Assessment of Incidentally Detected Simple Renal Cyst in Pediatric Patient Based on the Modified Bosniak Classification —Incidentally Detected Simple Renal Cyst in Pediatric

Renal cysts in pediatric patients are uncommon lesion. A modified Bosniak classification system for renal cysts based on US has been developed to evaluate pediatric renal cysts to identify the simple cyst or cystic tumour. Nevertheless, it is not widely used. In this retrospective study, all incidentally detected renal cysts by ultrasound performed in children and the reproducibility of modified Bosniak classification to guide the radiological and clinical follow up.

Modified MUSIC estimation for correlated signals with compressive sampling arrays

This paper addresses the issue of the direction of arrival （DOA） estimation under the compressive sampling （CS） framework. A novel approach, modified multiple signal classification （MMUSIC） based on the CS array （CSA-MMUSIC）, is proposed to resolve the DOA estimation of correlated signals and two closely adjacent signals. By using two random CS matrices, a large size array is compressed into a small size array, which effectively reduces the number of the front end circuit. The theoretical analysis demonstrates that the proposed approach has the advantages of low computational complexity and hardware structure compared to other MMUSIC approaches. Simulation results show that CSAMMUSIC can possess similar angular resolution as MMUSIC.

A homogenized approach to classify advanced gastric cancer patients with limited and adequate number of pathologically examined lymph nodes

Background:The prognosis of gastric cancer patients with a limited number of pathologically examined lymph nodes(eLN,<16)is dismal compared to those with adequately eLN(≥16),yet they are still classified within the same subgroups using the American Joint Committee on Cancer(AJCC)staging system.We aimed at formulating an easy-to-adopt and clinically reliable stratification approach to homogenize the classification for these two categories of patients.Methods:Patients staged according to the 8th AJCC pathological nodal(N)and tumor-node-metastasis(TNM)clas-sification were stratified into a Limited and Adequate eLN cohort based on their number of pathologically examined LNs.The statistical differences between the 5-year overall survival(OS)rates of both cohorts were determined and based on which,patients from the Limited eLN cohort were re-classified to a proposed modified nodal(N′)and TNM(TN′M)classification,by matching their survival rates with those of the Adequate eLN cohort.The prognostic perfor-mance of the N′and TN′M classification was then compared to a formulated lymph-node-ratio-based nodal classifica-tion,in addition to the 8th AJCC N and TNM classification.Results:Significant heterogeneous differences in 5-year OS between patients from the Limited and Adequate eLN cohort of the same nodal subgroups were identified(all P<0.001).However,no significant differences in 5-year OS were observed between the subgroups N0,N1,N2,and N3a of the Limited eLN cohort when compared with N1,N2,N3a,and N3b from the Adequate eLN cohort,respectively(P=0.853,0.476,0.114,and 0.230,respectively).A novel approach was formulated in which only patients from the Limited eLN cohort were re-classified to one higher nodal subgroup,denoted as the N′classification.This re-classification demonstrated superior stratifying and prognostic ability as compared to the 8th AJCC N and lymph-node-ratio classification(Akaike information criterion values[AIC]:12,276 vs.12,358 vs.12,283,respectively).The TN′M classification also demonstrated superior prognostic ability as compared to the 8th AJCC TNM classification(AIC value:12,252 vs.12,312).Conclusion:The proposed lymph node classification approach provides a clinically practical and reliable technique to homogeneously classify cohorts of gastric cancer patients with limited and adequate number of pathologically examined lymph nodes.