Assessment of hindlimb motor recovery affer severe thoracic spinal cord injury in rats: classification of CatWalk XT■ gait analysis parameters

Assessment of locomotion recovery in preclinical studies of experimental spinal cord injury remains challenging. We studied the CatWalk XT■gait analysis for evaluating hindlimb functional recovery in a widely used and clinically relevant thoracic contusion/compression spinal cord injury model in rats. Rats were randomly assigned to either a T9 spinal cord injury or sham laminectomy. Locomotion recovery was assessed using the Basso, Beattie, and Bresnahan open field rating scale and the CatWalk XT■gait analysis. To determine the potential bias from weight changes, corrected hindlimb(H) values(divided by the unaffected forelimb(F) values) were calculated. Six weeks after injury, cyst formation, astrogliosis, and the deposition of chondroitin sulfate glycosaminoglycans were assessed by immunohistochemistry staining. Compared with the baseline, a significant spontaneous recovery could be observed in the CatWalk XT■parameters max intensity, mean intensity, max intensity at%, and max contact mean intensity from 4 weeks after injury onwards. Of note, corrected values(H/F) of CatWalk XT■parameters showed a significantly less vulnerability to the weight changes than absolute values, specifically in static parameters. The corrected CatWalk XT■parameters were positively correlated with the Basso, Beattie, and Bresnahan rating scale scores, cyst formation, the immunointensity of astrogliosis and chondroitin sulfate glycosaminoglycan deposition. The CatWalk XT■gait analysis and especially its static parameters, therefore, seem to be highly useful in assessing spontaneous recovery of hindlimb function after severe thoracic spinal cord injury. Because many CatWalk XT■parameters of the hindlimbs seem to be affected by body weight changes, using their corrected values might be a valuable option to improve this dependency.

The Application of Deep Brain Stimulation for Parkinson’s Disease on the Motor Pathway:A Bibliometric Analysis across 10 Years

Background and Objective Since its initial report by James Parkinson in 1817,Parkinson’s disease(PD)has remained a central subject of research and clinical advancement.The disease is estimated to affect approximately 1%of adults aged 60 and above.Deep brain stimulation,emerging as an alternative therapy for end-stage cases,has offered a lifeline to numerous patients.This review aimed to analyze publications pertaining to the impact of deep brain stimulation on the motor pathway in patients with PD over the last decade.Methods Data were obtained from the Web of Science Core Collection through the library of Huazhong University of Science and Technology(China).The search strategy encompassed the following keywords:“deep brain stimulation”,“Parkinson’s disease”,“motor pathway”,and“human”,from January 1,2012,to December 1,2022.Additionally,this review visualized the findings using the Citespace software.Results The results indicated that the United States,the United Kingdom,Germany,and China were the primary contributors to this research field.University College London,Capital Medical University,and Maastricht University were the top 3 research institutions in the research area.Tom Foltynie ranked first with 6 publications,and the journals of Brain and Brain Stimulation published the greatest number of relevant articles.The prevailing research focal points in this domain,as determined by keywords“burst analysis”,“encompassed neuronal activity”,“nucleus”,“hyper direct pathway”,etc.Conclusion This study has provided a new perspective through bibliometric analysis of the deep brain stimulation therapy for treating patients with PD,which can shed light on future research to advance our comprehension of this particular field of study.

Design and analysis of a high loss density motor cooling system with water cold plates

Aiming at reducing the difficulty of cooling the interior of high-density motors,this study proposed the placement of a water cold plate cooling structure between the axial laminations of the motor stator.The effect of the cooling water flow,thickness of the plate,and motor loss density on the cooling effect of the water cold plate were studied.To compare the cooling performance of water cold plate and outer spiral water jacket cooling structures,a high-speed permanent magnet motor with a high loss density was used to establish two motor models with the two cooling structures.Consequently,the cooling effects of the two models were analyzed using the finite element method under the same loss density,coolant flow,and main dimensions.The results were as follows.(1)The maximum and average temperatures of the water cold plate structure were reduced by 25.5%and 30.5%,respectively,compared to that of the outer spiral water jacket motor;(2)Compared with the outer spiral water jacket structure,the water cold plate structure can reduce the overall mass and volume of the motor.Considering a 100 kW high-speed permanent magnet motor as an example,a water cold plate cooling system was designed,and the temperature distribution is analyzed,with the result indicating that the cooling structure satisfied the cooling requirements of the high loss density motor.

