Objective: In the manuscript titled “Liquid subcutaneous Levodopa-Carbidopa ND0612 effects on motor symptoms in individuals with Parkinson’s Disease: A systematic review and meta-analysis”, the objective was to con...Objective: In the manuscript titled “Liquid subcutaneous Levodopa-Carbidopa ND0612 effects on motor symptoms in individuals with Parkinson’s Disease: A systematic review and meta-analysis”, the objective was to conduct a systematic review with meta-analysis to investigate the effects ND0612 24-hour dosing regimen has on motor symptoms in individuals with Parkinson’s Disease (PD). Introduction: ND0612 is a novel minimally invasive continuous subcutaneous delivery system of liquid Levodopa-Carbidopa being investigated for the treatment of PD in individuals experiencing motor symptoms. Methods: A systematic literature search was conducted in PubMed, Cochrane, and EBSCO databases to identify randomized controlled trials investigating the effects of ND0612 on motor symptoms in individuals with PD. Outcomes included the Unified Parkinson’s Disease Rating Scale (UPDRS) Part II and Part III scores. Methodological quality was assessed using the Cochrane Grading of Recommendations Assessment, Development, and Evaluation approach. Meta-analysis was performed using a random effects model with the DerSimonian and Laird method to estimate the effects of the ND0612 24-hour dosing regimen on UPDRS Part II and Part III scores. Results: Three studies were included in our review. There were statistically significant reductions in UPDRS Part II scores (mean difference (MD) −3.299;95% confidence interval (CI) −3.438, −3.159) and in UPDRS Part III scores (MD −12.695;95% CI −24.428, −0.962) in the ND0612 24-hour dosing regimen. Results were based on very low certainty of evidence. Conclusion: Based on very low certainty evidence, the ND0612 24-hour dosing regimen is effective at improving motor symptoms in individuals with PD. Our findings suggest that ND0612 is more effective at improving UPDRS Part II and Part III scores in individuals with PD than other pharmacological and non-pharmacological treatments, warranting further study.展开更多
Background and Objective Since its initial report by James Parkinson in 1817,Parkinson’s disease(PD)has remained a central subject of research and clinical advancement.The disease is estimated to affect approximately...Background and Objective Since its initial report by James Parkinson in 1817,Parkinson’s disease(PD)has remained a central subject of research and clinical advancement.The disease is estimated to affect approximately 1%of adults aged 60 and above.Deep brain stimulation,emerging as an alternative therapy for end-stage cases,has offered a lifeline to numerous patients.This review aimed to analyze publications pertaining to the impact of deep brain stimulation on the motor pathway in patients with PD over the last decade.Methods Data were obtained from the Web of Science Core Collection through the library of Huazhong University of Science and Technology(China).The search strategy encompassed the following keywords:“deep brain stimulation”,“Parkinson’s disease”,“motor pathway”,and“human”,from January 1,2012,to December 1,2022.Additionally,this review visualized the findings using the Citespace software.Results The results indicated that the United States,the United Kingdom,Germany,and China were the primary contributors to this research field.University College London,Capital Medical University,and Maastricht University were the top 3 research institutions in the research area.Tom Foltynie ranked first with 6 publications,and the journals of Brain and Brain Stimulation published the greatest number of relevant articles.The prevailing research focal points in this domain,as determined by keywords“burst analysis”,“encompassed neuronal activity”,“nucleus”,“hyper direct pathway”,etc.Conclusion This study has provided a new perspective through bibliometric analysis of the deep brain stimulation therapy for treating patients with PD,which can shed light on future research to advance our comprehension of this particular field of study.展开更多
Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu...Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.展开更多
The present study reported a 42-year-old male patient who underwent conservative management for a spontaneous intracerebral hemorrhage in the left corona radiata and the basal ganglia. The patient presented with compl...The present study reported a 42-year-old male patient who underwent conservative management for a spontaneous intracerebral hemorrhage in the left corona radiata and the basal ganglia. The patient presented with complete weakness of the right upper and lower extremities at the onset of intracerebral hemorrhage; however, he showed progressive motor recovery to the level that he was able to extent the affected extremities against some resistance at 5 weeks after onset. The corticospinal tract of the affected (left) hemisphere connected to the left Broca's area at 3 weeks after onset as shown by diffusion tensor tractography. By contrast, this connection had disappeared at 5 weeks after onset as shown by diffusion tensor tractogaphy. Transcranial magnetic stimulation study showed that no motor evoked potential was elicited from the affected (left) hemisphere at 3 weeks after onset, but motor evoked potentials were elicited at 5 weeks after onset. These findings suggest that the connection between the injured corticospinal tract and Broca's area in this patient appears to be a compensation for severe motor weakness; consequently, the connection seems to disappear with motor recovery.展开更多
