Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.Ho...Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.However,the molecular mechanism underlying its efficacy remains unclear.In this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture method.Rats received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery occlusion.Day 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/min.CatWalk gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after MCAO.On the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot assay.The glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid chromatography.The results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive function.The modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded rats.In the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in Gria3.Transmission electron microscopy revealed a denser distribution the more distribution of postsynaptic glutamate receptor 2/3,which is an a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor,within 240 nm of the postsynaptic density in the contralateral cornu ammonis 3 region.The size and distribution of the synaptic vesicles within 100 nm of the presynaptic active zone were unchanged.Western blot analysis showed that modified constraint-induced movement therapy also increased the expression of glutamate receptor 2/3 and brain-derived neurotrophic factor in the hippocampus of rats with middle cerebral artery occlusion,but had no effect on Synapsin I levels.Besides,we also found modified constraint-induced movement therapy effectively reduced glutamate content in the contralateral hippocampus.This study demonstrated that modified constraint-induced movement therapy is an effective rehabilitation therapy in middle cerebral artery-occluded rats,and suggests that these positive effects occur via the upregulation of the postsynaptic membrane a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor expression.This study was approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.201802173 S)on March 3,2018.展开更多
The purpose of this work is to study the possibility of anionic dyes Reactive Red M-8B（RR） and Direct Green B（DG） adsorbed on chitosan-modified diatomite. The characteristics of adsorbent, adsorption isotherms and...The purpose of this work is to study the possibility of anionic dyes Reactive Red M-8B（RR） and Direct Green B（DG） adsorbed on chitosan-modified diatomite. The characteristics of adsorbent, adsorption isotherms and the influence of adsorption time, temperature and pH were researched in this work. The results show that the mo- dified diatomite had a much better adsorption capability than the natural diatomite. The adsorption capacities of chitosan-modified diatomite for RR and DG were 94.46 and 137.0 mg/g, respectively. Both adsorption time and adsorption temperature provided a positive effect on the dye adsorption. Within the experimental pH range, the adsorbance was enhanced at lower pH but reduced sharply at high pH. On the basis of the experimental results and discussion, electrostatic attraction is considered as the main mechanism of this chemisorption.展开更多
In the meizoseismal areas hit by the China Wenchuan earthquake on May 12, 2008, the disasterprone environment has changed dramatically, making the susceptibility assessment of debris flow more complex and uncertain. A...In the meizoseismal areas hit by the China Wenchuan earthquake on May 12, 2008, the disasterprone environment has changed dramatically, making the susceptibility assessment of debris flow more complex and uncertain. After the earthquake, debris flow hazards occurred frequently and effective susceptibility assessment of debris flow has become extremely important. Shenxi gully in Du Jiangyan city, located in the meizoseismal areas, was selected as the study area. Based on the research of disaster-prone environment and the main factors controlling debris flow, the susceptibility zonations of debris flow were mapped using factor weight method(FW), certainty coefficient method(CF) and geomorphic information entropy method(GI). Through comparative analysis, the study showed that these three methods underestimated susceptible degree of debris flow when used in the meizoseismal areas of Wenchuan earthquake. In order to solve this problem, this paper developed a modified certainty coefficient method(M-CF) to reflect the impact of rich loose materials on the susceptible degree of debris flow. In the modified method, the distribution and area of loose materials were obtained by field investigations and postearthquake remote sensing image, and four data sets, namely, lithology, elevation, slop and aspect, wereused to calculate the CF values. The result of M-CF method is in agreement with field investigations and the accuracy of the method is satisfied. The method has a wide application to the susceptibility assessment of debris flow in the earthquake stricken areas.展开更多