Simulation Research of Fault Model of Detecting Rotor Dynamic Eccentricity in Brushless DC Motor Based on Motor Current Signature Analysis

基于Ansoft／Maxwell设置动态偏心故障，建立求解电机电感和磁链的有限元模型，通过仿真，证明了将感应电机动态偏心故障的特征频率经过简化后，同样适用于无刷直流电动机。基于Ansoft／Simplorer建立无刷直流电动机系统的仿真模型。在电机稳态运行下，对定子电流进行傅里叶分析，研究并建立基于定子电流监测动态偏心故障的仿真模型：动态偏心故障与特征频率的关系、动态偏心故障程度与特征频率幅值的关系。进而研究了无刷直流电动机稳态运行时转速波动对偏心故障监测的影响。仿真结果表明，转子偏心程度加大，特征频率的幅值增加。

Analysis on the Problems in Start-up and Debugging of Two 600 MW Generating Units in Yangzhou No.2 Thermal Power Plant

The problems including excessive flow of attemperating water for boiler, failure of butterfly valve at the outlet of circulating water pump, burnt-out of thyristor for excitation regulator, load variation rate of CCS not complying with the contract target, etc. occurred during start-up and debugging of two 600 MW generating units in Yangzhou No.2 Thermal Power Plant. Through analysis on these problems. the remedial measures were put forward, to which can be referred for similar units.

Magnetic field and performance analysis of a tubular permanent magnet linear synchronous motor applied in elevator door system

A novel elevator door driven by tubular permanent magnet linear synchronous motor (TPMLSM) is presented. This TPMLSM applies axial magnet array topology of the secondary rod, air-cored armature windings and slotless structure of the forcer to improve the stability of the thrust. The influence of two major dimensions, the pitch and radius of the permanent magnet (PM), on magnetic field was studied and the best values were given by the finite element analysis (FEA). The magnetic field, back EMF and thrust of the motor were analyzed and the PM size was optimized to reduce the harmonic components of the magnetic field and improve the performance of the motor. Predicted results are validated by the experiment. It is shown that the performance of the motor and the novel elevator door system is satisfying.

Analysis and Design of Surface Permanent Magnet Synchronous Motor and Generator

This paper presents an analytical method to design the high-efficiency surface permanent magnet synchronous motor(SPMSM)or generator(SPMSG).The air-gap and permanent magnet size can be approximately determined based on our mathematics model,which is the most important part of SPMSM design.From our method,we can know that motor’s power out torque is related to the torque angle that we selected in our design and it affects the air-gap and permanent magnet size.If we choose a low torque angle,the motor or generator’s overload power handing capability will increase.The embrace value has a vital place in designing a motor or generator due to its effects on air gap flux density,cogging torque,efficiency and so on.In order to avoid the knee effect,the working point of the permanent magnet we selected in the design should be bigger than 0.5.The developed 36 slots,4 poles,surface mound permanent generator is proposed.The corresponding finite element analysis(FEA)model is built based on our design method.Structure optimization includes stator and rotor structure size,permanent magnet size,magnetic bridge and air gap length which are analyzed and simulated by ANSYS Maxwell 2D FEA.Thermal analysis is conducted,and the housing of the alternator is designed.The alternator prototype is fabricated and tested based on our design.

Fault detection and diagnosis of permanent-magnetic DC motors based on current analysis and BP neural networks

In order to guarantee quality during mass serial production of motors, a convenient approach on how to detect and diagnose the faults of a permanent-magnetic DC motor based on armature current analysis and BP neural networks was presented in this paper. The fault feature vector was directly established by analyzing the armature current. Fault features were extracted from the current using various signal processing methods including Fourier analysis, wavelet analysis and statistical methods. Then an advanced BP neural network was used to finish decision-making and separate fault patterns. Finally, the accuracy of the method in this paper was verified by analyzing the mechanism of faults theoretically. The consistency between the experimental results and the theoretical analysis shows that four kinds of representative faults of low power permanent-magnetic DC motors can be diagnosed conveniently by this method. These four faults are brush fray, open circuit of components, open weld of components and short circuit between armature coils. This method needs fewer hardware instruments than the conventional method and whole procedures can be accomplished by several software packages developed in this paper.

