2011. After the inception of e-procurement, there is no e-procurement assessment model to improve the e-GP system. The purpose of this research is to develop a conceptual framework and to design an e-procurement assessment model. With this view, we have considered one of the biggest entity Roads and Highways Department (RHD) of the Government of Bangladesh, for field study. Mixed methods along with FGD (Focus Group Discussion), KII (Key Informant Interview), and survey questionnaires are used to collect data from RHD, and then Statistical Package for Social Science (SPSS) software is used for regression analysis and hypothesis testing to develop the e-Procurement assessment model. The novel contribution of the study lies in the test of the hypothesis that focuses on developing the conceptual model of the e-procurement assessment system in Bangladesh. Findings of the study are essential for all Procurement Entity (PE) and suppliers <i>i.e. </i> contractors of RHD who are engaged in the construction of the infrastructure project development project.展开更多
BACKGROUND Mucocutaneous separation(MCS)is a common postoperative complication in enterostomy patients,potentially leading to significant morbidity.Early identification of risk factors is crucial for preventing this c...BACKGROUND Mucocutaneous separation(MCS)is a common postoperative complication in enterostomy patients,potentially leading to significant morbidity.Early identification of risk factors is crucial for preventing this condition.However,predictive models for MCS remain underdeveloped.AIM To construct a risk prediction model for MCS in enterostomy patients and assess its clinical predictive accuracy.METHODS A total of 492 patients who underwent enterostomy from January 2019 to March 2023 were included in the study.Patients were divided into two groups,the MCS group(n=110),and the non-MCS(n=382)based on the occurrence of MCS within the first 3 weeks after surgery.Univariate and multivariate analyses were used to identify the independent predictive factors of MCS and the model constructed.Receiver operating characteristic curve analysis was used to assess the model’s performance.RESULTS The postoperative MCS incidence rate was 22.4%.Suture dislodgement(P<0.0001),serum albumin level(P<0.0001),body mass index(BMI)(P=0.0006),hemoglobin level(P=0.0409),intestinal rapture(P=0.0043),incision infection(P<0.0001),neoadjuvant therapy(P=0.0432),stoma site(P=0.0028)and elevated intra-abdominal pressure(P=0.0395)were potential predictive factors of MCS.Suture dislodgement[P<0.0001,OR:28.007595%CI:(11.0901-82.1751)],serum albumin level(P=0.0008,OR:0.3504,95%CI:[0.1902-0.6485]),BMI[P=0.0045,OR:2.1361,95%CI:(1.2660-3.6235)],hemoglobin level[P=0.0269,OR:0.5164,95%CI:(0.2881-0.9324)],intestinal rapture[P=0.0351,OR:3.0694,95%CI:(1.0482-8.5558)],incision infection[P=0.0179,OR:0.2885,95%CI:(0.0950-0.7624)]and neoadjuvant therapy[P=0.0112,OR:1.9769,95%CI:(1.1718-3.3690)]were independent predictive factors and included in the model.The model had an area under the curve of 0.827 and good clinical utility on decision curve analysis.CONCLUSION The mucocutaneous separation prediction model constructed in this study has good predictive performance and can provide a reference for early warning of mucocutaneous separation in enterostomy patients.展开更多
The technological revolution has spawned a new generation of industrial systems,but it has also put forward higher requirements for safety management accuracy,timeliness,and systematicness.Risk assessment needs to evo...The technological revolution has spawned a new generation of industrial systems,but it has also put forward higher requirements for safety management accuracy,timeliness,and systematicness.Risk assessment needs to evolve to address the existing and future challenges by considering the new demands and advancements in safety management.The study aims to propose a systematic and comprehensive risk assessment method to meet the needs of process system safety management.The methodology first incorporates possibility,severity,and dynamicity(PSD)to structure the“51X”evaluation indicator system,including the inherent,management,and disturbance risk factors.Subsequently,the four-tier(risk point-unit-enterprise-region)risk assessment(RA)mathematical model has been established to consider supervision needs.And in conclusion,the application of the PSD-RA method in ammonia refrigeration workshop cases and safety risk monitoring systems is presented to illustrate the feasibility and effectiveness of the proposed PSD-RA method in safety management.The findings show that the PSD-RA method can be well integrated with the needs of safety work informatization,which is also helpful for implementing the enterprise's safety work responsibility and the government's safety supervision responsibility.展开更多
Objective:To analyze the technical indexes of students’online learning behavior analysis based on Kirkman’s evaluation model,sort out the basic indexes of online learning behavior,and extract scientific and efficien...Objective:To analyze the technical indexes of students’online learning behavior analysis based on Kirkman’s evaluation model,sort out the basic indexes of online learning behavior,and extract scientific and efficient evaluation indexes of online learning effect through statistical analysis.Methods:The online learning behavior data of Physiology of nursing students from 2021-2023 and the first semester of 22 nursing classes(3 and 4)were collected and analyzed.The preset learning behavior indexes were analyzed by multi-dimensional analysis and a correlation analysis was conducted between the indexes and the final examination scores to screen for the dominant important indexes for online learning effect evaluation.Results:The study found that the demand for online learning of nursing students from 2021-2023 increased and the effect was statistically significant.Compared with the stage assessment results,the online learning effect was statistically significant.Conclusion:The main indicators for evaluating and classifying online learning behaviors were summarized.These two indicators can help teachers predict which part of students need learning intervention,optimize the teaching process,and help students improve their learning behavior and academic performance.展开更多
The performance of corporate social responsibility is conducive to the con- tinuous improvement of their profitability, and promotes the upgrading of corporation value. However, it is difficult to confirm, calculate a...The performance of corporate social responsibility is conducive to the con- tinuous improvement of their profitability, and promotes the upgrading of corporation value. However, it is difficult to confirm, calculate and check the costs and benefits brought by the implementation of corporate social responsibility under the current ac- counting theory system, so it is difficult to estimate whether the fulfillment of corpo- rate social responsibility has any effects on the corporation value assessment. Therefore, based on corporate social responsibility, the correction mode of corpora- tion value assessment is put forward.展开更多