In this article, the authors study the exact traveling wave solutions of modified Zakharov equations for plasmas with a quantum correction by hyperbolic tangent function expansion method, hyperbolic secant expansion m...In this article, the authors study the exact traveling wave solutions of modified Zakharov equations for plasmas with a quantum correction by hyperbolic tangent function expansion method, hyperbolic secant expansion method, and Jacobi elliptic function ex- pansion method. They obtain more exact traveling wave solutions including trigonometric function solutions, rational function solutions, and more generally solitary waves, which are called classical bright soliton, W-shaped soliton, and M-shaped soliton.展开更多
目的比较internal brace(IB)与带线锚钉通过改良Broström术治疗慢性踝关节不稳的临床疗效。方法回顾性分析2019年5月至2022年2月在桂林市人民医院本院关节骨科行手术治疗的42例慢性踝关节外侧不稳患者资料,根据距腓前韧带修补所用...目的比较internal brace(IB)与带线锚钉通过改良Broström术治疗慢性踝关节不稳的临床疗效。方法回顾性分析2019年5月至2022年2月在桂林市人民医院本院关节骨科行手术治疗的42例慢性踝关节外侧不稳患者资料,根据距腓前韧带修补所用材料的不同将患者分为IB组(19例)和带线锚钉组(23例)。比较两组患者一般资料、手术时间、并发症发生率、术后完全负重行走时间、术后恢复跑步的时间、美国足踝外科协会(American Orthopedic Foot and Ankle Society,AOFAS)踝-后足功能评分、视觉模拟评分法(visual analog scale,VAS)评分。结果所有患者术后均获得随访,随访时间12~18个月,平均(13.8±5.3)个月。两组患者基线资料差异无统计学意义(P>0.05);两组各有1例术口拆线后再出现渗液,换药后愈合;两组各有2例术口区域感觉障碍,除IB组有1例术后半年仍未完全恢复外,其余3例术后2~3个月恢复;IB组患者术后6周随访时AOFAS评分优于带线锚钉组,差异有统计学意义(t=2.239,P=0.025),但术后6周时VAS评分比较差异无统计学意义(t=0.308,P=0.760);末次随访时AOFAS评分和VAS评分比较,两组之间差异无统计学意义(t=0.045,P=0.965;t=0.203,P=0.840);IB组术后完全负重行走时间、术后恢复跑步的时间显著早于带线锚钉组,差异有统计学意义(t=26.566,P<0.01;t=4.838,P<0.01)。结论IB与带线锚钉通过改良Broström术开放治疗慢性踝关节不稳的临床疗效满意,且使用IB在早期康复和重返运动方面优于带线锚钉。展开更多
In orthogonal frequency division multiplexing(OFDM) based muitihop communications,the conventional decodeand-forward(DF) relay scheme severely suffers from the error propagation problem.This drawback is serious in mui...In orthogonal frequency division multiplexing(OFDM) based muitihop communications,the conventional decodeand-forward(DF) relay scheme severely suffers from the error propagation problem.This drawback is serious in muitihop networks as errors made by any relay node may fail the decoder at the destination in great chance.In this paper,we propose a bit error rate(BER)modified DF protocol(BMDF) which can be applied to systems where error correction channel coding and M-ary modulation are used.By modeling all links except the last one as a binary symmetric channel(BSC),we derive a log likelihood ratio(LLR)modification function relying only on the accumulated BER of all previous links to be applied to the output of the soft demapper.Furthermore,to reduce the computational complexity and signaling overhead,the modification function is simplified from its original exponential expression and less BERs are delivered between nodes by making successive subcarriers share the same BER.In addition,for situations where the channel state information(CSI) of forward link is available,the proposed BMDF can be further enhanced by combining with subcarrier pairing(SP) and power allocation(PA),where a sorted-channel gain SP scheme and a greedy PA algorithm are proposed.The simulation results verify the significant performance improvement to the conventional DF.展开更多
In practical engineering,due to the noncontinuity characteristics of joints in rock slopes,in addition to plane failure,stepped sliding failure may occur for intermittently jointed rock slopes.Especially for intermitt...In practical engineering,due to the noncontinuity characteristics of joints in rock slopes,in addition to plane failure,stepped sliding failure may occur for intermittently jointed rock slopes.Especially for intermittently bedding jointed rock slopes,the correlation and difference in strength parameters between joints and rock bridges,along with the various failure modes and intermittency of rock bridges,contribute to the complexity of stepped failure modes and the unpredictability of failure regions.Based on the upper-bound limit analysis method and multi-sliders step-path failure mode,considering the shear and tensile failure of rock bridges and the weakened relationship between the strength parameters of rock bridges and jointed surfaces,by introducing the modified M-C failure criterion and the formula for calculating the energy consumption of tensile failure of rock bridges,two failure mechanisms are constructed to obtain the safety factor(F_(s))of intermittently jointed rock slopes.The sequential quadratic programming method is used to obtain the optimal upper-bound solution for F_(s).The influence of multiple key parameters(slope height H,horizontal distance L,Slope angleβ,shear strength parameters of the rock bridgeφr and cr,Dimensionless parameter u,weakening coefficients of the internal friction angle and cohesion between the rock bridges and joint surfaces Kφand Kc)on the stability analysis of intermittently jointed rock slopes under the shear failure mode of rock bridges as well as under the tensile failure mode is also explored.The reliability of the failure mechanisms is verified by comparative analysis with