In order to study neurotransmitter receptor regulation in the basal ganglia involved in the functional changes underlying levodopa-induced motor complications, quantitative autoradiography was used to observe receptor...In order to study neurotransmitter receptor regulation in the basal ganglia involved in the functional changes underlying levodopa-induced motor complications, quantitative autoradiography was used to observe receptor bindings of dopamine D1 and D2, N-methyl-D-aspartate (NMDA), amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) and amino butyric acid (GABA) in the basal ganglia of rats that had unilateral nigrostriatal lesions and had been chronically treated with levodopa until motor complications developed. The rats were randomly assigned to three groups: normal, denervated and treatment-complicated groups. The results showed that response duration to levodopa became progressively shorter and abnormal involuntary movement (AIM) score was progressively increased during the course of levodopa treatment. Chronic treatment augmented D1 receptors more than denervation, and reduced D2 receptors that were also increased by dopamine denervation. Striatal NMDA receptors were substantially up-regulated in the treatment-complicated group. Levodopa treatment did not change receptors of nigral AMPA, pallidal GABA, and subthalamic GABA, which remained the same as that in denervation group. However, chronic treatment reversed the increase of nigral GABA receptors caused by the lesion. It was concluded that a shortening of response duration and AIM mimicked levodopa-induced motor complications of Parkinson's patients. These data suggested that up-regulation of dopamine D1 and NMDA receptors in the striatum leads to an imbalance of stimulation through the striatal output pathways, which is associated with levodopa-induced motor complications.展开更多
A new method to calculate the motor temperature rising in electric vehicle (EV) is proposed based on the stator resistance identification. The measure theory of the motor temperature rising with the stator resistanc...A new method to calculate the motor temperature rising in electric vehicle (EV) is proposed based on the stator resistance identification. The measure theory of the motor temperature rising with the stator resistance is discussed at first. An enhanced magnetism motor dynamic math model is built which is the research object. Then the resistance identification system model is built on the mutual model reference adaptive,system (MRAS) theory. The simulation diagram of the mutual MRAS model is constructed and the resistance identification performance is studied in different motor states. Simulation results indicate that the stator resistance identification model with the mutual MRAS is effective. At the same time, the identification of motor temperature rising is possible with the identification of the stator resistance.展开更多
There are many documented sex differences in the clinical course,symptom expression profile,and treatment response of Parkinson’s disease,creating additional challenges for patient management.Although subthalamic nuc...There are many documented sex differences in the clinical course,symptom expression profile,and treatment response of Parkinson’s disease,creating additional challenges for patient management.Although subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease,the effects of sex on treatment outcome are still unclear.The aim of this retrospective observational study,was to examine sex differences in motor symptoms,nonmotor symptoms,and quality of life after subthalamic nucleus deep brain stimulation.Outcome measures were evaluated at 1 and 12 months post-operation in 90 patients with Parkinson’s disease undergoing subthalamic nucleus deep brain stimulation aged 63.00±8.01 years(55 men and 35 women).Outcomes of clinical evaluations were compared between sexes via a Student’s t-test and within sex via a paired-sample t-test,and generalized linear models were established to identify factors associated with treatment efficacy and intensity for each sex.We found that subthalamic nucleus deep brain stimulation could improve motor symptoms in men but not women in the on-medication condition at 1 and 12 months post-operation.Restless legs syndrome was alleviated to a greater extent in men than in women.Women demonstrated poorer quality of life at baseline and achieved less improvement of quality of life than men after subthalamic nucleus deep brain stimulation.Furthermore,Hoehn-Yahr stage was positively correlated with the treatment response in men,while levodopa equivalent dose at 12 months post-operation was negatively correlated with motor improvement in women.In conclusion,women received less benefit from subthalamic nucleus deep brain stimulation than men in terms of motor symptoms,non-motor symptoms,and quality of life.We found sex-specific factors,i.e.,Hoehn-Yahr stage and levodopa equivalent dose,that were related to motor improvements.These findings may help to guide subthalamic nucleus deep brain stimulation patient selection,prognosis,and stimulation programming for optimal therapeutic efficacy in Parkinson’s disease.展开更多
