Analysis of 2547 cases of multiple myeloma (MM)reported in China in 1980s sbowed that the clinical manifestations are characterized by multipliey. High misdiagnosis rate (69%) and multiple complications.while the mono...Analysis of 2547 cases of multiple myeloma (MM)reported in China in 1980s sbowed that the clinical manifestations are characterized by multipliey. High misdiagnosis rate (69%) and multiple complications.while the monoclonal protein had more than 25immunological types, IgG myeloma was the commonest (43.1%). Light chain subgroup trended to have a higher intidence of renal demage (76.9%). Plasma cell leukemia evenetually developed in 30 cases. In order to improve diagnosis and avoid misdiagnosis, the key points are 1, to better the recognition of clinical features of MM. 2.Patient should reteive urine Bence-Jones Protein,immunoglobulins, immunoelectropbresis, bone X-ray and multiple site bone marrow puncture whenever one of such manifestations as unexplained anemia, skeletal pain,proteinuria, elevation of ESR, hyperviscosity syndrome,hypercalcemia, hyperuricemia, clevatiou of alkaline phosphatase, pathological fractures and diffuse osteoporosis, 3. Immuno-binding clectrophoresis and immunofluorence antibody detection should be done for suspected cases with normal immunoglobulin level.展开更多
文摘Analysis of 2547 cases of multiple myeloma (MM)reported in China in 1980s sbowed that the clinical manifestations are characterized by multipliey. High misdiagnosis rate (69%) and multiple complications.while the monoclonal protein had more than 25immunological types, IgG myeloma was the commonest (43.1%). Light chain subgroup trended to have a higher intidence of renal demage (76.9%). Plasma cell leukemia evenetually developed in 30 cases. In order to improve diagnosis and avoid misdiagnosis, the key points are 1, to better the recognition of clinical features of MM. 2.Patient should reteive urine Bence-Jones Protein,immunoglobulins, immunoelectropbresis, bone X-ray and multiple site bone marrow puncture whenever one of such manifestations as unexplained anemia, skeletal pain,proteinuria, elevation of ESR, hyperviscosity syndrome,hypercalcemia, hyperuricemia, clevatiou of alkaline phosphatase, pathological fractures and diffuse osteoporosis, 3. Immuno-binding clectrophoresis and immunofluorence antibody detection should be done for suspected cases with normal immunoglobulin level.
