Based on introduction of economic transition of Kucong people, this paper presents two motivation mechanisms, namely, political pulling and economic promotion. For political pulling, it is required to build grass-root...Based on introduction of economic transition of Kucong people, this paper presents two motivation mechanisms, namely, political pulling and economic promotion. For political pulling, it is required to build grass-roots government service system in Zhemi Town and promote economic transition from external side; strengthen leadership of Party Committee of Zhemi Town in grass-roots government; enhance construction of grass-roots government in Zhemi Town; and regulate relationship between grass-roots government and village committee of Zhemi Town. For economic promotion, it is proposed to set up collective producers' cooperatives and promote economic transition of Kucong people from internal side. By taking pilot of Liuliu xinzhai Village production cooperative as an example, it puts forward that new production working cooperatives should be established to solve Kucong people's problem of not good at working separately. It is proposed to cultivate their agricultural activities through collectivization, promote development of its backward productivity, and strive for permanent residence and sustainable development of agriculture on the basis of economic development, finally to realize social development of Kucong people.展开更多
Before a pathogen even enters a cell, intrinsic immune defenses are active. This first-line defense is mediated by a variety of constitutively expressed cell proteins collectively termed "restriction factors"...Before a pathogen even enters a cell, intrinsic immune defenses are active. This first-line defense is mediated by a variety of constitutively expressed cell proteins collectively termed "restriction factors"(RFs), and they form a vital element of the immune response to virus infections. Over time, however, viruses have evolved in a variety ways so that they are able to overcome these RF defenses via mechanisms that are specific for each virus. This review provides a summary of the universal characteristics of RFs, and goes on to focus on the strategies employed by some of the most important RFs in their attempt to control human cytomegalovirus(HCMV) infection. This is followed by a discussion of the counter-restriction mechanisms evolved by viruses to circumvent the host cell's intrinsic immune defenses. RFs include nuclear proteins IFN-γ inducible protein 16(IFI16)(a Pyrin/HIN domain protein), Sp100, promyelocytic leukemia, and h Daxx; the latter three being the keys elements of nuclear domain 10(ND10). IFI16 inhibits the synthesis of virus DNA by downregulating UL54 transcription- a gene encoding a CMV DNA polymerase; in response, the virus antagonizes IFI16 via a process involving viral proteins UL97 and pp65(p UL83), which results in the mislocalizing of IFI16 into the cytoplasm. In contrast, viral regulatory proteins, including pp71 and IE1, seek to modify or disrupt the ND10 proteins and thus block or reverse their inhibitory effects upon virus replication. All in all, detailed knowledge of these HCMV counter-restriction mechanisms will be fundamental for the future development of new strategies for combating HCMV infection and for identifying novel therapeutic agents.展开更多
Based on the current situation of urbanization development in West China, this paper analyses main factors responsible for sluggish urbanization in West China as follows: impact of environment factor, impact of popula...Based on the current situation of urbanization development in West China, this paper analyses main factors responsible for sluggish urbanization in West China as follows: impact of environment factor, impact of population quality and quantity, lagging of public product service, stagnancy of technological development, backwardness of slow growth, and rigidity of system building. And then this paper analyses the restriction mechanism of urbanization in West China: at the superficial level, the constraints of urbanization in West China arise from the shortage of capital; at the profound level, the backward culture contributes to the constraints of urbanization in West China. The thread of resolving restriction mechanism of urbanization in West China is put forward from system, economy and culture. On the basis of this thread, we construct the power system for the development of urbanization in West China. The power system for urbanization in West China should be propelled by "four forces", namely, pull of external forces, cohesive strength of regional market environment, expansion power inside countryside, traction of industrial structure adjustment. Innovation is the engine of impetus for urbanization in West China; spatial clustering and modernization of industry is the major driving force for urbanization; the government behaviour, driving of foreign investment, great projects and other forces are supplementary power. Via the main power, we should take the market as medium to achieve the role of power in promoting urbanization.展开更多
The overall promotion of all-for-one tourism requires tourists' civilized behaviors. This paper focused on tourists' environmental responsible behaviors in the context of all-for-one tourism. On the basis of c...The overall promotion of all-for-one tourism requires tourists' civilized behaviors. This paper focused on tourists' environmental responsible behaviors in the context of all-for-one tourism. On the basis of clarifying the connotation, dimension and driving factors of tourists' environmental responsible behaviors, this paper firstly analyzed the relationship between all-for-one tourism and tourists' environmental responsible behaviors, and proposed that the development of all-for-one tourism was an important path to optimize and upgrade China's tourism industry and a new concept of sustainable development of tourism industry. The emergence of all-for-one tourism has formed a new tourism trend, which will drive tourists to behave more civilly. Tourists' environmental responsible behaviors are a "subject and share" concept, and from