参仙升脉口服液化学成分的UHPLC-Q Exactive Focus MS/MS快速分析

目的探究参仙升脉口服液的化学物质基础。方法利用超高效液相色谱-四极杆/静电场轨道阱高分辨质谱(UHPLC-Q Exactive Focus MS/MS)对参仙升脉口服液的化学成分进行整体、系统辨识。采用Thermo Accucore aQ C_(18)色谱柱(150 mm×2.1 mm,2.6μm),流动相0.1%甲酸水溶液(A)-甲醇(B)梯度洗脱,洗脱程序为0-13 min,5%-60%B;13-27 min,60%-95%B;27-30 min,95%B,流速0.3 mL·min^(-1),柱温30°C;质谱分析离子化方式为加热电喷雾离子化(H-ESI),扫描模式为正、负离子切换,扫描范围m/z 120-1800,碰撞能量30 eV、50 eV、70 eV。结果共鉴定出160个化学成分,包括29个黄酮类成分,24个有机酸类成分,21个生物碱类成分,19个萜类成分,15个苯丙素类成分,12个皂苷类成分和40个其他类成分;其中6个化学成分(芦丁、补骨脂苷、异补骨脂苷、补骨脂素、异补骨脂素和补骨脂酚)经对照品比对确认。结论该研究借助UHPLC-Q Exactive Focus MS/MS技术实现了参仙升脉口服液化学成分准确、快速、系统的分析和鉴定,为其化学物质基础的阐明和质量控制提供了重要依据。

Temperature rise induced by an annular focused transducer with a wide aperture angle in multi-layer tissue

In order to improve the operability and accuracy of high-intensity focused ultrasound （HIFU）, an annular focused transducer, whereby a B-ultrasound probe is placed in its center, is used to realize the real time monitoring and control of the treatment. In this paper, the spheroidal beam equation （SBE） was used to calculate the sound lield by an annular focused transducer with a wide aperture angle to first derive the heat deposition and the Pennes equation was used to calculate the temperature field in multi-layer tissue. We studied the effect of different parameters on the temperature of the tissues. The result shows that the focal length has a significant influence on both maximum liver temperature rise and skin temperature rise, and both increase with the increase in the focal length. When the frequency increases, the temperature rise first undergoes a rapid increase before gradually reaching a maximum, and then finally decreasing. The temperature rise increases while the inner radius decreases or the sound pressure increases. By choosing suitable parameters, the proper temperature rise both on the target tissue and skin via an annular tbcused transducer with a wide aperture angle can be obtained.

Simulation of thermal field induced by concave spherical transducer in multi-layer media

High intensity focused ultrasound(HIFU)therapy is an effective method in clinical treatment of tumors,in order to explore the bio-heat conduction mechanism of in multi-layer media by concave spherical transducer,temperature field induced by this kind of transducer in multi-layer media will be simulated through solving Pennes equation with finite difference method,and the influence of initial sound pressure,absorption coefficient,and thickness of different layers of biological tissue as well as thermal conductivity parameter on sound focus and temperature distribution will be analyzed,respectively.The results show that the temperature in focus area increases faster while the initial sound pressure and thermal conductivity increase.The absorption coefficient is smaller,the ultrasound intensity in the focus area is bigger,and the size of the focus area is increasing.When the thicknesses of different layers of tissue change,the focus position changes slightly,but the sound intensity of the focus area will change obviously.The temperature in focus area will rise quickly before reaching a threshold,and then the temperature will keep in the threshold range.

Selection Method of Multi-Objective Problems Using Genetic Algorithm in Motion Plan of AUV

To research the effect of the selection method of multi-objects genetic algorithm problem on optimizing result, thismethod is analyzed theoretically and discussed by using an autonomous underwater vehicle(AUV) as an object. A changingweight vtlue method is put forward and a selection formula is modified. Some experiments were implemented on an AUV.TwinBurger. The results shows that this method is effective and feasible.