theoretical results,numerical results,and landslide cases,and the variation rules of F_(s)with each key parameter are obtained.The results show that F_(s) varies linearly withφr and cr of the rock bridge and with K_(φ)and K_(c),whereas F_(s)changes nonlinearly with H and L.In particular,with the increase in Kφand Kc,Fs increases by approximately 52.78%and 171.02%on average,respectively.For rock bridge tensile failure,F_(s) shows a nonlinearly positive correlation withφr,cr,Kφand Kc.In particular,with the increase in Kφand Kc,Fs increases by approximately 13%and 61.69%on average,respectively.Fs decreases rapidly with increasing slope gradientβand decreasing dimensionless parameterμ.When Kφand Kc are both less than 1.0,the stepped sliding surface occurs more easily than the plane failure surface,especially in the case of tensile failure of the rock bridge.In addition,rock slopes with higher strength parameters,taller heights,and greater weakening coefficients are prone to rock bridge tension failure with lower Fs,and more attention should be given to the occurrence of such accidents in actual engineering.展开更多
The electrochemical and catalytic properties of PmClAn modified electrode were studied by cyclic voltammetry. The results showed that PmClAn had an excellent electroactivity and proton doping increased the electroacti...The electrochemical and catalytic properties of PmClAn modified electrode were studied by cyclic voltammetry. The results showed that PmClAn had an excellent electroactivity and proton doping increased the electroactivity. The Pt particles electrodeposited on PmClAn trend towards preferred orientation, and Pt(200) was the preferred face. It was also found that platinized PmClAn promotes isopropanol oxidation, the polymer is not only as a dispersion media of Pt particles forming a "microheterogeneous catalysis system", but also has effect on electronic properties of Pt.展开更多
基金supported by the National Natural Science Foundation of China,No.81871841(to YLB) and No.81772453(to DSX)
文摘Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.However,the molecular mechanism underlying its efficacy remains unclear.In this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture method.Rats received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery occlusion.Day 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/min.CatWalk gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after MCAO.On the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot assay.The glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid chromatography.The results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive function.The modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded rats.In the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in Gria3.Transmission electron microscopy revealed a denser distribution the more distribution of postsynaptic glutamate receptor 2/3,which is an a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor,within 240 nm of the postsynaptic density in the contralateral cornu ammonis 3 region.The size and distribution of the synaptic vesicles within 100 nm of the presynaptic active zone were unchanged.Western blot analysis showed that modified constraint-induced movement therapy also increased the expression of glutamate receptor 2/3 and brain-derived neurotrophic factor in the hippocampus of rats with middle cerebral artery occlusion,but had no effect on Synapsin I levels.Besides,we also found modified constraint-induced movement therapy effectively reduced glutamate content in the contralateral hippocampus.This study demonstrated that modified constraint-induced movement therapy is an effective rehabilitation therapy in middle cerebral artery-occluded rats,and suggests that these positive effects occur via the upregulation of the postsynaptic membrane a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor expression.This study was approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.201802173 S)on March 3,2018.
基金Supported by the Research Fund of Environmental Protection Bureau in Jilin Province,China(No.2007-13)
文摘The purpose of this work is to study the possibility of anionic dyes Reactive Red M-8B（RR） and Direct Green B（DG） adsorbed on chitosan-modified diatomite. The characteristics of adsorbent, adsorption isotherms and the influence of adsorption time, temperature and pH were researched in this work. The results show that the mo- dified diatomite had a much better adsorption capability than the natural diatomite. The adsorption capacities of chitosan-modified diatomite for RR and DG were 94.46 and 137.0 mg/g, respectively. Both adsorption time and adsorption temperature provided a positive effect on the dye adsorption. Within the experimental pH range, the adsorbance was enhanced at lower pH but reduced sharply at high pH. On the basis of the experimental results and discussion, electrostatic attraction is considered as the main mechanism of this chemisorption.