This paper presents a novel idea of utilizing the reactional torque of the conventional electric motor as a linear output for propulsion in addition to the conventional torque output of the rotor. The idea is demonstr...This paper presents a novel idea of utilizing the reactional torque of the conventional electric motor as a linear output for propulsion in addition to the conventional torque output of the rotor. The idea is demonstrated by a theoretical proposal of linearizing the stator of one of the most used motors </span><span style="font-family:Verdana;">in Electrical Vehicles and Hybrid Vehicles</span><span style="font-family:""><span style="font-family:Verdana;">. The proposed Linear Stator Motor is a </span><span style="font-family:Verdana;">simple modification without involving any functional change of the conventional motor. Though theoretical, the indicated possible input </span><span style="font-family:Verdana;">energy saving of more than 75% as compared to the conventional motor is no surprise, as by linearizing the stator, an almost equal linear propulsion output is added to the conventional rotor output. In addition to this remarkable saving in input energy, the proposed Linear Stator Motor that suits all type</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> of vehicle</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;">, can maintain propulsion without the need for a mechanical transmission system. Also, in </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">case of watercraft and aircraft vehicles, no external mechanical propulsion drive system is required. It is just an internal force that can push the vehicle forward, backward</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> or laterally, while the conventional rotor output can be utilized for energy recovery by driving a DC generator.展开更多
Since the Modbus RTU wired communication protocol of Siemens variable frequency motors is unstable and lacks a protection mechanism, there is a risk of user information leakage. Aiming at the problems of insufficient ...Since the Modbus RTU wired communication protocol of Siemens variable frequency motors is unstable and lacks a protection mechanism, there is a risk of user information leakage. Aiming at the problems of insufficient flexibility of traditional defense methods and poor defense effects, The present work proposed a new dual detection method based on MODBUS RTU, which combines the dual monitoring mechanism of “Address Resolution Protocol (ARP) request detection” and “ARP response detection”. In order to improve detection efficiency, two real-time updated linear tables are introduced, which can effectively deal with the three ARP spoofing methods of updating the ARP buffer. Based on the analysis of the hidden dangers of the Modbus RTU wired communication protocol, a wired connection between the S7-1200 PLC and the variable frequency motor was established, and a real experimental platform was constructed to demonstrate the attack. The intensity of ARP attacks has gradually increased over time. Through comparative experiments with traditional defense methods, it is proved that the algorithm enhances the protocol mechanism in principle, and is more flexible and reliable than traditional methods.展开更多
Aiming at the torque and flux ripples in the direct torque control and the time-varying parameters for permanent magnet synchronous motor (PMSM), a model predictive direct torque control with online parameter estimati...Aiming at the torque and flux ripples in the direct torque control and the time-varying parameters for permanent magnet synchronous motor (PMSM), a model predictive direct torque control with online parameter estimation based on the extended Kalman filter for PMSM is designed. By predicting the errors of torque and flux based on the model and the current states of the system, the optimal voltage vector is selected to minimize the error of torque and flux. The stator resistance and inductance are estimated online via EKF to reduce the effect of model error and the current estimation can reduce the error caused by measurement noise. The stability of the EKF is proved in theory. The simulation experiment results show the method can estimate the motor parameters, reduce the torque, and flux ripples and improve the performance of direct torque control for permanent magnet synchronous motor (PMSM).展开更多
