The flipped classroom model differs significantly from the traditional classroom teaching model and offers numerous advantages. This article draws inspiration from the flipped classroom concept, using the “Innovation...The flipped classroom model differs significantly from the traditional classroom teaching model and offers numerous advantages. This article draws inspiration from the flipped classroom concept, using the “Innovation and Entrepreneurship Education and Practice (Theory)” course as an example to introduce the innovation and characteristics of the flipped classroom model: it is problem-oriented, addressing the “pain points” in teaching, motivating students towards “active learning,” and integrating diverse teaching methods. In the conclusion, the article proposed suggestions on the application of this model, encouraging teachers to summarize their teaching experiences, enhance their knowledge base, and foster students’ awareness of innovation and entrepreneurship.展开更多
Vocational colleges are an important type of higher education in China.Higher vocational education aims to adapt to social needs and designs students’knowledge,ability,quality structure,and training plans based on th...Vocational colleges are an important type of higher education in China.Higher vocational education aims to adapt to social needs and designs students’knowledge,ability,quality structure,and training plans based on the cultivation of technical application skills.Emphasizing both theoretical teaching and practical training,graduates have the skills to work directly.At this stage,vocational education in China is in an important period of transformation and development.In order to better adapt to the rapid development of society,many vocational colleges have carried out management system reforms in student education management,with the aim of cultivating more high-quality and skilled talents that meet the needs of social development,and providing higher quality vocational education services for the country and society.In the process of physical education reform,due to regional and other factors,many reform models cannot adapt to the current situation of student education management in vocational colleges in the new era.Therefore,it is necessary to continuously explore new models suitable for vocational colleges.Based on the background of the physical education reform in vocational colleges,this article uses methods such as literature research and visits to analyze the current situation of education management in vocational colleges,the problems and possible reasons that exist in student education management in vocational colleges.This article discusses the possible new models of student education management in vocational colleges from the perspectives of repeated management methods,management concepts,management mechanisms,and evaluation systems,and elaborates on their new paths.Efforts are made to improve the management mode of student education in vocational colleges,innovate the management mechanism of vocational colleges,and actively explore the improvement of the management mode of student education in vocational colleges.展开更多
BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally low.AIM To explore the potential influencing factors,and the literature o...BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally low.AIM To explore the potential influencing factors,and the literature on successful culture rates of GCOs was reviewed using meta-analysis.METHODS PubMed,Web of Science,and EMBASE were searched for studies.Two trained researchers selected the studies and extracted data.STATA 17.0 software was used for meta-analysis of the incidence of each outcome event.The adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included studies.Funnel plots and Egger’s test were used to detect publication bias.Subgroup analyses were conducted for sex,tissue source,histo-logical classification,and the pathological tumor-node-metastasis(pTNM)cancer staging system.RESULTS Eight studies with a pooled success rate of 66.6%were included.GCOs derived from women and men had success rates of 67%and 46.7%,respectively.GCOs from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9%and 53.7%,respectively.GCOs of poorly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,respectively.GCOs with pTNM stages I-II and III-IV showed success rates of 38.3%and 65.2%,respectively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,respectively.GCOs generated with collagenase were more successful than those constructed with Liberase TH and TrypLE(72.1%vs 71%,respectively).EDTA digestion showed a 50%lower success rate than other methods(P=0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological type,and pTNM stage.Omitting Y-27632,and using Liberase TH,TrypLE,or collagenase yields greater success than EDTA.展开更多
Purpose-In order to solve the problem of inaccurate calculation of index weights,subjectivity and uncertainty of index assessment in the risk assessment process,this study aims to propose a scientific and reasonable c...Purpose-In order to solve the problem of inaccurate calculation of index weights,subjectivity and uncertainty of index assessment in the risk assessment process,this study aims to propose a scientific and reasonable centralized traffic control(CTC)system risk assessment method.Design/methodologylapproach-First,system-theoretic process analysis(STPA)is used to conduct risk analysis on the CTC system and constructs risk assessment indexes based on this analysis.Then,to enhance the accuracy of weight calculation,the fuzzy analytical hierarchy process(FAHP),fuzzy decision-making trial and evaluation laboratory(FDEMATEL)and entropy weight method are employed to calculate the subjective weight,relative weight and objective weight of each index.These three types of weights are combined using game theory to obtain the combined weight for each index.To reduce subjectivity and uncertainty in the assessment process,the backward cloud generator method is utilized to obtain the numerical character(NC)of the cloud model for each index.The NCs of the indexes are then weighted to derive the comprehensive cloud for risk assessment of the CTC system.This cloud model is used to obtain the CTC system's comprehensive risk assessment.The model's similarity measurement method gauges the likeness between the comprehensive risk assessment cloud and the risk standard cloud.Finally,this process yields the risk assessment results for the CTC system.Findings-The cloud model can handle the subjectivity and fuzziness in the risk assessment process well.The cloud model-based risk assessment method was applied to the CTC system risk assessment of a railway group and achieved good results.Originality/value-This study provides a cloud model-based method for risk assessment of CTC systems,which accurately calculates the weight of risk indexes and uses cloud models to reduce uncertainty and subjectivity in the assessment,achieving effective risk assessment of CTC systems.It can provide a reference and theoretical basis for risk management of the CTC system.展开更多