Tunnel water inrush is one of the common geological disasters in the underground engineering construction.In order to effectively evaluate and control the occurrence of water inrush,the risk assessment model of tunnel...Tunnel water inrush is one of the common geological disasters in the underground engineering construction.In order to effectively evaluate and control the occurrence of water inrush,the risk assessment model of tunnel water inrush was proposed based on improved attribute mathematical theory.The trigonometric functions were adopted to optimize the attribute mathematical theory,avoiding the influence of mutation points and linear variation zones in traditional linear measurement functions on the accuracy of the model.Based on comprehensive analysis of various factors,five parameters were selected as the evaluation indicators for the model,including tunnel head pressure,permeability coefficient of surrounding rock,crushing degree of surrounding rock,relative angle of joint plane and tunnel section size,under the principle of dimension rationality,independence,directness and quantification.The indicator classifications were determined.The links among measured data were analyzed in detail,and the objective weight of each indicator was determined by using similar weight method.Thereby the tunnel water inrush risk assessment model is established and applied in four target segments of two different tunnels in engineering.The evaluation results and the actual excavation data agree well,which indicates that the model is of high credibility and feasibility.展开更多
AIM:To explore the related risk factors for diabetic retinopathy(DR)in type 2 diabetes with insulin therapy.METHODS:We studied the relationships among blood glucose,serum C-peptide,plasma insulin,beta-cell function an...AIM:To explore the related risk factors for diabetic retinopathy(DR)in type 2 diabetes with insulin therapy.METHODS:We studied the relationships among blood glucose,serum C-peptide,plasma insulin,beta-cell function and the development of DR.Beta-cell function was assessed by a modified homeostasis model assessment(modified HOMA)which was gained by using C-peptide to replace insulin in the homeostasis model assessment(HOMA)of beta-cell function.We also studied the relationships between modified HOMA index and serum C-peptide response to 100 g tasteless steamed bread to determine the accuracy of modified HOMA.RESULTS:Our study group consisted of 170 type 2diabetic inpatients with DR(age:58.35±13.87y,mean±SD)and 205 type 2 diabetic inpatients with no DR(NDR)(age:65.52±11.59y).DR patients had higher age,longer diabetic duration,higher hypertension grade,higher postprandial plasma glucose,higher fluctuation level of plasma glucose,lower body mass index(BMI),lower postprandial serum insulin and C-peptide,lower fluctuation level of serum insulin and C-peptide(P【0.05).In our logistic regression model,duration of diabetes,hypertension grade,fasting plasma insulin and glycosylated hemoglobin(HbA1C)were significantly associated with the presence of DR after adjustment for confounding factors(P【0.05).CONCLUSION:Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlationanalysis,logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors(such as age,sex,duration of diabetes,BMI,hypertension grade,HbA1C,plasma insulin).Duration of diabetes,hypertension grade,fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics.展开更多
In this study, a risk-based management model is developed and applied to an industrial zone. The models proposed by the United States Environmental Protection Agency and Han Bing have been improved by adding a residua...In this study, a risk-based management model is developed and applied to an industrial zone. The models proposed by the United States Environmental Protection Agency and Han Bing have been improved by adding a residual ratio of volatile organic compounds (VOC) after boiling and deleting the related parameters in half-life. Using this improved model, an integrated process was used to assess human health risk level in the study area. Compared with water quality analysis, the results highlight the importance of applying an integrated approach for decision making on risk levels and water protection. The results of this study demonstrated that: (1) Compared with these permissible level standards in China (GB 3838-2002) and National Primary Drinking Water Regulations of the United States, the residents' daily life had not been affected by the groundwater in this area (except for relative bad water quality of HB3-4 and HB3-6); (2) The typical detected organic contaminants of all groundwater samples were chloroform, carbon tetrachloride, trichloroethylene and tetrachloroethene, and the pollution sources were mainly industrial sources by preliminary investigations; (3) As for groundwater, the non-carcinogenic risk values of all samples do not exceed the permissible level of 1.0 and the carcinogenic risk values are relatively lower than the permissible level of 1.00E-06 to 1.00E-04; (4) Drinking water pathway of trichloroethylene and tetrachloroethylene mainly contribute to increasing the health risk of residents' in study areas; (5) In terms of non-carcinogenic risk and carcinogenic risk, the health risk order for drinking water pathway and dermal contact pathway was: drinking water pathway 〉 dermal contact pathway.展开更多
To the potential oil-spill risk caused by offshore pipeline more attention has been paid after the Dalian oil spill incident from oil-pipeline explosion. Since then an issue about how to prevent and control the sudden...To the potential oil-spill risk caused by offshore pipeline more attention has been paid after the Dalian oil spill incident from oil-pipeline explosion. Since then an issue about how to prevent and control the sudden oil-spill from the offshore pipeline has been raised. In this paper, we proposed an optimized model to analyze the main causes(probability) of spill and the consequence with the fuzzy comprehensive assessment model. Considering the complicated assessment process for oil-spill, the assessment factor system involving the spill probability and consequence was established based on the operative manual and statistic leakage/damage data of offshore pipeline in order to estimate the integrated spill risk score automatically. The evaluated factors of spill probability could be grouped into five aspects: corrosion, fatigue, national damage, third party, and operational fault; the consequence evaluated factors of spill included hazard of oil and impact-controlling capability. With some modifications based on experts' opinions, each of the evaluated factors in our work was developed with a relative weight and evaluation criterion. A test example for an offshore pipeline in the Bohai waters was described to show how the model can be used for an actual case in more detail. By using the oil-spill risk assessment model, it is easy to determine the risk level associated with the ongoing activity and management level and hence to take the risk mitigation action immediately.展开更多
