Transcriptional regulation in the development and dysfunction of neocortical projection neurons

Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord.Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and synaptogenesis.These processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural activities.The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations.

Cascading multi-segment rupture process of the 2023 Turkish earthquake doublet on a complex fault system revealed by teleseismic P wave back projection method

In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back projection analysis.Data in two frequency bands(0.5-2 Hz and 1-3 Hz)are used in the imaging processes.The results show that the rupture of the first event extends about 200 km to the northeast and about 150 km to the southwest,lasting~90 s in total.The southwestern rupture is triggered by the northeastern rupture,demonstrating a sequential bidirectional unilateral rupture pattern.The rupture of the second event extends approximately 80 km in both northeast and west directions,lasting~35 s in total and demonstrates a typical bilateral rupture feature.The cascading ruptures on both sides also reflect the occurrence of selective rupture behaviors on bifurcated faults.In addition,we observe super-shear ruptures on certain fault sections with relatively straight fault structures and sparse aftershocks.

Diagnosis of indirectly driven double shell targets with point-projection hard x-ray radiography

We present an application of short-pulse laser-generated hard x rays for the diagnosis of indirectly driven double shell targets. Coneinserted double shell targets were imploded through an indirect drive approach on the upgraded SG-II laser facility. Then, based on thepoint-projection hard x-ray radiography technique, time-resolved radiography of the double shell targets, including that of their near-peakcompression, were obtained. The backlighter source was created by the interactions of a high-intensity short pulsed laser with a metalmicrowire target. Images of the target near peak compression were obtained with an Au microwire. In addition, radiation hydrodynamicsimulations were performed, and the target evolution obtained agrees well with the experimental results. Using the radiographic images, arealdensities of the targets were evaluated.

Accelerated Primal-Dual Projection Neurodynamic Approach With Time Scaling for Linear and Set Constrained Convex Optimization Problems

The Nesterov accelerated dynamical approach serves as an essential tool for addressing convex optimization problems with accelerated convergence rates.Most previous studies in this field have primarily concentrated on unconstrained smooth con-vex optimization problems.In this paper,on the basis of primal-dual dynamical approach,Nesterov accelerated dynamical approach,projection operator and directional gradient,we present two accelerated primal-dual projection neurodynamic approaches with time scaling to address convex optimization problems with smooth and nonsmooth objective functions subject to linear and set constraints,which consist of a second-order ODE(ordinary differential equation)or differential conclusion system for the primal variables and a first-order ODE for the dual vari-ables.By satisfying specific conditions for time scaling,we demonstrate that the proposed approaches have a faster conver-gence rate.This only requires assuming convexity of the objective function.We validate the effectiveness of our proposed two accel-erated primal-dual projection neurodynamic approaches through numerical experiments.

REFINEMENTS OF THE NORM OF TWO ORTHOGONAL PROJECTIONS

In this paper,some refinements of norm equalities and inequalities of combination of two orthogonal projections are established.We use certain norm inequalities for positive contraction operator to establish norm inequalities for combination of orthogonal projections on a Hilbert space.Furthermore,we give necessary and sufficient conditions under which the norm of the above combination of o`rthogonal projections attains its optimal value.

GLOBAL CONVERGENCE OF A CAUTIOUS PROJECTION BFGS ALGORITHM FOR NONCONVEX PROBLEMS WITHOUT GRADIENT LIPSCHITZ CONTINUITY

A cautious projection BFGS method is proposed for solving nonconvex unconstrained optimization problems.The global convergence of this method as well as a stronger general convergence result can be proven without a gradient Lipschitz continuity assumption,which is more in line with the actual problems than the existing modified BFGS methods and the traditional BFGS method.Under some additional conditions,the method presented has a superlinear convergence rate,which can be regarded as an extension and supplement of BFGS-type methods with the projection technique.Finally,the effectiveness and application prospects of the proposed method are verified by numerical experiments.