Multi-features Based Approach for Moving Shadow Detection

In the video-based surveillance application, moving shadows can affect the correct localization and detection of moving objects. This paper aims to present a method for shadow detection and suppression used for moving visual object detection. The major novelty of the shadow suppression is the integration of several features including photometric invariant color feature, motion edge feature, and spatial feature etc. By modifying process for false shadow detected, the averaging detection rate of moving object reaches above 90% in the test of Hall-Monitor sequence.

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

Short Baseline Positioning with an Improved Time Reversal Technique in a Multi-path Channel

在水下面的一条多路径隧道的存在极大地减少放系统的短基线的精确性。在这份报纸，到放系统的短基线的一面时间颠倒镜子的申请被调查。时间颠倒镜子技术允许声学的信号更好集中在未知环境，它有效地减少了多路径的扩大声学的信号象一样改进了集中的信号。时间颠倒操作员的 signal-to-noise 比率(SNR ) 极大地增加了并且能被 ensonifying 获得水。这种技术被环境并且因此少些影响对复杂的浅水环境更适用。数字模拟和水池实验被用来表明这种技术的效率。

A Comparative Study of Acute Hemodynamic Effects of Multi -site Cardiac Pacing in patients with cardiac function NYHA class ⅠtoⅡ without bundle branch block

Objective To compare the acute hemodynamic effects of five different pacing modes in patients with cardiac function NYHA class Ⅰ to Ⅱ without bundle branch block (BBB). Methods This study included 12 patients (SSS 7, Ⅲ°AVB 5) undergoing pacemaker implantation. Right ventricular apex (RVA), right ventricular outflow tract (RVOT), right ventricular bifocal (RV-Bi), left ventricular base (LVB) and bi -ventricular (Bi-Ⅴ) pacing at 60 -80 ppm were done in VVI mode prior to implantation of DDD pacemaker. The cardiac index (CI), mean pulmonary artery pressure (mPAP) and pulmonary capillary wedge pressure (PCWP) were measured with Swan - Ganz thermodilution catheter after 5 minutes of each pacing mode. Results (1) Comparing to pacing at RVA (CI: 2. 41± 0. 38 L/min per m2, PCWP: 16. 7 ±3.3 mmHg), the CI increased and the PCWP decreased significantly in pacing at RVOT(CI: 2. 63 ± 0.46, PCWP: 13. 8±2. 3), LVB(CI: 2. 78±0.52, PCWP: 14. 4±3.1), RV-Bi(CI: 2. 83±0.57, PCWP: 12. 8± 2. 5) and Bi -Ⅴ pacing (CI: 2. 94± 0.60, PCWP: 12. 7±2. 5), P < 0. 01, respectively. (2) The CI of RV-Bi and Bi-Ⅴ pacing was higher than that of RVOT and LVB pacing, the PCWP was lower, P < 0. 05, respectively. (3) There was no significant difference between RV - Bi pacing and Bi-Ⅴ pacing in CI and PCWP. Conclusion There is no significant difference between RV - Bi pacing and Bi -V pacing in the acute hemodynamic effects; however,dual - site pacing is much better than single site pacing in that aspect for patients with cardiac function NYHA class Ⅰ to Ⅱ without BBB. Among single site pacing, the RVOT and LVB pacing is better than RVA pacing in cardiac function.

Research on A Master - slave Multi - microcomputers Control System for Hollow Spindle Fancy Yarn Spinning Machine

In this paper, a successfully studied and developed master - slave muld - microcomputers control system based on PC - BUS for hollow spindle fancy yarn spinning machine, mainly Its overall scheme, software and hardware construction, is introduced. Spinning experiments show that the system achieves satisfactory result. This system can solve the diftkultles of mechatronical fusion between domestic hollow splndk fancy yarn spuming muchine and its microcomputer control technology.

On the Representation of Multi-layer Woven Structure

A quantitative method is developed to identify the structures of multi-layer woven fabric in this study. Six structural parameters are selected to represent the fabric structure. With some design criteria for the reinforcement of textile composites, the relationships among the structural parameters are derived for different binding patterns of the fabric structure. The conditions, which meet the requirements of structural cell stability,are also discussed.