The basic structure and cloud features of Typhoon Nida(2016) are simulated using a new microphysics scheme(Liuma) within the Weather Research and Forecasting(WRF) model. Typhoon characteristics simulated with the Lium...The basic structure and cloud features of Typhoon Nida(2016) are simulated using a new microphysics scheme(Liuma) within the Weather Research and Forecasting(WRF) model. Typhoon characteristics simulated with the Liuma microphysics scheme are compared with observations and those simulated with a commonly-used microphysics scheme(WSM6). Results show that using different microphysics schemes does not significantly alter the track of the typhoon but does significantly affect the intensity and the cloud structure of the typhoon. Results also show that the vertical distribution of cloud hydrometeors and the horizontal distribution of peripheral rainband are affected by the microphysics scheme. The mixing ratios of rain water and graupel correlate highly with the vertical velocity component and equivalent potential temperature at the typhoon eye-wall region. According to the simulation with WSM 6 scheme,it is likely that the very low typhoon central pressure results from the positive feedback between hydrometeors and typhoon intensity. As the ice-phase hydrometeors are mostly graupel in the Liuma microphysics scheme, further improvement in this aspect is required.展开更多
Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations...Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations for media managers to promote health communication via social media. Methods: Our custom model was derived from literature review, empirical research was tested by the use of questionnaire investigation, and then the collected data were analyzed by structural equation model tool SmartPLS. Finally, the custom model was modified according to the experimental results of SmartPLS. Results: A total of 239 (66.39%) of the respondents were female and 121 (33.61%) were male. The maximum of two stages of age were 18 - 29 (70.56%), 30 - 39 (13.89%). Wechat (60.28%), QQ Zone (55.22%), Micro-blog (48.89%) were the most commonly used social media to obtain health information. About 44.72% of respondents used social media to obtain health information multiple times a day. The whole numerical values of AVE, cronbach’s alpha, CR and square roots of AVE were above the benchmarks of themselves and showed great reliability and validity. All the 11 hypotheses had obvious statistical significance, the P-value of eight path coefficients exhibited <0.001, one path coefficient exhibited <0.01 and two path coefficients exhibited <0.05. Conclusions: A suitable model of consumer health information seeking behavior via social media was created and some inner relationships were found. Namely, gratification of health information and its platform had a positive effect on attitudes toward health information seeking behavior. Health information literacy and health status were proved to have a significant influence on attitudes toward health information seeking behavior, subject norms and perceived behavioral control respectively. In addition, attitudes toward the health information seeking behavior, subject norms and perceived behavioral control were proved to positively associate with health information seeking behavior intention.展开更多
An analysis of the impact of simulation modelling in three diverse crop-livestock improvement projects in Agricultural Research for Development(AR4D) reveals benefits across a range of aspects including identificati...An analysis of the impact of simulation modelling in three diverse crop-livestock improvement projects in Agricultural Research for Development(AR4D) reveals benefits across a range of aspects including identification of objectives, design and implementation of experimental programs, effectiveness of participatory research with smallholder farmers, implementation of system change and scaling-out of results.In planning change, farmers must consider complex interactions within both biophysical and socioeconomic aspects of their crop and animal production activities.For this, whole-farm models that include household models of food, workload and financial requirements have the most utility and impact.The analysis also proposes improvements in design and implementation of AR4 D projects to improve the utility of simulation modelling for securing positive agronomic and livestock outcomes and lasting legacies.展开更多
A new method for driving a One-Dimensional Stratiform Cold (1DSC) cloud model with Weather Research and Fore casting (WRF) model outputs was developed by conducting numerical experiments for a typical large-scale ...A new method for driving a One-Dimensional Stratiform Cold (1DSC) cloud model with Weather Research and Fore casting (WRF) model outputs was developed by conducting numerical experiments for a typical large-scale stratiform rainfall event that took place on 4-5 July 2004 in Changchun, China. Sensitivity test results suggested that, with hydrometeor pro files extracted from the WRF outputs as the initial input, and with continuous updating of soundings and vertical velocities (including downdraft) derived from the WRF model, the new WRF-driven 1DSC modeling system (WRF-1DSC) was able to successfully reproduce both the generation and dissipation processes of the precipitation event. The simulated rainfall intensity showed a time-lag behind that observed, which could have been caused by simulation errors of soundings, vertical velocities and hydrometeor profiles in the WRF output. Taking into consideration the simulated and observed movement path of the precipitation system, a nearby grid point was found to possess more accurate environmental fields in terms of their similarity to those observed in Changchun Station. Using profiles from this nearby grid point, WRF-1DSC was able to repro duce a realistic precipitation pattern. This study demonstrates that 1D cloud-seeding models do indeed have the potential to predict realistic precipitation patterns when properly driven by accurate atmospheric profiles derived from a regional short range forecasting system, This opens a novel and important approach to developing an ensemble-based rain enhancement prediction and operation system under a probabilistic framework concept.展开更多
Using the Weather Research and Forecasting(WRF)model with two different microphysics schemes,the Predicted Particle Properties(P3)and the Morrison double-moment parameterizations,we simulated a stratiform rainfall eve...Using the Weather Research and Forecasting(WRF)model with two different microphysics schemes,the Predicted Particle Properties(P3)and the Morrison double-moment parameterizations,we simulated a stratiform rainfall event on 20–21 April 2010.The simulation output was compared with precipitation and aircraft observations.The aircraft-observed moderate-rimed dendrites and plates indicated that riming contributed significantly to ice particle growth at the mature precipitation stage.Observations of dendrite aggregation and capped columns suggested that aggregation coexisted with deposition or riming and played an important role in producing many large particles.The domain-averaged values of the 24-h surface precipitation accumulation from the two schemes were quite close to each other.However,differences existed in the temporal and spatial evolutions of the precipitation distribution.An analysis of the surface precipitation temporal evolution indicated faster precipitation in Morrison,while P3 indicated slower rainfall by shifting the precipitation pattern eastward toward what was observed.The differences in precipitation values between the two schemes were related to the cloud water content distribution and fall speeds of rimed particles.P3 simulated the stratiform precipitation event better as it captured the gradual transition in the mass-weighted fall speeds and densities from unrimed to rimed particles.展开更多
