Glyceryl monooleate(GMO)is a polar lipid that can exist in various liquid crystalline phases in the presence of different amounts of water.It is regarded as a permeation enhancer due to its amphiphilic property.Variou...Glyceryl monooleate(GMO)is a polar lipid that can exist in various liquid crystalline phases in the presence of different amounts of water.It is regarded as a permeation enhancer due to its amphiphilic property.Various phases of GMO/solvent system containing sodium fluorescein were prepared to compare permeability using confocal laser scanning microscopy(CLSM).GMO was melted in a vial in a water bath heated to 45℃.Propylene glycol and hexanediol were homogeneously dissolved in the melted GMO.Sodium fluorescein in aqueous solution was diluted to various ratios and thoroughly mixed by an ultrasonic homogenizer.Each GMO/Solvent system with fluorescein was applied onto the epidermal side of excised pig skin and incubated overnight.CLSM was performed to observe how the GMO/solvent system in its different phases affect skin permeability.Cubic and lamellar phase formulations enhanced the fluorescein permeation through the stratum corneum.A solution system had the weakest permeability compared to the other two phases.Due to the amphiphilic nature of GMO,cubic and lamellar phases might reduce the barrier function of stratum corneum which was observed by CLSM as fluorescein accumulated in the dermis.Based on the results,the glyceryl monooleate lyotropic mixtures could be applied to enhance skin permeation in various topical and transdermal formulations.展开更多
We demonstrated a simple and effective dual-templating approach for the synthesis of hierarchically mesocellular carbon foams by using nonionic surfactant of sorbitan monooleate and silica colloid particles as sacrifi...We demonstrated a simple and effective dual-templating approach for the synthesis of hierarchically mesocellular carbon foams by using nonionic surfactant of sorbitan monooleate and silica colloid particles as sacrificial templates, and resorcinol/ formaldehyde as carbon source. The representative carbon foam has dual mesopore sizes of 4 and 10 nm, and possesses the specific surface area of 580 m^2/g and the total pore volume of 0.80 cm^3/g.展开更多
The water-based materials for mine gas absorption and explosion suppression were prepared, in which the mixed organic aggregate of Span80 and alkaline salt can be used as methane absorbent. Methane was used as a model...The water-based materials for mine gas absorption and explosion suppression were prepared, in which the mixed organic aggregate of Span80 and alkaline salt can be used as methane absorbent. Methane was used as a model of mine gas, and the absorptions of methane with different complex materials were studied using head space gas chromatography. Then the state of aqueous material was characterized with laser light scattering instrument and the effects of different complex materials on explosion suppression were preliminarily studied in explosion chamber which can simulate mine gas explosion. The research results showed that complex material could absorb methane and there was some corre- lation between the mean diameter of organic aggregate in aqueous material and the absorption effect. Additionally, the aqueous material could suppress the methane explosion to some degree. The material can absorb mine gas in atomization condition, therefore, degrease mine gas concentration and influence the distribution of mine gas in the space, and then suppress the mine gas explosion to some extent.展开更多
基金This study was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korean Ministry of Education,Science and Technology(2012002399)a grant of the Korean Healthcare Technology R&D Project,Ministry of Health and Welfare,Republic of Korea.(Grant No.:A103017).
文摘Glyceryl monooleate(GMO)is a polar lipid that can exist in various liquid crystalline phases in the presence of different amounts of water.It is regarded as a permeation enhancer due to its amphiphilic property.Various phases of GMO/solvent system containing sodium fluorescein were prepared to compare permeability using confocal laser scanning microscopy(CLSM).GMO was melted in a vial in a water bath heated to 45℃.Propylene glycol and hexanediol were homogeneously dissolved in the melted GMO.Sodium fluorescein in aqueous solution was diluted to various ratios and thoroughly mixed by an ultrasonic homogenizer.Each GMO/Solvent system with fluorescein was applied onto the epidermal side of excised pig skin and incubated overnight.CLSM was performed to observe how the GMO/solvent system in its different phases affect skin permeability.Cubic and lamellar phase formulations enhanced the fluorescein permeation through the stratum corneum.A solution system had the weakest permeability compared to the other two phases.Due to the amphiphilic nature of GMO,cubic and lamellar phases might reduce the barrier function of stratum corneum which was observed by CLSM as fluorescein accumulated in the dermis.Based on the results,the glyceryl monooleate lyotropic mixtures could be applied to enhance skin permeation in various topical and transdermal formulations.
基金supported by the National Natural Science Foundation of China(Nos.20473057 and 20673076)Shanghai Nanotechnology Promotion Center(Nos.0652nm030 and 0752nm006).
文摘We demonstrated a simple and effective dual-templating approach for the synthesis of hierarchically mesocellular carbon foams by using nonionic surfactant of sorbitan monooleate and silica colloid particles as sacrificial templates, and resorcinol/ formaldehyde as carbon source. The representative carbon foam has dual mesopore sizes of 4 and 10 nm, and possesses the specific surface area of 580 m^2/g and the total pore volume of 0.80 cm^3/g.
文摘The water-based materials for mine gas absorption and explosion suppression were prepared, in which the mixed organic aggregate of Span80 and alkaline salt can be used as methane absorbent. Methane was used as a model of mine gas, and the absorptions of methane with different complex materials were studied using head space gas chromatography. Then the state of aqueous material was characterized with laser light scattering instrument and the effects of different complex materials on explosion suppression were preliminarily studied in explosion chamber which can simulate mine gas explosion. The research results showed that complex material could absorb methane and there was some corre- lation between the mean diameter of organic aggregate in aqueous material and the absorption effect. Additionally, the aqueous material could suppress the methane explosion to some degree. The material can absorb mine gas in atomization condition, therefore, degrease mine gas concentration and influence the distribution of mine gas in the space, and then suppress the mine gas explosion to some extent.
