The clinical spectrum of diseases associated withmonoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components. The differential diagnosi...The clinical spectrum of diseases associated withmonoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components. The differential diagnosis is difficult and renal biopsy is essential. To distinguish many of these pathologies is necessary to use techniques that are not always avai-lable, even in tertiary central hospitals. This review will discuss the clinical presentation, pathologic features, treatment, prognosis and common diagnostic diffculties of these entities.展开更多
Monoclonal gammopathy of renal significance(MGRS)is a pathological state which presents with a spectrum of renal lesions.MGRS is characterized by pathogenic monoclonal immunoglobulins or light chains produced by a pre...Monoclonal gammopathy of renal significance(MGRS)is a pathological state which presents with a spectrum of renal lesions.MGRS is characterized by pathogenic monoclonal immunoglobulins or light chains produced by a premalignant plasma cell or B cell clone.In view of inadequate understanding in the past,the low detection rate of MGRS often results in poor outcomes and reduces quality of life of patients.Thus,MGRS stands for a group of clinical refractory renal diseases.To date,no standard treatment strategy for MGRS is available.Current consensus suggests a clone-directed approach that aims to eradicate the offending clone,but its long-term prognosis is not clear.In this article,we discuss the diagnostic methods,highlight treatment advances,and introduce integrated Chinese and Western medicine in the management of MGRS.展开更多
文摘The clinical spectrum of diseases associated withmonoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components. The differential diagnosis is difficult and renal biopsy is essential. To distinguish many of these pathologies is necessary to use techniques that are not always avai-lable, even in tertiary central hospitals. This review will discuss the clinical presentation, pathologic features, treatment, prognosis and common diagnostic diffculties of these entities.
文摘Monoclonal gammopathy of renal significance(MGRS)is a pathological state which presents with a spectrum of renal lesions.MGRS is characterized by pathogenic monoclonal immunoglobulins or light chains produced by a premalignant plasma cell or B cell clone.In view of inadequate understanding in the past,the low detection rate of MGRS often results in poor outcomes and reduces quality of life of patients.Thus,MGRS stands for a group of clinical refractory renal diseases.To date,no standard treatment strategy for MGRS is available.Current consensus suggests a clone-directed approach that aims to eradicate the offending clone,but its long-term prognosis is not clear.In this article,we discuss the diagnostic methods,highlight treatment advances,and introduce integrated Chinese and Western medicine in the management of MGRS.