The research of coupling WRF (Weather Research and Forecasting Model) with a land surface model is enhanced to explore the interaction of the atmosphere and land surface; however, regional applicability of WRF model...The research of coupling WRF (Weather Research and Forecasting Model) with a land surface model is enhanced to explore the interaction of the atmosphere and land surface; however, regional applicability of WRF model is questioned. In order to do the validation of WRF model on simulating forcing data for the Heihe River Basin, daily meteorological observation data from 15 stations of CMA (China Meteorological Administration) and hourly meteorological observation data from seven sites of WATER (Watershed Airborne Telemetry Experimental Research) are used to compare with WRF simulations, with a time range of a whole year for 2008. Results show that the average MBE (Mean Bias Error) of daily 2-m surface temperature, surface pressure, 2-m relative humidity and 10-m wind speed were -0.19 ℃, -4.49 hPa, 4.08% and 0.92 m/s, the average RMSE (Root Mean Square Error) of them were 2.11 ℃, 5.37 hPa, 9.55% and 1.73 m/s, and the average R (correlation coefficient) of them were 0.99, 0.98, 0.80 and 0.55, respectively. The average MBE of hourly 2-m surface temperature, surface pressure, 2-m relative humidity, 10-m wind speed, downward shortwave radiation and downward longwave were-0.16 ℃,-6.62 hPa,-5.14%, 0.26 m/s, 33.0 W/m^2 and-6.44 W/m^2, the average RMSE of them were 2.62 ℃, 17.10 hPa, 20.71%, 2.46 m/s, 152.9 W/m^2 and 53.5 W/m^2, and the average R of them were 0.96, 0.97, 0.70, 0.26, 0.91 and 0.60, respectively. Thus, the following conclusions were obtained: (1) regardless of daily or hourly validation, WRF model simulations of 2-m surface temperature, surface pressure and relative humidity are more reliable, especially for 2-m surface air temperature and surface pressure, the values of MBE were small and R were more than 0.96; (2) the WRF simulating downward shortwave radiation was relatively good, the average R between WRF simulation and hourly observation data was above 0.9, and the average R of downward longwave radiation was 0.6; (3) both wind speed and rainfall simulated from WRF model did not agree well with observation data.展开更多
We used a weather research and forecasting model to simulate a torrential rainstorm that occurred in Xinjiang, China during June 16–17, 2016. The model successfully simulated the rainfall area, precipitation intensit...We used a weather research and forecasting model to simulate a torrential rainstorm that occurred in Xinjiang, China during June 16–17, 2016. The model successfully simulated the rainfall area, precipitation intensity, and changes in precipitation. We identified a clear wave signal using the two-dimensional fast Fourier transform method; the waves propagated westwards, with wavelengths of 45–20 km, periods of 50–120 min, and phase velocities mainly concentrated in the-25 m/s to-10 m/s range. The results of wavelet cross-spectral analysis further confirmed that the waves were gravity waves, peaking at 11:00 UTC, June 17, 2016. The gravity wave signal was identified along 79.17–79.93°E, 81.35–81.45°E and 81.5–81.83°E. The gravity waves detected along 81.5–81.83°E corresponded well with precipitation that accumulated in 1 h, indicating that gravity waves could be considered a rainstorm precursor in future precipitation forecasts.展开更多
With economic development and rapid urbanization,increases in Gross Domestic Product and population in fastgrowing cities since the turn of the 21st Century have led to increases in energy consumption.Anthropogenic he...With economic development and rapid urbanization,increases in Gross Domestic Product and population in fastgrowing cities since the turn of the 21st Century have led to increases in energy consumption.Anthropogenic heat flux released to the near-surface atmosphere has led to changes in urban thermal environments and severe extreme temperature events.To investigate the effects of energy consumption on urban extreme temperature events,including extreme heat and cold events,a dynamic representation scheme of anthropogenic heat release(AHR)was implemented in the Advanced Research version of the Weather Research and Forecasting(WRF)model,and AHR data were developed based on energy consumption and population density in a case study of Beijing,China.Two simulations during 1999−2017 were then conducted using the developed WRF model with 3-km resolution with and without the AHR scheme.It was shown that the mean temperature increased with the increase in AHR,and more frequent extreme heat events were produced,with an annual increase of 0.02−0.19 days,as well as less frequent extreme cold events,with an annual decrease of 0.26−0.56 days,based on seven extreme temperature indices in the city center.AHR increased the sensible heat flux and led to surface energy budget changes,strengthening the dynamic processes in the atmospheric boundary layer that reduce AHR heating efficiency more in summer than in winter.In addition,it was concluded that suitable energy management might help to mitigate the impact of extreme temperature events in different seasons.展开更多
Two intense quasi-linear mesoscale convective systems(QLMCSs) in northern China were simulated using the WRF(Weather Research and Forecasting) model and the 3D-Var(three-dimensional variational) analysis system ...Two intense quasi-linear mesoscale convective systems(QLMCSs) in northern China were simulated using the WRF(Weather Research and Forecasting) model and the 3D-Var(three-dimensional variational) analysis system of the ARPS(Advanced Regional Prediction System) model.A new method in which the lightning density is calculated using both the precipitation and non-precipitation ice mass was developed to reveal the relationship between the lightning activities and QLMCS structures.Results indicate that,compared with calculating the results using two previous methods,the lightning density calculated using the new method presented in this study is in better accordance with observations.Based on the calculated lightning densities using the new method,it was found that most lightning activity was initiated on the right side and at the front of the QLMCSs,where the surface wind field converged intensely.The CAPE was much stronger ahead of the southeastward progressing QLMCS than to the back it,and their lightning events mainly occurred in regions with a large gradient of CAPE.Comparisons between lightning and non-lightning regions indicated that lightning regions featured more intense ascending motion than non-lightning regions;the vertical ranges of maximum reflectivity between lightning and non-lightning regions were very different;and the ice mixing ratio featured no significant differences between the lightning and non-lightning regions.展开更多