基金Financial support was provided by Ministry of Water Resources welfare industry funding(Grant No.201301058)Key Laboratory of Mountain Hazards and Earth Surface Processes independent project funding:Dynamic process and buried risk of debris flow in Shenxi gully after Wenchuan earthquakethe international cooperation project of Ministry of Science and Technology(Grant No.2013DFA21720)
文摘In the meizoseismal areas hit by the China Wenchuan earthquake on May 12, 2008, the disasterprone environment has changed dramatically, making the susceptibility assessment of debris flow more complex and uncertain. After the earthquake, debris flow hazards occurred frequently and effective susceptibility assessment of debris flow has become extremely important. Shenxi gully in Du Jiangyan city, located in the meizoseismal areas, was selected as the study area. Based on the research of disaster-prone environment and the main factors controlling debris flow, the susceptibility zonations of debris flow were mapped using factor weight method(FW), certainty coefficient method(CF) and geomorphic information entropy method(GI). Through comparative analysis, the study showed that these three methods underestimated susceptible degree of debris flow when used in the meizoseismal areas of Wenchuan earthquake. In order to solve this problem, this paper developed a modified certainty coefficient method(M-CF) to reflect the impact of rich loose materials on the susceptible degree of debris flow. In the modified method, the distribution and area of loose materials were obtained by field investigations and postearthquake remote sensing image, and four data sets, namely, lithology, elevation, slop and aspect, wereused to calculate the CF values. The result of M-CF method is in agreement with field investigations and the accuracy of the method is satisfied. The method has a wide application to the susceptibility assessment of debris flow in the earthquake stricken areas.
基金Supported by the National Natural Science Foundation of China (10871075)Natural Science Foundation of Guangdong Province,China (9151064201000040)
文摘In this article, the authors study the exact traveling wave solutions of modified Zakharov equations for plasmas with a quantum correction by hyperbolic tangent function expansion method, hyperbolic secant expansion method, and Jacobi elliptic function ex- pansion method. They obtain more exact traveling wave solutions including trigonometric function solutions, rational function solutions, and more generally solitary waves, which are called classical bright soliton, W-shaped soliton, and M-shaped soliton.
文摘目的比较internal brace(IB)与带线锚钉通过改良Broström术治疗慢性踝关节不稳的临床疗效。方法回顾性分析2019年5月至2022年2月在桂林市人民医院本院关节骨科行手术治疗的42例慢性踝关节外侧不稳患者资料,根据距腓前韧带修补所用材料的不同将患者分为IB组(19例)和带线锚钉组(23例)。比较两组患者一般资料、手术时间、并发症发生率、术后完全负重行走时间、术后恢复跑步的时间、美国足踝外科协会(American Orthopedic Foot and Ankle Society,AOFAS)踝-后足功能评分、视觉模拟评分法(visual analog scale,VAS)评分。结果所有患者术后均获得随访,随访时间12~18个月,平均(13.8±5.3)个月。两组患者基线资料差异无统计学意义(P>0.05);两组各有1例术口拆线后再出现渗液,换药后愈合;两组各有2例术口区域感觉障碍,除IB组有1例术后半年仍未完全恢复外,其余3例术后2~3个月恢复;IB组患者术后6周随访时AOFAS评分优于带线锚钉组,差异有统计学意义(t=2.239,P=0.025),但术后6周时VAS评分比较差异无统计学意义(t=0.308,P=0.760);末次随访时AOFAS评分和VAS评分比较,两组之间差异无统计学意义(t=0.045,P=0.965;t=0.203,P=0.840);IB组术后完全负重行走时间、术后恢复跑步的时间显著早于带线锚钉组,差异有统计学意义(t=26.566,P<0.01;t=4.838,P<0.01)。结论IB与带线锚钉通过改良Broström术开放治疗慢性踝关节不稳的临床疗效满意,且使用IB在早期康复和重返运动方面优于带线锚钉。
基金The authors would like to thank National Natural Science Foundation of China （No. 61072059）.