Computer-aided Pattern Design of Multi-bar Warp Knitted Fabrics

To meet the development trend of multi-bar warp knit-ting machine towards high-speed,advanced technologyand computer control and the requirements of variousproducts with small quantity,there are many researcheson the computer-aided pattern design of multi-barwarp knitted fabrics.In terms of the special propertiesof the computer-aided pattern design of multi-barwarp knitted fabrics,the Object Oriented Program(OOP)programming-Object Windows class Library(OWL)programming is selected.According to thecharacters of the OWL programming,various functionsare defined.Pattern design and technical parameters canbe output,which offers a great convenience for the fac-tory.

RECENT PROGRESS IN MULTI-BEAM KLYSTRON IN IECAS

Recent research progresses in Multi-Beam Klystron (MBK) in IECAS are briefly introduced in the letter. The S-band MBKs of IECAS have peak power of 120-250 kW, average power of 4-9 kW, efficiency of 35-45%, gain of 41-46 dB, beam voltage of 15-19 kV, and weight of 40-45 kg. Some key technical problems of MBK are also described and discussed. Among them,improving the design of MBK to obtain the required bandwidth, raising beam transmission to increase average power, eliminating oscillation and spray spectrum, overcoming window breakdown caused by magic mode, reducing breakdown times of electrongun, are most important things for the practical MBK. Besides, further research work in MBK in IECAS is commented.

电子制冷预浓缩-双柱气相色谱-质谱/氢火焰检测器法测定空气中104种挥发性有机物

基于吸附剂辅助电子制冷预浓缩技术,建立了多维切割双柱气相色谱-质谱/氢火焰离子化检测器(GC-MS/FID)同时测定环境空气中104种挥发性有机物(VOCs)的方法。将采集于苏玛罐中的环境空气样品在配有吸附剂的电子制冷预浓缩系统中富集、脱附、除水、除CO_2和浓缩,然后通过GC-MS/FID的多维切割单元将C_2～C_3组分和C_4～C_(12)组分分别引入PLOT柱和InterCap-624柱进行分离。C_2～C_3组分用FID检测,以保留时间定性、外标法定量;C_4～C_(12)组分采用电子轰击离子源质谱检测,以保留时间和特征离子定性、内标法定量。考察了冷阱吸附剂种类、辅助压力控制单元压力设置、双柱切换时间切割点等参数对分析结果的影响,优化了GC-MS/FID条件,并评估了在此优化条件下的方法性能。104种VOCs在0.044 6～0.892μmol/m^3范围内线性关系良好,相关系数(r)为0.998 4～0.999 9,对0.044 6μmol/m^3和0.223μmol/m^3水平的混合标准气体重复6次进样,平均回收率为86.4%～116.1%,相对标准偏差为0.9%～11.3%;方法的检出限为0.145～1.90μg/m^3,定量限为0.435～5.70μg/m^3。该法稳定性好,灵敏度高,操作简便,可用于环境空气中104种VOCs的测定。

基于光声-超声协同的多模成像系统

光声成像兼具声学成像和光学成像两者的优势,在生物医学领域表现出巨大的应用前景。实时成像、多模成像满足了对动态生理过程实时监控的需求,提高了临床诊断准确率,因而是生物医学成像技术发展的重要趋势。本项目拟集成光声-超声技术,在实现光声-超声双模实时成像的基础上,充分挖掘光声-超声两者物理效应的协同机制,解决两者不能独立解决时变复杂声学环境中的成像难题,实现两者不具备的新功能。本项目的研究顺应生物医学成像发展潮流,赋予光声-超声技术新的功能和应用空间,对于增强我国数字诊疗装备的技术竞争力具有积极意义。