Evaluation and projection of marine heatwaves in the South China Sea: insights from CMIP6 multi-model ensemble

This study evaluates the performance of 16 models sourced from the coupled model intercomparison project phase 6(CMIP6)in simulating marine heatwaves(MHWs)in the South China Sea(SCS)during the historical period(1982−2014),and also investigates future changes in SCS MHWs based on simulations from three shared socioeconomic pathway(SSP)scenarios(SSP126,SSP245,and SSP585)using CMIP6 models.Results demonstrate that the CMIP6 models perform well in simulating the spatial-temporal distribution and intensity of SCS MHWs,with their multi-model ensemble(MME)results showing the best performance.The reasonable agreement between the observations and CMIP6 MME reveals that the increasing trends of SCS MHWs are attributed to the warming sea surface temperature trend.Under various SSP scenarios,the year 2040 emerges as pivotal juncture for future shifts in SCS MHWs,marked by distinct variations in changing rate and amplitudes.This is characterized by an accelerated decrease in MHWs frequency and a notably heightened increase in mean intensity,duration,and total days after 2040.Furthermore,the projection results for SCS MHWs suggest that the spatial pattern of MHWs remains consistent across future periods.However,the intensity shows higher consistency only during the near-term period(2021−2050),while notable inconsistencies are observed during the medium-term(2041−2070)and long-term(2071−2100)periods under the three SSP scenarios.During the nearterm period,the SCS MHWs are characterized by moderate and strong events with high frequencies and relatively shorter durations.In contrast,during the medium-term period,MHWs are also characterized by moderate and strong events,but with longer-lasting and more intense events under the SSP245 and SSP585 scenarios.However,in the long-term period,extreme MHWs become the dominant feature under the SSP585 scenario,indicating a substantial intensification of SCS MHWs,effectively establishing a near-permanent state.

Polar-coordinate line-projection light-curing continuous 3D printing for tubular structures

3D printing techniques offer an effective method in fabricating complex radially multi-material structures.However,it is challenging for complex and delicate radially multi-material model geometries without supporting structures,such as tissue vessels and tubular graft,among others.In this work,we tackle these challenges by developing a polar digital light processing technique which uses a rod as the printing platform.The 3D model fabrication is accomplished through line projection.The rotation and translation of the rod are synchronized to project and illuminate the photosensitive material volume.By controlling the distance between the rod and the printing window,we achieved the printing of tubular structures with a minimum wall thickness as thin as 50 micrometers.By controlling the width of fine slits at the printing window,we achieved the printing of structures with a minimum feature size of 10 micrometers.Our process accomplished the fabrication of thin-walled tubular graft structure with a thickness of only 100 micrometers and lengths of several centimeters within a timeframe of just 100 s.Additionally,it enables the printing of axial multi-material structures,thereby achieving adjustable mechanical strength.This method is conducive to rapid customization of tubular grafts and the manufacturing of tubular components in fields such as dentistry,aerospace,and more.

Two Monte Carlo-based simulators for imaging-system modeling and projection simulation of flat-panel X-ray source

The advantages of a flat-panel X-ray source(FPXS)make it a promising candidate for imaging applications.Accurate imaging-system modeling and projection simulation are critical for analyzing imaging performance and resolving overlapping projection issues in FPXS.The conventional analytical ray-tracing approach is limited by the number of patterns and is not applicable to FPXS-projection calculations.However,the computation time of Monte Carlo(MC)simulation is independent of the size of the patterned arrays in FPXS.This study proposes two high-efficiency MC projection simulators for FPXS:a graphics processing unit(GPU)-based phase-space sampling MC(gPSMC)simulator and GPU-based fluence sampling MC(gFSMC)simulator.The two simulators comprise three components:imaging-system modeling,photon initialization,and physical-interaction simulations in the phantom.Imaging-system modeling was performed by modeling the FPXS,imaging geometry,and detector.The gPSMC simulator samples the initial photons from the phase space,whereas the gFSMC simulator performs photon initialization from the calculated energy spectrum and fluence map.The entire process of photon interaction with the geometry and arrival at the detector was simulated in parallel using multiple GPU kernels,and projections based on the two simulators were calculated.The accuracies of the two simulators were evaluated by comparing them with the conventional analytical ray-tracing approach and acquired projections,and the efficiencies were evaluated by comparing the computation time.The results of simulated and realistic experiments illustrate the accuracy and efficiency of the proposed gPSMC and gFSMC simulators in the projection calculation of various phantoms.