tourists' point of view, all-for-one tourism development is the most basic requirement. Secondly, based on the theory of "value-belief-norm", this paper focused on the strengthening mechanism of "interaction effect" between all-for-one tourism and tourists' environmental responsible behaviors, and put forward the idea of "double internalization strengthening" to guide tourists' environmental responsible behaviors from being passive to active, from individuals to groups. Finally, this paper discussed the promotion of environmental responsible behaviors of tourist's specific strategies from two aspects, "external drive" and "internal drive" to enhance the level of all-for-one tourism construction and strengthen the environment responsibility of tourists. "External drives" were as follows:(1) to make a scientific development plan to implement the "host and guest sharing" mechanism;(2) to optimize the landscape, the environment, services, enhance the local attachment of visitors;(3) to improve the infrastructure system, pay attention to the details of visitors' experience;(4) to strengthen environment education and publicity, deepening the quality of tourists' civilization construction, and strengthen the environmental responsible behaviors of tourists. "Internal drives" were as follows:(1) to strengthen the sense of environmental responsibility of tourists;(2) to establish a model of environmental responsible behaviors;(3) to strengthen the supervision of environmental responsible behaviors.展开更多
The solidification microstructures and the mechanism of grain refinement of electrolytic low titanium Al alloys were investigated by means of the wedge-shaped sample, the directional solidification and the rapid solid...The solidification microstructures and the mechanism of grain refinement of electrolytic low titanium Al alloys were investigated by means of the wedge-shaped sample, the directional solidification and the rapid solidification ribbon. The results show that the coarse columnar grains formed in pure Al are transformed into the equiaxed grains in electrolytic low titanium Al alloys. The grain refinement is resulted from the constitutional supercooling caused by Ti and heterogeneous nucleation of Al3Ti particles. Under the condition of normal cooling rate, the grains are refined by the increment of constitutional supercooling when the content of titanium is less than 0.2%. With the increment of content of titanium, the grains are mainly refined by heterogeneous nucleation of Al3Ti particles. The grain size is decreased with the increment of cooling rate. When the cooling rate is larger than 105℃/s, the grain size is decreased to 0.1-10μm, the grain refinement is resulted from the larger cooling velocities mainly. After directional solidification, the equiaxed grains can be formed and the Ti element is distributed at the center of the grains.展开更多
基金Supported by Scientific Research Foundation of Yunnan Provincial Department of Education (09C0212)
文摘Based on introduction of economic transition of Kucong people, this paper presents two motivation mechanisms, namely, political pulling and economic promotion. For political pulling, it is required to build grass-roots government service system in Zhemi Town and promote economic transition from external side; strengthen leadership of Party Committee of Zhemi Town in grass-roots government; enhance construction of grass-roots government in Zhemi Town; and regulate relationship between grass-roots government and village committee of Zhemi Town. For economic promotion, it is proposed to set up collective producers' cooperatives and promote economic transition of Kucong people from internal side. By taking pilot of Liuliu xinzhai Village production cooperative as an example, it puts forward that new production working cooperatives should be established to solve Kucong people's problem of not good at working separately. It is proposed to cultivate their agricultural activities through collectivization, promote development of its backward productivity, and strive for permanent residence and sustainable development of agriculture on the basis of economic development, finally to realize social development of Kucong people.
基金Supported by Italian Ministry of Education,University and Research--MIUR(PRIN 2012)to S.Landolfo(2012SNMJRL)and V.Dell’Oste(20127MFYBR)University of Turin,Research Funding 2014 to S.Landolfo,M.De Andrea,and V.Dell’OsteRegione Piemonte to S.Landolfo(PAR-FCS 2007/2013)
文摘Before a pathogen even enters a cell, intrinsic immune defenses are active. This first-line defense is mediated by a variety of constitutively expressed cell proteins collectively termed "restriction factors"(RFs), and they form a vital element of the immune response to virus infections. Over time, however, viruses have evolved in a variety ways so that they are able to overcome these RF defenses via mechanisms that are specific for each virus. This review provides a summary of the universal characteristics of RFs, and goes on to focus on the strategies employed by some of the most important RFs in their attempt to control human cytomegalovirus(HCMV) infection. This is followed by a discussion of the counter-restriction mechanisms evolved by viruses to circumvent the host cell's intrinsic immune defenses. RFs include nuclear proteins IFN-γ inducible protein 16(IFI16)(a Pyrin/HIN domain protein), Sp100, promyelocytic leukemia, and h Daxx; the latter three being the keys elements of nuclear domain 10(ND10). IFI16 inhibits the synthesis of virus DNA by downregulating UL54 transcription- a gene encoding a CMV DNA polymerase; in response, the virus antagonizes IFI16 via a process involving viral proteins UL97 and pp65(p UL83), which results in the mislocalizing of IFI16 into the cytoplasm. In contrast, viral regulatory proteins, including pp71 and IE1, seek to modify or disrupt the ND10 proteins and thus block or reverse their inhibitory effects upon virus replication. All in all, detailed knowledge of these HCMV counter-restriction mechanisms will be fundamental for the future development of new strategies for combating HCMV infection and for identifying novel therapeutic agents.