China develops solid fuelrocket technology completely de-pending on its own strength.Since the late 1950s,variouskinds of solid rocket engines de-veloped by the 4th Academy ofChina Aerospace Corporation(CASC)have been...China develops solid fuelrocket technology completely de-pending on its own strength.Since the late 1950s,variouskinds of solid rocket engines de-veloped by the 4th Academy ofChina Aerospace Corporation(CASC)have been used intomany positioning and recoveringtests of various satellites and over100 flight tests of various missileswith a 100% successful rate.InOctober,1982,especially,Chinasuccessfully launched a solid fuelrocket from a submarine underwater,which reflected China’shigh level in this field.China’scivilian solid rocket engines are asfollows:展开更多
A fuzzy sliding-mode control (FSMC) scheme based on T-S fuzzy models was proposed for the permanent magnet synchronous motor (PMSM) drive system to solve the speed tracking problem. A T-S fuzzy model was firstly forme...A fuzzy sliding-mode control (FSMC) scheme based on T-S fuzzy models was proposed for the permanent magnet synchronous motor (PMSM) drive system to solve the speed tracking problem. A T-S fuzzy model was firstly formed to represent the nonlinear system of PMSM. For converting the tracking control into a stabilization problem, a new control design was proposed to define the internal desired states. Then, the FSMC controller for PMSM system with parameter variation and load disturbance was designed based on the fuzzy model. The performance of the proposed controller was verified by experimental results on PMSM system. The results show that the FSMC scheme can drive the dynamics of PMSM into a designated sliding surface in finite time and guarantee the property of asymptotical stability. The information of upper bound of modeling errors as well as perturbations is not required when using the FSMC controller.展开更多
目的分析高-低频交互重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对中期帕金森病(Parkinson’s disease,PD)患者的影响。方法选取2019年9月至2022年3月到榆林市第二医院就诊的128例PD中期患者,随机分为高频组...目的分析高-低频交互重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对中期帕金森病(Parkinson’s disease,PD)患者的影响。方法选取2019年9月至2022年3月到榆林市第二医院就诊的128例PD中期患者,随机分为高频组、低频组、高-低频交互组及对照组,各32例。所有患者均接受PD常规药物治疗,高频组采用高频rTMS(10 Hz)治疗,低频组采用低频rTMS(1 Hz)治疗,高-低频交互组采用高-低频rTMS结合治疗,对照组接受rTMS假刺激干预。比较各组治疗前及治疗4周后的自主神经功能障碍情况、认知功能、运动功能、睡眠质量及日常生活能力量表(activity of daily living scale,ADL)。结果各组治疗4周后的PD自主神经症状量表(the scales for outcomes in Parkinson’s disease-autonomic,SCOPA-AUT)评分较治疗前明显降低,组间比较差异显著(P<0.05),且高-低频交互组的SCOPA-AUT评分显著低于对照组及低频组(P<0.05);治疗4周后各组蒙特利尔认知评估量表(montreal cognitive assessment scale,MoCA)评分较治疗前明显升高,但组间比较差异无统计学意义(P>0.05);治疗4周时,各组PD综合评分量表(unified Parkinson’s disease rating scale-Ⅲ,UPDRS-Ⅲ)评分及起立-行走-计时实验(time up and go test,TUGT)用时较治疗前明显降低,步速较治疗前显著加快,组间比较差异有统计学意义(P<0.05),以高-低频交互组最为显著;治疗4周时,各组PD睡眠量表(PD sleep scale,PDSS)评分较治疗前明显升高(P<0.05),以高-低频交互组最为显著;各组治疗4周时的ADL评分较治疗前明显提高,且高-低频交互组显著高于高频组、低频组及对照组(P<0.05)。结论高频(10 Hz)、低频(1 Hz)rTMS治疗PD疗效确切,其中高-低频交互治疗在改善患者自主神经功能损伤、运动功能及睡眠质量方面效果更佳,其对患者认知功能的干预效果还有待验证。展开更多
文摘Objective: In the manuscript titled “Liquid subcutaneous Levodopa-Carbidopa ND0612 effects on motor symptoms in individuals with Parkinson’s Disease: A systematic review and meta-analysis”, the objective was to conduct a systematic review with meta-analysis to investigate the effects ND0612 24-hour dosing regimen has on motor symptoms in individuals with Parkinson’s Disease (PD). Introduction: ND0612 is a novel minimally invasive continuous subcutaneous delivery system of liquid Levodopa-Carbidopa being investigated for the treatment of PD in individuals experiencing motor symptoms. Methods: A systematic literature search was conducted in PubMed, Cochrane, and EBSCO databases to identify randomized controlled trials investigating the effects of ND0612 on motor symptoms in individuals with PD. Outcomes included the Unified Parkinson’s Disease Rating Scale (UPDRS) Part II and Part III scores. Methodological quality was assessed using the Cochrane Grading of Recommendations Assessment, Development, and Evaluation approach. Meta-analysis was performed using a random effects model with the DerSimonian and Laird method to estimate the effects of the ND0612 24-hour dosing regimen on UPDRS Part II and Part III scores. Results: Three studies were included in our review. There were statistically significant reductions in UPDRS Part II scores (mean difference (MD) −3.299;95% confidence interval (CI) −3.438, −3.159) and in UPDRS Part III scores (MD −12.695;95% CI −24.428, −0.962) in the ND0612 24-hour dosing regimen. Results were based on very low certainty of evidence. Conclusion: Based on very low certainty evidence, the ND0612 24-hour dosing regimen is effective at improving motor symptoms in individuals with PD. Our findings suggest that ND0612 is more effective at improving UPDRS Part II and Part III scores in individuals with PD than other pharmacological and non-pharmacological treatments, warranting further study.
