financed by the Special Program of Super Rice of Ministry of Agriculture, China （02318802013231）;the National Public Services Sectors （Agricultural） Research Projects, Ministry of Agriculture, China （201303102）;...financed by the Special Program of Super Rice of Ministry of Agriculture, China （02318802013231）;the National Public Services Sectors （Agricultural） Research Projects, Ministry of Agriculture, China （201303102）;the Great Technology Project of Ningbo, China （2013C11001）展开更多
Molecular simulation was performed to study the interaction between CaCO3 crystal and several oligomer inhibitors, by using the equilibrium morphology method to calculate the growth morphology of CaCO3 without inhibit...Molecular simulation was performed to study the interaction between CaCO3 crystal and several oligomer inhibitors, by using the equilibrium morphology method to calculate the growth morphology of CaCO3 without inhibitors. The calculated morphology agreed well with SEM photographs. Then, a double-layer model was built to investigate the interaction between calcite crystal and oligomer inhibitors containing maleic anhydride （MA） and acrylic acid （AA）. Interaction energy per gram of an oligomer inhibitor was introduced as a scale of inhibition efficiency of different monomers. The results indicated that, for calcite scale inhibition, acrylamide （AM） and vinyl phosphonic acid （VPA） were the most efficient monomers, while allylsulfonic acid （AS） was the poorest. Increasing proportion of AM in dimer inhibitor molecule would improve the inhibition efficiency of MA, though, for a trimer, such as MA-AA-AM, certain sequence of monomers in the inhibitor molecule was necessary besides higher proportion of AM.展开更多
PLGA, m PEG diblock copolymer was synthesized by bulk ring-opening polymerization method. The double emulsion solvent evaporation method was used to prepare bovine serum albumin（BSA）-loaded microspheres. Optical mic...PLGA, m PEG diblock copolymer was synthesized by bulk ring-opening polymerization method. The double emulsion solvent evaporation method was used to prepare bovine serum albumin（BSA）-loaded microspheres. Optical microscopy was used to observe the whole microsphere fabrication process. It is confirmed that the proportion of inner aqueous phase is one of the most critical factors that determines the morphology of microspheres. Double emulsion droplets which have appropriate amount of inner aqueous phase can form closed and dense microspheres, while, too much inner aqueous phase will cause a collapse of the double emulsion droplets, resulting in a loss of drug. The proportion of inner aqueous phase was varied to prepare microspheres of different morphology. The results show that with increasing the amount of inner aqueous phase, a higher percent of broken microspheres and lower encapsulation efficiency appeared, and also, a more severe initial burst release and faster release rate.展开更多
基金financed by the Special Program of Super Rice of Ministry of Agriculture, China (02318802013231)the National Public Services Sectors (Agricultural) Research Projects, Ministry of Agriculture, China (201303102)the Great Technology Project of Ningbo, China (2013C11001)
文摘financed by the Special Program of Super Rice of Ministry of Agriculture, China （02318802013231）;the National Public Services Sectors （Agricultural） Research Projects, Ministry of Agriculture, China （201303102）;the Great Technology Project of Ningbo, China （2013C11001）
基金Financial support from the National Natural Science Foundation of China (No.50773063)National Basic Research Program of China(2010CB635111)Basic Research of National Defence are highly appreciated
文摘Molecular simulation was performed to study the interaction between CaCO3 crystal and several oligomer inhibitors, by using the equilibrium morphology method to calculate the growth morphology of CaCO3 without inhibitors. The calculated morphology agreed well with SEM photographs. Then, a double-layer model was built to investigate the interaction between calcite crystal and oligomer inhibitors containing maleic anhydride （MA） and acrylic acid （AA）. Interaction energy per gram of an oligomer inhibitor was introduced as a scale of inhibition efficiency of different monomers. The results indicated that, for calcite scale inhibition, acrylamide （AM） and vinyl phosphonic acid （VPA） were the most efficient monomers, while allylsulfonic acid （AS） was the poorest. Increasing proportion of AM in dimer inhibitor molecule would improve the inhibition efficiency of MA, though, for a trimer, such as MA-AA-AM, certain sequence of monomers in the inhibitor molecule was necessary besides higher proportion of AM.
基金financially supported by the Independent Innovation Foundation of Huazhong University of Science and Technology(No.2013ZHYX008)the National Natural Science Foundation of China(No.81370980)
文摘PLGA, m PEG diblock copolymer was synthesized by bulk ring-opening polymerization method. The double emulsion solvent evaporation method was used to prepare bovine serum albumin（BSA）-loaded microspheres. Optical microscopy was used to observe the whole microsphere fabrication process. It is confirmed that the proportion of inner aqueous phase is one of the most critical factors that determines the morphology of microspheres. Double emulsion droplets which have appropriate amount of inner aqueous phase can form closed and dense microspheres, while, too much inner aqueous phase will cause a collapse of the double emulsion droplets, resulting in a loss of drug. The proportion of inner aqueous phase was varied to prepare microspheres of different morphology. The results show that with increasing the amount of inner aqueous phase, a higher percent of broken microspheres and lower encapsulation efficiency appeared, and also, a more severe initial burst release and faster release rate.
