A new method of research on molecular evolution of proteinase superfamily

The molecular evolutionary tree, also known as a phylogenetic tree, of the serine proteinase superfamily was constructed by means of structural alignment. Three-dimensional structures of proteins were aligned by the SSAP program of Orengo and Taylor to obtain evolutionary distances. The resulting evolutionary tree provides a topology graph that can reflect the evolution of structure and function of homology proteinase. Moreover, study on evolution of the serine proteinase superfamily can lead to better understanding of the relationship and evolutionary difference among proteins of the superfamily, and is of significance to protein engineering, molecular design and protein structure prediction. Structure alignment is one of the useful methods of research on molecular evolution of protein.

丝氨酸蛋白酶超家族分子结构进化研究

采用刚体结构比较法进行蛋白质的结构比较，根据结构比较分数构建分子进化树， 研究丝氨酸蛋白酶超家族分子的进化规律。对分子进化树进行了一些初步分析，得到了一些有意义的结果。根据蛋白质的进化，可以比较精确的确定某物种的进化地位，对于物种的分类具有重要意义。通过对超家族分子进化的研究可以了解蛋白质超家族不同蛋白质之间的亲缘关系和蛋白质之间的进化差异，对于蛋白质工程分子设计提供帮助。