Analysis of the Comprehensive Physical Field for a New Flywheel Energy Storage Motor/Generator on Ships

A novel flywheel energy storage （FES） motor/generator （M/G） was proposed for marine systems. The purpose was to improve the power quality of a marine power system （MPS） and strengthen the energy recycle. Two structures including the magnetic or non-magnetic inner-rotor were contrasted in the magnetostatic field by using finite element analysis （FEA）. By optimally designing the size parameters, the average speed of FEA results of was 17 200 r/m, and the current was controlled between 62 and 68 A in the transient field. The electrical machine electromagnetism design was further optimized by the FEA in the temperature field, to find the local overheating point under the normal operation condition and provide guidance for the cooling system. Finally, it can be concluded from the comprehensive physical field analysis that the novel redundant structure M/G can improve the efficiency of the M/G and maintain the stability of the MPS.

Dynamic Analysis of Axial Magnetic Forces for DVD Spindle Motors

The axial magnetic force, induced by the complicated flux linkage distribution from rotor magnet and stator slotted, is constructed by different relative heights and calculated by 3D finite element method (FEM) to analyze the dynamic characteristics for a DVD spindle motor. The axial magnetic force is designed to provide an axial stiffness, and govern the natural frequency of the dynamic performance. According to the simulation results and experimental measurements, the dynamic behaviors are significantly improved with a variation of relative height of rotor magnet and stator slotted on a DVD spindle motor.

Rotor Strength Analysis of High-speed Permanent Magnet Synchronous Motors

为了对转子进行有效的冷却，在满足电机电磁性能的前提下，可通过减小保护套的厚度来尽可能增大定转子之间的气隙，因而必须对保护套和永磁体进行强度校核。将转子受力状况简化为平面应变问题，在此基础上推导出了两层过盈配合、三层过盈配合转子的应力场、应变场、位移场的解析公式，并利用有限元方法验证了解析公式的正确性。归纳了高速情况下热套式永磁转子强度设计准则，为转子的优化设计提供了理论依据。以一台额定转速120kr／min、10kW的高速永磁同步电机为例，给出了两种常用过盈配合高速电机转子的强度设计方法。

Dynamic Response Analysis of Motorized Spindle System

As to motorized spindle system, this paper builds a simplified 3D model of spindle and bearing, performs structure modal analysis, reveals its dynamic characteristics under the free model; furthermore, modifies bearing radial stiffness and number of model and studies the change of modal parameters. On this basis, through the harmonic response analysis of the finite element model, dy- namic response characteristic caused by imbalance of monitored spindle system and law of vibration response to different amount of unbalance is analyzed.

Analysis of Thermal Characteristics for a High Speed Motorized Spindle Based on the ANSYS Workbench

The high-speed motorized spindle, as the key component of machining centers and other high-end CNC machine tools, has performance directly affecting machining accuracy. According to the internal motor character- istics of the high speed motorized spindle in the paper, two major heat sources are analyzed and quantity of heat is calculated. The finite element analysis model of motorized spindle thermal characteristics is built through ap- plying the ANSYS Workbench. The thermal steady state, heat-structure coupling characteristics is carried out based on the cooling coefficient of thermal boundary conditions, and taking heating value of the bearing and mo- tor as thermal load, the temperature field distribution and thermal deformation of the spindle system are obtained, which prepare fox＂ the next thermal error modeling

Testing and Analysis of Induction Motor Electrical Faults Using Current Signature Analysis