Green manure use in China has declined rapidly since the 1980 s with the extensive use of chemical fertilizers.The deterioration of field environments and the demand for green agricultural products have resulted in mo...Green manure use in China has declined rapidly since the 1980 s with the extensive use of chemical fertilizers.The deterioration of field environments and the demand for green agricultural products have resulted in more attention to green manure.Human intervention and policy-oriented behaviors likely have large impacts on promoting green manure planting.However,little information is available regarding on where,at what rates,and in which ways(i.e.,intercropping green manure in orchards or rotating green manure in cropland) to develop green manure and what benefits could be gained by incorporating green manure in fields at the county scale.This paper presents the conversion of land use and its effects at small region extent(CLUE-S) model,which is specifically developed for the simulation of land use changes originally,to predict spatial distribution of green manure in cropland and orchards in 2020 in Pinggu District located in Beijing,China.Four types of land use for planting or not planting green manure were classified and the future land use dynamics(mainly croplands and orchards) were considered in the prediction.Two scenarios were used to predict the spatial distribution of green manure based on data from 2011:The promotion of green manure planting in orchards(scenario 1) and the promotion of simultaneous green manure planting in orchards and croplands(scenario 2).The predictions were generally accurate based on the receiver operating characteristic(ROC) and Kappa indices,which validated the effectiveness of the CLUE-S model in the prediction.In addition,the spatial distribution of the green manure was acquired,which indicated that green manure mainly located in the orchards of the middle and southern regions of Dahuashan,the western and southern regions of Wangxinzhuang,the middle region of Shandongzhuang,the eastern region of Pinggu and the middle region of Xiagezhuang under scenario 1.Green manure planting under scenario 2 occurred in orchards in the middle region of Wangxinzhuang,and croplands in most regions of Daxingzhuang,southern Pinggu,northern Xiagezhuang and most of Mafang.The spatially explicit results allowed for the assessment of the benefits of these changes based on different economic and ecological indicators.The economic and ecological gains of scenarios 1 and 2 were 175691 900 and143000 300 CNY,respectively,which indicated that the first scenario was more beneficial for promoting the same area of green manure.These results can facilitate policies of promoting green manure and guide the extensive use of green manure in local agricultural production in suitable ways.展开更多
Medication-related osteonecrosis of the jaw(MRONJ)is primarily associated with administering antiresorptive or antiangiogenic drugs.Despite significant research on MRONJ,its pathogenesis and effective treatments are s...Medication-related osteonecrosis of the jaw(MRONJ)is primarily associated with administering antiresorptive or antiangiogenic drugs.Despite significant research on MRONJ,its pathogenesis and effective treatments are still not fully understood.Animal models can be used to simulate the pathophysiological features of MRONJ,serving as standardized in vivo experimental platforms to explore the pathogenesis and therapies of MRONJ.Rodent models exhibit excellent effectiveness and high reproducibility in mimicking human MRONJ,but classical methods cannot achieve a complete replica of the pathogenesis of MRONJ.Modified rodent models have been reported with improvements for better mimicking of MRONJ onset in clinic.This review summarizes representative classical and modified rodent models of MRONJ created through various combinations of systemic drug induction and local stimulation and discusses their effectiveness and efficiency.Currently,there is a lack of a unified assessment system for MRONJ models,which hinders a standard definition of MRONJ-like lesions in rodents.Therefore,this review comprehensively summarizes assessment systems based on published peer-review articles,including new approaches in gross observation,histological assessments,radiographic assessments,and serological assessments.This review can serve as a reference for model establishment and evaluation in future preclinical studies on MRONJ.展开更多
基金2024 Key Project of Teaching Reform Research and Practice in Higher Education in Henan Province“Exploration and Practice of Training Model for Outstanding Students in Basic Mechanics Discipline”(2024SJGLX094)Henan Province“Mechanics+X”Basic Discipline Outstanding Student Training Base2024 Research and Practice Project of Higher Education Teaching Reform in Henan University of Science and Technology“Optimization and Practice of Ability-Oriented Teaching Mode for Computational Mechanics Course:A New Exploration in Cultivating Practical Simulation Engineers”(2024BK074)。
文摘This paper takes the assessment and evaluation of computational mechanics course as the background,and constructs a diversified course evaluation system that is student-centered and integrates both quantitative and qualitative evaluation methods.The system not only pays attention to students’practical operation and theoretical knowledge mastery but also puts special emphasis on the cultivation of students’innovative abilities.In order to realize a comprehensive and objective evaluation,the assessment and evaluation method of the entropy weight model combining TOPSIS(Technique for Order Preference by Similarity to Ideal Solution)multi-attribute decision analysis and entropy weight theory is adopted,and its validity and practicability are verified through example analysis.This method can not only comprehensively and objectively evaluate students’learning outcomes,but also provide a scientific decision-making basis for curriculum teaching reform.The implementation of this diversified course evaluation system can better reflect the comprehensive ability of students and promote the continuous improvement of teaching quality.
