Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Objective: In the manuscript titled Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals with Parkinsons Disease: A Systematic Review and Meta-Analysis, the objective was to conduct a systematic review with meta-analysis to investigate the effects that Rasagiline has on motor and non-motor symptoms in individuals with PD. Introduction: Rasagiline is a second-generation monoamine oxidase-B (MAO-B) inhibitor used both as monotherapy and adjunctive therapy for Parkinsons Disease (PD). Methods: A systematic literature search and meta-analysis were performed with randomized control trials that investigated the effects of Rasagiline on motor and non-motor symptoms in individuals with PD. The systematic search was conducted in PubMed, Cochrane, and EBSCO databases. Methodological quality was assessed using the Cochrane Grading Recommendations Assessment, Development and Evaluation approach. Results: Fourteen studies were included in our review. There were trivial to small and statistically significant improvements in motor symptoms for individuals with PD treated with Rasagiline compared to placebo. Non-motor symptoms showed no significant improvement with Rasagiline compared to placebo in five of six meta-analyses. Results were based on very low to moderate certainty of evidence. Conclusion: 1 mg/day Rasagiline significantly improved Parkinsonian motor symptoms in individuals with PD compared with placebo. For all outcomes, the 1 mg/day Rasagiline group was favored over the placebo group.

面部运动疗法结合穴位按压治疗贝尔面瘫的临床观察

目的探讨运用面部运动疗法结合穴位按压治疗贝尔面瘫的有效性。方法 58例贝尔面瘫患者随机分为对照组(n=29)和观察组(n=29)。对照组进行常规治疗;观察组除常规治疗外,增加面部肌肉运动疗法和穴位按压治疗。治疗前、治疗2周和治疗4周时两组分别进行面神经功能评分和疗效评估。结果对照组平均治疗时间为(29.62±12.15)d,观察组为(25.63±11.56)d,两组相比无显著性差异(P>0.05)。两组总有效率为100%。对照组完全恢复率58.6%,观察组72.4%,但无显著性差异(P>0.05)。随着治疗时间的延长,两组面神经功能评分显著降低(F=176.578,P<0.001)。两组相比,仅治疗2周时观察组面神经功能评分低于对照组(P<0.05)。但观察组的面神经功能评分始终存在低于对照组的趋势。结论面部运动疗法结合穴位按压治疗有促进贝尔面瘫恢复的趋势。

Empirical Analysis on Rural Financial Development and Farmers' Income Increase in China

The growth of farmer＇s incomes is cIoseIy reIated to rural finance. The research analyzed the dynamic reIationship of rural financial deveIopment, efficiency and farmer＇s incomes based on VAR modeI, and the resuIts indicated that the ex-pansion of rural finance wouId stimuIate farmer＇s incomes in a Iong term, and the growth of rural financial efficiency significantIy improves farmer＇s incomes in a short term, instead of a Iong term. Hence, it is necessary to introduce more credit funds and social funds to rural areas, deepen rural financial system reform and acceIerate use rate of Ioan capital and enhance guidance for farmers and township enterprises in use of Ioan capitals.

Assessment of Land Comprehensive Carrying Capacity in Lin'an City

According to regional characteristics and the actual situation in Lin ’an City, an evaluation index system of land comprehensive carrying capacity composed of three support subsystems （eco-environment, social and economic carrying capaci-ties） containing 22 evaluation indexes was established to evaluate the comprehen-sive carrying capacity of land resource in Lin’an City during 2005-2012. Meanwhile, based on the target data of overal land use plan, the level of land comprehensive carrying capacity was predicted at the end of the plan period （2020） .The results showed that land comprehensive carrying capacity had a significant growth in Lin ’an from 2005 to 2012, and the development trend was basical y sustainable. The sub-systems also had been greatly improved, in which the constant improvement of ec-ological environment carrying capacity made the largest contribution to the constant raising of land comprehensive carrying capacity. The degree of coordination between the systems was poor, in which eco-environment carrying capacity had the maxi-mum growth, far more than the social and economic carrying capacities. According to the land comprehensive carrying capacity in 2020, utilization of land resources in Lin＆#39;an city can achieve sustainable development in general. Final y, proposals of im-proving comprehensive carrying capacity were put forward in terms of the enhance-ment of eco-environment protection, accelerating economic development and policy guidance.