The proposed method deals with the emerging technique called as Motor Current Signature Analysis (MCSA) to diagnosis the stator faults of Induction Motors. The performance of the proposed method deals with the emerging technique called as Motor Current Signature Analysis (MCSA) and the Zero-Sequence Voltage Component (ZSVC) to diagnose the stator faults of Induction Motors. The unalleviated study of the robustness of the industrial appliances is obligatory to verdict the fault of the machines at precipitate stages and thwart the machine from brutal damage. For all kinds of industry, a machine failure escorts to a diminution in production and cost increases. The Motor Current Signature Analysis (MCSA) is referred as the most predominant way to diagnose the faults of electrical machines. Since the detailed analysis of the current spectrum, the method will portray the typical fault state. This paper aims to present dissimilar stator faults which are classified under electrical faults using MCSA and the comparison of simulation and hardware results. The magnitude of these fault harmonics analyzes in detail by means of Finite-Element Method (FEM). The anticipated method can effectively perceive the trivial changes too during the operation of the motor and it shows in the results.

Motion Analysis of an Electric Vehicle with Two Independent Drive Motors

Motion analyses are performed with the help of stability and simulation analysis, which can provide theoretical bases for applications of an electric vehicle with two independent drive motors. Compared with one-motor drive electric vehicle, the two-motor drive electric vehicle has the advantage of easy layout, simple power train and good drivability and handling characteristics. Analysis shows the method connecting armatures of two DC motors in parallel can function as mechanical differential without a steering sensor, which can simplify structure and increase reliability of the controller. Computer simulations and experiment are carried out to verify conclusions.

Effect of docosahexaenoic acid on the recovery of motor function in rats with spinal cord injury: a meta-analysis

Objective:Studies have shown that docosahexaenoic acid(DHA)has a beneficial effect in the treatment of spinal cord injury.A meta-analysis was used to study the effect of DHA on the neurological recovery in the rat spinal cord injury model,and the relationship between the recovery of motor function after spinal cord injury and the time and method of administration and the dose of DHA.Data source:Published studies on the effect of DHA on spinal cord injury animal models from seven databases were searched from their inception to January 2019,including PubMed,MEDLINE,EMBASE,the China National Knowledge Infrastructure,Wanfang,VIP,and SinoMed databases.The search terms included“spinal cord injury”“docosahexaenoic acid”,and“rats”.Data selection:Studies that evaluated the influence of DHA in rat models of spinal cord injury for locomotor functional recovery were included.The intervention group included any form of DHA treatment and the control group included treatment with normal saline,vehicle solution or no treatment.The Systematic Review Centre for Laboratory animal Experimentation’s risk of bias assessment tool was used for the quality assessment of the included studies.Literature inclusion,quality evaluation and data extraction were performed by two researchers.Meta-analysis was then conducted on all studies that met the inclusion criteria.Statistical analysis was performed on the data using RevMan 5.1.2.software.Outcome measures:The primary outcome measure was the score on the Basso,Beattie,and Bresnahan scale.Secondary outcome measures were the sloping plate test,balance beam test,stair test and grid exploration test.Results:A total of 12 related studies were included,3 of which were of higher quality and the remaining 9 were of lower quality.The highest mean Basso,Beattie,and Bresnahan scale score occurred at 42 days after DHA treatment in spinal cord injury rats.At 21 days after treatment,the mean difference in Basso,Beattie,Bresnahan scores between the DHA group and the control group was the most significant(pooled MD=4.14;95%CI=3.58–4.70;P<0.00001).In the subgroup analysis,improvement in the Basso,Beattie,and Bresnahan scale score was more significant in rats administered DHA intravenously(pooled MD=2.74;95%CI=1.41–4.07;P<0.0001)and subcutaneously(pooled MD=2.99;95%CI=2.29–3.69;P<0.00001)than in the groups administered DHA orally(pooled MD=3.04;95%CI=–1.01 to 7.09;P=0.14).Intravenous injection of DHA at 250 nmol/kg(pooled MD=2.94;95%CI=2.47–3.41;P<0.00001]and 1000 nmol/kg[pooled MD=3.60;95%CI=2.66–4.54;P<0.00001)significantly improved the Basso,Beattie,and Bresnahan scale score in rats and promoted the recovery of motor function.Conclusion:DHA can promote motor functional recovery after spinal cord injury in rats.The administration of DHA by intravenous or subcutaneous injection is more effective than oral administration of DHA.Intravenous injection of DHA at doses of 250 nmol/kg or 1000 nmol/kg is beneficial.Because of the small number and the low quality of the included studies,more high-quality research is needed in future to substantiate the results.