基金supported by the projects of the China Geological Survey(DD20221729,DD20190291)Zhuhai Urban Geological Survey(including informatization)(MZCD–2201–008).
文摘Machine learning is currently one of the research hotspots in the field of landslide prediction.To clarify and evaluate the differences in characteristics and prediction effects of different machine learning models,Conghua District,which is the most prone to landslide disasters in Guangzhou,was selected for landslide susceptibility evaluation.The evaluation factors were selected by using correlation analysis and variance expansion factor method.Applying four machine learning methods namely Logistic Regression(LR),Random Forest(RF),Support Vector Machines(SVM),and Extreme Gradient Boosting(XGB),landslide models were constructed.Comparative analysis and evaluation of the model were conducted through statistical indices and receiver operating characteristic(ROC)curves.The results showed that LR,RF,SVM,and XGB models have good predictive performance for landslide susceptibility,with the area under curve(AUC)values of 0.752,0.965,0.996,and 0.998,respectively.XGB model had the highest predictive ability,followed by RF model,SVM model,and LR model.The frequency ratio(FR)accuracy of LR,RF,SVM,and XGB models was 0.775,0.842,0.759,and 0.822,respectively.RF and XGB models were superior to LR and SVM models,indicating that the integrated algorithm has better predictive ability than a single classification algorithm in regional landslide classification problems.
文摘Zambia like any other country in most African regions is still grappling with the dynamics of harnessing technology for the betterment of Higher Education. The onset of the Covid 19 pandemic brought a test for the preparedness of the Zambian Higher Education Institutions (HEIs) in harnessing technology for pedagogical activities. As countries worldwide switched to electronic learning during the pandemic, the same could not be said for Zambian HEIs. Zambian HEIs struggled to conduct pedagogical activities on learning management platforms. This study investigated the factors affecting the implementation and assessment of learning Management systems in Zambia’s HEIs. With its focus on assessing: 1) system features, 2) compliance with regulatory standards, 3) quality of service and 4) technology acceptance as the four key assessment areas of an LMS, this article proposed a model for assessing learning management systems in Zambian HEIs. To test the proposed model, a software tool was also developed.
基金supported by the National Moon Exploration Program of China (No. TY3Q20110020)in part supported by the 13th Five-Year Community Technology Research Program of National Equipment Development Department of China (No.41409020301)the National Natural Science Foundation of China (50971094)
文摘With the development of EMC technology, EMC assessment has become increasingly important in EMC design. Although numerous EMC assessment models are available today, few of them can provide a tradeoff between efficiency and accuracy for the specific case of military vehicular communication systems. Face to this situation, a modified four-level assessment model is proposed in the paper. First, the development of EMC assessment technology is briefly reviewed, and the theoretical mechanism of EMI environment is introduced. Then, the architecture of the proposed model is outlined, and the assessment methods are explored. To demonstrate the application of it, an example involving a communication system in a military vehicle is presented. From the physical layer to the signal layer, a hierarchical assessment on the entire system is successfully performed based on the proposed model, and we can make a qualitative EMC assessment on the EMC performance of the system. Based on a comparison with the traditional model, we conclude that the proposed model is more accurate, more efficient and less time-consuming, which is suitable for the EMC assessment on militaryvehicular communication systems. We hope that the proposed model will serve as a useful reference for system-level EMC assessments for other systems.
基金supported by the CAS (Chinese Academy of Sciences) Action Plan for West Development Project "Watershed Allied Telemetry Experimental Research (WATER)"(grant number:KZCX2-XB2-09)the Global Change Research Program of China (2010CB951403)+2 种基金WP6 of FP7 topic ENV.2007.4.1.4.2 "Improving observing systems for water resource management"the National Natural Science Foundation of China (grant number:41071227)the Major Research Plan "Integrated Research on the Eco-Hydrological Process of Heihe Basin" of National Natural Science Foundation of China,topic (grant number:91025001)
文摘The ecosystem is important because it is the life sustaining system for human survival.Three ecosystem characteristics are:regional particularities,ecosystem complexity and conventional cultural particularities.This paper develops a remote sensing based dynamic model to assess grassland ecosystem service values involving multidisciplinary knowledge.The ecological value of grassland ecosystems is focused on using a remote sensing technique in the model,and setting up the framework for a dynamic assessing model.The grassland ecological services condition and value in 1985 is used as the benchmark.The dynamic model has two adjusting indicators:biomass and price index.The biomass is simulated using the CASA(Carnegie-Ames-Stanford Approach) model.The price index was obtained from statistics data published by the statistical bureau.Results show that the grassland ecosystem value in Gansu Province was 28.36 billion Chinese Yuan in 1985,140.37 billion in 1999 and 130.86 billion in 2002.