Spatiotemporal Evaluation and Future Projection of Diurnal Temperature Range over the Tibetan Plateau in CMIP6 Models

The diurnal temperature range(DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR variations over the Tibetan Plateau. It assesses 23 climate models from phase 6 of the Coupled Model Intercomparison Project(CMIP6) using CN05.1 observational data as validation, evaluating their ability to simulate DTR over the Tibetan Plateau. Then, the evolution of DTR over the Tibetan Plateau under different shared socioeconomic pathway(SSP) scenarios for the near,middle, and long term of future projection are analyzed using 11 selected robustly performing models. Key findings reveal:(1) Among the models examined, BCC-CSM2-MR, EC-Earth3, EC-Earth3-CC, EC-Earth3-Veg, EC-Earth3-Veg-LR,FGOALS-g3, FIO-ESM-2-0, GFDL-ESM4, MPI-ESM1-2-HR, MPI-ESM1-2-LR, and INM-CM5-0 exhibit superior integrated simulation capability for capturing the spatiotemporal variability of DTR over the Tibetan Plateau.(2) Projection indicates a slightly increasing trend in DTR on the Tibetan Plateau in the SSP1-2.6 scenario, and decreasing trends in the SSP2-4.5, SSP3-7.0, and SPP5-8.5 scenarios. In certain areas, such as the southeastern edge of the Tibetan Plateau, western hinterland of the Tibetan Plateau, southern Kunlun, and the Qaidam basins, the changes in DTR are relatively large.(3) Notably, the warming rate of maximum temperature under SSP2-4.5, SSP3-7.0, and SPP5-8.5 is slower compared to that of minimum temperature, and it emerges as the primary contributor to the projected decrease in DTR over the Tibetan Plateau in the future.

A new method of calculating crown projection area and its comparative accuracy with conventional calculations for asymmetric tree crowns

This paper introduces a new method of calculating crown projection area(CPA),the area of level ground covered by a vertical projection of a tree crown from measured crown radii through numerical interpolation and integration.This novel method and other four existing methods of calculating CPA were compared using detailed crown radius measurements from 30 tall trees of Eucalyptus pilularis variable in crown size,shape,and asymmetry.The four existing methods included the polygonal approach and three ways of calculating CPA as the area of a circle using the arithmetic,geometric and quadratic mean radius.Comparisons were made across a sequence of eight non-consecutive numbers(from 2 to 16)of measured crown radii for each tree over the range of crown asymmetry of the 30 trees through generalized linear models and multiple comparisons of means.The sequence covered the range of the number of crown radii measured for calculating the CPA of a tree in the literature.A crown asymmetry index within the unit interval was calculated for each tree to serve as a normative measure.With a slight overestimation of 2.2%on average and an overall mean error size of 7.9%across the numbers of crown radii that were compared,our new method was the least biased and most accurate.Calculating CPA as a circle using the quadratic mean crown radius was the second best,which had an average overestimation of 4.5%and overall mean error size of 8.8%.These two methods remained by and large unbiased as crown asymmetry increased,while the other three methods showed larger bias of underestimation.For the conventional method of using the arithmetic mean crown radius to calculate CPA as a circle,bias correction factors were developed as a function of crown asymmetry index to delineate the increasing magnitude of bias associated with greater degrees of crown asymmetry.This study reveals and demonstrates such relationships between the accuracy of CPA calculations and crown asymmetry and will help increase awareness among researchers and practitioners on the existence of bias in their CPA calculations and for the need to use an unbiased method in the future.Our new method is recommended for calculating CPA where at least four crown radius measurements per tree are available because that is the minimum number required for its use.

How do lateral septum projections to the ventral CA1 influence sociability?

Social dysfunction is a risk factor for several neuropsychiatric illnesses.Previous studies have shown that the lateral septum(LS)-related pathway plays a critical role in mediating social behaviors.Howeve r,the role of the connections between the LS and its downstream brain regions in social behavio rs remains unclea r.In this study,we conducted a three-chamber test using electrophysiological and chemogenetic approaches in mice to determine how LS projections to ventral CA1(vCA1)influence sociability.Our res ults showed that gamma-aminobutyric acid(GABA)-e rgic neuro ns were activated following social experience,and that social behavio rs were enhanced by chemogenetic modulation of these neurons.Moreover,LS GABAergic neurons extended their functional neural connections via vCA1 glutamatergic pyramidal neurons,and regulating LSGABA→vCA1Gluneural projections affected social behaviors,which were impeded by suppressing LSprojecting vCA1 neuronal activity or inhibiting GABAAreceptors in vCA1.These findings support the hypothesis that LS inputs to the vCA1 can control social prefe rences and social novelty behaviors.These findings provide new insights rega rding the neural circuits that regulate sociability.