功率分流式HEV电机参数动力性最优匹配

为解决功率分流式混合动力汽车在动力工况中受电机工作点制约系统无法同时发挥发动机和电机最大转矩的问题,提出以动力性最优为目标的双模式混合驱动系统电机参数匹配方法.基于双电机的转速、转矩与混合驱动系统的输入输出转速、转矩的关系,提出电机最高转速和峰值转矩的匹配方法.研究系统电功率分流特性与电机工作点的关系以及电机额定转速与电机输出转矩的关系,并提出电机额定转速的匹配方法.结合匹配实例分析两种模式下发动机和电机的工作状态.结果表明:提出的电机参数匹配方法可使系统同时发挥发动机和电机的最大转矩特性,实现了发动机与电机之间最优工作点的匹配,使系统获得最佳的动力特性.

A novel image encryption scheme based on Keplers third law and random Hadamard transform

In this paper, a novel image encryption scheme based on Keplers third law and random Hadamard transform is proposed to ensure the security of a digital image. First, a set of Kepler periodic sequences is generated to permutate image data, which is characteristic of the plain-image and the Keplers third law. Then, a random Hadamard matrix is constructed by combining the standard Hadamard matrix with the hyper-Chen chaotic system, which is used to further scramble the image coefficients when the image is transformed through random Hadamard transform. In the end, the permuted image presents interweaving diffusion based on two special matrices, which are constructed by Kepler periodic sequence and chaos system. The experimental results and performance analysis show that the proposed encrypted scheme is highly sensitive to the plain-image and external keys, and has a high security and speed, which are very suitable for secure real-time communication of image data.

Health-related quality of life in Parkinson's disease patients in northeastern Sicily, Italy An ecological perspective

Parkinson＇s disease has a negative impact on health-related quality of life in Parkinson＇s disease patients. Depression, cognitive impairment, coping strategies, dyskinesia, gait disorders and complications of dopaminergic drugs are the variables that most affect health-related quality of life. The ecological model of human development focuses attention on both individual and social environmental factors as targets for health interventions. From this perspective, the aim of this cross-sectional survey was to evaluate the influence of gender, family size and perceived autonomy on health-related quality of life in Parkinson＇s disease patients in nOrtheastern Sicily, Italy. Ninety Parkinson＇s disease patients, attending the Movement Disorders Clinic at IRCCS Centro Neurolesi ＂Bonino-Pulejo＂ （Messina）, were consecutively enrolled. The Unified Parkinson Disease Rating Scale motor subscale （UPDRS-Ⅲ） scores, the Parkinson Disease Questionnaire-39 Item scores （as a disease-specific measure of health-related quality of life）, scores on the Short Form （36） Health Survey Questionnaire （as a generic measure）, and answers to a brief checklist were recorded. A total of 85 Parkinson＇s disease patients （49% males and 51% females; mean age 70.8 ± 8.6 years mean UPDRS-Ⅲ 24.15 ± 6.55; mean disease duration 5.52 ± 4.65 years） completed the booklet of questionnaires. In the multivariate regression analysis, we included clinical and social variables as independent predictors of health-related quality of life. Our results suggest a potential compounding effect of ecological intrapersonal and interpersonal levels on health-related quality of life outcomes. Gender, self-evaluated autonomy and family size significantly impacted health-related quality of life. If quality of life is used as an indicator of treatment outcomes, an ecological perspective of the case history will be important to disclose relevant prognostic information and trigger personalized health care interventions.

快速组织处理试剂管理及控制系统设计

快速病理组织处理系统对临床快速诊断具有非常重要的意义,其中试剂管理子系统是整个系统的核心之一.本文采用带有大减速比的减速器配步进电机驱动自制的磁芯旋转开关,实现了试剂的精确和自动化管理.系统以STM32F103为核心控制芯片,在uC/OS平台上进行系统搭建及测试,实现了快速病理组织处理系统中试剂的自动管理、处理缸的清洗以及必要的恒温控制.

Improvement of the thermoelectric efficiency of pyrene-based molecular junction with doping engineering

In this study, the thermoelectric properties of pyrene molecule doped with boron and nitrogen atom at different sites of molecule are investigated using density functional theory and none-equilibrium Greens function formalism in the linear response regime. Our calculations show that when the impurities are added to the edge of the molecule, the anti-resonant peaks will appear in the transmission diagram in the vicinity of the Fermi energy level. So it increases the thermoelectric figure of merit of the system in comparison with the one that the impurity is located in the center of molecule. Additionally, the seebeck coefficient signs are not the same among the B, N, and N ＆ B doped devices, indicating that the types of the carriers can be changed with different types of doping.