基金This work was supported by Natural Science Foundation of Hainan Province of China(No.117212)National Natural Science Foundation of China(Nos.61633008,61374007,61601262 and 61701487)Natural Science Foundation of Heilongjiang Province of China(No.F2017005)and China Scholarship Council.
文摘This paper addresses the problem of assessing and optimizing the acoustic positioning system for underwater target localization with range measurement.We present a new three-dimensional assessment model to evaluate the optimal geometric beacon formation whether meets user requirements.For mathematical tractability,it is assumed that the measurements of the range between the target and beacons are corrupted with white Gaussian noise with variance,which is distance-dependent.Then,the relationship between DOP parameters and positioning accuracy can be derived by adopting dilution of precision(DOP)parameters in the assessment model.In addition,the optimal geometric beacon formation yielding the best performance can be achieved via minimizing the values of geometric dilution of precision(GDOP)in the case where the target position is known and fixed.Next,in order to ensure that the estimated positioning accuracy on the region of interest satisfies the precision required by the user,geometric positioning accuracy(GPA),horizontal positioning accuracy(HPA)and vertical positioning accuracy(VPA)are utilized to assess the optimal geometric beacon formation.Simulation examples are designed to illustrate the exactness of the conclusion.Unlike other work that only uses GDOP to optimize the formation and cannot assess the performance of the specified size,this new three-dimensional assessment model can evaluate the optimal geometric beacon formation for each dimension of any point in three-dimensional space,which can provide guidance to optimize the performance of each specified dimension.
基金supported by The Second Tibetan Plateau Scientific Expedition and Research (STEP) program(Grant No. 2019QZKK0102)the National Natural Science Foundation of China (Grant No. 41975135)+1 种基金the Natural Science Foundation of Sichuan,China (Grant No. 2022NSFSC1092)funded by the China Scholarship Council。
文摘The diurnal temperature range(DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR variations over the Tibetan Plateau. It assesses 23 climate models from phase 6 of the Coupled Model Intercomparison Project(CMIP6) using CN05.1 observational data as validation, evaluating their ability to simulate DTR over the Tibetan Plateau. Then, the evolution of DTR over the Tibetan Plateau under different shared socioeconomic pathway(SSP) scenarios for the near,middle, and long term of future projection are analyzed using 11 selected robustly performing models. Key findings reveal:(1) Among the models examined, BCC-CSM2-MR, EC-Earth3, EC-Earth3-CC, EC-Earth3-Veg, EC-Earth3-Veg-LR,FGOALS-g3, FIO-ESM-2-0, GFDL-ESM4, MPI-ESM1-2-HR, MPI-ESM1-2-LR, and INM-CM5-0 exhibit superior integrated simulation capability for capturing the spatiotemporal variability of DTR over the Tibetan Plateau.(2) Projection indicates a slightly increasing trend in DTR on the Tibetan Plateau in the SSP1-2.6 scenario, and decreasing trends in the SSP2-4.5, SSP3-7.0, and SPP5-8.5 scenarios. In certain areas, such as the southeastern edge of the Tibetan Plateau, western hinterland of the Tibetan Plateau, southern Kunlun, and the Qaidam basins, the changes in DTR are relatively large.(3) Notably, the warming rate of maximum temperature under SSP2-4.5, SSP3-7.0, and SPP5-8.5 is slower compared to that of minimum temperature, and it emerges as the primary contributor to the projected decrease in DTR over the Tibetan Plateau in the future.
基金funded by the National Natu-ral Science Foundation of China(Grant No.42075044 and No.41975112)a project supported by the Innovation Group Project of the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(Grant No.311022006).
文摘This study quantified the regional damages resulting from temperature and sea level changes using the Regional Integrated of Climate and Economy(RICE)model,as well as the effects of enabling and disabling the climate impact module on future emission pathways.Results highlight varied damages depending on regional economic development and locations.Specifically,China and Africa could suffer the most serious comprehensive damages caused by temperature change and sea level rise,followed by India,other developing Asian countries(OthAsia),and other high-income countries(OHI).The comprehensive damage fractions for China and Africa are projected to be 15.1%and 12.5%of gross domestic product(GDP)in 2195,with corresponding cumulative damages of 124.0 trillion and 87.3 trillion United States dollars(USD)from 2005 to 2195,respectively.Meanwhile,the comprehensive damage fractions in Japan,Eurasia,and Russia are smaller and projected to be lower than 5.6%of GDP in 2195,with cumulative damages of 6.8 trillion,4.2 trillion,and 3.3 trillion USD,respectively.Additionally,coastal regions like Africa,the European Union(EU),and OHI show comparable damages for sea level rise and temperature change.In China,however,sea level-induced damages are projected to exceed those from temperature changes.Moreover,this study indicates that switching the damage modules on or off affects the regional and global emission trajectories,but the magnitude is relatively small.By 2195,global emissions under the experiments with all of the damage modules switched off,only the sea level damage module switched on,and only the temperature damage module switched on,were 3.5%,2.3%and 1.2%higher than those with all of the damage modules switched on,respectively.