Computational Quantification of Map Projection Distortion by Fractal Dimension of Coastlines

Maps, essential tools for portraying the Earth’s surface, inherently introduce distortions to geographical features. While various quantification methods exist for assessing these distortions, they often fall short when evaluating actual geographic features. In our study, we took a novel approach by analyzing map projection distortion from a geometric perspective. We computed the fractal dimensions of different stretches of coastline before and after projection using the divide-and-conquer algorithm and image processing. Our findings revealed that map projections, even when preserving basic shapes, inevitably stretch and compress coastlines in diverse directions. This analysis method provides a more realistic and practical way to measure map-induced distortions, with significant implications for cartography, geographic information systems (GIS), and geomorphology. By bridging the gap between theoretical analysis and real-world features, this method greatly enhances accuracy and practicality when evaluating map projections.

Multi-Criteria Wildfire Risk Hazard Assessment in GIS Environment: Projection for the Future and Impact on RES Projects Installation Planning

It is alarming for the fact that Wildfires number, severity and consequently impact have significantly increased during the last years, an aftermath of the Climate Change. One of the most affected areas worldwide is Mediterranean, due to the unique combination of its type of vegetation and demanding climatic conditions. This research is focused on the Region of Epirus in Greece, an area with significant natural vegetation and a range of geomorphological aspects. In order to estimate the Wildfire Risk Hazard, several factors have been used: geomorphological (slope, aspect, elevation, TWI, Hydrographic network), social (Settlements and landfils, roads, overhead lines and substations), environmental (land cover) and climatic (Fire Weather Index). Through a multi-criteria decision analysis (MCDA) and an analytic hierarchy process (AHP) in a GIS environment, the Wildfire Risk Hazard has been estimated not only for current conditions but also for future projections for the near future (2031-2060) and the far future (2071-2100). The selected case study includes the potential impact of the Wildfires to the installed (or targeted to be installed) RES projects in the studied region.

基于Projection VOF方法的熔模铸造蜡模充型过程数值模拟

针对熔模铸造蜡模充型过程数值模拟软件自主开发,建立了流动场和温度场数学模型,采用Cross-WLF粘度模型描述蜡料的流变性能,基于Projection VOF方法进行蜡料流动过程速度场、压力场以及自由表面的求解。通过试验测量获取了K512型蜡料的热物理性能和流变性能的相关数据,拟合得到粘度模型参数。分别在蜡料常粘度和变粘度模型两种条件下对扳机铸件蜡模充型过程进行模拟,结果表明,所建立蜡模充型过程数学模型能较好地描述蜡料的动态流变特性和传热行为。

CMIP6 Evaluation and Projection of Precipitation over Northern China:Further Investigation

Based on 20 models from phase 6 of the Coupled Model Intercomparison Project(CMIP6),this article explored possible reasons for differences in simulation biases and projected changes in precipitation in northern China among the allmodel ensemble(AMME),“highest-ranked”model ensemble(BMME),and“lowest-ranked”model ensemble(WMME),from the perspective of atmospheric circulations and moisture budgets.The results show that the BMME and AMME reproduce the East Asian winter circulations better than the WMME.Compared with the AMME and WMME,the BMME reduces the overestimation of evaporation,thereby improving the simulation of winter precipitation.The three ensemble simulated biases for the East Asian summer circulations are generally similar,characterized by a stronger zonal pressure gradient between the mid-latitudes of the North Pacific and East Asia and a northward displacement of the East Asian westerly jet.However,the simulated vertical moisture advection is improved in the BMME,contributing to the slightly higher performance of the BMME than the AMME and WMME on summer precipitation in North and Northeast China.Compared to the AMME and WMME,the BMME projects larger increases in precipitation in northern China during both seasons by the end of the 21st century under the Shared Socioeconomic Pathway 5-8.5(SSP5-8.5).One of the reasons is that the increase in evaporation projected by the BMME is larger.The projection of a greater dynamic contribution by the BMME also plays a role.In addition,larger changes in the nonlinear components in the BMME projection contribute to a larger increase in winter precipitation in northern China.