The platform scheduling problem in battlefield is one of the important problems in military operational research.It needs to minimize mission completing time and meanwhile maximize the mission completing accuracy with...The platform scheduling problem in battlefield is one of the important problems in military operational research.It needs to minimize mission completing time and meanwhile maximize the mission completing accuracy with a limited number of platforms.Though the traditional certain models obtain some good results,uncertain model is still needed to be introduced since the battlefield environment is complex and unstable.An uncertain model is prposed for the platform scheduling problem.Related parameters in this model are set to be fuzzy or stochastic.Due to the inherent disadvantage of the solving methods for traditional models,a new method is proposed to solve the uncertain model.Finally,the practicability and availability of the proposed method are demonstrated with a case of joint campaign.展开更多
We prepared concretes(RC0, RC30, and RC100) with three different mixes. The poresize distribution parameters of RAC were examined by high-precision mercury intrusion method(MIM) and nuclear magnetic resonance(NMR...We prepared concretes(RC0, RC30, and RC100) with three different mixes. The poresize distribution parameters of RAC were examined by high-precision mercury intrusion method(MIM) and nuclear magnetic resonance(NMR) imaging. A capillary-bundle physical model with random-distribution pores(improved model, IM) was established according to the parameters, and dry-shrinkage strain values were calculated and verified. Results show that in all pore types, capillary pores, and gel pores have the greatest impacts on concrete shrinkage, especially for pores 2.5-50 and 50-100 nm in size. The median radii are 34.2, 31, and 34 nm for RC0, RC30, and RC100, respectively. Moreover, the internal micropore size distribution of RC0 differs from that of RC30 and RC100, and the pore descriptions of MIM and NMR are consistent both in theory and in practice. Compared with the traditional capillary-bundle model, the calculated results of IM have higher accuracy as demonstrated by experimental verifi cation.展开更多
The weather research and forecasting(WRF) model is a new generation mesoscale numerical model with a fine grid resolution(2 km), making it ideal to simulate the macro-and micro-physical processes and latent heatin...The weather research and forecasting(WRF) model is a new generation mesoscale numerical model with a fine grid resolution(2 km), making it ideal to simulate the macro-and micro-physical processes and latent heating within Typhoon Molave(2009). Simulations based on a single-moment, six-class microphysical scheme are shown to be reasonable, following verification of results for the typhoon track, wind intensity, precipitation pattern, as well as inner-core thermodynamic and dynamic structures. After calculating latent heating rate, it is concluded that the total latent heat is mainly derived from condensation below the zero degree isotherm, and from deposition above this isotherm. It is revealed that cloud microphysical processes related to graupel are the most important contributors to the total latent heat. Other important latent heat contributors in the simulated Typhoon Molave are condensation of cloud water, deposition of cloud ice, deposition of snow, initiation of cloud ice crystals, deposition of graupel, accretion of cloud water by graupel, evaporation of cloud water and rainwater,sublimation of snow, sublimation of graupel, melting of graupel, and sublimation of cloud ice. In essence, the simulated latent heat profile is similar to ones recorded by the Tropical Rainfall Measuring Mission, although specific values differ slightly.展开更多
Since 2010,there has been a new round of drug crises in the United States.The abuse of opioids has led to a sharp increase in the number of people involved in drug crimes in the United States.There is an urgent need t...Since 2010,there has been a new round of drug crises in the United States.The abuse of opioids has led to a sharp increase in the number of people involved in drug crimes in the United States.There is an urgent need to explore solutions to the drug crisis in the United States.In this paper,the model of in-depth analysis is established under the condition of obtaining the opioid data and the influence factor data of the large sample of five state[1].In the first part,we use the Highway Safety Research Institute model based on the differential equation model to predict the initial value,find the initial position of the drug transfer,and obtain the curve of the number of different groups over time by fitting the data,so that the curves can be predicted the changing trends of the groups in the future.It was found that in Kentucky State,the county's most likely to start using opioids were Pike and Bale.In Ohio,the county's most likely to start using opioids are Jackson and Scioto.In Pennsylvania State,Mercer and Lackawanna are the counties most likely to start using opioids.Martinsville and Galax are the counties where Virginia State is most likely to start using opioids.Logan and Mingo are the counties where West Virginia State is most likely to start using opioids.In the second part,the gray prediction model is used to further analyze the time series of each factor,the maximum likelihood estimation method is used to obtain the weight of each factor,and the weight coefficient matrix is used to simulate the multivariate regression equation,and the factors that have the greatest influence on opioid abuse are educational background and family composition.In the third part,the hypothesis test model of two groups(the data type is proportional)is used to verify the difference between the influence factors(including the predicted values)in the first two parts of the states,thus verifying the feasibility between them.At the same time,we put forward a few suggestions to combine the current situation in the United States with the CDC data.We believe that in order to address the opium crisis,the U.S.government needs to strengthen not only oversight of doctors'prescriptions,but also make joint efforts of all sectors of society to fundamentally reduce the barriers to the use of opioids.展开更多
文摘The flipped classroom model differs significantly from the traditional classroom teaching model and offers numerous advantages. This article draws inspiration from the flipped classroom concept, using the “Innovation and Entrepreneurship Education and Practice (Theory)” course as an example to introduce the innovation and characteristics of the flipped classroom model: it is problem-oriented, addressing the “pain points” in teaching, motivating students towards “active learning,” and integrating diverse teaching methods. In the conclusion, the article proposed suggestions on the application of this model, encouraging teachers to summarize their teaching experiences, enhance their knowledge base, and foster students’ awareness of innovation and entrepreneurship.