文摘The public procurement system in Bangladesh has been running by traditional manual process under the flagship of Public Procurement Act (PPA 2006) and Public Procurement Rules (PPR 2008). Public procurement agencies have been facing challenges in this manual tendering system. To overcome this problem and to bring reality to the “Digital Bangladesh” slogan, the Government of Bangladesh introduced the e-Procurement system under the e-GP (Electronic Government Procurement) guideline 2011. After the inception of e-procurement, there is no e-procurement assessment model to improve the e-GP system. The purpose of this research is to develop a conceptual framework and to design an e-procurement assessment model. With this view, we have considered one of the biggest entity Roads and Highways Department (RHD) of the Government of Bangladesh, for field study. Mixed methods along with FGD (Focus Group Discussion), KII (Key Informant Interview), and survey questionnaires are used to collect data from RHD, and then Statistical Package for Social Science (SPSS) software is used for regression analysis and hypothesis testing to develop the e-Procurement assessment model. The novel contribution of the study lies in the test of the hypothesis that focuses on developing the conceptual model of the e-procurement assessment system in Bangladesh. Findings of the study are essential for all Procurement Entity (PE) and suppliers <i>i.e. </i> contractors of RHD who are engaged in the construction of the infrastructure project development project.
基金Supported by the Zhejiang Province Medical and Health Science and Technology Plan Project,No.2022KY1427.
文摘BACKGROUND Mucocutaneous separation(MCS)is a common postoperative complication in enterostomy patients,potentially leading to significant morbidity.Early identification of risk factors is crucial for preventing this condition.However,predictive models for MCS remain underdeveloped.AIM To construct a risk prediction model for MCS in enterostomy patients and assess its clinical predictive accuracy.METHODS A total of 492 patients who underwent enterostomy from January 2019 to March 2023 were included in the study.Patients were divided into two groups,the MCS group(n=110),and the non-MCS(n=382)based on the occurrence of MCS within the first 3 weeks after surgery.Univariate and multivariate analyses were used to identify the independent predictive factors of MCS and the model constructed.Receiver operating characteristic curve analysis was used to assess the model’s performance.RESULTS The postoperative MCS incidence rate was 22.4%.Suture dislodgement(P<0.0001),serum albumin level(P<0.0001),body mass index(BMI)(P=0.0006),hemoglobin level(P=0.0409),intestinal rapture(P=0.0043),incision infection(P<0.0001),neoadjuvant therapy(P=0.0432),stoma site(P=0.0028)and elevated intra-abdominal pressure(P=0.0395)were potential predictive factors of MCS.Suture dislodgement[P<0.0001,OR:28.007595%CI:(11.0901-82.1751)],serum albumin level(P=0.0008,OR:0.3504,95%CI:[0.1902-0.6485]),BMI[P=0.0045,OR:2.1361,95%CI:(1.2660-3.6235)],hemoglobin level[P=0.0269,OR:0.5164,95%CI:(0.2881-0.9324)],intestinal rapture[P=0.0351,OR:3.0694,95%CI:(1.0482-8.5558)],incision infection[P=0.0179,OR:0.2885,95%CI:(0.0950-0.7624)]and neoadjuvant therapy[P=0.0112,OR:1.9769,95%CI:(1.1718-3.3690)]were independent predictive factors and included in the model.The model had an area under the curve of 0.827 and good clinical utility on decision curve analysis.CONCLUSION The mucocutaneous separation prediction model constructed in this study has good predictive performance and can provide a reference for early warning of mucocutaneous separation in enterostomy patients.
基金key technology project for the prevention and control of major workplace safety accidents in 2017 from the State Administration of Work Safety of China-the research on the identification and assessment technology and control system of major risks of enterprises for the prevention and control of severe accidents(Hubei-0002-2017AQ)supported by the Department of Emergency Management of Hubei Province,Wuhan 430064,China.
文摘The technological revolution has spawned a new generation of industrial systems,but it has also put forward higher requirements for safety management accuracy,timeliness,and systematicness.Risk assessment needs to evolve to address the existing and future challenges by considering the new demands and advancements in safety management.The study aims to propose a systematic and comprehensive risk assessment method to meet the needs of process system safety management.The methodology first incorporates possibility,severity,and dynamicity(PSD)to structure the“51X”evaluation indicator system,including the inherent,management,and disturbance risk factors.Subsequently,the four-tier(risk point-unit-enterprise-region)risk assessment(RA)mathematical model has been established to consider supervision needs.And in conclusion,the application of the PSD-RA method in ammonia refrigeration workshop cases and safety risk monitoring systems is presented to illustrate the feasibility and effectiveness of the proposed PSD-RA method in safety management.The findings show that the PSD-RA method can be well integrated with the needs of safety work informatization,which is also helpful for implementing the enterprise's safety work responsibility and the government's safety supervision responsibility.
基金Analysis and Research on Online Learning in Higher Vocational Colleges Based on Kirkpatrick Model-Taking the Course of Physiology as an Example(Project No.:D/2021/03/91)The excellent teaching team of Physiology of Suzhou Vocational College of Health Science and Technology in 2019(Project number:JXTD201912).