Robust least squares projection twin SVM and its sparse solution

Least squares projection twin support vector machine(LSPTSVM)has faster computing speed than classical least squares support vector machine(LSSVM).However,LSPTSVM is sensitive to outliers and its solution lacks sparsity.Therefore,it is difficult for LSPTSVM to process large-scale datasets with outliers.In this paper,we propose a robust LSPTSVM model(called R-LSPTSVM)by applying truncated least squares loss function.The robustness of R-LSPTSVM is proved from a weighted perspective.Furthermore,we obtain the sparse solution of R-LSPTSVM by using the pivoting Cholesky factorization method in primal space.Finally,the sparse R-LSPTSVM algorithm(SR-LSPTSVM)is proposed.Experimental results show that SR-LSPTSVM is insensitive to outliers and can deal with large-scale datasets fastly.

Projection of precipitation extremes over South Asia from CMIP6 GCMs

Extreme precipitation events are one of the most dangerous hydrometeorological disasters,often resulting in significant human and socio-economic losses worldwide.It is therefore important to use current global climate models to project future changes in precipitation extremes.The present study aims to assess the future changes in precipitation extremes over South Asia from the Coupled Model Intercomparison Project Phase 6(CMIP6)Global Climate Models(GCMs).The results were derived using the modified Mann-Kendall test,Sen's slope estimator,student's t-test,and probability density function approach.Eight extreme precipitation indices were assessed,including wet days(RR1mm),heavy precipitation days(RR10mm),very heavy precipitation days(RR20mm),severe precipitation days(RR50mm),consecutive wet days(CWD),consecutive dry days(CDD),maximum 5-day precipitation amount(RX5day),and simple daily intensity index(SDII).The future changes were estimated in two time periods for the 21^(st) century(i.e.,near future(NF;2021-2060)and far future(FF;2061-2100))under two Shared Socioeconomic Pathway(SSP)scenarios(SSP2-4.5 and SSP5-8.5).The results suggest increases in the frequency and intensity of extreme precipitation indices under the SSP5-8.5 scenario towards the end of the 21^(st) century(2061-2100).Moreover,from the results of multimodel ensemble means(MMEMs),extreme precipitation indices of RR1mm,RR10mm,RR20mm,CWD,and SDII demonstrate remarkable increases in the FF period under the SSP5-8.5 scenario.The spatial distribution of extreme precipitation indices shows intensification over the eastern part of South Asia compared to the western part.The probability density function of extreme precipitation indices suggests a frequent(intense)occurrence of precipitation extremes in the FF period under the SSP5-8.5 scenario,with values up to 35.00 d for RR1mm and 25.00-35.00 d for CWD.The potential impacts of heavy precipitation can pose serious challenges to the study area regarding flooding,soil erosion,water resource management,food security,and agriculture development.

Molecular mechanisms of lesion-induced axonal sprouting in the corticofugal projection:the role of glial cells

After injury of the central nervous system(CNS),neuronal circuits are known to remodel for functional recovery.In general,there are two strategies for the remodeling:axonal regeneration and sprouting(Figure 1A).Axonal regeneration is re-growth of injured neurons themselves,but axons hardly regenerate in the adult mammalian CNS(Silver and Miller,2004).On the other hand,axonal sprouting is new growth from intact or spared neurons to the denervated target by forming axon collaterals,compensating for damaged circuits.This process is a more effective way for circuit remodeling,as it does not necessarily require long axonal elongation.

Onto Orthogonal Projections in the Space of Polynomials Pn[x]

In this article, I consider projection groups on function spaces, more specifically the space of polynomials Pn[x]. I will show that a very similar construct of projection operators allows us to project into the subspaces of Pn[x] where the function h ∈Pn[x] represents the closets function to f ∈Pn[x] in the least square sense. I also demonstrate that we can generalise projections by constructing operators i.e. in Rn+1 using the metric tensor on Pn[x]. This allows one to project a polynomial function onto another by mapping it to its coefficient vector in Rn+1. This can be also achieved with the Kronecker Product as detailed in this paper.