基金the National Natural Science Foundation of China(No.81873467 and No.81670240).
文摘Background and Objective Since its initial report by James Parkinson in 1817,Parkinson’s disease(PD)has remained a central subject of research and clinical advancement.The disease is estimated to affect approximately 1%of adults aged 60 and above.Deep brain stimulation,emerging as an alternative therapy for end-stage cases,has offered a lifeline to numerous patients.This review aimed to analyze publications pertaining to the impact of deep brain stimulation on the motor pathway in patients with PD over the last decade.Methods Data were obtained from the Web of Science Core Collection through the library of Huazhong University of Science and Technology(China).The search strategy encompassed the following keywords:“deep brain stimulation”,“Parkinson’s disease”,“motor pathway”,and“human”,from January 1,2012,to December 1,2022.Additionally,this review visualized the findings using the Citespace software.Results The results indicated that the United States,the United Kingdom,Germany,and China were the primary contributors to this research field.University College London,Capital Medical University,and Maastricht University were the top 3 research institutions in the research area.Tom Foltynie ranked first with 6 publications,and the journals of Brain and Brain Stimulation published the greatest number of relevant articles.The prevailing research focal points in this domain,as determined by keywords“burst analysis”,“encompassed neuronal activity”,“nucleus”,“hyper direct pathway”,etc.Conclusion This study has provided a new perspective through bibliometric analysis of the deep brain stimulation therapy for treating patients with PD,which can shed light on future research to advance our comprehension of this particular field of study.
基金supported by the National Natural Science Foundation of China,No.82071254(to WZ).
文摘Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.
基金a grant from Daegu Metropolitan City R&D Project
文摘The present study reported a 42-year-old male patient who underwent conservative management for a spontaneous intracerebral hemorrhage in the left corona radiata and the basal ganglia. The patient presented with complete weakness of the right upper and lower extremities at the onset of intracerebral hemorrhage; however, he showed progressive motor recovery to the level that he was able to extent the affected extremities against some resistance at 5 weeks after onset. The corticospinal tract of the affected (left) hemisphere connected to the left Broca's area at 3 weeks after onset as shown by diffusion tensor tractography. By contrast, this connection had disappeared at 5 weeks after onset as shown by diffusion tensor tractogaphy. Transcranial magnetic stimulation study showed that no motor evoked potential was elicited from the affected (left) hemisphere at 3 weeks after onset, but motor evoked potentials were elicited at 5 weeks after onset. These findings suggest that the connection between the injured corticospinal tract and Broca's area in this patient appears to be a compensation for severe motor weakness; consequently, the connection seems to disappear with motor recovery.
基金supported by a grant from the National Natural Science Foundation of China (No.30770753)
文摘In order to study neurotransmitter receptor regulation in the basal ganglia involved in the functional changes underlying levodopa-induced motor complications, quantitative autoradiography was used to observe receptor bindings of dopamine D1 and D2, N-methyl-D-aspartate (NMDA), amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) and amino butyric acid (GABA) in the basal ganglia of rats that had unilateral nigrostriatal lesions and had been chronically treated with levodopa until motor complications developed. The rats were randomly assigned to three groups: normal, denervated and treatment-complicated groups. The results showed that response duration to levodopa became progressively shorter and abnormal involuntary movement (AIM) score was progressively increased during the course of levodopa treatment. Chronic treatment augmented D1 receptors more than denervation, and reduced D2 receptors that were also increased by dopamine denervation. Striatal NMDA receptors were substantially up-regulated in the treatment-complicated group. Levodopa treatment did not change receptors of nigral AMPA, pallidal GABA, and subthalamic GABA, which remained the same as that in denervation group. However, chronic treatment reversed the increase of nigral GABA receptors caused by the lesion. It was concluded that a shortening of response duration and AIM mimicked levodopa-induced motor complications of Parkinson's patients. These data suggested that up-regulation of dopamine D1 and NMDA receptors in the striatum leads to an imbalance of stimulation through the striatal output pathways, which is associated with levodopa-induced motor complications.