文摘Vocational colleges are an important type of higher education in China.Higher vocational education aims to adapt to social needs and designs students’knowledge,ability,quality structure,and training plans based on the cultivation of technical application skills.Emphasizing both theoretical teaching and practical training,graduates have the skills to work directly.At this stage,vocational education in China is in an important period of transformation and development.In order to better adapt to the rapid development of society,many vocational colleges have carried out management system reforms in student education management,with the aim of cultivating more high-quality and skilled talents that meet the needs of social development,and providing higher quality vocational education services for the country and society.In the process of physical education reform,due to regional and other factors,many reform models cannot adapt to the current situation of student education management in vocational colleges in the new era.Therefore,it is necessary to continuously explore new models suitable for vocational colleges.Based on the background of the physical education reform in vocational colleges,this article uses methods such as literature research and visits to analyze the current situation of education management in vocational colleges,the problems and possible reasons that exist in student education management in vocational colleges.This article discusses the possible new models of student education management in vocational colleges from the perspectives of repeated management methods,management concepts,management mechanisms,and evaluation systems,and elaborates on their new paths.Efforts are made to improve the management mode of student education in vocational colleges,innovate the management mechanism of vocational colleges,and actively explore the improvement of the management mode of student education in vocational colleges.
基金Supported by National Natural Science Foundation of China,No.82174309 and No.81973774National Administration of Traditional Chinese Medicine:2019 Project of Building Evidence-Based Practice Capacity for TCM,No.2019XZZX-XH013Shuguang Hospital Siming Foundation Research Special Project,No.SGKJ-202304.
文摘BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally low.AIM To explore the potential influencing factors,and the literature on successful culture rates of GCOs was reviewed using meta-analysis.METHODS PubMed,Web of Science,and EMBASE were searched for studies.Two trained researchers selected the studies and extracted data.STATA 17.0 software was used for meta-analysis of the incidence of each outcome event.The adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included studies.Funnel plots and Egger’s test were used to detect publication bias.Subgroup analyses were conducted for sex,tissue source,histo-logical classification,and the pathological tumor-node-metastasis(pTNM)cancer staging system.RESULTS Eight studies with a pooled success rate of 66.6%were included.GCOs derived from women and men had success rates of 67%and 46.7%,respectively.GCOs from surgery or biopsy/endoscopic submucosal dissection showed success rates of 70.9%and 53.7%,respectively.GCOs of poorly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,respectively.GCOs with pTNM stages I-II and III-IV showed success rates of 38.3%and 65.2%,respectively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,respectively.GCOs generated with collagenase were more successful than those constructed with Liberase TH and TrypLE(72.1%vs 71%,respectively).EDTA digestion showed a 50%lower success rate than other methods(P=0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological type,and pTNM stage.Omitting Y-27632,and using Liberase TH,TrypLE,or collagenase yields greater success than EDTA.
基金National Natural Science Foundation of China under Grant 62203468Technological Research and Development Program of China State Railway Group Co.,Ltd.under Grant J2023G007+2 种基金Young Elite Scientist Sponsorship Program by China Association for Science and Technology(CAST)under Grant 2022QNRC001Youth Talent Program Supported by China Railway SocietyResearch Program of Beijing Hua-Tie Information Technology Corporation Limited under Grant 2023HT02.
文摘Purpose-In order to solve the problem of inaccurate calculation of index weights,subjectivity and uncertainty of index assessment in the risk assessment process,this study aims to propose a scientific and reasonable centralized traffic control(CTC)system risk assessment method.Design/methodologylapproach-First,system-theoretic process analysis(STPA)is used to conduct risk analysis on the CTC system and constructs risk assessment indexes based on this analysis.Then,to enhance the accuracy of weight calculation,the fuzzy analytical hierarchy process(FAHP),fuzzy decision-making trial and evaluation laboratory(FDEMATEL)and entropy weight method are employed to calculate the subjective weight,relative weight and objective weight of each index.These three types of weights are combined using game theory to obtain the combined weight for each index.To reduce subjectivity and uncertainty in the assessment process,the backward cloud generator method is utilized to obtain the numerical character(NC)of the cloud model for each index.The NCs of the indexes are then weighted to derive the comprehensive cloud for risk assessment of the CTC system.This cloud model is used to obtain the CTC system's comprehensive risk assessment.The model's similarity measurement method gauges the likeness between the comprehensive risk assessment cloud and the risk standard cloud.Finally,this process yields the risk assessment results for the CTC system.Findings-The cloud model can handle the subjectivity and fuzziness in the risk assessment process well.The cloud model-based risk assessment method was applied to the CTC system risk assessment of a railway group and achieved good results.Originality/value-This study provides a cloud model-based method for risk assessment of CTC systems,which accurately calculates the weight of risk indexes and uses cloud models to reduce uncertainty and subjectivity in the assessment,achieving effective risk assessment of CTC systems.It can provide a reference and theoretical basis for risk management of the CTC system.
