MPW （magnetic pulse welding） is a solid state joining technology that allows for the generation of strong metallic bonds, even between dissimilar metals. Due to the absence of external heat, critical intermetallic p...MPW （magnetic pulse welding） is a solid state joining technology that allows for the generation of strong metallic bonds, even between dissimilar metals. Due to the absence of external heat, critical intermetallic phases can largely be avoided. In this process, Lorentz forces are utilized for the rapid acceleration of at least one of the two metallic joining partners leading to the controlled high velocity impact between them. The measurement of the collision conditions and their targeted manipulation are the key factors of a successful process development. Optical measuring techniques are preferred, since they are not influenced by the prevalent strong magnetic field in the vicinity of the working coil. In this paper, the characteristic high velocity impact flash during MPW was monitored and evaluated using phototransistors in order to measure the time of the impact. The results are in good accordance with the established PDV （photon Doppler velocimetry） and show a good repeatability. Furthermore, the collision front velocity was investigated using adapted part geometries within a series of tests. This velocity component is one of the key parameters in MPW; its value decreases along the weld zone. With the help of this newly introduced measurement tool, the magnetic pressure distribution or the joining geometry can be adjusted more effectively.展开更多
Chemodynamic therapy kills cancer cells with reactive oxygen species generated by endogenous triggers in the tumor microenvironment.Although chemodynamic therapy is blossoming in recent years,their therapy process sti...Chemodynamic therapy kills cancer cells with reactive oxygen species generated by endogenous triggers in the tumor microenvironment.Although chemodynamic therapy is blossoming in recent years,their therapy process still faces a series of hampers.The unknown catalytic activity of chemodynamic therapy reagents may lead to unpredictable therapy effects,so it is necessary to reveal the therapeutic mechanism of chemodynamic therapy and develop self-monitoring probes.In this mini-review,we summarize and illustrate the most recent progress of chemodynamic therapy,focusing on the applications of magnetic imaging and optical imaging probe for monitoring cancer chemodynamic therapy.Furthermore,we also discuss the potential challenges and the further directions of this field.展开更多
Objective: This paper aims to designing a pulsed strong magnetic fields generator. Methods: A large value capacitor was used to store electric energy, coil was used for producing magnetic fields, main control, circuit...Objective: This paper aims to designing a pulsed strong magnetic fields generator. Methods: A large value capacitor was used to store electric energy, coil was used for producing magnetic fields, main control, circuit control charge, sampling,discharge, etc. Results: The generator provided a pulsed magnetic field with the amplitude of intensity from 0.1-2 T and variable time interval of pulse from 4 s-1 min. It was not only to be operated easily but also performed reliably. Conclusion: The generator will be applied in special clinical diagnosis, therapy and other fields.展开更多
文摘MPW （magnetic pulse welding） is a solid state joining technology that allows for the generation of strong metallic bonds, even between dissimilar metals. Due to the absence of external heat, critical intermetallic phases can largely be avoided. In this process, Lorentz forces are utilized for the rapid acceleration of at least one of the two metallic joining partners leading to the controlled high velocity impact between them. The measurement of the collision conditions and their targeted manipulation are the key factors of a successful process development. Optical measuring techniques are preferred, since they are not influenced by the prevalent strong magnetic field in the vicinity of the working coil. In this paper, the characteristic high velocity impact flash during MPW was monitored and evaluated using phototransistors in order to measure the time of the impact. The results are in good accordance with the established PDV （photon Doppler velocimetry） and show a good repeatability. Furthermore, the collision front velocity was investigated using adapted part geometries within a series of tests. This velocity component is one of the key parameters in MPW; its value decreases along the weld zone. With the help of this newly introduced measurement tool, the magnetic pressure distribution or the joining geometry can be adjusted more effectively.
基金supported by the National Natural Science Foundation of China(Nos.21804039 and 51872088)the Science and Technology Project of Hunan Province,China(No.2020RC3022)the Fundamental Research Funds for the Central Universities,China.
文摘Chemodynamic therapy kills cancer cells with reactive oxygen species generated by endogenous triggers in the tumor microenvironment.Although chemodynamic therapy is blossoming in recent years,their therapy process still faces a series of hampers.The unknown catalytic activity of chemodynamic therapy reagents may lead to unpredictable therapy effects,so it is necessary to reveal the therapeutic mechanism of chemodynamic therapy and develop self-monitoring probes.In this mini-review,we summarize and illustrate the most recent progress of chemodynamic therapy,focusing on the applications of magnetic imaging and optical imaging probe for monitoring cancer chemodynamic therapy.Furthermore,we also discuss the potential challenges and the further directions of this field.
文摘Objective: This paper aims to designing a pulsed strong magnetic fields generator. Methods: A large value capacitor was used to store electric energy, coil was used for producing magnetic fields, main control, circuit control charge, sampling,discharge, etc. Results: The generator provided a pulsed magnetic field with the amplitude of intensity from 0.1-2 T and variable time interval of pulse from 4 s-1 min. It was not only to be operated easily but also performed reliably. Conclusion: The generator will be applied in special clinical diagnosis, therapy and other fields.