Biofeedback therapy improves motor function following stroke Meta-analysis of 14 articles from Chinese Medical Institutions

OBJECTIVE： To evaluate feasibility of biofeedback therapy in China Medical Institutions to improve dysfunction following stroke. DATA SOURCE： A computer-based online search of publications was conducted using the Vip and PubMed Databases to identify publications that addressed biofeedback. The search key words included ＂electromyogram＂, ＂biofeedback＂, and ＂stroke＂. In total, 81 articles were retrieved. DATA SELECTION： Studies closely related to biofeedback, or studies with contents recently published in the same study field or in authorized journals, were included. Duplicated articles were excluded. Following full-text retrieval of selected articles, a total of 14 articles were collected, which addressed randomized, controlled trials of biofeedback therapy for dysfunction after stroke. Methodological quality was assessed for randomized, controlled trials using criteria from Cochrane reviewers＇ handbook. Results were analyzed using Revman 4.2 software. MAIN OUTCOME MEASURES： Outcomes and evaluation indices were expressed by odds ratio （OR）, weighted mean difference （WMD）, and 95% confidence interval （95% CO. Potential publication bias was presented using the funnel plot. RESULTS： The study included 14 randomized, controlled trials of 1 147 patients. Following biofeedback therapy, meta-analysis results demonstrated that： （1） The total effective rate was significantly greater in the biofeedback therapy group compared with the control group [OR = 3.46, 95% Cl （2.09, 5.73）, P = 0.62]. （2） Electromyogram changes were better in biofeedback therapy patients compared to the control group [WMD= 22.31, 95% C/（17.19, 27.43）, P〈 0.001]. （3） Motor function was better in biofeedback therapy patients compared with the control group [WMD = 12.43, 95% CI （6.71, 18.16）, P 〈 0.001]. （4） Daily living activities were better in biofeedback therapy patients compared with the control group [WMD= 18.11, 95% C/（15.77, 20.44）, P= 0.36]. （5） Joint range of motion was better in biofeedback therapy patients compared with the control group [WMD = 6.43, 95% Cl （4.44, 8.41）, P = 0.77]. Sensitivity analysis also demonstrated similar results after eliminating articles that described unknown diagnostic criteria and statistical methods. CONCLUSION： Following stroke, biofeedback therapy for dysfunction was shown to result in significant and valid outcomes, increased motor function and electromyogram values, improved joint range of motion, and improved daily living activities.

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

Dynamical Analysis of DC Shunt Motor Powered by PV Generator Using Perturbation and Observation as MPPT Technique

This paper presents the perturbation and observation (P & O) algorithm as maximum power point tracking (MPPT) method for the dynamical analysis of DC shunt motor fed by photovoltaic generator at different solar irradiance levels. At each solar intensity, the maximum power point of current/voltage (I/V) characteristic of the PV generator is achieved by perturbation and observation algorithm. The nonlinear behavior of (I/V) characteristics of the PV generator at various solar intensities and the magnetization curve of the ferromagnetic material of the DC shunt motor are described by high order polynomial mathematical expression. The dynamical analysis of the DC shunt motor fed by PV generator at different solar intensity has been carried out, also the dynamical analysis of DC shunt motor is investigated at a step change in solar intensity levels with fixed load at motor.

Analysis of the Magnetic Flux Density, the Magnetic Force and the Torque in a 3D Brushless DC Motor

As permanent magnet motors and generators produce torque, vibration occurs through the small air gap due to the alternating magnetic forces created by the rotating permanent magnets and the current switching of the coils. The magnetic force can be calculated from the flux density by finite element methods and the Maxwell stress tensor in cy-lindrical coordinates. In this paper the magnetic flux density, the magnetic force and the torque of a real three dimen-sional brushless DC motor are simulated using Maxwell 3 D V 11.1.