基金Ministry of Science and Technology of China(2017YFC1501406)National Key Research and Development Plan Program of China(2017YFA0604500)CMA Youth Founding Program(Q201706&NWPC-QNJJ-201702)
文摘The basic structure and cloud features of Typhoon Nida(2016) are simulated using a new microphysics scheme(Liuma) within the Weather Research and Forecasting(WRF) model. Typhoon characteristics simulated with the Liuma microphysics scheme are compared with observations and those simulated with a commonly-used microphysics scheme(WSM6). Results show that using different microphysics schemes does not significantly alter the track of the typhoon but does significantly affect the intensity and the cloud structure of the typhoon. Results also show that the vertical distribution of cloud hydrometeors and the horizontal distribution of peripheral rainband are affected by the microphysics scheme. The mixing ratios of rain water and graupel correlate highly with the vertical velocity component and equivalent potential temperature at the typhoon eye-wall region. According to the simulation with WSM 6 scheme,it is likely that the very low typhoon central pressure results from the positive feedback between hydrometeors and typhoon intensity. As the ice-phase hydrometeors are mostly graupel in the Liuma microphysics scheme, further improvement in this aspect is required.
文摘Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations for media managers to promote health communication via social media. Methods: Our custom model was derived from literature review, empirical research was tested by the use of questionnaire investigation, and then the collected data were analyzed by structural equation model tool SmartPLS. Finally, the custom model was modified according to the experimental results of SmartPLS. Results: A total of 239 (66.39%) of the respondents were female and 121 (33.61%) were male. The maximum of two stages of age were 18 - 29 (70.56%), 30 - 39 (13.89%). Wechat (60.28%), QQ Zone (55.22%), Micro-blog (48.89%) were the most commonly used social media to obtain health information. About 44.72% of respondents used social media to obtain health information multiple times a day. The whole numerical values of AVE, cronbach’s alpha, CR and square roots of AVE were above the benchmarks of themselves and showed great reliability and validity. All the 11 hypotheses had obvious statistical significance, the P-value of eight path coefficients exhibited <0.001, one path coefficient exhibited <0.01 and two path coefficients exhibited <0.05. Conclusions: A suitable model of consumer health information seeking behavior via social media was created and some inner relationships were found. Namely, gratification of health information and its platform had a positive effect on attitudes toward health information seeking behavior. Health information literacy and health status were proved to have a significant influence on attitudes toward health information seeking behavior, subject norms and perceived behavioral control respectively. In addition, attitudes toward the health information seeking behavior, subject norms and perceived behavioral control were proved to positively associate with health information seeking behavior intention.
基金the various projects and others who participated in the review and to ACIAR and CSIRO for logistical and financial supportPC was a research manager for these projects in CSIRO
文摘An analysis of the impact of simulation modelling in three diverse crop-livestock improvement projects in Agricultural Research for Development(AR4D) reveals benefits across a range of aspects including identification of objectives, design and implementation of experimental programs, effectiveness of participatory research with smallholder farmers, implementation of system change and scaling-out of results.In planning change, farmers must consider complex interactions within both biophysical and socioeconomic aspects of their crop and animal production activities.For this, whole-farm models that include household models of food, workload and financial requirements have the most utility and impact.The analysis also proposes improvements in design and implementation of AR4 D projects to improve the utility of simulation modelling for securing positive agronomic and livestock outcomes and lasting legacies.
基金jointly supported by the Main Direction Program of Knowledge Innovation of the Chinese Academy of Sciences(Grant No.KZCX2EW203)the National Key Basic Research Program of China(Grant No.2013CB430105)the National Department of Public Benefit Research Foundation(Grant No.GYHY201006031)
文摘A new method for driving a One-Dimensional Stratiform Cold (1DSC) cloud model with Weather Research and Fore casting (WRF) model outputs was developed by conducting numerical experiments for a typical large-scale stratiform rainfall event that took place on 4-5 July 2004 in Changchun, China. Sensitivity test results suggested that, with hydrometeor pro files extracted from the WRF outputs as the initial input, and with continuous updating of soundings and vertical velocities (including downdraft) derived from the WRF model, the new WRF-driven 1DSC modeling system (WRF-1DSC) was able to successfully reproduce both the generation and dissipation processes of the precipitation event. The simulated rainfall intensity showed a time-lag behind that observed, which could have been caused by simulation errors of soundings, vertical velocities and hydrometeor profiles in the WRF output. Taking into consideration the simulated and observed movement path of the precipitation system, a nearby grid point was found to possess more accurate environmental fields in terms of their similarity to those observed in Changchun Station. Using profiles from this nearby grid point, WRF-1DSC was able to repro duce a realistic precipitation pattern. This study demonstrates that 1D cloud-seeding models do indeed have the potential to predict realistic precipitation patterns when properly driven by accurate atmospheric profiles derived from a regional short range forecasting system, This opens a novel and important approach to developing an ensemble-based rain enhancement prediction and operation system under a probabilistic framework concept.
基金supported by the National Key Research and Development Program of China (Grant No. 2018YFC1507900)the National Natural Science Foundation of China (Grant Nos. 41575131, 41530427 and 41875172)
文摘Using the Weather Research and Forecasting(WRF)model with two different microphysics schemes,the Predicted Particle Properties(P3)and the Morrison double-moment parameterizations,we simulated a stratiform rainfall event on 20–21 April 2010.The simulation output was compared with precipitation and aircraft observations.The aircraft-observed moderate-rimed dendrites and plates indicated that riming contributed significantly to ice particle growth at the mature precipitation stage.Observations of dendrite aggregation and capped columns suggested that aggregation coexisted with deposition or riming and played an important role in producing many large particles.The domain-averaged values of the 24-h surface precipitation accumulation from the two schemes were quite close to each other.However,differences existed in the temporal and spatial evolutions of the precipitation distribution.An analysis of the surface precipitation temporal evolution indicated faster precipitation in Morrison,while P3 indicated slower rainfall by shifting the precipitation pattern eastward toward what was observed.The differences in precipitation values between the two schemes were related to the cloud water content distribution and fall speeds of rimed particles.P3 simulated the stratiform precipitation event better as it captured the gradual transition in the mass-weighted fall speeds and densities from unrimed to rimed particles.