基金Sponsored by the National"863"Program Project(2005AA501650)
文摘A new method to calculate the motor temperature rising in electric vehicle (EV) is proposed based on the stator resistance identification. The measure theory of the motor temperature rising with the stator resistance is discussed at first. An enhanced magnetism motor dynamic math model is built which is the research object. Then the resistance identification system model is built on the mutual model reference adaptive,system (MRAS) theory. The simulation diagram of the mutual MRAS model is constructed and the resistance identification performance is studied in different motor states. Simulation results indicate that the stator resistance identification model with the mutual MRAS is effective. At the same time, the identification of motor temperature rising is possible with the identification of the stator resistance.
基金support by the National Nature Science Foundation of China,Nos.81830033,61761166004(both to JGZ)。
文摘There are many documented sex differences in the clinical course,symptom expression profile,and treatment response of Parkinson’s disease,creating additional challenges for patient management.Although subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease,the effects of sex on treatment outcome are still unclear.The aim of this retrospective observational study,was to examine sex differences in motor symptoms,nonmotor symptoms,and quality of life after subthalamic nucleus deep brain stimulation.Outcome measures were evaluated at 1 and 12 months post-operation in 90 patients with Parkinson’s disease undergoing subthalamic nucleus deep brain stimulation aged 63.00±8.01 years(55 men and 35 women).Outcomes of clinical evaluations were compared between sexes via a Student’s t-test and within sex via a paired-sample t-test,and generalized linear models were established to identify factors associated with treatment efficacy and intensity for each sex.We found that subthalamic nucleus deep brain stimulation could improve motor symptoms in men but not women in the on-medication condition at 1 and 12 months post-operation.Restless legs syndrome was alleviated to a greater extent in men than in women.Women demonstrated poorer quality of life at baseline and achieved less improvement of quality of life than men after subthalamic nucleus deep brain stimulation.Furthermore,Hoehn-Yahr stage was positively correlated with the treatment response in men,while levodopa equivalent dose at 12 months post-operation was negatively correlated with motor improvement in women.In conclusion,women received less benefit from subthalamic nucleus deep brain stimulation than men in terms of motor symptoms,non-motor symptoms,and quality of life.We found sex-specific factors,i.e.,Hoehn-Yahr stage and levodopa equivalent dose,that were related to motor improvements.These findings may help to guide subthalamic nucleus deep brain stimulation patient selection,prognosis,and stimulation programming for optimal therapeutic efficacy in Parkinson’s disease.
文摘This paper presents a novel idea of utilizing the reactional torque of the conventional electric motor as a linear output for propulsion in addition to the conventional torque output of the rotor. The idea is demonstrated by a theoretical proposal of linearizing the stator of one of the most used motors </span><span style="font-family:Verdana;">in Electrical Vehicles and Hybrid Vehicles</span><span style="font-family:""><span style="font-family:Verdana;">. The proposed Linear Stator Motor is a </span><span style="font-family:Verdana;">simple modification without involving any functional change of the conventional motor. Though theoretical, the indicated possible input </span><span style="font-family:Verdana;">energy saving of more than 75% as compared to the conventional motor is no surprise, as by linearizing the stator, an almost equal linear propulsion output is added to the conventional rotor output. In addition to this remarkable saving in input energy, the proposed Linear Stator Motor that suits all type</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> of vehicle</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;">, can maintain propulsion without the need for a mechanical transmission system. Also, in </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">case of watercraft and aircraft vehicles, no external mechanical propulsion drive system is required. It is just an internal force that can push the vehicle forward, backward</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> or laterally, while the conventional rotor output can be utilized for energy recovery by driving a DC generator.
文摘Since the Modbus RTU wired communication protocol of Siemens variable frequency motors is unstable and lacks a protection mechanism, there is a risk of user information leakage. Aiming at the problems of insufficient flexibility of traditional defense methods and poor defense effects, The present work proposed a new dual detection method based on MODBUS RTU, which combines the dual monitoring mechanism of “Address Resolution Protocol (ARP) request detection” and “ARP response detection”. In order to improve detection efficiency, two real-time updated linear tables are introduced, which can effectively deal with the three ARP spoofing methods of updating the ARP buffer. Based on the analysis of the hidden dangers of the Modbus RTU wired communication protocol, a wired connection between the S7-1200 PLC and the variable frequency motor was established, and a real experimental platform was constructed to demonstrate the attack. The intensity of ARP attacks has gradually increased over time. Through comparative experiments with traditional defense methods, it is proved that the algorithm enhances the protocol mechanism in principle, and is more flexible and reliable than traditional methods.