文摘Objective:To analyze the technical indexes of students’online learning behavior analysis based on Kirkman’s evaluation model,sort out the basic indexes of online learning behavior,and extract scientific and efficient evaluation indexes of online learning effect through statistical analysis.Methods:The online learning behavior data of Physiology of nursing students from 2021-2023 and the first semester of 22 nursing classes(3 and 4)were collected and analyzed.The preset learning behavior indexes were analyzed by multi-dimensional analysis and a correlation analysis was conducted between the indexes and the final examination scores to screen for the dominant important indexes for online learning effect evaluation.Results:The study found that the demand for online learning of nursing students from 2021-2023 increased and the effect was statistically significant.Compared with the stage assessment results,the online learning effect was statistically significant.Conclusion:The main indicators for evaluating and classifying online learning behaviors were summarized.These two indicators can help teachers predict which part of students need learning intervention,optimize the teaching process,and help students improve their learning behavior and academic performance.
文摘The performance of corporate social responsibility is conducive to the con- tinuous improvement of their profitability, and promotes the upgrading of corporation value. However, it is difficult to confirm, calculate and check the costs and benefits brought by the implementation of corporate social responsibility under the current ac- counting theory system, so it is difficult to estimate whether the fulfillment of corpo- rate social responsibility has any effects on the corporation value assessment. Therefore, based on corporate social responsibility, the correction mode of corpora- tion value assessment is put forward.
基金Project(2013CB036004) supported by National Basic Research Program(973)of ChinaProject(51378510) supported by National Natural Science Foundation of China
文摘Tunnel water inrush is one of the common geological disasters in the underground engineering construction.In order to effectively evaluate and control the occurrence of water inrush,the risk assessment model of tunnel water inrush was proposed based on improved attribute mathematical theory.The trigonometric functions were adopted to optimize the attribute mathematical theory,avoiding the influence of mutation points and linear variation zones in traditional linear measurement functions on the accuracy of the model.Based on comprehensive analysis of various factors,five parameters were selected as the evaluation indicators for the model,including tunnel head pressure,permeability coefficient of surrounding rock,crushing degree of surrounding rock,relative angle of joint plane and tunnel section size,under the principle of dimension rationality,independence,directness and quantification.The indicator classifications were determined.The links among measured data were analyzed in detail,and the objective weight of each indicator was determined by using similar weight method.Thereby the tunnel water inrush risk assessment model is established and applied in four target segments of two different tunnels in engineering.The evaluation results and the actual excavation data agree well,which indicates that the model is of high credibility and feasibility.
文摘AIM:To explore the related risk factors for diabetic retinopathy(DR)in type 2 diabetes with insulin therapy.METHODS:We studied the relationships among blood glucose,serum C-peptide,plasma insulin,beta-cell function and the development of DR.Beta-cell function was assessed by a modified homeostasis model assessment(modified HOMA)which was gained by using C-peptide to replace insulin in the homeostasis model assessment(HOMA)of beta-cell function.We also studied the relationships between modified HOMA index and serum C-peptide response to 100 g tasteless steamed bread to determine the accuracy of modified HOMA.RESULTS:Our study group consisted of 170 type 2diabetic inpatients with DR(age:58.35±13.87y,mean±SD)and 205 type 2 diabetic inpatients with no DR(NDR)(age:65.52±11.59y).DR patients had higher age,longer diabetic duration,higher hypertension grade,higher postprandial plasma glucose,higher fluctuation level of plasma glucose,lower body mass index(BMI),lower postprandial serum insulin and C-peptide,lower fluctuation level of serum insulin and C-peptide(P【0.05).In our logistic regression model,duration of diabetes,hypertension grade,fasting plasma insulin and glycosylated hemoglobin(HbA1C)were significantly associated with the presence of DR after adjustment for confounding factors(P【0.05).CONCLUSION:Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlationanalysis,logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors(such as age,sex,duration of diabetes,BMI,hypertension grade,HbA1C,plasma insulin).Duration of diabetes,hypertension grade,fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics.
基金supported by National Science and Technology Major Project(No2009 ZX 05039-003,2009 ZX 05039-004,2011ZX05060-005)the National Natural Science Foundation of China(No 2010CB428801-1)state-owned land resources investigation(1212010430351)
文摘In this study, a risk-based management model is developed and applied to an industrial zone. The models proposed by the United States Environmental Protection Agency and Han Bing have been improved by adding a residual ratio of volatile organic compounds (VOC) after boiling and deleting the related parameters in half-life. Using this improved model, an integrated process was used to assess human health risk level in the study area. Compared with water quality analysis, the results highlight the importance of applying an integrated approach for decision making on risk levels and water protection. The results of this study demonstrated that: (1) Compared with these permissible level standards in China (GB 3838-2002) and National Primary Drinking Water Regulations of the United States, the residents' daily life had not been affected by the groundwater in this area (except for relative bad water quality of HB3-4 and HB3-6); (2) The typical detected organic contaminants of all groundwater samples were chloroform, carbon tetrachloride, trichloroethylene and tetrachloroethene, and the pollution sources were mainly industrial sources by preliminary investigations; (3) As for groundwater, the non-carcinogenic risk values of all samples do not exceed the permissible level of 1.0 and the carcinogenic risk values are relatively lower than the permissible level of 1.00E-06 to 1.00E-04; (4) Drinking water pathway of trichloroethylene and tetrachloroethylene mainly contribute to increasing the health risk of residents' in study areas; (5) In terms of non-carcinogenic risk and carcinogenic risk, the health risk order for drinking water pathway and dermal contact pathway was: drinking water pathway 〉 dermal contact pathway.