基金supported by grant from the National High Technology Research and Development Program (863) of China (Grant No.2009AA122104)grants from the National Natural Science Foundation of China (No.40901202, No.40925004)+1 种基金supported by the CAS Action Plan for West Development Program (Grant No.KZCX2-XB2-09)Chinese State Key Basic Research Project (Grant No.2007CB714400)
文摘The research of coupling WRF (Weather Research and Forecasting Model) with a land surface model is enhanced to explore the interaction of the atmosphere and land surface; however, regional applicability of WRF model is questioned. In order to do the validation of WRF model on simulating forcing data for the Heihe River Basin, daily meteorological observation data from 15 stations of CMA (China Meteorological Administration) and hourly meteorological observation data from seven sites of WATER (Watershed Airborne Telemetry Experimental Research) are used to compare with WRF simulations, with a time range of a whole year for 2008. Results show that the average MBE (Mean Bias Error) of daily 2-m surface temperature, surface pressure, 2-m relative humidity and 10-m wind speed were -0.19 ℃, -4.49 hPa, 4.08% and 0.92 m/s, the average RMSE (Root Mean Square Error) of them were 2.11 ℃, 5.37 hPa, 9.55% and 1.73 m/s, and the average R (correlation coefficient) of them were 0.99, 0.98, 0.80 and 0.55, respectively. The average MBE of hourly 2-m surface temperature, surface pressure, 2-m relative humidity, 10-m wind speed, downward shortwave radiation and downward longwave were-0.16 ℃,-6.62 hPa,-5.14%, 0.26 m/s, 33.0 W/m^2 and-6.44 W/m^2, the average RMSE of them were 2.62 ℃, 17.10 hPa, 20.71%, 2.46 m/s, 152.9 W/m^2 and 53.5 W/m^2, and the average R of them were 0.96, 0.97, 0.70, 0.26, 0.91 and 0.60, respectively. Thus, the following conclusions were obtained: (1) regardless of daily or hourly validation, WRF model simulations of 2-m surface temperature, surface pressure and relative humidity are more reliable, especially for 2-m surface air temperature and surface pressure, the values of MBE were small and R were more than 0.96; (2) the WRF simulating downward shortwave radiation was relatively good, the average R between WRF simulation and hourly observation data was above 0.9, and the average R of downward longwave radiation was 0.6; (3) both wind speed and rainfall simulated from WRF model did not agree well with observation data.
基金Project supported by China Special Fund for Meteorological Research in the Public Interest(Grant No.GYHY201406002)the National Natural Science Foundation of China(Grant Nos.41575065 and 41405049)+1 种基金the National Natural Science Foundation International Cooperation Project,China(Grant No.41661144024)Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDA17010100)
文摘We used a weather research and forecasting model to simulate a torrential rainstorm that occurred in Xinjiang, China during June 16–17, 2016. The model successfully simulated the rainfall area, precipitation intensity, and changes in precipitation. We identified a clear wave signal using the two-dimensional fast Fourier transform method; the waves propagated westwards, with wavelengths of 45–20 km, periods of 50–120 min, and phase velocities mainly concentrated in the-25 m/s to-10 m/s range. The results of wavelet cross-spectral analysis further confirmed that the waves were gravity waves, peaking at 11:00 UTC, June 17, 2016. The gravity wave signal was identified along 79.17–79.93°E, 81.35–81.45°E and 81.5–81.83°E. The gravity waves detected along 81.5–81.83°E corresponded well with precipitation that accumulated in 1 h, indicating that gravity waves could be considered a rainstorm precursor in future precipitation forecasts.
基金This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA23090102)the National Natural Science Foundation of China(Grant No.41830967)+2 种基金the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(Grant No.QYZDY-SSW-DQC012)the National Key Research and Development Program of China(Grant Nos.2018YFC1506602 and 2020YFA0608203)We also thank the National Meteorological Information Center,China Meteorological Administration,for data support.
文摘With economic development and rapid urbanization,increases in Gross Domestic Product and population in fastgrowing cities since the turn of the 21st Century have led to increases in energy consumption.Anthropogenic heat flux released to the near-surface atmosphere has led to changes in urban thermal environments and severe extreme temperature events.To investigate the effects of energy consumption on urban extreme temperature events,including extreme heat and cold events,a dynamic representation scheme of anthropogenic heat release(AHR)was implemented in the Advanced Research version of the Weather Research and Forecasting(WRF)model,and AHR data were developed based on energy consumption and population density in a case study of Beijing,China.Two simulations during 1999−2017 were then conducted using the developed WRF model with 3-km resolution with and without the AHR scheme.It was shown that the mean temperature increased with the increase in AHR,and more frequent extreme heat events were produced,with an annual increase of 0.02−0.19 days,as well as less frequent extreme cold events,with an annual decrease of 0.26−0.56 days,based on seven extreme temperature indices in the city center.AHR increased the sensible heat flux and led to surface energy budget changes,strengthening the dynamic processes in the atmospheric boundary layer that reduce AHR heating efficiency more in summer than in winter.In addition,it was concluded that suitable energy management might help to mitigate the impact of extreme temperature events in different seasons.