基金Supported by the National Natural Science Foundation (51178372)
文摘Based on the current situation of urbanization development in West China, this paper analyses main factors responsible for sluggish urbanization in West China as follows: impact of environment factor, impact of population quality and quantity, lagging of public product service, stagnancy of technological development, backwardness of slow growth, and rigidity of system building. And then this paper analyses the restriction mechanism of urbanization in West China: at the superficial level, the constraints of urbanization in West China arise from the shortage of capital; at the profound level, the backward culture contributes to the constraints of urbanization in West China. The thread of resolving restriction mechanism of urbanization in West China is put forward from system, economy and culture. On the basis of this thread, we construct the power system for the development of urbanization in West China. The power system for urbanization in West China should be propelled by "four forces", namely, pull of external forces, cohesive strength of regional market environment, expansion power inside countryside, traction of industrial structure adjustment. Innovation is the engine of impetus for urbanization in West China; spatial clustering and modernization of industry is the major driving force for urbanization; the government behaviour, driving of foreign investment, great projects and other forces are supplementary power. Via the main power, we should take the market as medium to achieve the role of power in promoting urbanization.
基金Sponsored by Zhejiang Provincial Philosophy and Social Science Planning Project(17NDJC218YB)Project of Hangzhou Col ege of Commerce,Zhejiang Gongshang University(2016YJ-06)+1 种基金National Natural Science Foundation of China(41661034)Public Welfare Project of International Scientific and Technology Cooperation Project of Science Technology Department of Zhejiang Province(2016C34003)
文摘The overall promotion of all-for-one tourism requires tourists' civilized behaviors. This paper focused on tourists' environmental responsible behaviors in the context of all-for-one tourism. On the basis of clarifying the connotation, dimension and driving factors of tourists' environmental responsible behaviors, this paper firstly analyzed the relationship between all-for-one tourism and tourists' environmental responsible behaviors, and proposed that the development of all-for-one tourism was an important path to optimize and upgrade China's tourism industry and a new concept of sustainable development of tourism industry. The emergence of all-for-one tourism has formed a new tourism trend, which will drive tourists to behave more civilly. Tourists' environmental responsible behaviors are a "subject and share" concept, and from tourists' point of view, all-for-one tourism development is the most basic requirement. Secondly, based on the theory of "value-belief-norm", this paper focused on the strengthening mechanism of "interaction effect" between all-for-one tourism and tourists' environmental responsible behaviors, and put forward the idea of "double internalization strengthening" to guide tourists' environmental responsible behaviors from being passive to active, from individuals to groups. Finally, this paper discussed the promotion of environmental responsible behaviors of tourist's specific strategies from two aspects, "external drive" and "internal drive" to enhance the level of all-for-one tourism construction and strengthen the environment responsibility of tourists. "External drives" were as follows:(1) to make a scientific development plan to implement the "host and guest sharing" mechanism;(2) to optimize the landscape, the environment, services, enhance the local attachment of visitors;(3) to improve the infrastructure system, pay attention to the details of visitors' experience;(4) to strengthen environment education and publicity, deepening the quality of tourists' civilization construction, and strengthen the environmental responsible behaviors of tourists. "Internal drives" were as follows:(1) to strengthen the sense of environmental responsibility of tourists;(2) to establish a model of environmental responsible behaviors;(3) to strengthen the supervision of environmental responsible behaviors.
基金Project(0621000600) supported by the Innovation Fund for Outstanding Scholar of Henan Province, China
文摘The solidification microstructures and the mechanism of grain refinement of electrolytic low titanium Al alloys were investigated by means of the wedge-shaped sample, the directional solidification and the rapid solidification ribbon. The results show that the coarse columnar grains formed in pure Al are transformed into the equiaxed grains in electrolytic low titanium Al alloys. The grain refinement is resulted from the constitutional supercooling caused by Ti and heterogeneous nucleation of Al3Ti particles. Under the condition of normal cooling rate, the grains are refined by the increment of constitutional supercooling when the content of titanium is less than 0.2%. With the increment of content of titanium, the grains are mainly refined by heterogeneous nucleation of Al3Ti particles. The grain size is decreased with the increment of cooling rate. When the cooling rate is larger than 105℃/s, the grain size is decreased to 0.1-10μm, the grain refinement is resulted from the larger cooling velocities mainly. After directional solidification, the equiaxed grains can be formed and the Ti element is distributed at the center of the grains.