基金the Marine Public Welfare Research Project of China (No. 201205012)Preferential Funding of Tianjin
文摘To the potential oil-spill risk caused by offshore pipeline more attention has been paid after the Dalian oil spill incident from oil-pipeline explosion. Since then an issue about how to prevent and control the sudden oil-spill from the offshore pipeline has been raised. In this paper, we proposed an optimized model to analyze the main causes(probability) of spill and the consequence with the fuzzy comprehensive assessment model. Considering the complicated assessment process for oil-spill, the assessment factor system involving the spill probability and consequence was established based on the operative manual and statistic leakage/damage data of offshore pipeline in order to estimate the integrated spill risk score automatically. The evaluated factors of spill probability could be grouped into five aspects: corrosion, fatigue, national damage, third party, and operational fault; the consequence evaluated factors of spill included hazard of oil and impact-controlling capability. With some modifications based on experts' opinions, each of the evaluated factors in our work was developed with a relative weight and evaluation criterion. A test example for an offshore pipeline in the Bohai waters was described to show how the model can be used for an actual case in more detail. By using the oil-spill risk assessment model, it is easy to determine the risk level associated with the ongoing activity and management level and hence to take the risk mitigation action immediately.
基金supported by the Special Fund for Agroscientific Research in the Public Interest,China(20110300501-01)the Special Fund for First-Class University (4572-18101510)
文摘Green manure use in China has declined rapidly since the 1980 s with the extensive use of chemical fertilizers.The deterioration of field environments and the demand for green agricultural products have resulted in more attention to green manure.Human intervention and policy-oriented behaviors likely have large impacts on promoting green manure planting.However,little information is available regarding on where,at what rates,and in which ways(i.e.,intercropping green manure in orchards or rotating green manure in cropland) to develop green manure and what benefits could be gained by incorporating green manure in fields at the county scale.This paper presents the conversion of land use and its effects at small region extent(CLUE-S) model,which is specifically developed for the simulation of land use changes originally,to predict spatial distribution of green manure in cropland and orchards in 2020 in Pinggu District located in Beijing,China.Four types of land use for planting or not planting green manure were classified and the future land use dynamics(mainly croplands and orchards) were considered in the prediction.Two scenarios were used to predict the spatial distribution of green manure based on data from 2011:The promotion of green manure planting in orchards(scenario 1) and the promotion of simultaneous green manure planting in orchards and croplands(scenario 2).The predictions were generally accurate based on the receiver operating characteristic(ROC) and Kappa indices,which validated the effectiveness of the CLUE-S model in the prediction.In addition,the spatial distribution of the green manure was acquired,which indicated that green manure mainly located in the orchards of the middle and southern regions of Dahuashan,the western and southern regions of Wangxinzhuang,the middle region of Shandongzhuang,the eastern region of Pinggu and the middle region of Xiagezhuang under scenario 1.Green manure planting under scenario 2 occurred in orchards in the middle region of Wangxinzhuang,and croplands in most regions of Daxingzhuang,southern Pinggu,northern Xiagezhuang and most of Mafang.The spatially explicit results allowed for the assessment of the benefits of these changes based on different economic and ecological indicators.The economic and ecological gains of scenarios 1 and 2 were 175691 900 and143000 300 CNY,respectively,which indicated that the first scenario was more beneficial for promoting the same area of green manure.These results can facilitate policies of promoting green manure and guide the extensive use of green manure in local agricultural production in suitable ways.
基金supported by the National Natural Science Foundation of China(No.81921002,No.81900970)Young Physician Innovation Team Project(No.QC202003)from Ninth People’s Hospital,Shanghai Jiao Tong University School of MedicineShanghai Sailing Program(19YF1426000)jointly。
文摘Medication-related osteonecrosis of the jaw(MRONJ)is primarily associated with administering antiresorptive or antiangiogenic drugs.Despite significant research on MRONJ,its pathogenesis and effective treatments are still not fully understood.Animal models can be used to simulate the pathophysiological features of MRONJ,serving as standardized in vivo experimental platforms to explore the pathogenesis and therapies of MRONJ.Rodent models exhibit excellent effectiveness and high reproducibility in mimicking human MRONJ,but classical methods cannot achieve a complete replica of the pathogenesis of MRONJ.Modified rodent models have been reported with improvements for better mimicking of MRONJ onset in clinic.This review summarizes representative classical and modified rodent models of MRONJ created through various combinations of systemic drug induction and local stimulation and discusses their effectiveness and efficiency.Currently,there is a lack of a unified assessment system for MRONJ models,which hinders a standard definition of MRONJ-like lesions in rodents.Therefore,this review comprehensively summarizes assessment systems based on published peer-review articles,including new approaches in gross observation,histological assessments,radiographic assessments,and serological assessments.This review can serve as a reference for model establishment and evaluation in future preclinical studies on MRONJ.