文摘In orthogonal frequency division multiplexing(OFDM) based muitihop communications,the conventional decodeand-forward(DF) relay scheme severely suffers from the error propagation problem.This drawback is serious in muitihop networks as errors made by any relay node may fail the decoder at the destination in great chance.In this paper,we propose a bit error rate(BER)modified DF protocol(BMDF) which can be applied to systems where error correction channel coding and M-ary modulation are used.By modeling all links except the last one as a binary symmetric channel(BSC),we derive a log likelihood ratio(LLR)modification function relying only on the accumulated BER of all previous links to be applied to the output of the soft demapper.Furthermore,to reduce the computational complexity and signaling overhead,the modification function is simplified from its original exponential expression and less BERs are delivered between nodes by making successive subcarriers share the same BER.In addition,for situations where the channel state information(CSI) of forward link is available,the proposed BMDF can be further enhanced by combining with subcarrier pairing(SP) and power allocation(PA),where a sorted-channel gain SP scheme and a greedy PA algorithm are proposed.The simulation results verify the significant performance improvement to the conventional DF.
基金supported by the National Natural Science Foundation of China(Nos.52208369,52309138,52209142,51978666)the Department of Science and Technology of Sichuan Province(2023NSFSC0284).
文摘In practical engineering,due to the noncontinuity characteristics of joints in rock slopes,in addition to plane failure,stepped sliding failure may occur for intermittently jointed rock slopes.Especially for intermittently bedding jointed rock slopes,the correlation and difference in strength parameters between joints and rock bridges,along with the various failure modes and intermittency of rock bridges,contribute to the complexity of stepped failure modes and the unpredictability of failure regions.Based on the upper-bound limit analysis method and multi-sliders step-path failure mode,considering the shear and tensile failure of rock bridges and the weakened relationship between the strength parameters of rock bridges and jointed surfaces,by introducing the modified M-C failure criterion and the formula for calculating the energy consumption of tensile failure of rock bridges,two failure mechanisms are constructed to obtain the safety factor(F_(s))of intermittently jointed rock slopes.The sequential quadratic programming method is used to obtain the optimal upper-bound solution for F_(s).The influence of multiple key parameters(slope height H,horizontal distance L,Slope angleβ,shear strength parameters of the rock bridgeφr and cr,Dimensionless parameter u,weakening coefficients of the internal friction angle and cohesion between the rock bridges and joint surfaces Kφand Kc)on the stability analysis of intermittently jointed rock slopes under the shear failure mode of rock bridges as well as under the tensile failure mode is also explored.The reliability of the failure mechanisms is verified by comparative analysis with theoretical results,numerical results,and landslide cases,and the variation rules of F_(s)with each key parameter are obtained.The results show that F_(s) varies linearly withφr and cr of the rock bridge and with K_(φ)and K_(c),whereas F_(s)changes nonlinearly with H and L.In particular,with the increase in Kφand Kc,Fs increases by approximately 52.78%and 171.02%on average,respectively.For rock bridge tensile failure,F_(s) shows a nonlinearly positive correlation withφr,cr,Kφand Kc.In particular,with the increase in Kφand Kc,Fs increases by approximately 13%and 61.69%on average,respectively.Fs decreases rapidly with increasing slope gradientβand decreasing dimensionless parameterμ.When Kφand Kc are both less than 1.0,the stepped sliding surface occurs more easily than the plane failure surface,especially in the case of tensile failure of the rock bridge.In addition,rock slopes with higher strength parameters,taller heights,and greater weakening coefficients are prone to rock bridge tension failure with lower Fs,and more attention should be given to the occurrence of such accidents in actual engineering.
文摘The electrochemical and catalytic properties of PmClAn modified electrode were studied by cyclic voltammetry. The results showed that PmClAn had an excellent electroactivity and proton doping increased the electroactivity. The Pt particles electrodeposited on PmClAn trend towards preferred orientation, and Pt(200) was the preferred face. It was also found that platinized PmClAn promotes isopropanol oxidation, the polymer is not only as a dispersion media of Pt particles forming a "microheterogeneous catalysis system", but also has effect on electronic properties of Pt.