基于智能多终端质量控制系统的聚焦功能在临床护理质量管理中的应用

目的:探讨基于智能多终端质量控制系统的聚焦功能在临床护理质量管理中的应用效果。方法:选择2020年7—12月南京医科大学第一附属医院统计系统运行前的170个护理单元的护士长及415名护士设为运行前组,选择2021年7—12月基于智能多终端质量控制系统的聚焦功能运行后的170个护理单元的护士长及415名护士设为运行后组,比较两组的临床护理问题发现率、护理质量管理效率、护士知晓三级护理质控检查结果的时间、护理人员对质控方式满意度。结果:运行后组的问题发现率和巡查执行率结果均高于运行前组,差异有统计学意义(P<0.05)。运行后组计划制定耗时、信息录入耗时、统计分析各环节耗时均短于运行前组,差异有统计学意义(P<0.05)。运行后组护士知晓范围大于运行前,知晓时间短于运行前组,差异有统计学意义(P<0.05);运行后组护士对质控的满意度高于运行前组,差异有统计学意义(P<0.05)。结论:基于智能多终端质量控制系统的聚焦功能让护理质量管理环节质控和过程质控简单化,节约了护理管理时间,有效提高了质量管理效率,提升了护理风险管理,促进了科学决策、智能管理,并提高了护士对质控的满意度。

紫外-可见光谱水质检测系统的多束LED光纤耦合研究

针对紫外-可见光谱水质检测系统单个LED光源输出功率低、光束质量差的问题,提出了一种多束紫外LED光源与光纤合束耦合的结构设计方案。运用ZEMAX光学分析软件开展了仿真设计研究,针对紫外LED光源与光纤耦合发散角较大的问题,设计了非球面准直透镜,准直后发散角为0.403mrad;针对光束尺寸与光纤的匹配问题,进行了消色差双分离聚焦耦合透镜的设计。实验结果表明,合束LED光束汇聚的弥散斑的RMS尺寸为186.412μm,GEO点尺寸为290.071μm,光束中95%以上的能量集中在300μm以内,实现了多束LED光源与光纤的高效耦合。

多向聚焦波作用下透水潜堤消波特性数值模拟研究

本文采用非静压模型NHWAVE建立高精度三维波浪数值水槽,对多向聚焦波作用下透水和不透水潜堤消波特性进行数值模拟研究。通过计算结果与实验数据的对比,验证了该模型模拟多向聚焦波产生传播及多孔介质内流动的能力,进一步考虑了有效波高、水深、谱峰周期和传播角度等因素对潜堤消波特性的影响。结果表明:潜堤对多向聚焦波的最大波幅、最大水位、沿水深平均最大流速和波能均有显著消减作用,且透水潜堤因孔隙介质的存在消波性能更好。随着有效波高增大,堤顶处波浪破碎点前移,不透水潜堤消波性能受波高影响较大。水深越大,潜堤消波性能越低。透水潜堤对长周期波浪消减效果较差。传播角度越小,聚焦位置处波幅越大,波浪非线性作用越强。研究结果可为我们进一步保护沿海设施免受极端海洋环境的影响提供一定的参考。

基于TR的SIMO-UWB系统空间复用预编码器设计

针对单输入多输出超宽带(SIMO-UWB)系统中多码流干扰和符号间干扰的问题,提出功率受限的时间反演(TR)块对角化-最小均方误差(TR-BD-MMSE)预编码器以抑制干扰。预编码器是基于TR的空时聚焦特性,采用缩短的等效信道设计,并将预滤波器和预编码器进行级联,置于SIMO-UWB系统的发射端,最后使用标准UWB信道模型进行仿真实验。仿真结果表明:该方案不仅可以降低UWB接收机的复杂度,而且能够对抗SIMO-UWB系统的符号间干扰和多码流干扰,提升SIMO-UWB系统容量。

多靶点重复经颅磁刺激联合目标导向式功能锻炼在脑出血患者康复治疗中的应用

目的探讨多靶点重复经颅磁刺激(MTF-rTMS)联合目标导向式功能锻炼在脑出血患者康复治疗中的应用效果。方法78例脑出血患者随机分为两组,对照组采用目标导向式功能锻炼进行干预,研究组在对照组基础上进行MTF-rTMS干预,比较两组的步态情况、神经功能和日常生活能力。结果干预后,研究组的步频、步速高于对照组,步幅大于对照组(P<0.05)。干预后,研究组的NIHSS评分低于对照组,BI评分高于对照组(P<0.05)。结论MTF-rTMS联合目标导向式功能锻炼在脑出血患者康复治疗中的应用效果较好,可改善患者的步态情况、神经受损情况,提高患者的日常生活能力。