文摘Aiming at the torque and flux ripples in the direct torque control and the time-varying parameters for permanent magnet synchronous motor (PMSM), a model predictive direct torque control with online parameter estimation based on the extended Kalman filter for PMSM is designed. By predicting the errors of torque and flux based on the model and the current states of the system, the optimal voltage vector is selected to minimize the error of torque and flux. The stator resistance and inductance are estimated online via EKF to reduce the effect of model error and the current estimation can reduce the error caused by measurement noise. The stability of the EKF is proved in theory. The simulation experiment results show the method can estimate the motor parameters, reduce the torque, and flux ripples and improve the performance of direct torque control for permanent magnet synchronous motor (PMSM).
文摘China develops solid fuelrocket technology completely de-pending on its own strength.Since the late 1950s,variouskinds of solid rocket engines de-veloped by the 4th Academy ofChina Aerospace Corporation(CASC)have been used intomany positioning and recoveringtests of various satellites and over100 flight tests of various missileswith a 100% successful rate.InOctober,1982,especially,Chinasuccessfully launched a solid fuelrocket from a submarine underwater,which reflected China’shigh level in this field.China’scivilian solid rocket engines are asfollows:
基金Project (60835004) supported by the National Natural Science Foundation of China
文摘A fuzzy sliding-mode control (FSMC) scheme based on T-S fuzzy models was proposed for the permanent magnet synchronous motor (PMSM) drive system to solve the speed tracking problem. A T-S fuzzy model was firstly formed to represent the nonlinear system of PMSM. For converting the tracking control into a stabilization problem, a new control design was proposed to define the internal desired states. Then, the FSMC controller for PMSM system with parameter variation and load disturbance was designed based on the fuzzy model. The performance of the proposed controller was verified by experimental results on PMSM system. The results show that the FSMC scheme can drive the dynamics of PMSM into a designated sliding surface in finite time and guarantee the property of asymptotical stability. The information of upper bound of modeling errors as well as perturbations is not required when using the FSMC controller.
文摘目的分析高-低频交互重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)对中期帕金森病(Parkinson’s disease,PD)患者的影响。方法选取2019年9月至2022年3月到榆林市第二医院就诊的128例PD中期患者,随机分为高频组、低频组、高-低频交互组及对照组,各32例。所有患者均接受PD常规药物治疗,高频组采用高频rTMS(10 Hz)治疗,低频组采用低频rTMS(1 Hz)治疗,高-低频交互组采用高-低频rTMS结合治疗,对照组接受rTMS假刺激干预。比较各组治疗前及治疗4周后的自主神经功能障碍情况、认知功能、运动功能、睡眠质量及日常生活能力量表(activity of daily living scale,ADL)。结果各组治疗4周后的PD自主神经症状量表(the scales for outcomes in Parkinson’s disease-autonomic,SCOPA-AUT)评分较治疗前明显降低,组间比较差异显著(P<0.05),且高-低频交互组的SCOPA-AUT评分显著低于对照组及低频组(P<0.05);治疗4周后各组蒙特利尔认知评估量表(montreal cognitive assessment scale,MoCA)评分较治疗前明显升高,但组间比较差异无统计学意义(P>0.05);治疗4周时,各组PD综合评分量表(unified Parkinson’s disease rating scale-Ⅲ,UPDRS-Ⅲ)评分及起立-行走-计时实验(time up and go test,TUGT)用时较治疗前明显降低,步速较治疗前显著加快,组间比较差异有统计学意义(P<0.05),以高-低频交互组最为显著;治疗4周时,各组PD睡眠量表(PD sleep scale,PDSS)评分较治疗前明显升高(P<0.05),以高-低频交互组最为显著;各组治疗4周时的ADL评分较治疗前明显提高,且高-低频交互组显著高于高频组、低频组及对照组(P<0.05)。结论高频(10 Hz)、低频(1 Hz)rTMS治疗PD疗效确切,其中高-低频交互治疗在改善患者自主神经功能损伤、运动功能及睡眠质量方面效果更佳,其对患者认知功能的干预效果还有待验证。