AIM The study was aimed at the unknown mechanisms of gastrointestinal symptoms and accompanied malnutrition in patients following partial gastrectomy. METHODS Thirty six patients who had their gastric resection at...AIM The study was aimed at the unknown mechanisms of gastrointestinal symptoms and accompanied malnutrition in patients following partial gastrectomy. METHODS Thirty six patients who had their gastric resection at least five years ago and forty one normal controls were included in the study. Nutritional status as indicated by anthropometry measurements, glucose hydrogen breath test G HBT) before and after antibiotic treatment and mouth cecum transit time (MCTT) with lactose hydrogen breath test (L HBT) were simultaneously determined. The Student's t test was used for statistical analysis of all the data of the study. RESULTS Anthropometry measurements showed that decreased values (at least 10% lower than the ideal values) of body weight (BW), triceps skinfold thickness (TSF) and mid arm circumference (MC) were observed in 63 2%, 94 7% and 73 3% of the patients studied respectively. A positive result of 50g G HHBT was seen in 10 out of 26 patients (38 5%) who undertook the test. Six of the 9 patients with negative 50g G HBT were positive following a 80g G HBT. Hydrogen excretion in six patients with positive 50g or 80g G BHT were significantly decreased after antibiotic treatment. Further studies of 25 L BHT showed a significant difference of MCTTs either between the post gastrectomy patients with or without chronic diarrhea, or between patient and control groups, i.e., an average MCTT of 58 8, 85 7 and 105 9 minutes in each group. CONCLUSION Malnutrition was common in patients a few years after their gastrectomies. About forty percent of positive G HBT, and effective antibiotic treatment and reduced MCTT determination were observed in these patients. The results suggested that bacterial overgrowth and increased small bowel transit may play a role in the development of gastrointestinal symptoms and related malnutrition in patients following gastrectomy.展开更多
文摘AIM The study was aimed at the unknown mechanisms of gastrointestinal symptoms and accompanied malnutrition in patients following partial gastrectomy. METHODS Thirty six patients who had their gastric resection at least five years ago and forty one normal controls were included in the study. Nutritional status as indicated by anthropometry measurements, glucose hydrogen breath test G HBT) before and after antibiotic treatment and mouth cecum transit time (MCTT) with lactose hydrogen breath test (L HBT) were simultaneously determined. The Student's t test was used for statistical analysis of all the data of the study. RESULTS Anthropometry measurements showed that decreased values (at least 10% lower than the ideal values) of body weight (BW), triceps skinfold thickness (TSF) and mid arm circumference (MC) were observed in 63 2%, 94 7% and 73 3% of the patients studied respectively. A positive result of 50g G HHBT was seen in 10 out of 26 patients (38 5%) who undertook the test. Six of the 9 patients with negative 50g G HBT were positive following a 80g G HBT. Hydrogen excretion in six patients with positive 50g or 80g G BHT were significantly decreased after antibiotic treatment. Further studies of 25 L BHT showed a significant difference of MCTTs either between the post gastrectomy patients with or without chronic diarrhea, or between patient and control groups, i.e., an average MCTT of 58 8, 85 7 and 105 9 minutes in each group. CONCLUSION Malnutrition was common in patients a few years after their gastrectomies. About forty percent of positive G HBT, and effective antibiotic treatment and reduced MCTT determination were observed in these patients. The results suggested that bacterial overgrowth and increased small bowel transit may play a role in the development of gastrointestinal symptoms and related malnutrition in patients following gastrectomy.