基金supported jointly by the National Key Basic Research and Development (973) Program of China (Grant No. 2014CB441401)the National Natural Science Foundation of China (Grant Nos. 41405007, 41175043, 41475002, and 41205027)
文摘Two intense quasi-linear mesoscale convective systems(QLMCSs) in northern China were simulated using the WRF(Weather Research and Forecasting) model and the 3D-Var(three-dimensional variational) analysis system of the ARPS(Advanced Regional Prediction System) model.A new method in which the lightning density is calculated using both the precipitation and non-precipitation ice mass was developed to reveal the relationship between the lightning activities and QLMCS structures.Results indicate that,compared with calculating the results using two previous methods,the lightning density calculated using the new method presented in this study is in better accordance with observations.Based on the calculated lightning densities using the new method,it was found that most lightning activity was initiated on the right side and at the front of the QLMCSs,where the surface wind field converged intensely.The CAPE was much stronger ahead of the southeastward progressing QLMCS than to the back it,and their lightning events mainly occurred in regions with a large gradient of CAPE.Comparisons between lightning and non-lightning regions indicated that lightning regions featured more intense ascending motion than non-lightning regions;the vertical ranges of maximum reflectivity between lightning and non-lightning regions were very different;and the ice mixing ratio featured no significant differences between the lightning and non-lightning regions.
基金supported by the National Natural Science Foundation of China(61573017)
文摘The platform scheduling problem in battlefield is one of the important problems in military operational research.It needs to minimize mission completing time and meanwhile maximize the mission completing accuracy with a limited number of platforms.Though the traditional certain models obtain some good results,uncertain model is still needed to be introduced since the battlefield environment is complex and unstable.An uncertain model is prposed for the platform scheduling problem.Related parameters in this model are set to be fuzzy or stochastic.Due to the inherent disadvantage of the solving methods for traditional models,a new method is proposed to solve the uncertain model.Finally,the practicability and availability of the proposed method are demonstrated with a case of joint campaign.
基金Funded by the National Natural Science Foundation of China(51202304)the China Postdoctoral Science Foundation(2014M552320)+1 种基金Scientific,the Technological Talents’Special Funds of Wanzhou District and Scientific and Technological Research Program of Chongqing Municipal Education Commission(KJ1401016)the Youth Project of Chongqing Three Gorges College(13QN-20)
文摘We prepared concretes(RC0, RC30, and RC100) with three different mixes. The poresize distribution parameters of RAC were examined by high-precision mercury intrusion method(MIM) and nuclear magnetic resonance(NMR) imaging. A capillary-bundle physical model with random-distribution pores(improved model, IM) was established according to the parameters, and dry-shrinkage strain values were calculated and verified. Results show that in all pore types, capillary pores, and gel pores have the greatest impacts on concrete shrinkage, especially for pores 2.5-50 and 50-100 nm in size. The median radii are 34.2, 31, and 34 nm for RC0, RC30, and RC100, respectively. Moreover, the internal micropore size distribution of RC0 differs from that of RC30 and RC100, and the pore descriptions of MIM and NMR are consistent both in theory and in practice. Compared with the traditional capillary-bundle model, the calculated results of IM have higher accuracy as demonstrated by experimental verifi cation.
基金The National Key Basic Research Program of China under contract No.2014CB953904the Natural Science Foundation of Guangdong Province under contract No.2015A030311026the National Natural Science Foundation of China under contract Nos 41275145 and 41275060
文摘The weather research and forecasting(WRF) model is a new generation mesoscale numerical model with a fine grid resolution(2 km), making it ideal to simulate the macro-and micro-physical processes and latent heating within Typhoon Molave(2009). Simulations based on a single-moment, six-class microphysical scheme are shown to be reasonable, following verification of results for the typhoon track, wind intensity, precipitation pattern, as well as inner-core thermodynamic and dynamic structures. After calculating latent heating rate, it is concluded that the total latent heat is mainly derived from condensation below the zero degree isotherm, and from deposition above this isotherm. It is revealed that cloud microphysical processes related to graupel are the most important contributors to the total latent heat. Other important latent heat contributors in the simulated Typhoon Molave are condensation of cloud water, deposition of cloud ice, deposition of snow, initiation of cloud ice crystals, deposition of graupel, accretion of cloud water by graupel, evaporation of cloud water and rainwater,sublimation of snow, sublimation of graupel, melting of graupel, and sublimation of cloud ice. In essence, the simulated latent heat profile is similar to ones recorded by the Tropical Rainfall Measuring Mission, although specific values differ slightly.
文摘Since 2010,there has been a new round of drug crises in the United States.The abuse of opioids has led to a sharp increase in the number of people involved in drug crimes in the United States.There is an urgent need to explore solutions to the drug crisis in the United States.In this paper,the model of in-depth analysis is established under the condition of obtaining the opioid data and the influence factor data of the large sample of five state[1].In the first part,we use the Highway Safety Research Institute model based on the differential equation model to predict the initial value,find the initial position of the drug transfer,and obtain the curve of the number of different groups over time by fitting the data,so that the curves can be predicted the changing trends of the groups in the future.It was found that in Kentucky State,the county's most likely to start using opioids were Pike and Bale.In Ohio,the county's most likely to start using opioids are Jackson and Scioto.In Pennsylvania State,Mercer and Lackawanna are the counties most likely to start using opioids.Martinsville and Galax are the counties where Virginia State is most likely to start using opioids.Logan and Mingo are the counties where West Virginia State is most likely to start using opioids.In the second part,the gray prediction model is used to further analyze the time series of each factor,the maximum likelihood estimation method is used to obtain the weight of each factor,and the weight coefficient matrix is used to simulate the multivariate regression equation,and the factors that have the greatest influence on opioid abuse are educational background and family composition.In the third part,the hypothesis test model of two groups(the data type is proportional)is used to verify the difference between the influence factors(including the predicted values)in the first two parts of the states,thus verifying the feasibility between them.At the same time,we put forward a few suggestions to combine the current situation in the United States with the CDC data.We believe that in order to address the opium crisis,the U.S.government needs to strengthen not only oversight of doctors'prescriptions,but also make joint efforts of all sectors of society to fundamentally reduce the barriers to the use of opioids.